ACS Applied Materials & Interfaces
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2025
·
IF 8.2
Ying Yu,Yuan Cheng,Shiwei Xu,Wanyun Song,Mingming Wang,Liqiang Song,Kejia Zhu,Tao Zhang
Noninvasive prenatal diagnosis based on fetal cells (cell-based NIPD) offers a safer alternative to traditional invasive procedures but remains limited by the low abundance of fetal nucleated red blood cells (FNRBCs) in maternal circulation and the inefficiency of current isolation techniques. Here, we present a functionalized interventional system for in situ hematologic cell capture (FISHC) directly from peripheral blood, eliminating the need for blood withdrawal and ex vivo processing. FISHC features a carboxybetaine methacrylate (CBMA)-functionalized medical wire with immobilized FNRBC-specific antibodies, enabling high-specificity cell capture under physiological conditions. In vivo validation in a pregnant monkey model confirms its feasibility for efficient and minimally invasive fetal cell retrieval. FISHC represents a paradigm shift in cell-based NIPD and holds promise for broader biomedical applications, including circulating tumor cell detection and real-time liquid biopsy technologies.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Dianhui Wu,Ziqiang Chen,Mingtao Ma,Wenzhe Li,Zhengcong Peng,Zhenbao Shi,Jinglong Zhang,Hua Liu,Guangfa Xie,Jian Lu
Aging plays a crucial role in enhancing the flavor of Huangjiu. This study aims to elucidate the changes in taste attributes of aged Huangjiu and explore the correlation between non-volatile compounds. It showed that aging made the sourness, bitterness, and astringency more pronounced. The content of organic acids and amino acids exhibited specific patterns with aging years. The total taste activity value of organic acids showed an increasing trend, peaking at 54.40 in Huangjiu aged 15 years, which served as a key indicator of sourness intensity. A total of 22 potential contributors to umami and 18 to bitterness were screened based on weighted gene coexpression network analysis. The total content of potential umami contributors was significantly higher in fresh Huangjiu and aging stage I, but declined in later periods, while bitterness contributors increased gradually throughout the aging process. This study provided theoretical support for the taste characteristics of aged Huangjiu.
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Open Veterinary Journal
·
2025
·Vol. 15
·期 4
·1836
·
IF 1
Jin-Kui Ma,Qian-Ru Lin,Zhi-Yao Liu,Jia-Min Wang,Xin Peng,Yu-Tong Lin,Li-Zhen Nie,Xiao-Chen Huang
Background: Food spoilage, particularly in meat products, presents a significant economic and health concern, necessitating the development of reliable and user-friendly monitoring methods. Aim: This study presents the development and evaluation of novel colorimetric films for real-time monitoring of meat freshness. Methods: Films were formulated using anthocyanin (AHO) and betacyanin (BTA) from purple cabbage and red dragon fruit, respectively, embedded within polyvinyl alcohol and carboxymethyl cellulose matrix. Two pigment ratios, AHO:BTA (1:3) and (3:1), were compared to evaluate mechanical properties, antioxidant activity, and ammonia sensitivity. Results: The AHO:BTA (1:3) film demonstrated higher tensile strength, whereas the (3:1) film exhibited greater antioxidant capacity and ammonia responsiveness. Colorimetric changes were assessed across the pH range, showing sensitivity to pH shifts. The films were then applied to beef, lamb, fish, and pork samples, and their color alterations during storage under ambient and refrigerated conditions were correlated with total volatile basic nitrogen and pH levels. Conclusion: The results show a strong correlation between film color changes and established meat spoilage indicators, demonstrating the potential of these natural pigment-based films for effective, nontoxic, and visual monitoring of meat freshness.
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FOOD RESEARCH INTERNATIONAL
·
2025
·
IF 8
ZiHan Wang,MengHuan Liu,QiHang Bu,Ning Jiang,Jia Kan,RongXue Sun,QianYuan Liu,Cheng Wang
Food packaging films and preservatives can extend the shelf life of aquatic products, but removing the fishy odor remains a huge challenge. This study reports the successful fabrication of high-performance nanofiber films integrated with deodorization, antibacterial and antioxidant properties through electrospinning and based on the precise construction of micro/nano structure. Quaternary chitosan and polyvinyl alcohol were selected as electrospinning materials to prepare nanofiber films with varied micro/nano structures by adjusting the applied voltage. As the voltage was increased, the specific surface area and the pore area of the nanofiber films initially increased and then decreased. The larger pore area and specific surface area of nanofiber films offered more adsorption sites for fishy odor, thereby enhancing the capture of these odors. At the applied voltage of 20 kV, the electrospun nanofiber films exhibited the highest adsorption rate (78.28 %). Additionally, the addition of thymol endowed the nanofiber films with excellent antibacterial and antioxidant properties, effectively extending the shelf life of grass carp while reducing the production of the fishy odor. Therefore, the strategies and mechanisms behind this superior performance were expected to inspire the design of novel aquatic products packaging films in the future.
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MOLECULES
·
2024
·Vol. 29
·期 15
·3508
·
IF 4.2
Jielei Fan,Ruoxue Wang,Xiaodong Zheng,Hancheng Jiang,Xiuli Hu
The chemical tolerance of ketoenamine covalent organic frameworks (COFs) is excellent; however, the tight crystal structure and low surface area limit their applications in the field of catalysis. In this work, a porous single-atom iron catalyst (FeSAC) with a core–shell structure and high surface area was synthesized by using Schiff base COF nanospheres as the core and ketoenamine COF nanosheets growth on the surfaces. Surface defects were created using sodium cyanoborohydride etching treatment to increase specific surface area. The dye degradation experiments by peroxymonosulfate (PMS) catalyzed by the FeSAC proved that methylene blue can be degraded with a degradation rate constant of 0.125 min−1under the conditions of 0.1 g L−1catalyst dosage and 0.05 g L−1peroxymonosulfate. The FeSAC/PMS system effectively degrades various pollutants in the pH range of 4–10 with over 80% efficiency for four cycles and can be recovered by soaking in iron salt solution. Free radical quenching experiments confirmed that singlet oxygen and superoxide radicals are the main active species for catalysis.
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Advanced Healthcare Materials
·
2024
·
IF 10
Ziting Bao,Sheng Lu,Duo Zhang,Guanyu Wang,Xiaolin Cui,Guozhen Liu
Type 2 diabetes is rapidly emerging as a global public health problem. While blood glucose monitoring has been the primary method of managing diabetes for decades, the increasing global prevalence of the disease suggests that there might be a need to identify additional biomarkers for a more precise early diagnosis. Herein, a microneedle patch based wearable sensor is developed for the purpose of diabetic diagnosis. Utilizing methacrylic acid modified gelatin and polyvinyl alcohol in the fabrication of microneedles has improved their mechanical properties for skin penetration and increased swelling capacity for interstitial fluid extraction, thanks to the double crosslinking mechanism. The fabricated microneedles are further integrated with test paper functionalized with enzyme and dye molecules to detect multiple signature biomarkers of diabetes in vivo through a colorimetric reaction. Such a wearable microneedle patch holds significant promise for the real-time monitoring of various biomarkers related to chronic diseases and aging.
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Buildings
·
2024
·Vol. 14
·期 12
·3835
·
IF 3.1
Yang Zheng,Zhi-Yuan Zhang,Yisong Liu,Xiaozhu Zhang,Shaoguo Kang,Leyang Lv,Junbo Zhou
The utilization of silicomanganese slag (SiMnS) as a precursor for alkali-activated materials (AAMs) is considered as an efficient approach for sustainable and eco-friendly large-scale resource utilization. However, sodium silicate solutions account for more than 50% of the production costs and carbon emissions of AAMs. In this study, AAM activators were prepared by silica-containing waste (acid leaching residue of boron mud, BM-AR) and NaOH as raw materials, and were successfully substituted for commercial sodium silicate-NaOH activators. Results indicated that the NaOH dosage had a great effect on the concentration and modulus of the activator. With the appropriate dosage of NaOH (NaOH: BM-AR = 0.4–0.7), suitable moduli of AAM activators can be produced at a wide range of solid/liquid ratios (L/S = 3–4.5) under mild conditions (80–100 °C). The compressive strength of the SiMnS AAM specimens prepared by this activator can reach 68.58 MPa, and its hydration products were mainly hydrated calcium silicate and amorphous silica–alumina gel, indicating the successful preparation of AAM. Calculation showed that the carbon emission of the AAMs prepared in this study was 12.4% and 37.6% of that of OPC and commercial water glass/NaOH-activated AAMs, and the cost was only 67.14% and 60.78% of them. The process achieves the use of waste materials to replace commercial activators, and is expected to be extended to a variety of AAMs raw materials and silica-containing waste. This makes it a highly promising alternative method for the production of AAMs, particularly the ‘just add water’ AAMs.
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Food Chemistry-X
·
2024
·
IF 6.5
Lin Zhang,Lin Han,Jinye Yang,Qinxiu Sun,Ke Li,Sangeeta Prakash,Xiuping Dong
This study investigated the impact of ice temperature storage on quality and bacterial composition of processed fish paste products (PFP). Freezing curve revealed the ice temperature was −1 °C. Electric nose (e-nose) showed significant changes in volatile components within 8 days. Results of total volatile basic nitrogen (TVB-N) showed that PFP stored at 4 °C reached its limit after 2 days, whereas PFP stored at ice temperature remained stable for 6 days. Thiobarbituric acid reactive substances (TBARS) demonstrated delayed oxidation in PFP stored at ice temperature compared to 4 °C. TCA-soluble peptides indicated that the protein degradation was suppressed by ice temperature. Additionally, ice temperature inhibited microbial growth and altered bacterial composition. High-throughput sequencing revealed that Pseudomonas , Brochothrix , Carnobacterium were dominant at 4 °C, while Acinetobacter , Pseudomonas , Janthinobacterium and Brochothrix were dominant at ice temperature. In summary, ice temperature might be a potential method for maintaining the freshness of PFP.
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ADVANCED MATERIALS
·
2025
·
IF 26.8
Jun Cheng,Yao Shen,Yulu Gu,Tongyue Xiang,Hui Shen,Yi Wang,Zhenyang Hu,Zhen Zheng,Zhilong Yu,Qin Wu,Yinghui Wang,Tiancong Zhao,Yunfei Xie
A low-cost, high-precision, and secure real-time system for monitoring food freshness can significantly improve spoilage issues, yet traditional colorimetric sensor arrays often suffer from chemical dyes’ high toxicity and limited color changes. Here, a metal-polyphenol network colorimetric sensor array (MPN-CSA) is built for detecting total volatile base nitrogen (TVB-N) markers of meat freshness. The multi-level competitive coordination process between the metal-polyphenol system and amine substances endows the system with color changes far beyond those of traditional dyes (reaching a detection limit of 300 ppb). By integrating convolutional neural network (CNN) technology, an online platform is developed for monitoring meat freshness, achieving an overall detection accuracy rate of 99.83%. This environmentally friendly, economically viable MPN-CSA that monitors the freshness of meat in complex storage environments can be incorporated into food packaging boxes, enabling consumers and suppliers to assess the freshness of meat in real-time, thus helping to reduce food waste and prevent foodborne illnesses.
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JOURNAL OF MEMBRANE SCIENCE
·
2025
·
IF 9
Dan Qiu,Yanping Zhang,Zishun Xu,Qing Fang,Jiaqin Cao,Xiuxiu Mu,Fan Hu,Hongxing Liu,Chuner Lin,Linghui Wang
Organic solvent nanofiltration (OSN) has emerged as a promising separation technology for product purification and solvent recycling in organic solution. Crosslinked polyimide (PI) membranes were widely used in the OSN system. However, the existence of some drawbacks, such as low utilization of crosslinkers and generation of profuse organic waste, hindered the development. Furthermore, when crosslinkers of large molecular weight were applied, the crosslinking degree of membranes was usually found to be insufficient, restricting their performance in harsh solvent systems. In this work, PEI with specific protonation degree, performing as a crosslinker, was directly introduced into PI solution for the preparation of OSN membranes. The partially activated PEI would graft onto PI chains, which could improve the retention of PEI chains during the membrane forming process, while preventing the gelation of PI solution. The as-prepared PEI/PI membrane showed enhanced hydrophilicity and highly positive charge with the isoelectric point as high as 9.1. The PEI/PI membranes were post-treated by K 2 CO 3 solution, aiming to further improve the crosslinking degree. The PEI/PI membranes exhibited good organic solvent resistance even in N, N-dimethylformamide (DMF), with the tensile strength of 0.28 MPa and permeance of 2.38 L m −2 h −1 bar −1 . Meanwhile, the dye/salt separation performance of the membrane was carried out by using DMF/H 2 O (1:9 w/w) as the solvent, and the rejection for several dyes was above 97 %, with the rejection for salts below 8 %. After 80 h test, the membrane maintained high rejection for Congo Red and Methyl Blue and low rejection for salt, with the permeation retained at 20 L m −2 h −1 bar −1 , indicating excellent anti-fouling performance. The controlled activation method takes the advantage of high utilization and reaction efficiency, as well as simple procedure, rendering it valuable for fabrication of OSN membranes.
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