Nature Communications
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2026
·
IF 18.1
Liu Andeng,Luo Yingjin,Zou Yuxi,Li Shengyou,Dong Yixin,Sun Lan,Yang Yun,Zhou Hao,Ye Meidan,Guo Wenxi
Protein hydrogels are highly valued for their biocompatibility and biodegradability, yet their practical use has been limited by poor mechanical strength and dehydration. Polymer‒water interactions govern hydrogel mechanics, whereas dehydration causes failure, rendering water retention and hydration-mediated mechanics critical research focuses. Here, we introduce an ion-mediated hydration engineering (IMHE) strategy that reworks the aqueous states within silk fibroin hydrogels via controlled dehydration‒rehydration. This process converts free water into bound water, which enhances chain mobility and stabilizes hierarchical structures. The resulting hydrogel (HSF-MIN) exhibits distinct properties: a 186-fold increase in compressive strength (5.6 MPa), nearly 100% compressible deformation, superelasticity, and long-term stability (maintaining ~80% hydration over 1 year) while maintaining low hysteresis (<5%). These enhancements enable long-term high-performance sensing using low-hysteresis pressure sensors and high-fidelity bioelectric acquisition. We further introduce a water‒polymer interaction model to elucidate the strength‒elasticity synergy. Notably, IMHE also has universality in gelatin hydrogels, thus providing a way for the preparation of high-performance hydrogels.
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BIOMATERIALS
·
2026
·
IF 13.6
Xianghang Chen,Beini Wang,Jiayan Hui,Wei Shen,Longyang Xu,Anwen Lai,Rong Huang,Fuyi Yan,Qimin Yao,Zheng Zhang,Jie Xu,Xiong Cai,Fenzan Wu,Siwang Hu,Jian Xiao,Zhenglin Li
Spinal cord injury (SCI) causes pathological extracellular matrix (ECM) deposition and tissue stiffening, impeding axonal regeneration and disrupting homeostasis. Galardin-mediated inhibition of matrix metalloproteinases reduces ECM deposition and promotes recovery, but systemic administration fails to adequately address local microenvironment deterioration. We therefore explore a localized biomaterial delivery strategy via regulating the crosslinking degree of hydrogel matrix, in which high-crosslinking density of hydrogel (HCGH) tends to exacerbate neuroinflammation via Piezo1 activation as well as Wwtr1-dependent macrophage reprogramming. Based on this, we fabricate an integrated therapeutic platform where pH-responsive curcumin-succinate self-assembled prodrug nanoparticles (co-loaded with Galardin and basic fibroblast growth factor, denoted as CrS-GF NPs) are encapsulated in a low-crosslinking hydrogel (LCGH). By thorough testing on the compression spinal cord injury model of mice, the LCGH@CrS-GF system not only modulates excessive ECM deposition and neuroinflammation, but also provides sufficient neurotrophic support, thereby facilitating smooth axonal regeneration and functional restoration of the damaged spinal cords in a collaborative manner. Our study highlights the importance of using hydrogels with tailored crosslinking density to deliver therapeutics for SCI repair by stimulating beneficial biological responses and manipulating ECM deposition.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Baoqi Ding,Susu Zhang,Wenju Jiang,Wenxin Qu,Yuan Tan,Zhiwei Ding,Weizhe Tian,Ye Yuan,Chunguang Ren,Zongliang Liu,Qun Liu
A hydrogel loaded Chlorella and berberine was constructed based on carboxymethyl chitosan, κ-carrageenan and silk fibroin. • The hydrogel exhibited excellent sustained oxygen-producing capacity. • The hydrogel demonstrated remarkable antibacterial activity and high biocompatibility. • The hydrogel can facilitate wound healing and promote tissue regeneration. Hypoxia and bacterial infection synergistically impede skin wound healing, posing significant clinical challenges. Conventional oxygen-releasing agents and antimicrobial agents are constrained by poor biocompatibility and the emergence of drug resistance. Consequently, the development of biocompatible, non-resistance-inducing oxygen-releasing antimicrobial wound dressings is of paramount importance. This study presents a κ-carrageenan (κ-Cr)/carboxymethyl chitosan (CMCS) hydrogel wound dressing loaded with Chlorella and berberine (BBR). Chlorella facilitates stable and sustained oxygen release with excellent biocompatibility, while berberine exhibits broad-spectrum antimicrobial activity without inducing drug resistance. In vitro experiments reveal that under light conditions, the hydrogel releases a cumulative 8 mg/mL of oxygen within 8 h and reduces bacterial viability to 2%, demonstrating excellent sustained oxygen-release and antimicrobial properties. The hydrogel matrix, formed via electrostatic cross-linking of κ-carrageenan and carboxymethyl chitosan, enhances adhesive performance, endowing the dressing with outstanding mechanical properties and skin adhesiveness. In vivo studies using a rat full-thickness skin wound model demonstrate the hydrogel's remarkable wound-healing efficacy: the wound healing rate reaches 98% by day 10, highlighting the hydrogel's ability to accelerate wound repair. Overall, this multifunctional hydrogel wound dressing holds substantial promise in the field of skin wound healing and provides a promising therapeutic strategy for patients with complex healing needs.
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FOOD CHEMISTRY
·
2026
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IF 10.4
Mengting Zhao,Yingxue Tang,Xiaoyu Yin,Majida AL-Wraikat,Junfeng Fan,Xiangning Chen,Bolin Zhang
This study develops MOF patches for controlled NO release in produce preservation. • MOF loading effectively protects NO donors from loss during wet-casting fabrication. • Three metal-node MOF patches enable differential NO release profiles. • Patch integrates moisture absorption, microorganism and respiration inhibition. • MOF patches significantly extend produce shelf life while reducing precursor loss. Nitric oxide (NO) preservation suffers from instability and safety issues via conventional single-exposure treatments, while wet-casting methods cause substantial NO donor loss. This study developed metal-organic framework (MOF)-mediated controlled-release patches to address these limitations. Three MOFs (Cu-MOF, Zn-MOF, Fe-MOF) with distinct pore structures were synthesized, achieving 26.9%–38.2% L-arginine loading. The resulting gelatin-polyacrylic acid sodium hydrogel patches exhibited tensile strength of 3.03–4.84 MPa and elongation at break of 131.3%–240.1%, and dissolution rates of 12.4%–17.2%. They also showed significant antimicrobial activity against E. coli, S. aureus, and A. niger . MOF loading elevated precursor utilization efficiency to 70%–82.5%. The patches achieved sustained release of H₂O₂ (8.0–9.6 mmol/g) and NO (41.7–50.6 ppm) over 12 days, extending cherry tomato shelf life to 12 days at room temperature while maintaining total bacterial levels within safe limits. This work establishes MOF-mediated controlled release for green preservative gas utilization. Download: Download high-res image (189KB) Download: Download full-size image
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ACS Nano
·
2026
·Vol. 20
·期 29
·20892-20908
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IF 17.3
He Yang,Zhao Jieling,Sun Hongqiang,Zhang Zhen,Xu Junbo,Yang Guang,Li Xilin,Zhou Shaobing
Small-diameter vascular grafts (SDVGs) are indispensable
devices
for clinical revascularization. However, their efficacy is compromised
by acute thrombosis and restenosis, which ultimately jeopardize sustained
patency. To address this challenge, we developed a bifacially micropatterned
nanofibrous SDVG (BMN-SDVG) with distinct topographies tailored for
its luminal and abluminal surfaces. The luminal square micropatterns
selectively promote rapid endothelial coverage and functional maturation,
thereby establishing an antithrombogenic endothelial monolayer. Simultaneously,
the abluminal groove micropatterns guide the circumferential alignment
and contractile differentiation of smooth muscle cells to prevent
restenosis. In an abdominal aorta interposition model, the BMN-SDVG
maintained 100% patency with physiological blood flow velocity, demonstrating
robust vascular regeneration during the critical early remodeling
phase. This spatially orchestrated dual-layer BMN-SDVG offers a clinically
translatable solution for sustained SDVG patency.
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BIOMACROMOLECULES
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2026
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IF 5.9
Wang Junpeng,Hao Feijing,Xu Chengwei,Lin Kai,Wang Hongxiang,Xing Yuanyuan,Liu Wentao,Liu Hao,Li Na,Xia Weidong
Infected
diabetic wounds are complicated by bacterial infection,
oxidative stress, and hyperglycemia, limiting conventional monotherapies.
Combination therapies suffer from uncontrolled release and poor responsiveness
to pathological cues. Here, we report a nanoparticle-cross-linked
hydrogel that integrates structural integrity with environment-triggered
delivery. We utilized self-assembled epigallocatechin gallate (EGCG)-tobramycin
(TOB) nanoparticles as dynamic cross-linkers within a phenylboronic
acid-modified gelatin network. The engineered system provides dual-stage
responsiveness: the hydrogel disassembles under the hallmark hyperglycemic
and acidic conditions of diabetic wounds, releasing the nanoparticles,
which then dissociate under acidity to synchronize drug release. Such
sequential disassembly acts as a synergistic “one-two punch,”
allowing EGCG to scavenge ROS and remodel the inflammatory microenvironment,
while TOB provides prolonged antibacterial action. In vivo , the system significantly reduced bacterial load, accelerated epithelial
regeneration, and promoted high-quality wound healing. By seamlessly
coupling nanocontrolled release with microenvironmental sensing, we
present a precision-engineered platform for the synergistic treatment
of recalcitrant diabetic wounds.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
·
IF 8.7
Xiaoming Zhang,Shuxia Wu,Cheng Tang,Ziyue Yang,Wenjuan Wang,Yujuan Xu,Cong Li,Hui Zhou,Baocai Xu
Three polysaccharides were incorporated into MTGase-mediated MP gel systems. • Conformational changes of composite MP gels depended on polysaccharide ionic types. • Combined addition promoted water entrapment effect in composite MP gels. • Cationic CS were the most effective at improving WHC and texture properties of MP gels. Myofibrillar protein (MP) gels with desirable textural properties are highly favored by consumers. In the present study, the effects of different charged polysaccharides, including neutral dextran (DX), anionic κ -carrageenan (KC) and cationic chitosan (CS), on the thermal gelation properties of microbial transglutaminase (MTGase)-mediated MP were investigated. The results suggested that the thermal gelation characteristics of the composite gel systems formed by combining MTGase with each of the three polysaccharides were improved, regardless of polysaccharide charge types. Furthermore, cationic CS was the most effective in increasing water-holding capacity (WHC), texture properties, and viscoelastic characteristics of the composite gels, followed by neutral DX and then anionic KC. Based on the results of water status and distribution, the incorporation of the three polysaccharides strengthened the water entrapment effect of MTGase-mediated MP gel networks. Additionally, cationic CS displayed the greatest effect on driving the generation of β-sheet structures, facilitating the formation of disulfide bonds and enhancing hydrophobic interactions, thereby contributing to the formation of a uniform and well-organized gel matrix. These findings provide theoretical support for formulation optimization and quality improvement of meat products by modulating MP during thermal processing. Download: Download high-res image (178KB) Download: Download full-size image
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2026
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IF 9.6
Gaoyi Zheng,Yanjun Yu,Cancan Shan,Yingtong Guo,Mei Cui,Renliang Huang,Wei Qi,Rongxin Su
Skin-adhered electrocardiography (ECG) demands electrodes that maintain low and stable skin–electrode coupling during motion while remaining soft, adhesive, and, ideally, transparent for accurate placement. However, conductive hydrogels rarely combine optical transparency with electronic conductivity because conductive polymers such as polypyrrole (PPy) aggregate in water. Herein, we develop a transparent, self-adhesive hydrogel bioelectrode enabled by incorporating APS-pretreated polypyrrole-phosphorylated cellulose nanofibers (PPy-PCNF) into a crosslinked poly(acrylic acid)/gelatin (PAA/Gel) network. PCNF serves as a charged nanofibrous scaffold that stabilizes PPy in water, while APS-assisted radical pretreatment reduces the apparent size of PPy-rich aggregates and yields an optically clearer conductive dispersion. The PAA/Gel matrix integrates covalent crosslinking with reversible hydrogen bonding and electrostatic interactions, enabling mechanical compliance and durable skin adhesion. The optimized hydrogel achieves >700% stretchability, 21.8 kPa skin adhesion and 2.26 S·m −1 conductivity; optical transmittance at 660 nm (2 mm thickness) decreases from 56.8% to 22.6% as PPy-PCNF loading increases. When applied as a self-adhered ECG electrode, it captures clear cardiac waveforms with signal quality comparable to commercial Ag/AgCl electrodes, enabling continuous heart-rate readout under rest and motion. Overall, this work provides a scalable dispersion-and-network strategy to unify transparency, adhesion, and electronic conduction in wearable hydrogel bioelectrodes for stable electrophysiological monitoring. Download: Download high-res image (175KB) Download: Download full-size image
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
·
IF 15
Miao Dazhuang,Suo Xiaopeng,Geng Xinqian,Yang Ying,Wang Gaoming,Zhou Yang,Jia Yunhe,Yang Shuofei,Li Heping,Li Gaohua
Diabetic wounds are characterized by persistent inflammation, impaired angiogenesis, and delayed tissue regeneration, yet effective strategies to regulate the pathological immune microenvironment remain limited. Here, integrated single-cell transcriptomics and multi-omics analyses revealed significant enrichment of endoplasmic reticulum stress (ERS)-related signaling in pro-inflammatory macrophages within diabetic wounds, suggesting a potential mechanism driving chronic inflammation. To target this process, we developed an injectable dynamic hydrogel (GPOK-2@EVs) incorporating Artemisia argyi-derived extracellular vesicles (EVs) for localized immunomodulatory therapy. The hydrogel was formed through dual dynamic crosslinking between phenylboronic acid-modified gelatin and oxidized konjac glucomannan, providing self-healing capability, injectability, tissue adhesion, and pH/ROS-responsive degradation for sustained EV release. In vitro experiments demonstrated that GPOK-2@EVs exhibited excellent biocompatibility and effectively reprogrammed macrophages toward an anti-inflammatory phenotype, accompanied by reduced inflammatory cytokine secretion, alleviated ERS activation, decreased ROS accumulation, and improved mitochondrial integrity. GPOK-2@EVs significantly enhanced endothelial angiogenic activities, including cytoskeletal remodeling, tube formation, and migration. In a diabetic mouse wound model, GPOK-2@EVs accelerated wound closure, promoted granulation tissue formation and collagen deposition, enhanced vascularization, and suppressed inflammatory and ERS responses. These findings demonstrate that EV-loaded dynamic hydrogels can modulate the inflammatory microenvironment and promote diabetic wound regeneration, providing a promising biomaterial strategy for chronic wound therapy. Graphical GPOK-2@EVs hydrogel promotes wound healing through ROS-responsive EV release, macrophage modulation, inflammatory cytokine reduction, and enhanced angiogenesis.
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FOOD RESEARCH INTERNATIONAL
·
2026
·
IF 8.8
Mengke Li,Mengle Li,Ying Qian,Xiangsong Chen,Jianglin Chen,Long Jin,Lili Cao,Min Pang
Hydrogels formed via synergistic TGase covalent and gelatin physical crosslinks. • Varying GEL/PPI ratio enabled tunable mechanical properties and microstructures. • Adding gelatin significantly improved PPI hydrogels' water-holding capacity. • Dual-crosslinked hydrogels exhibited high fatigue resistance and thermal stability. Pea protein isolate (PPI) is rich in essential amino acids and exhibits low allergenicity; nevertheless, its poor gelation performance constrains its use in gel-based systems. To overcome this limitation, this study introduced gelatin (GEL) to modify pea protein isolate and constructed a double-crosslinked composite hydrogel based on a plant-animal protein combination via transglutaminase (TGase). The effects of different GEL/PPI ratios on the structure, mechanical properties, thermal stability, and swelling behavior of the hydrogels were investigated. The results showed that TGase effectively mediated covalent cross-linking between GEL and PPI. As the proportion of PPI increased, the hardness, gel strength, fatigue resistance, and shape recovery of the hydrogels decreased. All hydrogels demonstrated a high water content (>80%), and the incorporation of GEL significantly enhanced the water-holding capacity. SEM observation revealed that the hydrogels displayed a honeycomb-like porous structure. With increasing PPI content, the pores became smaller, the pore walls thickened, and the structural density increased. TGA and DSC analyses indicated that all hydrogels possessed good thermal stability. The swelling capacity decreased with the introduction of PPI, and all gels conformed to the Schott second-order kinetic model. XRD patterns suggested that all gel samples were predominantly amorphous in structure. These findings demonstrate that double-crosslinked PPI can produce hydrogels with higher mechanical strength, water-holding capacity, and stability, thereby improving the functional properties of PPI. This study provides a theoretical basis for developing novel edible hydrogels. Download: Download high-res image (118KB) Download: Download full-size image
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Food Bioscience
·
2026
·
IF 6.2
Jianshe Huang,Huipeng Zhu,Qiuying Yao,Tifeng Jiao,Lu Wang,Xiaoyu Li,Dawei Gao
Malus baccata polyphenols (MBP) possess considerable bioactivity but suffer from poor physicochemical stability, which limits their practical applications. In this study, coaxial electrospinning was employed to fabricate core-sheath nanofibers (PM-GZ nanofibers) for MBP encapsulation, using PVA/MBP (PM) as the core solution and gelatin/zein (GZ) as the sheath solution. The effects of electrospinning parameters on the morphology and properties of the nanofibers were systematically investigated. Under the optimized conditions (14 wt% PVA, 0.6 wt% MBP, 19 kV voltage, 10 cm receiving distance, 0.1 mL/h core flow rate, 0.5 mL/h sheath flow rate, and 15-19G coaxial needle), the obtained nanofibers exhibited smooth, continuous, and bead-free morphology with distinct core-sheath structures and an average fiber diameter of 120.87 ± 19.29 nm. Furthermore, the nanofibers showed high encapsulation efficiency, favorable thermal stability, enhanced mechanical properties, and improved protection of MBP, attributable to hydrogen bonding and hydrophobic interactions within the fiber matrix. Overall, this study demonstrates that coaxially electrospun core-sheath nanofibers are a promising strategy to significantly enhance the stability and delivery efficiency of natural polyphenols.
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Applied Materials Today
·
2026
·
IF 7
Gang Liu,Dan Mei,Hao Wu,Wei Zhang
A hydrogel assembly was developed for the sustained delivery of hydrophilic and hydrophobic drugs. • The hydrogel assembly was able to provide sustained drug release. • The CO₂ bubbles within the hydrogel provided ultrasound imaging signals. Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by sustained joint inflammation and prolonged pain. Conventional oral combination therapy often suffers from mismatched release profiles of hydrophilic and hydrophobic drugs and lacks real-time monitoring capability. To address these challenges, we developed a gastric-floating core-shell hydrogel assembly for the sustained co-delivery of acetaminophen (APAP) and methotrexate (MTX). The poly(vinyl alcohol) (PVA) core encapsulates the analgesic APAP, while the silk fibroin (SF) shell, featuring methanol-induced β-sheet structures, carries the anti-inflammatory MTX. This spatial compartmentalization enables independent control over the release profiles of the two drugs. Sodium bicarbonate embedded in the shell reacts with gastric acid to generate CO₂ bubbles, which are stably retained by the dense β-sheet network, conferring buoyancy for up to 48 h. Notably, these retained CO₂ bubbles serve as intrinsic ultrasound contrast agents, enabling real-time imaging of gastric retention without the need for exogenous contrast agents. In vitro drug release studies demonstrate sustained release of both APAP and MTX. This integrated platform combines spatially compartmentalized dual-drug delivery, prolonged gastric retention, and non-invasive monitoring, offering a promising strategy for oral RA therapy. Download: Download high-res image (229KB) Download: Download full-size image
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危险品化学品经营许可证（带存储）