GREEN CHEMISTRY
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2026
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IF 10.6
Danni Liu,Kaige Zhang,Wenli Zhao,Xiaopo Niu,Xiangwen Zhang,Qingfa Wang
To address the challenges of complex separation and high energy consumption in producing high-density biofuels from biomass, developing high-efficiency bifunctional catalyst to integrate carbon-carbon coupling and hydrodeoxygenation processes is highly desired. Herein, a bifunctional catalyst with RuOx anchored on the edge of NbOPO4 nanosheets was successfully fabricated through an impregnation-calcination method, enabling one-pot solvent-free conversion of lignin-derived phenol and benzyl alcohol into polycycloalkane perhydrofluorene. The NbOPO4 nanosheet edges were enriched in oxygen vacancies and were prone to anchoring RuOx species preferentially. The optimized 3%RuOx/NbOPO4 exhibited abundant Ru-O-Nb interfacial species, which synergized with Brønsted acid sites (BASs) to enhance the alkylation performance. The in-situ generated Ru0 species from the Ru-O-Nb interfacial species exhibited superior hydrogen dissociation capability, then the synergistic interaction with BASs through hydrogen spillover significantly boosted the hydrodeoxygenation efficiency. 3%RuOx/NbOPO4 with more Ru-O-Nb interfacial species exhibited high conversion of benzyl alcohol (98%) and yield towards perhydrofluorene (72%) under mild conditions (160 °C, 3 h) with a low environmental E-factor (≤2.8). Mechanistic studies identified the cyclization hydrogenation of oxygenated intermediates as the rate-determining step, and the product dicyclohexylmethane was mainly formed from the selective ring opening of perhydrofluorene over the synergy metal-acid sites of 3%RuOx/NbOPO4. This study provides a deep insight into designing efficient bifunctional catalysts for sustainable aviation fuel production through process integration.
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Nanomaterials
·
2026
·Vol. 16
·期 3
·164
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IF 4.3
Chao Meng,Xiaofeng Hao,Shuanjin Wang,Dongmei Han,Sheng Huang,Jin Li,Min Xiao,Yuezhong Meng
High-temperature proton exchange membranes (HT-PEMs) are critical components of high-temperature fuel cells, facilitating proton transport and acting as a barrier to fuel and electrons; however, their performance is hampered by persistent issues of phosphoric acid leaching and oxidative degradation. Herein, a novel HT-PEM with abundant hydrogen bond network is constructed by incorporating nanoscale polyhedral oligomeric silsequioxane functionalized with eight pendent sulfhydryl groups (POSS-SH) into poly(4,4′-diphenylether-5,5′-bibenzimidazole) (OPBI) matrix. POSS, a cage-like nanostructured hybrid molecule, features a well-defined silica core and highly designable surface organic groups, offering unique potential for enhancing membrane performance at the molecular level. Through controlled reactions between sulfhydryl groups and allyl glycidyl ether (AGE), two functional POSS crosslinkers—octa-epoxide POSS (OE-POSS) and mixed sulfhydryl-epoxy POSS (POSS-S-E)—were synthesized. These were subsequently used to fabricate crosslinked OPBI membranes (OPBI-OE-POSS and OPBI-POSS-S-E) via epoxy–amine coupling. The OPBI-POSS-S-E membranes demonstrated exceptional oxidative stability, which is attributed to the free radical scavenging ability of the retained sulfhydryl groups on the nano-sized POSS framework. After soaking in Fenton’s reagent at 80 °C for 108 h, the OPBI-POSS-S-E-20% membrane retained 79.4% of its initial weight, significantly surpassing both the OPBI-OE-POSS-20% and pristine OPBI membranes. The PA-doped OPBI-POSS-S-E-20% membrane achieved a proton conductivity of 50.8 mS cm−1at 160 °C, and the corresponding membrane electrode assembly delivered a peak power density of 724 mW cm−2, highlighting the key role of POSS as a nano-modifier in advancing HT-PEM performance.
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MICROCHEMICAL JOURNAL
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2026
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IF 5.2
Fenfen Zeng,Fuhui Luo,Yangting Ou,Wanting Liang,Xu Ren,Fengxiang Zhang,Hanqing Pang,Wei Shi
The simultaneous extraction of bioactive compounds with differing polarities from plant matrices remains a significant challenge. This study was conducted to overcome the drawbacks of traditional extraction methods for the precious medicinal herb Hedyotis diffusa (HD), such as their low extraction efficiency, incapacity to completely utilize HD, and instability of active ingredients. To this end, a biphasic DES with ultrasound assistance was developed for the simultaneous extraction of high-value iridoids and triterpenes from HD. Following a thorough screening process that encompassed 56 two-phase combinations, the choline chloride-acetic acid (ChCl-Aa)/L-menthol-n-octanoic acid (Men-Oa) system was identified as the optimal formulation. Through the implementation of polarity regulation and response surface methodology, this optimal biphasic DES attained extraction yields of 15.65 ± 0.19 mg/g for five target compounds under mild conditions (41.65 °C, 30.71 min, liquid-solid ratio 15.73 mL/g, hydrophilic-to-hydrophobic phase volume ratio 0.77), which is a 2–3-fold improvement over traditional extraction methods. Characterization results indicated that the DES facilitated target release primarily by forming hydrogen-bond networks, which not only enhanced solubilization but also contributed to the disruption of cell wall. This disruptive effect was further augmented by the biphasic interface generated under ultrasonication, leading to significantly improved extraction efficiency. This strategy establishes a green and efficient approach for the valorization of plant resources.
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MACROMOLECULES
·
2026
·
IF 5.7
Shijing Yan,Yingying Han,Meng Wu,Zhiwei Yang,Hui You,Weihua Xu,Jun Du,Cailiu Yin
The development of sustainable electronics demands materials that combine high performance with designed degradability, yet achieving this balance remains a challenge. Here, we demonstrate that systematically engineering the soft-segment molecular weight in fully degradable, biobased polyurethanes (PUs) unlocks a suite of tunable properties for high-performance pressure sensing. By varying poly(butylene adipate) (PBA) diol molecular weight in networks containing isosorbide and acid-cleavable hexahydrotriazine, we establish that longer PBA chains enhance soft-segment crystallinity and elongation (up to 978%), while an optimal intermediate molecular weight (2000 g/mol) yields the highest tensile strength (25.7 MPa) and excellent biocompatibility. This optimized PU exhibits robust shape-memory behavior (Rf > 98%) and undergoes controlled dual degradation: enzymatic (up to 50% mass loss in 6 weeks) and complete acid-triggered dissolution, enabling quantitative recovery of conductive carbon black filler. A microstructured composite sensor fabricated from this material achieves high sensitivity (15.32 kPa–1) with fast response/recovery and successfully monitors human motion. This work establishes molecular design rules for degradable PUs and provides a viable pathway toward sustainable, high-performance flexible electronics.
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LANGMUIR
·
2026
·
IF 4.4
Tianyu Liu,Chongling Cheng,Dayang Wang
Steel corrosion, an inherent degradation of critical infrastructure, remains a pervasive global challenge. Here we report a serendipitous discovery of a corrosion-induced self-passivation strategy for steel in aqueous mixtures of polymaleic acid (PMA), phosphoric acid, and zinc phosphate (PMAPAZ) driven by the spontaneous formation of dense γ-Fe2O3/PMA nanohybrid coating. This corrosion-induced coating effectively inhibits steel corrosion under aggressive conditions, including high acidity (pH 1.5), high chloride (5 wt %), and elevated temperature (120 °C), achieving an ultraslow corrosion rate (<2 μm·year–1) in 3.5 wt % NaCl under ambient conditions. This superior anticorrosion performance can also be accomplished by directly applying PMAPAZ solutions or solution-infused dressings to a rusty steel surface without prior surface preparation, enabling simple, on-site repair and documented corrosion protection during natural outdoor atmospheric exposure for over 1 year. Our findings offer a regenerative and practical solution to a long-standing challenge in the steel industry, turning the inevitability of corrosion into a single-step opportunity for durable self-passivation.
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Pharmaceutics
·
2026
·Vol. 18
·期 3
·393
·
IF 6.9
Zhongcheng Tang,Wenting Chen,Ting Zhang,Yu He,Haitong Wan
Objective: The objective is to investigate and optimize the β-cyclodextrin inclusion process for volatile oils in Ligusticum Chuanxiong–Vinegar cyperus rotundus based on Quality by Design (QbD) principles.Methods: First, ligustilide and α-cyperone were selected as inclusion process indicator components using high-performance liquid chromatography–tandem mass spectrometry (HPLC-MS). Single-factor experiments were conducted to preselect the inclusion speed based on ligustilide and α-cyperone content as evaluation criteria. Subsequently, using the inclusion rates of ligustilide and α-cyperone as evaluation criteria, a factorial design was employed to investigate the inclusion temperature, inclusion time, and the volume ratio of β-cyclodextrin solution to essential oil, thereby optimizing the inclusion process parameters. Finally, the inclusion process parameters were validated, and the inclusion rates were determined. The obtained inclusion complexes were characterized by microscopic analysis, Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction analysis (XRD), and differential scanning calorimetry (DSC). Furthermore, phase dissolution studies and molecular docking were employed for confirmation.Results: The optimal process parameters were determined as follows: encapsulation speed of 300 rpm, β-cyclodextrin solution excess of 6, encapsulation time of 2.5~3 h, and encapsulation temperature of 30~35 °C. The encapsulation rates for ligustilide and α-cyperone in the resulting inclusion complex were 63.15~64.74% and 71.33~76.89%, respectively. Structural characterization confirmed the formation of the inclusion complex.Conclusions: This inclusion process is reliable and provides a reference for preparing β-cyclodextrin inclusion complexes of volatile oils in formulations containing the Chuanxiong–Vinegar cyperus rotundus drug pair.
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Pharmaceutics
·
2026
·Vol. 18
·期 4
·433
·
IF 6.9
Zhanghong Yao,Fei Song,Yan Liang,Yunfeng Liu,Weifeng Zhu,Yongmei Guan,Lili Liu
Background: Total glycosides of peony (TGP) have therapeutic potential for immune-related and inflammatory skin diseases, but their skin absorption is not satisfactory. This study aims to investigate howEvodia rutaecarpavolatile oil (VO-ER) enhances the permeability of TGP.Methods: Safety assessment was conducted through cell delivery and skin erythema tests. The chemical composition of VO-ER was identified via GC-MS. The study was conducted using modified Franz diffusion cells, microdialysis, confocal laser scanning microscopy (CLSM), attenuated total reflection–Fourier transform infrared spectroscopy (ATR-FTIR), molecular docking and molecular dynamics simulations (MD), laser Doppler flowmetry (LDF), and the western blotting method.Results: The study found that VO-ER promotes the permeation of total glycosides of peony in a concentration-dependent manner by disrupting the intercellular lipid tissue structure, downregulating the expression of claudin-1, claudin-7, and occludin, and improving local microcirculation, thereby promoting the absorption of TGP.Conclusions: VO-ER enhances the transdermal absorption of TGP through multiple mechanisms, such as disrupting the skin lipid barrier, downregulating tight junction proteins, and improving local skin microcirculation. This study provides a theoretical basis for VO-ER as a safe and effective new transdermal penetration enhancer, offering support for the development of topical preparations containingEvodia rutaecarpaandPaeonia lactiflora.
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ADVANCED FUNCTIONAL MATERIALS
·
2026
·
IF 19.9
Jianqi Ye,Jinhua Lu,Lanqing Li,Xinhao Wan,Jialu Wang,Haoxin Fan,Fangyuan Ma,Shan Chen,Dan Wen
Developing flexible, self-sufficient power generators is of significance for burgeoning wearable electronics. Biofuel cells (BFC) that harness perspiration metabolites can potentially offer a promising route toward simultaneous energy generation and self-powered sensing. However, insufficient power supply and susceptible enzyme-induced instability hinder widespread adoption. Herein, an enzyme-free hybrid glucose BFC is designed employing nitrogen-phosphorus doped carbon (NPC) flexible film derived from self-assembly graphene/polymer hydrogels, incorporating platinum nanoparticles for glucose oxidation and manganese dioxide-based O 2 -independent capacitive cathode. The O 2 -independent design eliminates potential interference to the anodic reaction, enabling a markedly enhanced maximum power density of 680 µW cm −2 and an open circuit voltage of 0.92 V, alongside operational stability exceeding 30 days. When functioning as the self-powered glucose sensor, it offers a wide range of 0.05–20 mM. Integrated into a conformal wearable system, the device enables bioenergy harvesting from human sweat and real-time glucose monitoring via compact signal processing electronics. This work underscores the potential of flexible hybrid BFC systems and paves the way for powering next-generation wearable bioelectronics in personalized healthcare.
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CHEMISTRY-A EUROPEAN JOURNAL
·
2026
·
IF 3.6
Yue Gui,Jincheng Liu,Ping Yang,Jingxian Zhu,Yiran Xu,Jing Wang,Xin Dong,Tongming Sun,Yanfeng Tang,Minmin Wang
This study successfully fabricated a freestanding ZnO@(NiFe)OOH nano-heterostructure array electrocatalyst with high hydrophilicity for efficient electrocatalytic nitrate reduction to ammonia (NO 3 RR) in neutral media. The material integrates the large specific surface area of one-dimensional ZnO nanoarrays with the electronic modulation capability of heterogeneous interfaces, which significantly enhances nitrate adsorption and activation, promotes proton supply, and effectively suppresses the hydrogen evolution side reaction. The highly hydrophilic surface further accelerates electrolyte diffusion, nitrate ion transport, and product desorption. In a neutral electrolyte of 0.1 M PBS containing 0.15 M KNO 3 at a potential of −1.0 V (vs. RHE), the catalyst achieves an ammonia production rate of 4.86 mg·h −1 ·cm −2 with a Faradaic efficiency of 85.58%, while generating minimal byproducts, demonstrating excellent catalytic selectivity and stability. This work provides a new strategy for the structural design and performance enhancement of NO 3 RR electrocatalysts, which holds significance for advancing green ammonia synthesis and enabling efficient conversion of nitrate in water pollution control. Graphical A self-supported ZnO@(NiFe)OOH core-shell array enables efficient nitrate-to-ammonia conversion. The ZnO core accelerates NO 3 -diffusion and prevents active site coverage while enhancing conductivity and stability. The (NiFe)OOH shell facilitates intermediate conversion and suppresses hydrogen evolution by weakening H+ adsorption. Its surface hydroxyl groups promote water dissociation, ensuring a local proton supply. In neutral media, this design achieves superior performance: at −1.0 V vs RHE in 0.15 M KNO 3 , it delivers an NH3 yield of 4.86 mg h −1 cm −2 and a faradaic efficiency of 85.58%.
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JOURNAL OF PERIODONTOLOGY
·
2026
·
IF 4.5
Bei Gao,Jin Bai,Rui Xiao,Jiaqi Li,Mengying Wang,Ziyi Wang,Zhihui Feng,Jianfeng Shi,Zhongbo Liu
Background Postmenopausal osteoporosis (PMOP) leads to systemic bone metabolism disorders, significantly affecting oral bone health and complicating treatment. Osteocytes, the most abundant cells in bone tissue, play a crucial role in bone remodeling through cellular communication. However, the mineralized bone matrix surrounding osteocytes presents significant challenges for studying their dendritic networks. Methods Eight week old C57BL/6J female mice were randomly assigned to either a Sham group or an ovariectomized (OVX) group. The PMOP animal model was established via bilateral ovariectomy and analyzed after 12 weeks. Osteocyte dendrites and the lacuno-canalicular network (LCN) were examined via SEM and immunohistochemical staining. Quantification of nodes and connectomic measurements were performed for LCN and phalloidin network analyses. Furthermore, the expression levels of MMP13 and CTSK were assessed via immunohistochemical staining and real-time PCR. Results Our findings revealed that both Sham and OVX mice exhibited two distinct morphological types of osteocyte lacunar structures in the mandible. In Sham mice, direct communication was observed between osteocytes, adjacent cells, and blood vessels via canaliculi. In contrast, connectivity analysis of the osteocyte dendritic network in OVX mice revealed a reduced material transport capacity between cells compared with Sham controls. OVX-induced systemic osteoporosis altered the osteocyte dendritic network and lacunar canaliculi in the mandible, potentially due to periluminal canalicular remodeling. Conclusions This study offers new insights into the changes and mechanisms affecting the dendritic network and lacunar canaliculi of mandibular osteocytes in postmenopausal osteoporosis, contributing to a deeper understanding of oral bone lesions in this condition. Plain Language Summary After menopause, many women develop osteoporosis—a condition where bones become weak and break easily. This not only affects bones such as the spine or hips but also damages the jawbone, making dental treatments harder. We wanted to understand how osteoporosis weakens the jawbone by studying tiny bone cells called osteocytes, which act like “messengers” controlling bone health. Using advanced microscopy and special staining techniques, we mapped communication networks between osteocytes in the jawbone (like tracing telephone wires between cells). We then compared bone structures between healthy mice and mice with osteoporosis after ovary removal. Osteoporosis damaged the “wires” (dendrites) connecting osteocytes, reducing their ability to share nutrients and signals. It also widened tunnels (canaliculi) around osteocytes—like potholes in roads—disrupting their links to blood vessels and neighboring cells. These changes likely occur because osteoporosis impairs the bone's self-repair system around these tunnels. Our discovery that osteoporosis breaks bone cell networks reveals a new mechanism for jawbone weakening, paving the way for better dental treatments, protective drugs, and patient education.
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PHYTOTHERAPY RESEARCH
·
2026
·
IF 8.1
Huimao Liu,Dan Yang,Hanyan Cheng,Lijuan Cao,Xu Song,Xun Zhou,Yuanfeng Zou,Lixia Li,Renyong Jia,Dongmei Zhang,Mingyue Li,Zhongqiong Yin
Resveratrol (RSV), a dietary polyphenol widely present in traditional medicinal plants and foods, exhibits antioxidant and anti-inflammatory properties that are relevant to ethnopharmacological strategies for protecting against environmental neurotoxicants. Given increasing real-world co-exposure to lead (Pb) and cadmium (Cd), elucidating RSV's capacity to preserve gut–brain axis (GBA) homeostasis has direct translational relevance for populations relying on phytochemical interventions. Sprague–Dawley rats were randomized into control, Pb–Cd model, and RSV treatment groups (10, 20, or 40 mg/kg). For 4 weeks, rats received Pb (300 mg/L) and Cd (50 mg/L) in drinking water with daily RSV. Cognitive function was assessed by Morris water maze; barrier integrity by Evans blue assay, histology, and Western blot for ZO-1/Occludin; synaptic ultrastructure by TEM; microbiota composition by 16S rRNA sequencing; and short-chain fatty acids (SCFAs) by GC-MS. Neurotransmitters (5-HT, GABA, SP, VIP) and cytokines (IL-6, IL-1β, TNF-α) were measured by ELISA. RSV improved spatial learning, reduced EB extravasation, preserved synaptic ultrastructure and proteins (BDNF, SYN, PSD-95), and restored intestinal architecture with increased ZO-1/Occludin. RSV attenuated cytokine release, normalized goblet cells, reversed dysbiosis by restoring Lactobacillaceae/Prevotellaceae, and increased acetate, propionate, and butyrate. It reinstated 5-HT and GABA while reducing SP and restoring VIP across serum, colon, and hippocampus. RSV attenuated Pb–Cd–associated neurotoxicity and was accompanied by improved intestinal and BBB-related readouts, partial normalization of gut microbiota features and SCFA levels, and preservation of synaptic and neurotransmitter-related markers, consistent with a link to gut–brain axis function. This study is among the first to test RSV in a Pb–Cd co-exposure model using a multi-dose regimen with integrated behavioral, barrier, microbial, and neurochemical endpoints.
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TALANTA
·
2026
·
IF 6.7
Chen-Chen Bai,Chen-Ri Su,Yu-Jun Shi,Jun-Li Qian,Long-Xin Yang,Zhi-Peng Li,Sen Gao,Lin Zhao,Xian-Hua Wang
Listeria monocytogenes ( L. monocytogenes ), as a prevalent foodborne pathogen, is a major threat to global public health due to its high mortality rate and strong survival ability under limited conditions. Herein, a novel ampicillin grafted tetracarboxylic functionalized magnetic nanoparticles (ATMN) was fabricated and combined with real-time loop-mediated isothermal amplification (LAMP) for ultrasensitive detection of L . monocytogenes . Within one tube, ATMN could specifically capture target L. monocytogenes by the selective recognition between ampicillin on ATMN and penicillin binding proteins on the surface of L. monocytogenes , and then effectively isolate its DNA mainly through hydrogen bonds between carboxy on ATMN and DNA after in situ lysis. Interestingly, continuous enrichment and separation within one tube could obtain template DNA. Subsequently, the DNA was analyzed by real-time LAMP for accurate detection, in which the specific hly gene of L . monocytogenes was selected as an indicator. To prove the practicability, ATMN linked real-time LAMP (ATMN-LAMP) strategy was proposed for rapid, specific, and ultrasensitive detection determination of L . monocytogenes in lettuce and raw pork. The ATMN-LAMP strategy exhibited ultrahigh sensitivity with limit of detection of 78 CFU mL −1 , and was successfully used for detecting L . monocytogenes in spiked real samples with recovery between 97.2% and 102.8% and relative standard deviation no more than 5.3%, respectively. Therefore, we believe that the ATMN-LAMP strategy exhibits the characteristics of low cost, high efficiency, and simple operation, and is expected to become a universal method for detecting various pathogens in complex biological samples.
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