MOLECULES
·
2021
·Vol. 26
·期 2
·372
·
IF 4.412
Qing-Qing Wang,Shu-Guang Zhang,Jian Jiao,Peng Dai,Wei-Hua Zhang
A series of fluorinated 7-hydroxycoumarin derivatives containing an oxime ether moiety have been designed, synthesized and evaluated for their antifungal activity. All the target compounds were determined by1H-NMR,13C-NMR, FTIR and HR-MS spectra. The single-crystal structures of compounds4e,4h,5hand6cwere further confirmed using X-ray diffraction. The antifungal activities againstBotrytis cinerea(B. cinerea),Alternariasolani(A. solani),Gibberella zeae(G. zeae),Rhizoctorzia solani(R. solani),Colletotrichum orbiculare(C. orbiculare) andAlternaria alternata(A. alternata) were evaluated in vitro. The preliminary bioassays showed that some of the designed compounds displayed the promising antifungal activities against the above tested fungi. Strikingly, the target compounds5fand6hexhibited outstanding antifungal activity againstB. cinereaat 100 μg/mL, with the corresponding inhibition rates reached 90.1 and 85.0%, which were better than the positive control Osthole (83.6%) and Azoxystrobin (46.5%). The compound5fwas identified as the promising fungicide candidate againstB. cinereawith the EC50values of 5.75 μg/mL, which was obviously better than Osthole (33.20 μg/mL) and Azoxystrobin (64.95 μg/mL). Meanwhile, the compound5fshowed remarkable antifungal activities againstR. solaniwith the EC50values of 28.96 μg/mL, which was better than Osthole (67.18 μg/mL) and equivalent to Azoxystrobin (21.34 μg/mL). The results provide a significant foundation for the search of novel fluorinated 7-hydroxycoumarin derivatives with good antifungal activity.Keywords:fluorinated 7-hydroxycoumarin;oxime ether derivatives;synthesis;crystal structure;antifungal activity
研究领域:
有机化学
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药物化学
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植物保护学
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产品关联
DOI
PubMed
高影响因子
BIOCHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 3.8
Jing Fang,Lingzhi Luo,Wenyan Li,Hao Li
Ethanol, as an important solvent and basic chemical feedstock, has widespread applications in the pharmaceutical, food, and fine chemical industries, including processes such as absorption, washing, and extraction. However, methanol and water are inevitable by-products in the industrial production of ethanol, whether through biological fermentation or chemical synthesis. Particularly methanol, which is harmful to both health and the environment, is typically present in ethanol products at low concentrations, posing a significant challenge for its effective removal. We designed citric acid-modified 4 A zeolites and a bimetallic organic framework Cu@ZIF-7. Under optimal modification conditions, the modified 4 A zeolite showed a 39.15% and 37.21% increase in selectivity for methanol and water, respectively, compared to the initial 4 A zeolite. The yield of qualified products increased by 44.71%. Furthermore, Cu@ZIF-7 exhibited a methanol adsorption capacity of 1.125 mg·g -1 , which is 3.42 times that of the initial 4 A zeolites. Density Functional Theory (DFT) calculations confirmed that the introduced Cu sites are associated with this enhanced methanol adsorption capacity. Experimental evidence suggests that these adsorbents perform exceptionally in purifying ethanol, particularly in the removal of trace methanol. As a new, environmentally friendly separation method, it holds great potential for obtaining high-purity ethanol.
研究领域:
化学工程
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材料科学
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环境科学
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产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2022
·
IF 10.53
Jinyin Lv,Xuerong Zhou,Jianhua Yang,Lei Wang,Jinming Lu,Gaohong He,Yingchao Dong
A well-intergrown and defect-free tubular KAUST-7 membrane was fabricated via in-situ synthesis assisted by fluorinated molecular building block using green solvent of water on coarse asymmetric α-Al 2 O 3 tubes. The strategy averted the serious corrosion of high-concentration hydrofluoric acid (HF) to α-Al 2 O 3 supports due to the substitution of HF with the pre-synthesized NiNbOF 5 , overcoming the difficulty of serious corrosion to supports compared to traditional one-pot synthesis. The pH manipulation of synthesis solution is proved crucial to the fabrication of defect-free KAUST-7 membranes. In addition, effects of reactant concentration, crystallization temperature and reaction solvents on the morphology and separation performance of KAUST-7 membrane were investigated. The optimized KAUST-7 membrane M4 exhibited a H 2 perm-selectivity of 17.7 over CO 2 for H 2 /CO 2 binary mixture with a H 2 permeance of 2.2 × 10 −7 mol m −2 s −1 Pa −1 at 25 °C and 1 bar, while the H 2 /CO 2 separation factor just had a slight decrease when test temperature increased to 120 °C. The formation mechanism of KAUST-7 membranes via in-situ method in this work was investigated by exposing a bare α-Al 2 O 3 tube into NiNbOF 5 aqueous solution at the pH of 4.0 at 130 °C for 12 h. XPS and FT-IR observations revealed the formation of AlF x O y or AlF x species, which were deduced to be acted as linkers to connect with 2D Ni (II)-pyrazine layers, promoting the heterogeneous nucleation of KAUST-7 crystals on the surface of Al 2 O 3 support.
研究领域:
材料科学
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化学工程
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产品关联
DOI
高影响因子
OPTICAL MATERIALS
·
2025
·
IF 4.2
Tao Wei,Lei Xu,Duanduan He,Heyun Xu,Fei Long,Chaoyong Deng,Xucheng Li
A series of Eu 2+ -activated β-Ca 3 (PO 4 ) 2 -type Ca 9 MgNa(PO 4 ) 7 phosphors were successfully synthesized via high-temperature solid-state reaction. The substitution effects of Zn 2+ for Mg 2+ and Li + for Na + on the local coordination environments and luminescence characteristics of Eu 2+ were systematically investigated. The results demonstrate that Eu 2+ ions predominantly occupy the Ca1/Ca2, Ca3, and Na sites in Ca 9 MgNa(PO 4 ) 7 , corresponding to emission peaks at blue(1), blue(2), and green, respectively. Zn 2+ substitution for Mg 2+ induces lattice expansion, which reduces the occupancy probability of Eu 2+ at Ca1/Ca2 sites while lowering the formation energy of Ca3 sites, thereby significantly enhancing Ca3 and Na + site emissions but reducing Ca1/Ca2 site intensity. Subsequent Li + substitution for Na + causes contraction of the Li/NaO 6 polyhedra, reducing the capacity of the Na sites to accommodate Eu 2+ . Concurrently, the adjacent Ca(3)O 9 polyhedra undergo expansion, promoting preferential Eu 2+ occupancy at the Ca3 sites and consequently enhancing the emission intensity at blue(1).
研究领域:
材料化学
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无机化学
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发光材料
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固体物理
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光学材料
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产品关联
DOI
高影响因子
CHEMOSPHERE
·
2019
·
IF 5.108
Xin Liu,Baoling Yuan,Jing Zou,Lingbin Wu,Lin Dai,Hongfang Ma,Kai Li,Jun Ma
The activation of persulfate by Fe(II) coupled with hydroxylamine (the HA/Fe(II)/PS system) was highly effective for the degradation of refractory organic contaminants under acidic pH conditions. However, owing to the precipitation of ferric hydroxide and/or the slow reduction from Fe(III) to Fe(II), the HA/Fe(II)/PS system was invalid under neutral and alkaline pH conditions. In this study, it was observed that the degradation of acid orange 7 (AO7) was strongly enhanced over the wide pH range of 2–9 when trace Cu(II) (0.5–5 μM) was spiked into the HA/Fe(II)/PS system. It was evident that Cu(I) was generated via the reduction of Cu(II) by HA in the bimetallic system at both pH 3 and pH 8, and the steady concentration of Fe(II) in the bimetallic system was much higher than that in the HA/Fe(II)/PS system due to the rapid reaction between Fe(III) and Cu(I). Quenching experiments using tert-butyl alcohol, methanol and sodium bromide as the scavengers and electron spin resonance experiments confirmed that the primary reactive species responsible for AO7 degradation were sulfate radical at both pH 3 and pH 8, rather than hydroxyl radical and Cu(III). Nevertheless, sulfate radical was mainly produced by Fe(II)-activated PS at pH 3, while both Cu(I) and Fe(II) made important contributions to the generation of sulfate radical at pH 8. The bimetallic system was also highly effective in degrading other organic contaminants, such as phenol, diclofenac, reactive red 2 and orange G. This study might provide a promising idea based on Fe(II)-activated PS for degrading organic contaminants over a wide pH range.
研究领域:
环境科学
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化学工程
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
·
2019
·Vol. 95
·期 4
·1135-1145
·
IF 2.659
Jinying Du,Wensi Xu,Jie Liu,Zhiwei Zhao
BACKGROUND A novel carbon-based modified MnFe 2 O 4 catalyst was first developed to produce sulfate radicals (SO 4 −• ) by activation of persulfate (PS). The catalyst was fabricated with a mixture of MnFe 2 O 4 nanoparticles and chitosan (which could form a large amount of carbon-based biomass after pyrolysis) annealed at 600 °C and was referred to as CM-600. RESULTS The microstructure of the composite catalyst CM-600 showed that MnFe 2 O 4 was supported on the surface of carbon-based sheets. After modification by pyrolysis, the specific surface area of MnFe 2 O 4 enlarged significantly and thus the contact area between catalyst and PS increased. X-ray diffraction, Fourier transform infrared spectroscopy, Raman spectroscopy and X-ray photoelectron spectroscopy were used to characterize the components of CM-600. In comparison with the MnFe 2 O 4 /PS system, the activation of PS by CM-600 was enhanced prominently, while 99.0% Acid Orange 7 (AO7) removal was achieved after reacting for 30 min. Investigations of influencing factors indicated the optimal treatment parameters. The two reactive species in the degradation process, namely free radicals (SO 4 −• and hydroxyl radicals ( • OH)) and non-radicals (singlet oxygen, 1 O 2 ), were confirmed by quenching tests and electron spin resonance spectroscopy. The corresponding degradation mechanism was proposed and SO 4 −• was generated primarily via the activation of PS by Mn II and Fe II . CONCLUSION The research demonstrated that the composite catalyst CM-600 improved the property of MnFe 2 O 4 for catalyzing PS and thus enlarged the practical application of SO 4 −• oxidation technology in pollutant degradation in aqueous environments. © 2019 Society of Chemical Industry
研究领域:
环境科学
·
材料科学
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DOI
高影响因子
CHEMOSPHERE
·
2018
·
IF 4.427
Zhipan Wen,Yalei Zhang,Gang Cheng,Yingru Wang,Rong Chen
In this study, nanosized ordered magnetic mesoporous Fe-Ce bimetal oxides (Nanosized-MMIC) with highly well-ordered inner-connected mesostructure were successfully synthesized through the KIT-6 template method. This Nanosized-MMIC displayed excellent adsorption capacities for As(V), Cr(VI) and AO7, and the corresponding calculated maximum adsorption capacities of material were 111.17, 125.28 and 156.52 mg/g, respectively. As(V) and Cr(VI) removal by Nanosized-MMIC were slightly dependent on the ionic strength but highly solution pH-dependent, the coexistent silicate and phosphate ions competed remarkably with both As(V) and Cr(VI) for the adsorption active site. Mechanisms indicated As(V) and Cr(VI) formed inner-sphere complexes on Nanosized-MMIC interface via the electrostatic interaction and surface complexation, while the total organic carbon (TOC) change demonstrated that AO7 could be removed completely and no organic intermediates formed through the adsorption process. In addition, Nanosized-MMIC also possessed superior adsorption performance in As(V)/Cr(VI)-AO7 binary systems, and the reusable and regeneration properties indicated that the obtained nanomaterials could maintain at a comparatively high level after several recycling. Finally, fixed-bed experiments suggested the Nanosized-MMIC was expected to have a promising excellent nano-adsorbent with high application potential for co-existed toxic heavy metals and organic dyes removal in practical wastewater treatment .
研究领域:
环境科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2019
·Vol. 43
·期 37
·14728-14738
·
IF 3.069
Huiping Wang,Libang He,Peng Zhang,Jie Zhang,Zhenhua Chen,Xiuli Ren,Xifan Mei
The targeted delivery of therapeutic drugs into cancer cells is a facile method to improve therapeutic efficacy. Focusing on this point, doxorubicin (DOX)-loaded hydroxyapatite (HAP) nanorods with folic acid (FA) modification (DOX@HAP-FA) have been developed for efficient antitumor treatment. In this study, DOX@HAP-FA exhibited satisfactory drug loading efficiency and significantly reduced the viability of the MCF-7 cells. Western blot assays demonstrated that DOX@HAP-FA could increase the expression of Bax (a pro-apoptotic protein) and decrease the expression of Bcl-2 (an anti-apoptotic protein). Furthermore, DOX@HAP-FA could markedly enhance mitochondrial cytochrome C leakage and thereby activate an apoptotic cascade associated with it. Thus, the designed DOX@HAP-FA nanorods showed promising potentials for targeted drug delivery in cancer therapy.
研究领域:
癌症治疗
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药物递送系统
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分子生物学
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细胞生物学
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产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2022
·Vol. 33
·期 24
·19477-19489
·
IF 2.779
Zhao Jianwen,Dong Jun,Zhou Jian,Wang Linsheng
White light-emitting diodes (WLEDs) are of paramount importance in the development of lighting and display in replace of inefficient fluorescence as well as incandescent lamps. In this work, Tb 3+ , and Tm 3+ were both introduced into a novel phosphate host Ca 9 Nd(PO 4 ) 7 . The X-ray diffraction (XRD) analyses make sure that the materials have been synthesized successfully. Further XRD Rietveld refinements were used to shed light on the site preference and the variations of crystal lattice parameters. Strong blue light emission was observed after careful optimization of the doping concentration. Theoretical computation on the basis of density functional theory checks the reliability of the phosphate host for doping luminescent centers. At last, a near-ultraviolet commercial LED chip was used with these materials to make a prototype WLED device. They possess a highly stable warm white light emission upon various driving currents (color temperature is constant 4000 K). The work has shown intriguing prospects of Ca 9 Nd(PO 4 ) 7 : Tm 3+ , Tb 3+ in lighting and display applications.
研究领域:
材料科学
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光学工程
✓ 已验证
DOI
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2025
·
IF 7.3
Qiuli Zhang,Jiahui Liu,Saifei Hu,Chengxian Yin,Naixin Lv,Rong Wei
Metal-organic framework (MOF) materials have significant advantages in corrosion protection due to their remarkable specific surface area and exceptional porosity. This work combined cerium dioxide (CeO 2 ) nanoparticles and zeolitic imidazolate framework-7 (ZIF-7) with the long-chain hydrophobic agent hexadecyltrimethoxysilane (HDTMS) to create a composite nanostructure (CeO 2 @ZIF-7@HDTMS) with a multistage barrier function. The structure takes CeO 2 nanoparticles as the core to achieve chemical corrosion inhibition by using its oxygen-deficient property; ZIF-7 is induced to form an ordered microporous adsorption layer at its periphery by surface carboxylic acid molecules; and ultimately, the outer repulsive barrier is constructed with the help of hydrophobic modification of HDTMS, thus forming a synergistic anticorrosion mechanism in three dimensions, namely physical barrier, chemical passivation, and hydrophobic protection, and constructing a ‘Physical barrier + double synergistic corrosion inhibition’ three-level protection system. The successful preparation of CeO 2 @ZIF-7@HDTMS nanoparticles was confirmed by a number of characterization tools, such as field emission scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FT-IR). Subsequently, they were well characterized by electrodynamic polarization curves, electrochemical impedance spectroscopy (EIS), and salt spray test aspects, which indicated that CeO 2 @ZIF-7@HDTMS epoxy composite coatings have good corrosion protection and hydrophobic properties. After 60 days of immersion, EIS analysis showed that the impedance of the 1.0 % EP/CeO 2 @ZIF-7@HDTMS coating was still as high as 4.636 × 10 8 Ω·cm 2 and its low-frequency impedance was about two orders of magnitude higher than that of the pure epoxy coating, which further indicated that the composite coating could provide excellent corrosion resistance and durability. In conclusion, CeO 2 @ZIF-7@HDTMS nanoparticles as fillers offer an innovative idea for the development of multifunctional and long-life anticorrosive coatings, broaden the application of metal oxide@MOF composites, and open up a new direction for the design and preparation of nanostructured materials.
研究领域:
材料科学
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腐蚀防护
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纳米技术
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL HEALTH PERSPECTIVES
·
2024
·
IF 10.1
Rongyi Ye,Zhiming Li,Hongyi Xian,Yizhou Zhong,Boxuan Liang,Yuji Huang,Da Chen,Mingzhu Dai,Shuqin Tang,Jie Guo,Ruobing Bai,Yu Feng,Zhenguo Chen,Xingfen Yang,Zhenlie Huang
Background:
Micro- and nanoplastics (MNPs) and homosalate (HMS) are ubiquitous emerging environmental contaminants detected in human samples. Despite the well-established endocrine-disrupting effects (EDEs) of HMS, the interaction between MNPs and HMS and its impact on HMS-induced EDEs remain unclear.
Objectives:
This study aimed to investigate the influence of MNPs on HMS-induced estrogenic effects and elucidate the underlying mechanisms in vitro and in vivo.
Methods:
We assessed the impact of polystyrene nanospheres (PNSs; 50 nm, 1.0mg/L) on HMS-induced MCF-7 cell proliferation (HMS: 0.01–1μM, equivalent to 2.62–262μg/L) using the E-SCREEN assay and explored potential mechanisms through transcriptomics. Adult zebrafish were exposed to HMS (0.0262–262μg/L) with or without PNSs (50 nm, 1.0mg/L) for 21 d. EDEs were evaluated through gonadal histopathology, fertility tests, steroid hormone synthesis, and gene expression changes in the hypothalamus–pituitary–gonad–liver (HPGL) axis.
Results:
Coexposure of HMS and PNSs resulted in higher expression of estrogen receptor α (ESR1) and the mRNAs of target genes (pS2, AREG, and PGR), a greater estrogen-responsive element transactivation activity, and synergistic stimulation on MCF-7 cell proliferation. Knockdown of serum and glucocorticoid-regulated kinase 1 (SGK1) rescued the MCF-7 cell proliferation induced by PNSs alone or in combination with HMS. In zebrafish, coexposure showed higher expression of SGK1 and promoted ovary development but inhibited spermatogenesis. In addition, coexposure led to lower egg hatchability, higher embryonic mortality, and greater larval malformation. Coexposure also modulated steroid hormone synthesis genes (cyp17a2, hsd17β1, esr2b, vtg1, and vtg2), and resulted in higher 17β-estradiol (E2) release in females. Conversely, males showed lower testosterone, E2, and gene expressions of cyp11a1, cyp11a2, cyp17a1, cyp17a2, and hsd17β1.
研究领域:
环境科学
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毒理学
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分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS
·
2021
·
IF 3.995
Chao Chen,Haijian Li,Zhao Qin,Changjian Wang,Yi Xu,Zhihua Sun,Siyu Xu,Jianhua Yi,Fengqi Zhao
Hexanitro complex K 2 Ba[Ni(NO 2 ) 6 ] was prepared via the co-precipitation method, and its composition and morphology were characterized by XRD , SEM , XPS and FT-IR techniques. The catalytic performances of K 2 Ba[Ni(NO 2 ) 6 ] for CL-20, FOX-7 and TKX-50 thermolysis were also discussed and studied by using DSC and TG-DTG-MS. After K 2 Ba[Ni(NO 2 ) 6 ] were mixed with CL-20, the activation energy ( E a ) of thermolysis reaction was increased, while the heat release was greatly improved, and the transformation from NH 3 to NO occurred. It is attributed to that the decomposition products of K 2 Ba[Ni(NO 2 ) 6 ] have strong effects on the oxidation of the radicals and the electrons transfer . Besides, the thermolysis E a of FOX-7 by addition of the K 2 Ba[Ni(NO 2 ) 6 ] was increased by 81.03 kJ mol −1 , and the heat release was greatly increased. In addition to that the two-step separate thermolysis processes of pure FOX-7 was almost replaced by a one-step exothermic reaction for the FOX-7/K 2 Ba[Ni(NO 2 ) 6 ] mixture, which was due to that Ni 2+ cations could effectively increase the activity of amino groups in the FOX-7 thermolysis process. Finally, K 2 Ba[Ni(NO 2 ) 6 ] scarcely has the thermolysis catalytic activity of TKX-50 owing to the influence of metal cations on the decomposition of the hydroxylamine . Furtherly, the characteristics of ignition and flame propagation on the three energetic mixtures were strongly correlated to their thermolysis pathway and mechanism. The comparative study on the effects of K 2 Ba[Ni(NO 2 ) 6 ] to the CL-20, FOX-7 and TKX-50 thermolysis and ignition showed that the hexanitro complex has great significance on promoting the heat release efficiency of solid propellants for future study.
研究领域:
材料科学
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化学动力学
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含能材料
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催化化学
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热分析
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）