Regenerative Biomaterials
·
2021
·Vol. 8
·期 3
·
IF 6.353
Wang Qiaoying,Wu Changqiang,Li Xiaoting,Yang Dixiao,Shi Liangjun
We have designed and developed an effective drug delivery system using biocompatible polymer of poly (ethylene glycol)-polyaspartic acid (mPEG-PAsp) for co-loading the chemotherapy drugs paclitaxel (PTX) and cisplatin (CP) in one nano-vehicle. This study aimed to improve the anti-cancer efficacy of combinations of chemotherapy drugs and reduce their side effects. mPEG-PAsp-(PTX/Pt) nano-micelles disperse well in aqueous solution and have a narrow size distribution (37.8 ± 3.2 nm) in dynamic light scattering (DLS). Drug release profiles found that CP released at pH 5.5 was significantly faster than that at pH 7.4. MPEG-PAsp-(PTX/Pt) nano-micelles displayed a significantly higher tumor inhibitory effect than mPEG-PAsp-PTX nano-micelles when the polymer concentrations reached 50 μg/mL. Our data indicated that polymer micelles of mPEG-PAsp loaded with the combined drug exert synergistic anti-tumor efficacy on SKOV3 ovarian cells via different action mechanisms. Results from our studies suggested that mPEG-PAsp-(PTX/Pt) nano-micelles are promising alternatives for carrying and improving the delivery of therapeutic drugs with different water solubilities.
研究领域:
药学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 43
·26943-26951
·
IF 3.108
Huajun Zheng,Ping Niu,Zhefei Zhao
Carbon quantum dot sensitized Pt@Bi2WO6/FTO electrodes (simplified as CQDs-Pt@Bi2WO6/FTO) were successfully prepared by loading platinum particles onto Bi2WO6 nanoplates via a photo-deposition method and sensitized carbon quantum dots (CQDs) via a dip-coating method. The photoelectro-catalytic properties of the Pt@Bi2WO6/FTO and CQDs-Pt@Bi2WO6/FTO electrodes for methanol oxidation were investigated. The results indicated that the CQDs-Pt@Bi2WO6/FTO electrode shows higher photoelectro-catalytic activity and better stability than that of the Pt@Bi2WO6/FTO electrode. The higher photoelectro-catalytic performance for methanol oxidation was attributed due to the special synergetic effects between the photocatalytic and electrocatalytic process under solar light irradiation. More importantly, the introduction of CQDs broaden the photoresponse range of the Bi2WO6 material and improves the mobility of the photocarriers. Meanwhile, the doped CQDs act as preferential adsorption sites for the intermediate carbonaceous species during methanol oxidation. This not only alleviates CO poisoning towards the Pt particles, but also improves the efficiency of methanol oxidation by constructing a new type of CQDs-Pt electrocatalyst. The composite material, which combines the dual function of photocatalysis and electrocatalysis will be a promising candidate for new photoelectro-catalytic fuel cells.
研究领域:
材料科学
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电化学
✓ 已验证
产品关联
DOI
高影响因子
PATHOLOGY RESEARCH AND PRACTICE
·
2022
·
IF 3.309
Jianfa Wu,Xiaohong Ni,Zhen Yu,Suqin Wu,Zhou Liu
Background CRNDE is known to be an important predictive factor of prognosis in many tumors; however, its role in cisplatin resistance is still unknown in ovarian cancer. The aim of the current research was to investigate the association between CRNDE and cisplatin resistance. Materials and methods QRT-PCR and in situ hybridization assay were employed to detect the expression of CRNDE in ovarian cancer cells and tissues; CCK8 assay, AnnexinV-FITC apoptosis assay and Trans-well assay, to determine the cell proliferation , apoptosis and invasion; and RNA-pull down assay, mass spectrometry analysis, gene microarray to search the targeted gene of CRNDE and SRSF1 . Association of CRNDE with SRSF1 was determined in ovarian cancer cells and nude mice . Results It was found that CRNDE and SRSF1 expression were higher in the cisplatin resistant ovarian cancer cells than their control cells. High expression of CRNDE and SRSF1 led to cisplatin resistance. While inhibition of CRNDE or SRSF1 sensitized ovarian cancer to cisplatin in vitro and in vivo. Moreover, as indicated in RIP assay, SRSF1 was potentially the targeted gene of CRNDE, and CRNDE promoting SRSF1 expression to induce cisplatin resistance; as indicated in gene microassay, there was significantly positive correlation between SRSF1 and TIA1 , and SRSF1 promoting TIA1 expression. Conclusion In conclusion, CRNDE induced cisplatin resistance in ovarian cancer through SRSF1/TIA1 signaling pathway ; thus, CRNDE inhibitor or SRSF1 inhibitor combined with cisplatin might act as a novel promising approach to ovarian cancer.
研究领域:
肿瘤学
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分子生物学
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遗传学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2023
·
IF 13.6
Hanqin Weng,Yi Wang,Fuhai Li,Yusa Muroya,Shinichi Yamashita,Sheng Cheng
Recovery of platinum group metals (PGMs) including palladium (Pd), rhodium (Rh), and ruthenium (Ru) from high-level radioactive liquid waste (HLLW) possesses enormous environmental and economic benefits. A non-contact photoreduction method was herein developed to selectively recover each PGM from HLLW. Soluble Pd(II), Rh(III), and Ru(III) ions were reduced to insoluble zero-valent metals and separated from simulated HLLW containing neodymium (Nd) as a representative for lanthanides , another main component in HLLW. Detailed investigation on the photoreduction of different PGMs revealed that Pd(II) could be reduced under 254- or 300-nm UV exposure using either ethanol or isopropanol as reductants. Only 300-nm UV light enabled the reduction of Rh(III) in the presence of ethanol or isopropanol. Ru(III) was the most difficult to reduce, which was only realized by 300-nm UV illumination in isopropanol solution. The effects of pH was also studied, suggesting that lower pH favored the separation of Rh(III) but hindered the reduction of Pd(II) and Ru(III). A delicate three-step process was accordingly designed to achieve the selective recovery of each PGM from simulated HLLW. Pd(II) was reduced by 254-nm UV light with the help of ethanol in the first step. Then Rh(III) was reduced by 300-UV light in the second step after the pH was adjusted to 0.5 to suppress the Ru(III) reduction. In the third step, Ru(III) was reduced by 300-nm UV light after isopropanol was added and the pH was adjusted to 3.2. The separation ratios of Pd, Rh, and Ru exceeded 99.8%, 99.9%, and 90.0%, respectively. Meanwhile, all Nd(III) still remained in the simulated HLLW. The separation coefficients between Pd/Rh and Rh/Ru exceeded 56,000 and 75,000, respectively. This work may provide an alternative method to recover PGMs from HLLW, which minimize the secondary radioactive wastes compared with other approaches.
研究领域:
环境科学
·
核化学与放射化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2021
·
IF 5.816
Rongcheng Mo,Xiaoran Zhang,Zhenyu Chen,Shangli Huang,Yanjie Li,Lizhe Liang,Zhi Qun Tian,Pei Kang Shen
Developing platinum-based nanoparticles on carbon catalysts with high activity and stability for oxygen reduction reaction (ORR) is of great significance for the practical application of fuel cells. Herein, a synchronous strategy of preparing nano-sized PtCo supported on atomic Co and N co-doped carbon nanorods (PtCo/Co–N–C NR) was developed to replace the conventional method of impregnating Pt sources into ready-made carbon materials , in which metal-organic frameworks (MOFs) with Co and Zn ions of rhombic dodecahedron were first prepared using 2-methylimidazole as building block and then their morphology was transformed into porous nanorods via the reduction of Co ions to Co–B–O complex in the MOFs by NaBH 4 ; subsequently, Pt was deposited on the Co–Zn MOF nanorods through the displacement reaction of PtCl 6 2 - and metallic Co and coordination between MOF and PtCl 6 2 - ; after pyrolysis and acid-leaching process, highly dispersed PtCo/Co–N–C NR was obtained. Attributed to its unique characteristics of hierarchical pore structure , uniform PtCo alloy nanoparticles with the average size of 7.0 nm and strong supporting interaction effect, the catalyst exhibits high ORR activity and stability with the mass activity of 577.0 mA mg −1 Pt and specific activity of 1.4 mA cm −2 at 0.9 V vs RHE in 0.1 M HClO 4 , which is about 3.6 times and 3.5 times high than that of commercial Pt/C catalyst respectively. This strategy would provide a flexible route to develop highly active and stable ORR electrocatalysts with various morphologies for optimizing the exposure of active sites.
研究领域:
材料科学
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电化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF POWER SOURCES
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2015
·
IF 6.217
De-Jun Chen,Qian-Li Zhang,Jin-Xia Feng,Ke-Jian Ju,Ai-Jun Wang,Jie Wei,Jiu-Ju Feng
In this work, a simple, rapid and facile one-pot wet-chemical co-reduction method is developed for synthesis of bimetallic Au–Pt alloyed nanochains supported on reduced graphene oxide (Au–Pt NCs/RGO), in which caffeine is acted as a capping agent and a structure-directing agent, while no any seed, template, surfactant or polymer involved. The as-prepared nanocomposites display enlarged electrochemical active surface area, significantly enhanced catalytic activity and better stability for methanol and ethylene glycol oxidation , compared with commercial Pt–C (Pt 50 wt%), PtRu–C (Pt 30 wt% and Ru 15 wt%) and Pt black.
研究领域:
材料科学
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电化学
✓ 已验证
产品关联
DOI
高影响因子
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2015
·Vol. 17
·期 46
·31170-31176
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IF 4.493
Haidong Zhao,Rui Liu,Yong Guo,Shengchun Yang
In the current research, the PtxAgy (x/y = 86/14, 79/21, 52/48, 21/79, 11/89) nanoparticles (NPs) are synthesized in the KNO3–LiNO3 molten salts without using any organic surfactant or solvent. The SEM results suggest that when the content of Ag is higher than 48%, the wormlike PtxAgy nanotubes (NTs) can be synthesized. The diameter of the PtxAgyNTs shows a slow decrease with the increase of Ag content. The TEM and HRTEM results indicate that the growth of hollow PtxAgy NTs undergoes an oriented attachment process and a Kirkendall effect approach. The results of cyclic voltammetry (CV) measurement indicate that the Pt52Ag48 catalyst presents a remarkable enhancement for methanol electrooxidation, while the Pt86Ag14 catalyst prefers electrochemically oxidizing formic acid compared with that of the commercially available Pt black.
研究领域:
材料科学
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电化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBON
·
2014
·
IF 6.16
Dandan Zhu,Liangjun Li,Jinjun Cai,Min Jiang,Jingbo Qi,Xuebo Zhao
A novel pyridine-containing metal-organic framework (MOF), [Zn(bpdc)DMA]·DMF, was first constructed by solvothermal reaction of 2,2′-bipyridine-5,5′-dicarboxylate ( bpdc ) with zinc nitrate, and then it was converted to nitrogen-doped porous carbons (NPCs) by direct carbonization . The as-prepared porous carbon (NPC800) was characterized by scanning electron microscopy (SEM), X-ray powder diffraction (XRD), N 2 sorption isotherms, and X-ray photoelectron spectroscopy. NPC800 was modified onto glassy carbon electrode surface for investigating its electrochemical applications. Cyclic voltammetry (CV) and linear sweep voltammetry were performed to evaluate the electrocatalytic activity of NPC800 for oxygen reduction reaction (ORR) in alkaline solution. NPC800 exhibited better ORR activity than commercial Pt/C. Pt-catalyst supported on NPCs (Pt/NPC800) was prepared by means of electrodeposition and characterized by SEM, Energy dispersive spectrometry and XRD. The electrocatalytic activity and stability of Pt/NPC800 for methanol oxidation reaction (MOR) were estimated in acidic methanol solution by CV and chronoamperometric curves, respectively. Pt/NPC800 showed catalytic role for MOR, and also had better stability than Pt-catalyst supported on commercial Vulcan XC-72.
研究领域:
材料科学
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电化学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry A
·
2015
·Vol. 3
·期 10
·5352-5359
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IF 7.443
Li-Li He,Pei Song,Ai-Jun Wang,Jie-Ning Zheng,Li-Ping Mei,Jiu-Ju Feng
In this work, a general strategy was developed for the facile synthesis of bimetallic AuM (M = Pt or Pd) alloyed flowerlike-assembly nanochains (FANs) with the assistance of diprophylline as a structure-directing and stabilizing agent. The morphologies, crystal structures, and compositions of AuPt and AuPd FANs were investigated primarily by transmission electron microscopy (TEM), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). The formation mechanism was discussed in some detail by varying the concentration of diprophylline. The as-prepared AuM FANs displayed improved catalytic activities and better stabilities for oxygen reduction reaction (ORR) compared to commercial E-TEK Pt/C, Pt black and Pd black.
研究领域:
材料科学
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电化学
✓ 已验证
产品关联
DOI
高影响因子
CHINESE JOURNAL OF CATALYSIS
·
2017
·
IF 2.813
Jifen Liang,Xiaoming Zhang,Lingyan Jing,Hengquan Yang
ABSTRACT Due to the advantages of high surface areas, large pore volumes and pore sizes, abundant nitrogen content that favored the metal-support interactions, N-doped ordered mesoporous carbons are regarded as a kind of fascinating and potential support for the synthesis of effective supported catalysts. Here, a N-doped ordered mesoporous carbon with a high N content (9.58 wt%), high surface area (417 m 2 /g), and three-dimensional cubic structure was synthesized successfully and used as an effective support for immobilizing Pt nanoparticles (NPs). The positive effects of nitrogen on the metal particle size enabled ultrasmall Pt NPs (about 1.0 ± 0.5 nm) to be obtained. Moreover, most of the Pt NPs are homogeneously dispersed in the mesoporous channels. However, using the ordered mesoporous carbon without nitrogen as support, the particles were larger (4.4 ± 1.7 nm) and many Pt NPs were distributed on the external surface, demonstrating the important role of the nitrogen species. The obtained N-doped ordered mesoporous material supported catalyst showed excellent catalytic activity (conversion 100%) and selectivity (>99%) in the hydrogenation of halogenated nitrobenzenes under mild conditions. These values are much higher than those achieved using a commercial Pt/C catalyst (conversion 89% and selectivity 90%). This outstanding catalytic performance can be attributed to the synergetic effects of the mesoporous structure, N-functionalized support, and stabilized ultrasmall Pt NPs. Moreover, such supported catalyst also showed excellent catalytic performance in the hydrogenation of other halogenated nitrobenzenes and nitroarenes. In addition, the stability of the multifunctional catalyst was excellent and it could be reused more than 10 times without significant losses of activity and selectivity. Our results conclusively show that a N-doped carbon support enable the formation of ultrafine metal NPs and improve the reaction activity and selectivity.
研究领域:
材料科学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2014
·
IF 2.93
Jing-Jing Lv,Shan-Shan Li,Jie-Ning Zheng,Ai-Jun Wang,Jian-Rong Chen,Jiu-Ju Feng
In this work, a simple and facile method is developed in the synthesis of well-dispersed PtAg nanoflowers on reduced graphene oxide nanosheets (PtAg/RGOs) under solvothermal conditions, using ethylene glycol as a reducing agent and hexadecyl trimethyl ammonium bromide (CTAB) as capping and stabilizing agents. The as-prepared nanocomposites show a superior electrocatalytic activity , good tolerance, and better stability toward the oxidation of formic acid and ethylene glycol in alkaline media , compared with the commercial Pt/C (10 wt%) catalyst. For the oxidation of formic acid , the PtAg nanoflowers own thirty times higher of the catalytic currents than those of the commercial Pt/C catalyst. Meanwhile, for the oxidation of ethylene glycol, the ratio of forward current ( j F ) to reverse current ( j R ) is high up to 8.4, which is almost four times higher than that of the commercial Pt/C catalyst. This strategy provides a promising platform for direct formic acid and ethylene glycol fuel cells.
研究领域:
材料科学
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电化学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2021
·
IF 5.816
Yuanchao Pei,Yajuan Niu,Wanjun Zhang,Yaxin Zhang,Jie Ma,Zhiyong Li
Tunable microstructure of microemulsion self-assembly systems has the prominent application as nanoreactors in reaction processes. Scientific and technological interest in microemulsions derived from the confinement effect of polar or nonpolar domains for hydrophilic/hydrophobic molecules. Benefiting from the tunable nature, ionic liquids-based self-assembly systems have been demonstrated as a versatile platform for catalytic reaction , drug delivery, functional materials fabrication and among others. In this work, ionic liquids microemulsions were designed by using ionic liquids as apolar phase and surfactant . The phase equilibrium and microstructure were studied through phase diagram , conductivity method and dynamic light scattering . Ionic liquids-in-water microemulsions were proposed as nanoreactor for fabrication of nanosized platinum/titanium dioxide composites. The size, morphology and catalytic performance can be tuned by the microemulsion structure through its confinement effect. The hydrolysis of ammonia borane catalyzed by these composites exhibits better catalytic activity with higher turnover frequency and lower activation energy of the reaction. It is believed that the nanoreactors constructed from versatile ionic liquids will provide new guidance in designing advanced scientific applications.
研究领域:
材料科学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）