COMBUSTION AND FLAME
·
2023
·
IF 4.4
LongJin Du,Jianzhong Liu,Binghong Chen,ZhiHao Sun,WeiJuan Yang
B/JP-10 suspension fuel has very high energy density and high application prospects, but energy release during its actual combustion is incomplete. In this study, the surfaces of boron nanoparticles were modified by coating the particles with LiF and AP using a two-solvent method. Thermogravimetric experiments show that the ignition temperature of boron decreases from 772°C to 599°C when the LiF coating amount is 20 wt%. In a laser ignition experiment, the AP-modified B/JP-10 suspension fuel displayed a relatively obvious "microburst" phenomenon at the end of the combustion process . The "microburst" intensifies as the amount of AP coating increases; this behavior has positive implications for the release of energy from the boron in the fuel. The oxidation of boron in 10 wt% LiF-modified fuel increased from 26.35% to 36.22% without an increase in the ambient oxygen partial pressure . AP modification increases not only the oxidation rate of boron in the fuel but also the amount of oxidizing gas produced by decomposition, and this increases the burning intensity of JP-10. LiF and AP modification can destroy the shell layer of the agglomerates formed by the combustion of suspended fuels. LiF makes it difficult to close the shell layer by reacting with B 2 O 3 to form easily sublimated substances and flaky crystals. AP breaks the shell structure due to the high pressure generated by the "microburst", thus forming a porous configuration on the surface of the agglomerate.
研究领域:
燃烧工程
·
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Sha Ao,Xiang Luo,Mengyu Huang,Hongze Wu,Yuanyuan Chen,Haonan Chen,Jiafei Li,Yanyan Zhou,Xuguang Yin,Tao Cai,Qun Yang,Liping Deng,Kewu Zhu
Hyaluronic acid (HA), an endogenous polysaccharide comprising alternating D -glucuronic acid and N -acetylglucosamine units, is renowned for its high hydrophilicity, biocompatibility , and biodegradability. These attributes have rendered HA invaluable across medical and drug delivery fields. HA can be altered through physical, chemical, or enzymatic methods to improve the properties of the modified substances. In this work, we synthesized a derivative via the esterification of HA with poly(glyceryl)10-stearate (PG10-C18), designated as HA-PG10-C18. This novel derivative was employed to fabricate a nano co-delivery system (HA-PG10-C18@Res-NE) for fish oil and resveratrol (Res), aiming to enhance their stability and bioaccessibility. An exhaustive investigation of HA-PG10-C18@Res-NE revealed that the HA-modified system displayed superior physicochemical stability, notably in withstanding oxidation and neutralizing free radicals . Moreover, in vitro simulated digestion underscored the system's enhanced bioaccessibility of Res and more efficient release of free fatty acids . These outcomes underscore the strategic advantage of HA in modifying PG10-C18 for nanoemulsion formulation. Consequently, HA-PG10-C18 stands as a promising emulsifier for encapsulating lipophilic bioactives in functional foods, nutraceuticals , and pharmaceuticals.
研究领域:
药物递送
·
营养保健品
·
药学
·
食品科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF BIOMATERIALS APPLICATIONS
·
2025
·
IF 2.5
Zhihua Wang,Denghui Li,Yanghao Wang,Ping Yuan,Wan Zhang,Yihe Zhang,Fei He,Jianyi Yang,Hangchuan Bi,Hao Duan
(1)Background: Inflammation plays a key role in spinal cord injury (SCI), where excessive inflammatory responses exacerbate neural damage and hinder regeneration. Modulating macrophage polarization, particularly through the sustained release of IL-10 to promote the anti-inflammatory M2 phenotype, represents a promising strategy to mitigate inflammation. In this study we developed a Hyaluronic Acid Methacryloyl (HAMA) hydrogel capable of sustained IL-10 release to regulate macrophage polarization and explore its therapeutic potential. (2)Methods: A photo-curable HAMA hydrogel was synthesized via methacrylation and designed for the sustained release of IL-10. The structural and functional properties were characterized using NMR and FT-IR. In vitro assays, including immunofluorescence, flow cytometry, and Western blotting, were performed to evaluate IL-10’s effect on macrophage polarization. The anti-inflammatory and reparative effects of the hydrogel were further validated in a rat SCI. (3)Results: The HAMA hydrogel with sustained IL-10 release demonstrated excellent biocompatibility. It significantly promoted macrophage polarization to the anti-inflammatory M2 phenotype by increasing the expression of CD206. In vivo studies demonstrated that the group treated by HAMA with IL-10 exhibited recovery of sensory and motor functions, along with improvement of the inflammatory microenvironment at the site of injury. (4)Conclusion: The HAMA hydrogel with sustained IL-10 release effectively alleviates inflammation, enhances motor function after SCI, and serves as a promising immunomodulatory platform. This novel approach presents considerable potential for improving neural regeneration.
研究领域:
生物材料学
·
神经科学
·
免疫学
✓ 已验证
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Huirong Zou,Wenjuan Zhu,Jingtao Zhao,Su Zhou,Shiqing Xu,Lei Lei
Lanthanide-doped fluoride nanoscintillators (NSs) have emerged as promising candidates for X-ray imaging. However, strong afterglow, long lifetime, and poor irradiation stability pose key challenges for real-time dynamic X-ray imaging. In this study, the sub-10 nm Lu 6 O 5 F 8 :Tb NSs with tunable morphologies are prepared via incorporating Li + /Na + ions. The X-ray excited optical luminescence (XEOL) intensity of the Lu6O5F8:15Tb/10Li NSs is stronger than that of NaLuF 4 :15 Tb NSs with a similar particle size while its afterglow is only ≈2.7% compared to that of NaLuF 4 :15 Tb NSs. Utilizing the Lu 6 O 5 F 8 :15 Tb/10Li NSs-integrated film as a scintillator screen, a high resolution of ≈21.6 lp/mm is achieved. Even at a low dose of 0.23 µGy, the fringe detail in the electron device is clearly observed in the X-ray image. The afterglow intensity of the Lu 6 O 5 F 8 :10Eu/10Li NSs decays to 0.7% at 40 µs, which is better than that of CsI:Tl (3.6%@40 µs). Moreover, the Lu 6 O 5 F 8 :10Eu/10Li NSs with a lifetime of 1.65 µs are verified for use in dynamic 3D X-ray imaging. These findings represent a significant advancement in the development of new NSs for high-performance dynamic X-ray imaging.
研究领域:
材料科学
·
纳米技术
·
医学成像
✓ 已验证
产品关联
DOI
高影响因子
PLANTA MEDICA
·
2016
·Vol. 82
·期 03
·230-237
·
IF 1.99
Xueli Zhang,Jiajia Lv,Liling Wang,Hua Shao
Taxanes are a class of bioactive compounds isolated from the Taxus species. 10-Deacetylbaccatin III is one of the popular taxane compounds with antitumor activity, but the pharmacokinetic profile of this compound remains elusive. Previously, we prepared the taxane fractions from the twigs and leaves of Taxus chinensis var. mairei containing 20.4 % 10-deacetylbaccatin III. This study aimed to investigate the pharmacokinetics of 10-deacetylbaccatin III and biodistribution, and explore the potential changes when it was administered in the form of taxane extracts. A simple, sensitive, and reliable liquid chromatography-tandem mass spectrometry method was developed and validated for the quantitative determination of 10-deacetylbaccatin III in biosamples. The results showed that 10-deacetylbaccatin III, after oral dosing, displayed a quick absorption into the blood and distribution into major organs. Oral administration of 10-deacetylbaccatin III in the form of taxane mixtures led to a 16-fold increase in the systemic exposure of pure 10-deacetylbaccatin III, with the AUC0-U in the plasma increasing from 25.75 ± 11.34 to 231.36 ± 70.12 µg h/L (p T. chinensis var. mairei, which contributed to an enhanced systemic exposure of pharmacologically active taxanes.
研究领域:
药理学
·
植物化学
·
药物代谢
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NEUROPHARMACOLOGY
·
2025
·
IF 4.6
Wei Wang,Yingzhuo Ding,Chunxia Yu,Qingqing Chi,Xia Fu,Mengjiao Deng,Dongxia Duan,Jinbao Wei,Ronghua Ding,Yufei Xi,Qin Li,Le Ma
Neuro-inflammation contributes to neuropathic pain by sensitizing ionic channels. Kinsenoside, a traditional Chinese medicine, has recognized anti-inflammatory properties. However, it remains unclear whether kinsenoside can be used for pain therapy. Network pharmacology analysis revealed that 57 % of its targets are associated with pain, including inflammation and synaptic transmission. The analgesic effects of kinsenoside were confirmed in SNL and formalin rat models, with ED50 values of 47.99 μg and 36.80 μg, respectively. Transcriptome and WGCNA analyses indicated the involvement of cytokine release, anti-inflammatory activity, and synapse enrichment in the blue module. Furthermore, we confirmed that kinsenoside's efficacy was mainly mediated by IL-10 induction, phosphorylation of STAT3, and SOCS3 expression. Pretreatment with kinsenoside significantly inhibited the release of TNF-α, IL-1β, and IL-6. Kinsenoside also attenuated ER stress in both microglia and neural cells. Molecular docking analysis demonstrated significantly high binding energies of IL-10, STAT3, and SOCS3 with MHC. Additionally, whole-cell recordings revealed that bath application of kinsenoside reduced the frequency and amplitude of spinal glutamatergic transmission in a dose-dependent manner. In summary, pharmacological prediction and biological validation collectively indicate that kinsenoside significantly exerts significant analgesic effects by attenuating ER stress and inhibiting inflammatory responses via the IL-10/p-STAT3/SOCS3 axis, precisely regulating spinal glutamatergic transmission for pain relief.
研究领域:
药理学
·
神经科学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Xiaodan Wu,Chengdong Nie,Mengqiong Deng,Linan Sun,Ying Wang,Jingru Zhao,Yujie Fu,Yourong Duan,Ying Sun
In this study, natural polysaccharides were first modified to synthesize natural functional monomers (NFMs). Subsequently, a natural novel NFM-based imprinted hydrogel microsphere was prepared for the specific recognition and enrichment of 7-xylulose-10-deacetylpaclitaxel (7-X-10-DTA). Molecular dynamics computational simulations were employed to screen and compare the functional monomers. Subsequently, the optimal preparation and application conditions of NMIHM were determined, with a maximum adsorption capacity of 71.77 mg mL −1 . The adsorption behavior of NMIHM for 7-X-10-DTA conforms to the pseudo-second-order kinetic model and the Langmuir model for monolayer adsorption, representing a spontaneous exothermic process. When used as a solid-phase extraction filler, NMIHM increased the content of 7-X-10-DTA by 13.36 times after enrichment in Taxus × media Rehde. The 7-X-10-DTA extracted in this study exhibited low half-maximal inhibitory concentration (IC50) values of 0.3205 μM and 0.7636 μM against cervical cancer Hela cells and prostate cancer PC-3 cells, respectively, demonstrating a more potent killing effect on these two types of cancer cells. This research is expected to accelerate the research and development of natural functional monomers and the advancement of molecular imprinting technology, thereby promoting the rapid development of practical separation applications.
研究领域:
药学
·
生物化学
·
分离科学与技术
✓ 已验证
产品关联
DOI
高影响因子
MATERIALS TECHNOLOGY
·
2022
·
IF 3.297
Shichao Wu,Xiaobing Yang,Xiangrui Yang
Due to the complexity of cancer, combination therapy has been widely used in the clinic. The use of two kinds of anticancer agents with a synergistic effect may achieve excellent therapeutic effects, especially against drug-resistant tumours. In this paper, MTX and HCPT loaded pullulan nanoparticles (MHNPs) were prepared for tumour-targeted synergistic therapy. In the nanoparticles, MTX could serve as both a targeting ligand and a cytotoxic agent. The MHNPs possessed a size of 185.7 ± 16.7 nm and a sustained release profile of the dual drug over a period of 48 h. The cytotoxicity assays stated that the MHNPs exhibited an enhanced killing ability to HeLa cells than the individual drug loaded NPs. These results suggest that the MHNPs could be a potential carrier with an efficient antitumor effect for tumour-targeted drug delivery.
研究领域:
药学
·
癌症研究
·
纳米技术
·
药物递送系统
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES
·
2022
·
IF 3.848
Xiaojun Yuan,Qi Wang,Qing Zhao,Zehua Bai,Chen Chen,Haifeng Xie
The activation of matrix metalloproteinases (MMPs) is responsible for degradation of the hybrid layer . The effect of 10-methacryloyloxydecyl dihydrogen phosphate (10-MDP) on biodegradation of the hybrid layer remains unknown. This study aimed to evaluate the effects of 10-MDP and its Ca salt on MMP-9 activity and dentin-bonding durability. 10-MDP-Ca salt was synthesized and characterized by X-ray diffraction (XRD) and nuclear magnetic resonance (NMR). The effects of chlorhexidine (CHX), 10-MDP, and 10-MDP-Ca salt on MMP activity were evaluated by in-situ zymography, MMP-9 inhibition assay, and hydroxyproline (HYP) assay. Dentin-resin bonded specimens were fabricated with using CHX or 10-MDP, including Single Bond 2 (Ctr), CHX + Single Bond 2 (CHX), 10-MDP + Single Bond 2 (10-MDP), and SBU (SBU). Micro-tensile bond strength (μTBS) and nanoleakage tests were performed after 24-h or two-years water storage. XRD and NMR confirmed the presence of 10-MDP-Ca salt. The relative inhibition percentages of recombinant MMP-9 for 10-MDP and 10-MDP-Ca salt were 8.04 ± 0.83% and 55.96 ± 1.82% respectively. HYP assay showed that 10-MDP, CHX, and 10-MDP-Ca salt conditioning decreased collagen degradation. Water storage weakened μTBS of all the groups, with the Ctr and CHX groups showing more significant decreases ( P < 0.05). After aging, the Ctr and CHX groups also presented more nanoleakage, and the CHX group showed more in-situ zymography fluorescence than the 10-MDP and SBU groups. The capacity to inhibit MMP-9 activity, decrease HYP release, and reduce nanoleakage of 10-MDP and its salt contribute to improvement of dentin-bonding durability.
研究领域:
牙科材料
·
生物材料
·
牙科学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MEDICINAL CHEMISTRY
·
2025
·
IF 6.8
Haidong Tian,LanLan Lin,Huijun Guo,Jiadi Liu,Rong Gan,Qiyue Zhang,Duling Xu,Hongyan Li
The side effects of hydroxycamptothecin (HCPT) limit its clinical application in antitumor. The surface of hollow mesoporous polydopamine (HMPDA) was modified with the ANGPT2-specific peptide GSFIHSVPRH (GSF), followed by loading HCPT and indocyanine green (ICG) to form a drug-delivery system (ICG-GSF-HMPDA@HCPT). The morphology, particle size, HCPT loading capacity, and HCPT-release properties were characterized. The biocompatibility and antitumor efficacy of the delivery system were validated through in vitro and in vivo experiments. Micropositron emission tomography (PET)/computed tomography (CT) imaging showed that 68Ga-labeled GSF accumulated in the xenograft, and the targeting of GSF toward gastric cancer was confirmed. ICG-GSF-HMPDA@HCPT inhibited cell viability, colony formation, cell invasion, and migration of HGC-27 cells and showed a better suppression of xenograft development than HMPDA@HCPT. Furthermore, blood biochemical assays showed that ICG-GSF-HMPDA@HCPT exhibited favorable biosafety. Thus, the HCPT-loaded HMPDA modified with the ANGPT2-specific peptide was successfully constructed and served as a potent delivery for GC-targeted therapy.
研究领域:
肿瘤学
·
药剂学
·
纳米医学
·
分子靶向治疗
·
转化医学
·
生物材料
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry C
·
2025
·
IF 5.1
Junhui Wu,Baoping Yang,Jiahao Zhou,Ming Zhong,Yong Ding,kun zhao,Ye Yuan
Triboelectric nanogenerators (TENGs) are capable of effectively scavenging ambient tiny mechanical energy and converting it into electrical energy, offering significant potential for applications in self-powered sensing and electrical energy storage systems. However, the practical utility of TENGs in high-humidity environments is severely restricted due to the detrimental effects of moisture. Herein, we have fabricated a TENG utilizing a CAU-10-(SO3H)0.08(OH)0.92/polyvinyl chloride (PVC) composite film as the negative triboelectric layer and Al foil as the positive triboelectric layer, which exhibits the ability to sustain stable output voltage and current even in highly ambient humidity conditions. At a relative humidity (RH) of 20%, the 2 wt%-CAU-10-(SO3H)0.08(OH)0.92//PVC composite film-based TENG achieved an open-circuit voltage (Voc) of 318 V, a short circuit-current (Isc) of 30 μA, a short-circuit charge transfer (Qsc) of 77 nC and a peak power of 2.69 mW. The device still maintains stable output voltage and current signals even at 90% RH. There is no obvious decline in the output voltage of the TENG after continuous working for about 36,000 operational cycles. Through a transformer and a rectifier circuit, the TENG was capable of charging a 10 mF capacitor to 2.7 V in 3.48 h, which was subsequently employed for water electrolysis to generate hydrogen. After 30 electrolysis cycles, the system produced 54 µL of H2 at a rate of 143.6 µL/h/m². This work offers a reference for the development of CAU-10-(SO3H)0.08(OH)0.92-based composites with humidity resistance, which is essential for the application of TENGs in high-humidity environments.
研究领域:
材料科学
·
能源技术
·
环境工程
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2018
·
IF 6.042
Jiayan Du,Jinhu Wang,Wei Huang,Yuequan Deng,Yi He
In this work, 9-mesityl-10-methylacridinium ion (Acr+-Mes) is found to act as an effective photocatalyst mimicking the function of oxidase. Upon visible light illumination, the excited Acr+-Mes is able to exhibit superior enzymatic catalytic activity for small molecular substrates as well as protein biomacromolecule (cytochrome c). The experiment results demonstrate that the Acr+-Mes oxidase mimic shows higher affinity to 3,3′,5,5′-tetramethylbenzidine (TMB) than natural horseradish peroxidase or the reported molecule oxidase mimic. The reaction mechanism is ascribed to the strong oxidation property of the long-lived electron-transfer state (Acr•-Mes•+) and the electron transfer from Acr•-Mes radical to dissolved oxygen to generate superoxide radicals, which can easily oxidize various substrates. On the basis of these observations, the light-activatable Acr+-Mes with an oxidase-like activity as the probe is utilized for cost-effective, sensitive, and highly selective colorimetric detection of two biothiols (L-cysteine and L-glutathione). The lowest detectable concentrations of L-Cys and L-GSH is 100 nM, which is lower than that of most of the reported methods for biothiols. Beyond this, we construct a series of visual molecular logic gates (AND, INH, and NOR) using the oxidase mimic-involved reaction systems.
研究领域:
生物化学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）