JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2017
·
IF 2.323
Huanxin Li,Junwei Zhang,Yonghui Dou,Li Xu,Guoji Liu
Data of liquid–liquid equilibria (LLE) for water + 1,6-hexanediamine + 1-butanol and water + 1,6-hexanediamine + 1-pentanol ternary systems were determined at T = 298.2, 308.2, and 318.2 K under atmospheric pressure. The distribution coefficients and selectivity factors calculated from LLE data were applied to evaluate the feasibility and effectiveness of extracting 1,6-hexanediamine from the aqueous solution. The results showed that the selectivity factors decrease with the amount of 1,6-hexanediamine increasing in the aqueous phase, and the effect of temperature is insignificant in this study. The nonrandom two-liquid and universal quasichemical activity coefficient models were also applied to regress the experimental equilibrium data of the two ternary systems and the root mean square deviation values between the correlated and experimental results were lower than 0.7%. It turned out that these phase equilibrium behaviors can be described by the two models. Meanwhile, the binary model parameters were acquired from the relevant process simulations.
研究领域:
化学工程
·
物理化学
✓ 已验证
DOI
高影响因子
JOURNAL OF ORGANIC CHEMISTRY
·
2022
·
IF 4.198
Yueyue Zhu,Rupeng Dai,Chaoqun Huang,Wang Zhou,Xiaoyuan Zhang,Kundi Yang,Hongmei Wen,Wei Li,Jian Liu
In this study, we report a novel and efficient synthetic method to construct isoquinolone scaffold via the Rh(III)-catalyzed (4 + 2) annulation of benzamide with an unreported coupling reagent methyl 2-chloroacrylate. Accordingly, other valuable 1,2-benzothiazine and naphtho[1′,2′:4,5]imidazo[1,2-a]pyridine derivatives are also obtained through a similar synthetic protocol. Thus, our developed method is highlighted by high yield and reaction versatility.
研究领域:
有机化学
·
药物化学
✓ 已验证
DOI
高影响因子
FREE RADICAL BIOLOGY AND MEDICINE
·
2024
·
IF 7.1
Yiming Zhou,Mengting Zhang,Siyu Lu,Li Liu,Zhigui Duan,Fang Wei,Guolin Li
Purpose While reactive oxygen species (ROS) have been identified as key redox signaling agents contributing to aging process, which and how specific oxidants trigger healthy longevity remain unclear. This paper aimed to explore the precise role and signaling mechanism of superoxide (O 2 •− ) in health and longevity. Methods A tool for precise regulation of O 2 •− levels in vivo was developed based on the inhibition of superoxide dismutase 1 (SOD1) by tetrathiomolybdate (TM) in Caenorhabditis elegans ( C. elegans ). Then, we examined the effects of TM on lifespan, reproduction, lipofuscin accumulation, mobility, and stress resistance. Finally, the signaling mechanism for longevity induced by TM-O 2 •− was screened by transcriptome analysis and tested in sod-1 and argk-1 RNAi strains, sod-2 , sod-3 , and daf-16 mutants. Results TM promoted longevity in C. elegans with a concomitant extension of healthy lifespan as indicated by increasing fertility and mobility and reducing lipofuscin accumulation, as well as enhanced resistance to different abiotic stresses. Mechanically, TM could precisely regulate O 2 •− levels in nematodes via modulating SOD1 activity. An O 2 •− scavenger Mn(III)TBAP abolished TM-induced lifespan extension, while an O 2 •− generator paraquat at low concentration mimicked the life prolongation effects. The longevity in TM-treated worms was abolished by sod-1 RNAi but was not affected in sod-2 or sod-3 mutants. Further transcriptome analysis revealed arginine kinase ARGK-1 and its downstream insulin/insulin-like growth factor 1 signaling (IIS) as potential effectors for TM-O 2 •‾ -induced longevity, and argk-1 RNAi or daf-16 mutant nullified the longevity. Conclusions These findings indicate that it is feasible to precisely control specific oxidant in vivo and O 2 •− orchestrates TM-induced health and longevity in C. elegans via ARGK-1-IIS axis.
研究领域:
衰老
·
分子生物学
·
遗传学
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产品关联
DOI
PubMed
高影响因子
NORDIC PULP & PAPER RESEARCH JOURNAL
·
2024
·
IF 0.9
Tianhao Wang,Luyang Wang,Shun Liu,Lin Chen,Xin Jin,Haitang Liu,Xiaoyuan Liao
In this work, a strategy of in situ 3D hierarchical porous HKUST-1/cellulose/chitosan (CSGA/HKUST-1) composite aerogels were synthesized using ethylene glycol diglycidyl ether (EGDE) as a cross-linking agent. The effect of EGDE on CSGA/HKUST-1 and the adsorption of tetracycline (TC) was investigated: the composite aerogel (CSGA) was produced by the ring-opening reaction of the epoxy group of EGDE in alkaline solution. The chemical structure of CSGA/HKUST-1 composite aerogel was characterized by FT-IR, XRD and XPS.49.33 % mass loading of CSGA1/HKUST-1 was achieved and N 2 adsorption and desorption experiment showed the BET specific surface area reached 694.514 m 2 g −1 . SEM observed the CSGA/HKUST-1 composite aerogel pores were filled with a large number of octahedral HKUST-1 crystal particles. CSGA/HKUST-1 composite aerogel has excellent tetracycline adsorption capacity (285.7 mg g −1 ), and the removal efficiency remained at 92.7 % after five cycles of adsorption–desorption. The pseudo-second-order kinetic model and Langmuir model adsorption mechanism was successfully concluded. This study can provide ideas for in situ synthesis of MOFs on 3D composite aerogel to prepare adsorption materials, improve the mass loading rate of MOFs and prevent MOFs from falling off, etc., and enrich the application of MOFs materials in the treatment of antibiotic pollutants.
研究领域:
材料科学
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环境科学
·
生物学
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Mingwei Zhang,Cheng-Bin Hong,Zhaoying Ding,Yujing Weng,Honghui Gong,Haiyong Wang,Yulong Zhang,Yuhe Liao,Haichao Liu
Hydrogenolysis of glycerol is an important reaction in biomass valorization, and requires efficient catalysts for selectively removing its hydroxyl groups to yield valuable chemicals, such as 1-propanol and 1,2-propanediol. In this work, we synthesized a porous and non-stoichiometric tungsten oxide (WO x ) by a solvothermal method, and a serious of WO x -supported Pt and Mn ((Mn)Pt/WO x ) catalysts by reduction with H 2 at different temperatures. On these catalysts, the product selectivity in the glycerol hydrogenolysis was significantly influenced by the presence of the Mn species and reduction temperatures. The catalysts after reduction with H 2 at lower temperatures favored the formation of 1-propanol, affording a yield of 88.0 % at 240 °C, while those reduced at higher temperatures facilitated the formation of 1,2-propanediol in a yield of 93.0 % under the same reaction conditions. Extensive analysis of these catalysts by in-situ and ex-situ characterizations showed that the high-temperature reduction led to the formation of MnWO 4 on the Mn/Pt/WO x catalysts and the consequent decrease in the acidic sites and increase in the basic sites, facilitating the alkali-assisted dehydrogenation of glycerol and selective formation of 1,2-propanediol. This study provides fundamental insights into the role of the W and Mn species in tuning the selectivity of the glycerol hydrogenolysis, which will be valuable for designing catalysts towards the valorization of other biomass-based feedstocks.
研究领域:
催化化学
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生物质转化
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Yuting Li,Yueyang Xu,Erjian Huang,Liming Kong,Yongping Zeng
Thiophene-like sulfides present in fuel oil release sulfur oxides (SO x ) during combustion, which pose significant risks for both environmental sustainability and public health. Adsorption desulfurization (ADS) has garnered considerable attention because of its mild operating conditions, low production costs, and minimal impact on the octane number of fuels. Metal-organic frameworks used as desulfurizing adsorbents provide several advantages, including a high specific surface area and easily adjustable structures . Here, we synthesized the micro/mesoporous adsorbent CeO 2 @HP-HKUST-1 (CeO 2 @Hierarchical Porous-Hong Kong University of Science and Technology-1) through the hybridization of salicylic acid (SA) using a solvothermal method. We assessed the adsorption performance of CeO 2 @HP- HKUST-1 _ 1.5 for benzothiophene and thiophene through batch and breakthrough adsorption experiments. The adsorption capacities for thiophene and benzothiophene were measured at 21.2 mg S/g and 35.3 mg S/g, respectively. Remarkably, in competitive toluene experiments, the adsorption capacity for benzothiophene remained significant at 28.9 mg S/g, due to enhanced Ce–S bonding interactions and the exposure of unsaturated metal centers of Cu. Additionally, regeneration experiments demonstrated that CeO 2 @HP-HKUST-1 retained excellent adsorption capacities after four cycles. These findings highlight the potential of CeO 2 @HP-HKUST-1 as an effective adsorbent for desulfurization applications.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CRYSTAL GROWTH & DESIGN
·
2025
·
IF 3.4
Hongyu Wang,Fumin Wang,Kaiwei Wang,Xubin Zhang,Changhao Bing,Xiaolu Fan,Tongxue Zhang,Syed Mujtaba ul Hassan
Developing an approach for the efficient synthesis of TS-1 zeolites with desirable morphologies and tunable coordination environments for Ti active sites is a pivotal challenge in the design of high-performance catalysts and zeolite crystal engineering. Herein, we report a cost-effective and efficient additive, guanidinoacetic acid (GAA), and conduct a systematic study on the synthesis of plate-like TS-1 zeolites using GAA as an additive. Introducing GAA during hydrothermal synthesis not only modulates the morphology of TS-1 crystals but also permits GAA to adequately chemically interact with titanium precursors to form hexa-coordinated Ti species. TS-1 zeolites with a controllable b-axis thickness in the range of 80–110 nm, and abundant framework Ti and hexa-coordinated Ti species are successfully achieved by optimizing the synthetic parameters. Through SEM, FT-IR, XPS, TEM, and XRD analysis, the mechanism of GAA altering crystal growth is mainly to inhibit the growth of the (010) plane. A b-axis-oriented TS-1 zeolite enriched with hexa-coordinated Ti species displays better catalytic performance in the 1-hexene epoxidation reaction than the conventional TS-1 zeolite containing only framework Ti species (35 vs 24%). This can be ascribed to the more active hexa-coordinated Ti species and shorter diffusion distance. This synthetic strategy provides a way to change the zeolite morphology and tune the number and distribution of Ti species in TS-1 zeolites.
研究领域:
催化材料
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晶体工程
·
化学合成
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF LOSS PREVENTION IN THE PROCESS INDUSTRIES
·
2024
·
IF 3.6
Chenyang Pu,Zhi Wang,Boren Zheng,Bin Zhang
1,2,4-Triazole is a common intermediate used in the synthesis of pesticides and medicine, and has a very wide range of applications. As a kind of polynitrogen heterocycles, 1,2,4-triazole will release a lot of heat during thermal decomposition. If there is no comprehensive understanding of its pyrolysis behavior, there will be a very large thermal safety risk in the process involving 1,2,4-triazole in industrial production. At the same time, the instability of the substance may be affected by the presence of impurities, and the existing research on this aspect is quite scarce. Therefore, it is very necessary to study the effect of adding other substances on the thermal decomposition of 1,2, 4-triazole. The thermal decomposition characteristics and thermal runaway behavior of 1,2, 4-triazoles were revealed by thermodynamic experiments and various kinetic theoretical methods. According to the risk matrix, the thermal runaway danger level of 1,2, 4-triazole was determined to be level Ⅲ, which was an unacceptable risk. The results show that 1,2, 4-triazole has a huge heat release and the effect of thermal runaway is serious. In this study, three substances involved in the industrial production of fluconazole and flutriafol mixed with 1,2, 4-triazole were selected to explore their influence on the thermal decomposition of 1,2, 4-triazole under non-working conditions. DSC and ARC experiments consistently showed that these three impurities could reduce the reaction heat release of 1,2, 4-triazole to varying degrees, and confirmed that these three impurities could reduce the risk of thermal runaway of 1,2, 4-triazole to varying degrees. Among them, sodium hydride has the most outstanding performance, both in terms of reducing reaction heat release and reducing adiabatic temperature rise. The results can provide reference for loss control of 1,2,4-triazole in industrial applications.
研究领域:
化学工程
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热力学
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安全科学
✓ 已验证
DOI
高影响因子
Reaction Kinetics Mechanisms and Catalysis
·
2012
·Vol. 108
·期 2
·531-544
·
IF 0.829
He Min-Qiang,Pan Ai-Xia,Xie Ji-Min,Jiang De-Li,Yuan Xin-Hua,Chen Min
Phosphotungstic heteropoly acid (PW) supported on various oxides (SiO 2 , TiO 2 , K-10 montmorillonite and γ-Al 2 O 3 ) were synthesized and used as catalysts for Friedel–Crafts acylation of pyrene with acetic anhydride to 1-acetylpyrene for the first time. The as-prepared catalysts were characterized by specific surface area measurement, X-ray diffraction, infrared spectroscopy, and temperature programmed desorption of ammonia. SiO 2 -supported phosphotungstic heteropoly acid (PW/SiO 2 , 40 wt%) was found to be the most active catalyst in the acylation giving 91.8 % yield and 100 % selectivity for 1-acetylpyrene at reaction temperature of 60 °C under ambient pressure. The effect of PW Loading, PW/SiO 2 amount, molar ratio of reactants, reaction temperature and reaction time on the catalytic acylation reaction were studied in detail to optimize the process parameters. The reusability of the PW/SiO 2 catalyst was appraised, and the possible pathway for the production of the Friedel–Crafts acylation of pyrene with acetic anhydride catalyzed by phosphotungstic heteropoly acid was also discussed briefly.
研究领域:
化学工程
·
催化科学
✓ 已验证
DOI
高影响因子
HISTOCHEMISTRY AND CELL BIOLOGY
·
2025
·Vol. 163
·期 1
·1-15
·
IF 2.1
Zhong Wen-Jing,Xiong Jian-Bing,Zhang Chen-Yu,Jin Ling,Yang Nan-Shi-Yu,Sha Han-Xi,Liu Yu-Biao,Duan Jia-Xi,Guan Cha-Xiang,Zhou Yong,Su Feng
Pulmonary fibrosis (PF) is an insidious, progressive, and fatal age-associated disease that occurs primarily in older adults and has a poor prognosis. Alveolar epithelial cell (AEC) senescence is the critical pathological mechanism of PF. The accumulation of oxygen radicals, commonly referred to as reactive oxygen species (ROS), strongly contributes to cellular senescence. The triggering receptor expressed on myeloid cells-1 (TREM-1) is a pattern recognition receptor. Triggering via TREM-1 results in ROS, leading to the amplification of inflammation. However, whether TREM-1 is involved in PF by inducing oxidative stress to exacerbate AEC senescence remains unclear. We first observed that blockade of TREM-1 during the fibrotic phase attenuated bleomycin (BLM)-induced PF in mice, with decreased expression of senescence-related proteins, including p16, p21, p53, and γ-H2AX, in the lung tissue. Moreover, TREM-1 blockade during the fibrosis stage restored antioxidant levels by increasing the percentage of Nrf2- and HO-1-positive cells in mice with PF. Notably, TREM-1 was highly expressed in surfactant-associated protein (SPC)-positive AECs in mice with PF. In vitro, blocking TREM-1 activated Nrf2 antioxidant signaling, thereby decreasing intracellular ROS levels and diminishing BLM-induced senescence in AECs. Furthermore, inhibition of Nrf2/HO-1 partially counteracted the anti-senescence effect of blocking TREM-1 in BLM-treated AECs. In this study, we reported that TREM-1 stimulated the senescence of AECs, induced ROS and exacerbated PF. We also provide compelling evidence suggesting that the Nrf2/HO-1 signaling pathway underpins TREM-1-triggered senescence. Therefore, our findings provide new insights into the molecular mechanisms associated with TREM-1 and AEC senescence in the pathogenesis of PF.
研究领域:
医学
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分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 15
·9316-9320
·
IF 3.108
Li-Long Jiang,Xiangzhou Zeng,Mengkai Li,Man-Qing Wang,Tong-Yu Su,Xiao-Chun Tian,Jing Tang
We synthesized a HKUST-1 metal–organic framework (MOF) on indium tin oxide (ITO) using an electrodeposited Cu film. The electrodeposited Cu/ITO was used as a source of Cu ions, which were linked with benzene-1,3,5-tricarboxylic acid on the ITO surface to form HKUST-1. Synthesized HKUST-1/ITO was characterized by X-ray diffraction (XRD), Raman spectroscopy and scanning electron microscopy (SEM), which showed that the morphology of the HKUST-1 framework was nearly octahedral. Our results also revealed that the growth of HKUST-1 depended on the potential and synthesis time used. This method can be applied to fabricate ordered patterns of HKUST-1 on ITO substrates, offering a new way to grow MOFs on many other kinds of conductive substrates.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
PLoS One
·
2013
·Vol. 8
·期 8
·e70565
·
IF 3.73
Luyan Guo,Yanyan Xing,Rui Pan,Mingliang Jiang,Zheng Gong,Liqing Lin,Junbing Wang,Guoyin Xiong,Jun Dong
Curcumin is a molecule found in turmeric root that has anti-inflammatory, antioxidant, and anti-tumor properties and has been widely used as both an herbal drug and a food additive to treat or prevent neurodegenerative diseases. To explore whether curcumin is able to ameliorate HIV-1-associated neurotoxicity, we treated a murine microglial cell line (N9) and primary rat cortical neurons with curcumin in the presence or absence of neurotoxic HIV-1 gp120 (V3 loop) protein. We found that HIV-1 gp120 profoundly induced N9 cells to produce reactive oxygen species (ROS), tumor necrosis factor-α (TNF-α) and monocyte chemoattractant protein-1 (MCP-1). HIV-1 gp120 also induced apoptosis of primary rat cortical neurons. Curcumin exerted a powerful inhibitory effect against HIV-1 gp120-induced neuronal damage, reducing the production of ROS, TNF-α and MCP-1 by N9 cells and inhibiting apoptosis of primary rat cortical neurons. Curcumin may exert its biological activities through inhibition of the delayed rectification and transient outward potassium (K + ) current, as curcumin effectively reduced HIV-1 gp120-mediated elevation of the delayed rectification and transient outward K + channel current in neurons. We conclude that HIV-1 gp120 increases ROS, TNF-α and MCP-1 production in microglia, and induces cortical neuron apoptosis by affecting the delayed rectification and transient outward K + channel current. Curcumin reduces production of ROS and inflammatory mediators in HIV-1-gp120-stimulated microglia, and protects cortical neurons against HIV-1-mediated apoptosis, most likely through inhibition of HIV-1 gp120-induced elevation of the delayed rectification and transient outward K + current.
研究领域:
神经科学
·
免疫学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）