JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2021
·
IF 8.128
Wenhui Zheng,Lijuan Xu,Yangyang Li,Yudong Huang,Bing Li,Zaixing Jiang,Guolin Gao
Conductive hydrogels have attracted significant attention in the area of wearable pressure sensors due to their mechanical flexibility, conductivity and self-healing capability. At subzero temperatures , water-based conductive hydrogels unavoidably lose their elasticity and conductivity which limits their practical usages at low temperatures. However, traditional conductive hydrogels are short of moisturizing and anti-freezing ability due to the limitation of pure water solvent, which greatly restricts their application in extreme environments. In this study, an anti-freezing and moisturizing conductive double network organohydrogel was prepared by incorporating thioctic acid (TA) with polyvinyl alcohol-borate (PVA-PB) in carbon nanotubes (CNTs) that were dispersed in water (H 2 O) and ethylene glycol (EG). The as-prepared PVA-B-TA-CNTs organohydrogel presented outstanding anti-freezing performance (−60 o C), long-term moisturizing property (30 days), excellent stability (400 cycles) and fascinating conductive sensitivity (S = 0.625 kPa −1 ). The occurrence of dynamic covalent disulfide bonds and noncovalent hydrogen bonds endow the conductive organohydrogels with brilliant remoldability and self-healing ability, which are significant for practical applications. These remarkable advantages make PVA-B-TA-CNTs organohydrogel to have enormous potential in the application of wearable and flexible pressure sensors, human-healthy monitor, and intelligence devices.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2021
·Vol. 222
·期 6
·2000429
·
IF 2.527
Jumin Yang,Valenzuela Cristian,Anjie Dong,Jianhua Zhang
The double network (DN) hydrogels, especially the physically crosslinked DN hydrogels, have attracted increasing attention due to their high reconfigurability, multi-sensitivity, and efficient energy dissipation, but their applications still suffer from the relatively low mechanical strength, complex preparation process, and insufficient functionality. In this work, a simple but efficient strategy to fabricate robust and multitasking polyvinyl alcohol (PVA)/poly( N -acryloyl glycinamide) (PNAGA) DN hydrogels via an ultraviolet (UV)-initiated one-pot in situ polymerization and a subsequent freezing-thawing treatment is reported. The PVA/PNAGA DN hydrogels are fully physically linked DN network via multiple hydrogen bonding interactions, which contain hard PVA crystalline microdomains and soft PNAGA regions. The synergetic multiple hydrogen bonding interactions and the cooperation of hard and soft regions in PVA/PNAGA hydrogels as well as the polyhydroxy matrix can not only impart the PVA/PNAGA hydrogels with super mechanical strength, high toughness, good stretchability, and rapid shape-recoverability, but also endow the hydrogels with tailorable self-healability, multiple shape memory, and actuation function. Considering the easily available materials, simple preparation process, and highly multitasking properties, this novel strategy should greatly enrich the methodological toolbox for the synthesis of robust and multifunctional hydrogels for the diversity of applications.
✓ 已验证
产品关联
DOI
高影响因子
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
·
2021
·Vol. 118
·期 43
·e2112704118
·
IF 11.205
Guopu Chen,Fengyuan Wang,Min Nie,Hui Zhang,Han Zhang,Yuanjin Zhao
Mesenchymal stem cells (MSCs), which exert regulatory effects on various immune cells, have been a promising therapy for inflammatory bowel disease treatment. However, their therapeutic effects are limited by lack of nutritional supply, immune system attack, and low accumulation on the target site. Here, inspired by the natural incubation mechanism of roe, we present immune-isolating, wet-adhesive, and nutrient-rich microcapsules for therapeutic MSCs encapsulation. The adhesive shells were fabricated by ionic cross-linking of alginate and visible curing of epsilon-poly-L-lysine-graft-methacrylamide and dopamine methacrylamide, which encapsulated the liquid core of the MSCs and roe proteins. Due to the core-shell construction of the resultant microcapsules, the MSCs might escape from attack of the immune system while still maintaining immunomodulating functions. In addition, the roe proteins encapsulated in the core phase offered sufficient nutrient supply for MSCs’ survival and proliferation. Furthermore, after intraperitoneal transplantation, the wet-adhesive radicals on the shell surface could immobilize the MSCs-encapsulating microcapsules onto the bowel. Based on these features, practical values of the roe-inspired microcapsules with MSCs encapsulation were demonstrated by applying them to treat dextran sulfate sodium (DSS)–induced colitis through increasing residence time, regulating immune imbalance, and relieving disease progression. We believe that the proposed roe-inspired microcapsules with MSCs encapsulation are potential for clinical application.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PLoS One
·
2021
·Vol. 16
·期 3
·e0247948
·
IF 3.24
Shiliang Xu,Mengke Cui,Renjie Chen,Qiaoqing Qiu,Jiacai Xie,Yuxin Fan,Xiaohu Dai,Bin Dong
With the increasing demand for energy, fracturing technology is widely used in oilfield operations over the last decades. Typically, fracturing fluids contain various additives such as cross linkers, thickeners and proppants, and so forth, which makes it possess the properties of considerably complicated components and difficult processing procedure. There are still some difficult points needing to be explored and resolved in the hydroxypropyl guar gum (HPG) removal process, e.g., high viscosity and removal of macromolecular organic compounds. Our works provided a facile and economical HPG removal technology for fracturing fluids by designing a series of processes including gel-breaking, coagulation and precipitation according to the diffusion double layer theory. After this treatment process, the fracturing fluid can meet the requirements of reinjection, and the whole process was environment friendly without secondary pollution characteristics. In this work, the fracturing fluid were characterized by scanning electron microscopy (SEM), Energy dispersive X-ray (EDX), X-ray diffraction (XRD) and Fourier transformed infrared (FTIR) spectroscopy technologies, etc. Further, the micro-stabilization and destabilization mechanisms of HPG in fracturing fluid were carefully investigated. This study maybe opens up new perspective for HPG removal technologies, exhibiting a low cost and strong applicability in both fundamental research and practical applications.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMACROMOLECULES
·
2021
·
IF 6.988
Yajie Zhong,Farzad Seidi,Chengcheng Li,Zhangmin Wan,Yongcan Jin,Junlong Song,Huining Xiao
Hydrogels as a wound dressing, integrated with ultrastretchability, rapid self-healing, and excellent antimicrobial activity, are in high demand, particularly for joint skin wound healing. Herein, a multifunctional and ductile composite hydrogel was developed using poly(vinyl alcohol) (PVA)-borax gel as a matrix that was synergized or dual-reinforced with dopamine-grafted oxidized carboxymethyl cellulose (OCMC-DA) and cellulose nanofibers (CNF). Moreover, neomycin (NEO), an aminoglycoside antibiotic with multifunctional groups, was incorporated into the hydrogel network as both an antibacterial agent and a cross-linker. The dynamic reversible borate ester linkages and hydrogen bonds between OCMC-DA, PVA, and CNF, along with dynamic cross-linking imine linkages between NEO and OCMC-DA, endowed the hydrogel with excellent self-healing ability and stretchability (3300%). The as-reinforced networks enhanced the mechanical properties of hydrogels significantly. More remarkably, the composite hydrogel with improved biodegradability and biocompatibility is pH-responsive and effective against a broad spectrum of bacteria, which is attributed to the controllable release of NEO for steady availability of the antibiotic on the wound location. Overall, the antimicrobial hydrogel with rapid self-healing and reliable mechanical properties holds significant promise as dressing material for wound healing.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2021
·
IF 7.46
Gang-gang Zhang,Xiao-cui Lai,Neng-shui Ding,Qi-rong Xiong,Shuai Hou,Hong-wei Duan,Wei-hua Lai
Flower-like gold nanoparticle (AuNF) is widely used as a probe. However, the performance of conventional AuNF is not satisfactory because of complex synthesis, insufficient uniformity, and ordinary optical performance. In this paper, a novel chrysanthemum-like Au@polydopamine (AuNC@PDA) prepared using one-pot method was compared with conventional AuNF@polydopamine (AuNF@PDA) prepared using three-step method. AuNC@PDA had more branch structures with more uniform petaloid shape and narrower particle size distribution compared with AuNF@PDA. The grayscale of AuNC@PDA both in aqueous solution and on nitrocellulose membrane was approximately threefold higher than that of AuNF@PDA. Because of PDA coating, the stability and coupling efficiency of AuNC@PDA were much higher than that of conventional nanoprobes − AuNF and AuNS (gold nanosphere). These results indicated that AuNC@PDA had superior morphological and optical performance. The AuNC@PDA was first utilized as a probe in immunochromatographic assay (ICA), and compared with conventional AuNF@PDA. The limits of detection (LOD) of ICA based on AuNC@PDA, AuNS, and AuNF@PDA were 1.59, 9.58, and 5.13 mIU/mL, respectively, when human chorionic gonadotropin was detected as the target. The LOD of ICA based on AuNC@PDA had 6.0-fold and 3.3-fold improvement compared with that based on AuNS and AuNF@PDA, respectively. Our results could be used as a basis for developing novel probes in practical ICA applications.
✓ 已验证
产品关联
DOI
高影响因子
CELLULOSE
·
2021
·Vol. 28
·期 10
·6133-6146
·
IF 5.044
Du Peng,Ding Qijun,Zhao Chuanshan,Jiang Yifei,Han Wenjia,Li Xia
Abstract Nanofibrillated cellulose is obtained from cellulose resources (e.g., Natural cellulose, bacterial cellulose) and is deemed to be environmentally friendly, green, and inexhaustible. Accordingly, we reported an innovative method for fluorine-free water- and oil/grease-repellent surface based on porous cellulose-based materials. In order to improve oil/grease resistance, sulfonated nanofibrillated cellulose (SNFC) was coated on the surface to fill the porous, the obtained paper was soaked in chitosan aqueous solution as the second layer. The-SNFC-chitosan-coated paper was applied with modified polyvinyl alcohol (MPVA) as the third layer to increase water resistance and water vapour transmittance. The experimental results showed 5.2 g/m 2 SNFC, 2.5 g/m 2 chitosan and 7% MPVA demonstrated excellent kit rating value of 12/12 (maximum grease resistance) (oil resistance contact angle is 103.93°), good water resistance (water contact angle is 108.6°) and high water vapour transmission rate (4.8 × 10 –14 g cm/cm 2 s Pa) under the condition of 90% relative humidity. This non-fluorinated and practical method is an excellent alternative to existing fluorinated materials, which will further promote the development of cellulose-based packaging. Graphic abstract
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2021
·Vol. 31
·期 14
·2007457
·
IF 18.808
Lei Zhou,Cong Dai,Lei Fan,Yuhe Jiang,Can Liu,Zhengnan Zhou,Pengfei Guan,Yu Tian,Jun Xing,Xiaojun Li,Yian Luo,Peng Yu,Chengyun Ning,Guoxin Tan
Biocompatible hydrogel adhesives with multifunctional properties, including injectability, fast self-healing, and suitable on-demand detachment, are highly desired for minimally invasive procedures, but such materials are still lacking. Herein, an injectable self-healing biocompatible hydrogel adhesive with thermoresponsive reversible adhesion based on two extracellular matrix-derived biopolymers, gelatin and chondroitin sulfate, is developed to be used as a surgical adhesive for sealing or reconnecting ruptured tissues. The resulting hydrogels present good self-healing and can be conveniently injected through needles. The strong tissue adhesion at physiological temperatures originates from the Schiff base and hydrogen bonding interactions between the hydrogel and tissue that can be weakened at low temperatures, thereby easily detaching the hydrogel from the tissue in the gelation state. In vivo and ex vivo rat model show that the adhesives can effectively seal bleeding wounds and fluid leakages in the absence of sutures or staples. Specifically, a proof of concept experiment in a damaged rat liver model demonstrates the ability of the adhesives to act as a suitable laparoscopic sealant for laparoscopic surgery. Overall, the adhesive has several advantages, including low cost and ease of production and application that make it an exceptional multifunctional tissue adhesive/sealant, effective in minimally invasive surgical applications.
✓ 已验证
产品关联
DOI
高影响因子
CHEMOSPHERE
·
2020
·
IF 5.778
Xing Cao,Rui Ma,Qiushi Zhang,Weibing Wang,Qinxiong Liao,Shichang Sun,Peixin Zhang,Xiangli Liu
Magnesium potassium phosphate cement (MKPC) is prepared from MgO and KH 2 PO 4 through an acid-base reaction and has been widely used in the rapid repairs of building structures and the solidification/stabilization (S/S) of heavy metals (HMs). The use of sludge incineration residue (SIR) rich in phosphorus resources to prepare SIR-based MKPC can achieve the reclamation of SIR and efficient HM S/S. Herein, based on the exploration of the optimal MKPC magnesia/phosphate ratio (M/P), the effects of SIR and HMs on the performance of the matrix and its interaction mechanism were comprehensively investigated. The results indicated that the compressive strength of the SIR-based MKPC increased first and then decreased with the gradual increase of SIR incorporation; the optimal was reached at 40.31 MPa when the SIR incorporation was 5 wt%. The peak signal and crystal lattice of Pb 2 (PO 4 ) 3 indicated that there is a mixed effect between HMs (in SIR) and KH 2 PO 4 . The Visual MINTEQ analysis results also indicated that HMs are precipitated as HM phosphates. The formation of HM phosphates not only increases the M/P (with 30 wt% SIR, M/P increased by 0.019), affecting the microstructure and changing the compressive strength of the matrix, but also promotes the transformation of HMs from the bioavailable to the more stable residual forms. The residual forms of the six HMs were all above 84% after S/S. Therefore, the SIR-based MKPC preparation significantly immobilized the HMs; particularly, the leaching toxicities of Cu (96.6%) and Zn (96.3%) were alleviated.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Min Zhang,Feng Deng,Lele Tang,Hui Wu,Yonghao Ni,Lihui Chen,Liulian Huang,Xiaoqing Hu,Shan Lin,Cuicui Ding
Collagen-based hydrogels have been regarded as one of the most popular biomaterials for applications in biomedical engineering as scaffolds, cell or drug carriers and medical implants. Despite numerous studies on collagen-based hydrogels, their applications are still extremely limited due to lack of multi-functionalities. Herein, we present a facile method to prepare a multifunctional, extremely soft collagen-based hydrogel via the introduction of collagen (COL), guar gum (GG), poly(N-isopropylacrylamide) (PNIPAM), graphene oxide (GO) and borax through the formation of both reversible and permanent networks. The resultant hydrogels (COL–GG–PNIPAMs) exhibited desirable properties, including processability, injectability and remoldability. Remarkably, the COL–GG–PNIPAMs stretched manually up to 50 times their initial length before rupturing (from 2 to 100 cm), indicating their super-ductile deformation; when cut, the hydrogels self-healed within a short time period (less than 3 min) without any external stimuli. In addition, the COL–GG–PNIPAMs showed excellent thermal sensitivity and NIR-responsive properties. The potential application of ionic conductive COL–GG–PNIPAMs for strain sensing was also tested by monitoring real-time large-scale movements of the human body or facial micro-expressions. Moreover, the COL–GG–PNIPAMs exhibited a healing ratio of 81.0% for mouse skin wounds, which was higher than that of the blank group (63.6%), demonstrating an enhanced skin wound repair effect. These prominent features of COL-GG-PNIPAMs will broaden versatile collagen-based hydrogels for a variety of applications.
✓ 已验证
产品关联
DOI
高影响因子
CORROSION SCIENCE
·
2020
·
IF 6.479
Yufei Tang,Lixia Zhu,Ping Zhang,Kang Zhao,Zixiang Wu
The surface of a medical magnesium alloy treated by micro-arc oxidation was coated with magnesium phosphate-based bio-piezoelectric bone cement. The high tensile adhesive strength of the obtained composite coating was 6.83 MPa due to mechanical locking and its chemical reaction. The corrosion degradation property of the bio-piezoelectric composite coating in simulated body fluid improved because the negative surface charge after polarization led to the balance between degradation and deposition rates during apatite deposition. After the coating was soaked in simulated body fluid (SBF) for 7days, the weight loss rate of the sample considerably decreased to 1.03%, and the average corrosion rate decreased to 3.33 mm/year.
✓ 已验证
产品关联
DOI
高影响因子
Bioactive Materials
·
2020
·
IF 8.724
Lei Zhou,Lei Fan,Feng-Miao Zhang,Yuhe Jiang,Min Cai,Cong Dai,Yi-An Luo,Ling-Jie Tu,Zheng-Nan Zhou,Xiao-Jun Li,Cheng-Yun Ning,Kai Zheng,Aldo R. Boccaccini,Guo-Xin Tan
Biopolymer based hydrogels are characteristic of their biocompatibility and capability of mimicking extracellular matrix structure to support cellular behavior. However, these hydrogels suffer from low mechanical properties, uncontrolled degradation, and insufficient osteogenic activity, which limits their applications in bone regeneration. In this study, we developed hybrid gelatin (Gel)/oxidized chondroitin sulfate (OCS) hydrogels that incorporated mesoporous bioactive glass nanoparticles (MBGNs) as bioactive fillers for bone regeneration. Gel-OCS hydrogels could be self-crosslinked in situ under physiological conditions in the presence of borax. The incorporation of MBGNs enhanced the crosslinking and accelerated the gelation. The gelation time decreased with increasing the concentration of MBGNs added. Incorporation of MBGNs in the hydrogels significantly improved the mechanical properties in terms of enhanced storage modulus and compressive strength. The injectability of the hydrogels was not significantly affected by the MBGN incorporation. Also, the proliferation and osteogenic differentiation of rat bone marrow mesenchymal stem cells in vitro and rat cranial defect restoration in vivo were significantly promoted by the hydrogels in the presence of MBGNs. The hybrid Gel-OCS/MBGN hydrogels show promising potential as injectable biomaterials or scaffolds for bone regeneration/repair applications given their tunable degradation and gelation behavior as well as favorable mechanical behavior and osteogenic activities.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）