CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
·
2022
·
IF 1.193
Guan-Ting XU,Tian-Sheng ZHAO,Kun ZHANG,Li-Zhen GUO,Yong-Qin HE,Jian-Hua HU,Yi-Jing LIAO,Xi MAI,Na LI
Iron ions (Fe 3+ ) and ascorbic acid (AA) are of great significance to living organisms. Herein, carbon dots (C-dots)-based “off-on” fluorescent probe was designed for Fe 3+ and AA analysis. In presence of Fe 3+ , the fluorescence of C-dots was immediately quenched, and the quenching mechanism was deduced to be inner filter effect (IFE). The fluorescent C-dot probe shows response to Fe 3+ in range of 10–500 µM with a limit of detection (LOD) of 0.9 µM. Interestingly, when AA was introduced to the C-dots-Fe 3+ system, the fluorescence of C-dots was significantly recovered, which could be ascribed to the oxidation-reduction reaction between Fe 3+ and AA. Based “off-on” fluorescent C-dots probe, the linear range of 5–500 µM was obtained with LOD of 0.4 µM. Moreover, the AA-induced fluorescence enhancement can be recognized by smartphone, which greatly extends the application in resource-limited areas.
研究领域:
分析化学
·
环境科学
·
生物化学
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产品关联
DOI
高影响因子
DRUG DELIVERY
·
2021
·
IF 6.419
Ya-Wen Zhang,Ling-Lan Tu,Yi Zhang,Jie-Chao Pan,Gao-Li Zheng,Li-Na Yin
Liver fibrosis is a major global health concern. Management of chronic liver disease is severely restricted in clinics due to ineffective treatment approaches. However, a lack of targeted therapy may aggravate this condition. Asiatic acid (AA), a pentacyclic triterpenoid acid, can effectively protect the liver from hepatic disorders. However, the pharmaceutical application of AA is limited by low oral bioavailability and poor targeting efficiency. This study synthesized a novel liver-targeting material from PEG-SA, chemically linked to ursodeoxycholic acid (UA), and utilized it to modify AA nanostructured lipid carriers (UP-AA-NLC) with enhanced targeting and improved efficacy. The formulation of UP-AA-NLC was optimized via the Box–Behnken Experimental Design (BBD) and characterized by size, zeta potential, TEM, DSC, and XRD. Furthermore, in vitro antifibrotic activity and proliferation of AA and NLCs were assessed in LX-2 cells. The addition of UP-AA-NLC significantly stimulated the TGF-beta1-induced expression of α-SMA, FN1, and Col I α1. In vivo near-infrared fluorescence imaging and distribution trials in rats demonstrated that UP-AA-NLC could significantly improve oral absorption and liver-targeting efficiency. Oral UP-AA-NLC greatly alleviated carbon tetrachloride-induced liver injury and fibrosis in rats in a dosage-dependent manner, as reflected by serum biochemical parameters (AST, ALT, and ALB), histopathological features (H&E and Masson staining), and antioxidant activity parameters (SOD and MDA). Also, treatment with UP-AA-NLC lowered liver hydroxyproline levels, demonstrating a reduction of collagen accumulation in the fibrotic liver. Collectively, optimized UP-AA-NLC has potential application prospects in liver-targeted therapy and holds great promise as a drug delivery system for treating liver diseases.
研究领域:
药理学
·
肝病学
·
药物递送系统
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Zhiguo Sun,Honglong Wang,Xiaoguang Wang,Jiali Li,Qinghua Lin
Water superabsorbent resin has widely use potential in industrial field. Nevertheless, certain drawbacks restrain design and commercial profit achieving. A core lies in an efficient balance between water absorption, degradation and “green production”. Exploring a method to prepare a material that sustaining proper water absorption, degradation and “green production” or ensuring a fine cognization on reaction mechanism is in demand. In this work, pure corn starch was irradiated by an electron beam (EB) in air then treated by AA, AM grafting. Later, microstructure and macroscopic properties were explored by FT-IR, XPS, 13 C NMR, XRD, TGA, water and NaCl solution absorption, water retention, solid residue (SR) and monomer use efficiency rate (ER) analysis. Main results reveal that a reaction temperature, period, AA neutralization level, AM-AA, (NH 4 ) 2 S 2 O 8 and N, N-methylenebisacrylamide (MBA) amounts as 60 ℃, 2 h, 80 %, M AM :M AA :M St = (05 _ 0.8):10:1, M (NH4)2S2O8 :M St and M MBA :M St as 1 and 0.1 _ 0.5 wt% is an optimized condition for starch grafting AA, AM. Grafting reaction mainly occurred at C-6 site C-OH bond, initialing severe amorphization and a thermal-decomposition temperature elevation near 120 °C. Pure water and NaCl solution absorption capabilities-( Q H2O and Q NaCl solution ) were linearly promoted vs absorbed dose. A sample- St(500 kGy)- g -AA-AM-sustaining Q H2O and Q NaCl solution as 1098 and 82.1 g/g was achieved, which is in lined with commercial use standard (GB/T 22875–2018, Q H2O ≥ 20 g/g, Q NaCl solution ≥ 40 g/g). In addition, this sample displayed rapid water absorption response, excellent water retention and monomer use rates. A period as 3 min absorption achieved more than 80 wt% water absorption capability. A 60 °C, 24 h period heating leaved off more than 40 wt% absorbed water. AA, AM use rate is close to 95 %, according to “green production” category. It seems a possessing fine comprehensive property and being cleanly produced water absorbent resin was prepared via EB irradiation and starch grafting AA, AM and reaction mechanism was presented. This prepared material possibly sustains potential commercial profit and given reaction mechanism might promote starch AA, AM grafting product design.
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2016
·
IF 2.76
Ye Zhu,Qiong Hu,Wei Wei,Chenglin Yi,Xiaoya Liu
In this study a type of colloidal particles with a cross-linked poly(divinylbenzene) (poly(DVB)) core and a poly(acrylic acid- r -styrene) (PAS) shell were directly prepared by reversible addition-fragmentation chain transfer (RAFT)-mediated cross-linking copolymerization. The particle size, morphology, zeta potential and pH responsibility were studied. The emulsification study showed that PAS-Poly(DVB) colloidal particles were effective particulate emulsifiers when homogenized with various oils including toluene, white oil, isooctyl palmitate, dicaprylyl carbonate, silicone oil, and propylheptyl caprylate. Additionally, the emulsification performance of PAS-Poly(DVB) colloidal particles at different pH values were investigated. Gelled white oil- in -water high internal phase emulsions (HIPEs) were formed at a high oil volume fraction of 80% when the colloidal particles were flocculated at low pH value. The addition of base can trigger the demulsification of the HIPEs, exhibiting a pH-responsive behavior. The effects of oil phase volume fraction on emulsion rheological properties were investigated. Both the emulsion viscosity and storage modulus (G′) progressively increased with the increasing of oil phase volume fraction. These results suggest that our work provides a convenient and feasible way to prepare effective particulate emulsifiers via the direct chemical reaction, and the PAS-Poly(DVB) colloidal particles have promising potential application in the oil industry and preparation and exploitation of smart materials.
研究领域:
材料科学
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化学工程
✓ 已验证
DOI
高影响因子
RSC Advances
·
2021
·Vol. 11
·期 28
·17212-17221
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IF 3.361
Haining Song,Yifei Zhou,Zexin Li,Haifeng Zhou,Fenglei Sun,Zhenlei Yuan,Peng Guo,Guangjun Zhou,Xiaoqiang Yu,Jifan Hu
Dual-function and multi-function sensors can use the same material or detection system to achieve the purpose of detection of two or more substances. Due to their high sensitivity and specificity, dual-function and multi-function sensors have potential applications in many fields. In this article, we designed a dual-function sensor to detect Sn(II) and ascorbic acid (AA) based on the inner filter effect (IFE) between NaYF4:Yb,Er@NaYF4@PAA (UCNPs@PAA) and Fe(II)–1,10-phenanthroline complex. Fe(II)–1,10-phenanthroline complex has strong absorption in most of the ultraviolet-visible light range (350 nm–600 nm), and this absorption band overlaps with the green emission peak of UCNPs@PAA at 540 nm; Fe(II)–1,10-phenanthroline complex can significantly quench the green light emission of UCNPs@PAA. When Sn(II) or AA is added to the UCNPs@PAA/Fe(III)/1,10-phenanthroline, they can reduce Fe(III) to Fe(II). Fe(II) can react with 1,10-phenanthroline to form an orange complex, thereby quenching the green light emission of UCNPs@PAA. And the quenching efficiency is related to the concentration of Sn(II) and AA; there is a linear relationship between quenching efficiency and the concentration of Sn(II) and AA, within a certain concentration range the detection limits of this dual-function sensor for Sn(II) and AA are 1.08 μM and 0.97 μM, respectively. In addition, the dual-function sensor can also detect Sn(II) and AA in tap and spring water.
研究领域:
分析化学
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材料科学
·
环境科学
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产品关联
DOI
PubMed
高影响因子
ARCHIV DER PHARMAZIE
·
2019
·Vol. 353
·期 2
·1900231
·
IF 2.145
Xiujie Liu,Xin Chen,Kai Qiu,Zhihao Zhang
A series of 4-methoxy-3-arylamido- N -(substitutedphenyl)benzamides 6a – u were designed according to the splicing principle of structural design in the medicinal chemistry theory and were synthesized in five steps: nitration, acylation, ammoniation, reduction, and secondary ammoniation. The structures of the target compounds were characterized and verified by infrared, 1 H nuclear magnetic resonance (NMR), 13 C NMR, and electron spray ionization spectroscopy. Their in vitro antiplatelet aggregation activities induced by adenosine diphosphate (ADP) or arachidonic acid (AA) were assessed by Born's method. The biological evaluation revealed that all compounds exhibited certain levels of activities in both of the antiplatelet aggregation assays; compounds 6c (IC 50 = 3.84 μM) and 6f (IC 50 = 3.12 μM) displayed the strongest antiplatelet aggregation activities in the ADP-induced and AA-induced assay, separately. Moreover, compounds that had stronger activities were chosen for cell toxicity testing via the cell counting kit-8 assay. The results indicated that none of the compounds had obvious cell toxicity against L929 cells at the doses of 10 and 20 μM. It is worth pointing out that compound 6c showed the highest antiplatelet activity and the lowest cell toxicity. In general, 4-methoxy-3-arylamido- N -(substitutedphenyl)benzamides have the potential to become a kind of safer and more effective antiplatelet agents.
研究领域:
药物化学
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药理学
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DOI
PubMed
高影响因子
Small Methods
·
2025
·
IF 9.1
Yueyan Wang,Yuhan Ma,Yongqi Zhang,Ruilin Liu,Luzhen Li,Naiwen Zhang,Peijie Wang,Lisheng Zhang
Methylammonium lead iodide (MAPbI 3 ) has been considered as the most influential component to boost the rapid development of perovskite photovoltaic devices during the past decade. However, the volatility of organic compounds (Methylammonium ions) causes excessive residual PbI 2 during the fabrication and storage process of MAPbI 3 films. The doping of various reduced graphene oxide (L-AA-rGO) is systematically induced into MAPbI 3 precursor ink to regulate the crystallization process, resulting in obtaining a high-quality perovskite film. The higher content of oxygen-containing functional groups (carboxyl and hydroxyl) and flexible sp 3 skeleton structure is successfully obtained in L-AA-rGO(LT), which is favored to form stable coordination bonds with uncoordinated Pb 2+ ions via lone pairs of electrons. Therefore, this functional L-AA-rGO(LT) not only passivates deep-level defects Pb 0 with its functional groups, but also absorbs the perovskite lattice structure with its special sp 3 carbon network to release its residual stress within the perovskite film. This work provides a new method to develop the efficiency and stability of MAPbI 3 perovskite solar cells via doping functional L-AA-rGO.
研究领域:
材料科学
·
光伏技术
·
纳米材料
·
钙钛矿太阳能电池
·
薄膜制备
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产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2023
·
IF 3.9
Li’an Jiang,Song Tian,Yuhui Xie,Xue Lv,Shulin Sun
Traditional hydrogels with a single-crosslinked network structure suffer from poor stretchability, low sensitivity, and easy contamination, which seriously affect their practical application in the strain sensor field. To overcome these shortcomings, herein, a multiphysical crosslinking strategy (ionic crosslinking and hydrogen bonding) was designed to prepare a hydrogel strain sensor based on chitosan quaternary ammonium salt (HACC)-modified P(AM-co-AA) (acrylamide-co-acrylic acid copolymer) hydrogels. The ionic crosslinking for the double-network P(AM-co-AA)/HACC hydrogels was achieved by an immersion method with Fe3+ as crosslinking sites, which crosslinked with the amino group (−NH2) on HACC and the carboxyl group (−COOH) on P(AM-co-AA) and enabled the hydrogels to recover and reorganize rapidly, resulting in a hydrogel-based strain sensor with excellent tensile stress (3 MPa), elongation (1390%), elastic modulus (0.42 MPa), and toughness (25 MJ/m3). In addition, the prepared hydrogel exhibited high electrical conductivity (21.6 mS/cm) and sensitivity (GF = 5.02 at 0–20% strain, GF = 6.84 at 20–100% strain, and GF = 10.27 at 100–480% strain). Furthermore, the introduction of HACC endowed the hydrogel with excellent antibacterial properties (up to 99.5%) and excellent antibacterial activity against bacteria of three forms, bacilli, cocci, and spores. The flexible, conductive, and antibacterial hydrogel can be applied as a strain sensor for real-time detection of human motions such as joint movement, speech, and respiration, which exhibits a promising application prospect in wearable devices, soft robotic systems, and other fields.
研究领域:
材料科学
·
生物医学工程
·
高分子化学
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产品关联
DOI
PubMed
高影响因子
Polymers
·
2025
·Vol. 17
·期 16
·2230
·
IF 4.9
Zexing Deng,Litong Shen,Qiwei Cheng,Ying Li,Qianqian Liu,Xin Zhao
Conventional conductive hydrogels are susceptible to swelling in aquatic environments; which compromises their mechanical integrity; a limitation that poses a potential challenge to their long-term stability and application. In this study, a zwitterionic ion-conductive hydrogel was fabricated from polyvinyl alcohol (PVA), acrylic acid (AA), and [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (SMBA), forming a dual-network structure. A copolymer of zwitterionic SBMA and AA formed the first network, and PVA formed the second network by repeated freeze–thawing. The equilibrium state of zwitterionic SBMA was modulated by AA to protonate the SBMA, which resulted in the conversion of -SO3−to -SO3H; thus, hydrogels had the anti-swelling property driven by electrostatic repulsion. In addition, the prepared hydrogels possessed excellent mechanical properties (tensile strength of 0.76 MPa, elongation at break of 322%, and compressive strength of 0.97 MPa at 75% compressive strain) and remarkable anti-swelling properties (80% swelling after 120 h of immersion). Owing to the zwitterionic nature of SBMA, the hydrogel also showed inherent antimicrobial properties and high electrical conductivity, which could be capable of monitoring human movement and physiological signals. This work provides a facile strategy for designing hydrogels with remarkable mechanical properties and anti-swelling characteristics, expanding the application environment of hydrogels in flexible sensing
研究领域:
材料科学
·
高分子科学
·
生物医学工程
·
柔性电子学
·
传感器
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Redox Biology
·
2019
·
IF 7.793
Shen-Fei Wang,Xin Liu,Mo-Yu Ding,Shuangcheng Ma,Jing Zhao,Ying Wang,Shaoping Li
Reducing agents are crucial for the management of maladaptive inflammation-induced macrophage death and hematopoietic toxicity of chemotherapy. 2- O - β - d -glucopyranosyl- l -ascorbic acid (AA-2 β G), a unique AA (or vitamin C) derivative identified in Lycium barbarum , exhibited enhanced free radical scavenging activity compared with AA and its synthetic derivative AA-2 α G. AA-2 β G protected hydrogen peroxide-induced cell death in murine macrophage RAW264.7 cells. Treatment with AA-2 β G eliminated oxidative stress and the ratio of cellular glutathione to glutathione disulfide more effectively than AA and AA-2 α G. AA-2 β G also significantly reduced the fluorescent intensity of DCFH-DA triggered by chemotherapeutic agent camptotehcin-11 but not fluorouracil. AA, AA-2 α G, and AA-2 β G significantly decreased Keap-1expression, and increased the expression levels of nuclear factor E2-related factor 2 (Nrf2) and heme oxygenase-1. All compounds triggered the nuclear translocation of Nrf2, while the ability of AA-2 β G to enhance the Nrf2-DNA binding affinity was approximately two fold as those of AA and AA-2 α G. Sodium ascorbate cotransporters (SVCT) inhibitors, sulfinpyrazone, phloretin, and 3- O -methyglucose, potently abrogated the free radical scavenging activities of AA, AA-2 α G, and AA-2 β G. The cellular uptake efficacy of AA-2 α G and AA-2 β G was less than 10% of AA, while the inhibition of SVCT with sulfinpyrazone considerably diminished the uptake efficacy of these compounds. AA-2 α G and AA-2 β G are more stable in the Fenton reagents than AA. In summary, AA-2 β G from L. barbarum with excellent free radical scavenging activity is a promising natural AA derivative for further pharmacological evaluation.
研究领域:
药理学
·
免疫学
·
肿瘤学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2018
·Vol. 54
·期 7
·5865-5876
·
IF 2.993
Zhou Zhao-Xi,Li Yue-Wei,Zheng Yang-Qing,Luo Zhen,Gong Cui-Ran,Xu Ying,Wu Li-Xin
The adipic acid glycidyl methacrylate (AA-GMA) containing double bond of carbon and hydroxyl as an ultraviolet-polyurethane dual-curing oligomer was prepared as a precursor to resin for three-dimensional (3D) printing. A dual-curing resin for 3D printing was formulated from the AA-GMA, PHDI (hexamethylene diisocyanate-based polyisocyanates, mainly trimer) and other reagents. The dual-curing oligomer AA-GMA was synthesized by the epoxide ring-opening reaction with dicarboxylic acid and the molecular structure of which was characterized by FTIR and 1 H NMR analyses. AA-GMA has the double bond which could be cured via ultraviolet irradiation in the 3D printing process, and the hydroxyl could be cured by PU curing agent PHDI at the thermal post-curing process. The PHDI was not only employed as a diluent in the 3D printing process, but also acted as a reactant for post-curing. Compared to the traditional single-curing resin, this dual-curing resin could provide products with increased crosslinking density, flexibility and reduced volumetric shrinkage rate. The tensile strength of dual-curing sample was improved to 64 MPa after adding 20 wt% PHDI, which showed 18% boost compared to the sample without the PHDI. For the sample with a content of 30 wt% PHDI, the glass transition temperature ( T g ) was about 121 °C, presenting 35 °C higher than that of the blank sample.
研究领域:
材料科学
·
化学工程
·
高分子科学
·
3D打印技术
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产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Hong Chen,Junyan Liu,Mengna Wan,Shangyi Zhao,Xiaolong Li,Chuan Liu,Xuanping Zhao,Junjie Li,Qingzhen Ma,Cuixiang Li,Xueqin Wang
Fruit juice is kind of popular beverage food worldwidely, and its total antioxidant capacity (TAC) is generally considered as an important index for people’s rational diet, thus accurate evaluation of its TAC is essential for human health guidance. Herein, we constructed a sensitive Fe 3 O 4 @MnO 2 nanocatalyst that was delicately cored with magnetite nanoparticles (Fe 3 O 4 NPs) and encapsulated with manganese dioxide (MnO 2 ) nanoshells for fast and accurate TAC colorimetric analysis in fruit juice. The data showed the fabricated Fe 3 O 4 @MnO 2 nanocatalysts performed with remarkable oxidase mimetic activities and could catalyze oxidization of colorimetric substrate without additional H 2 O 2 , and the limit of detection (LOD) was about 0.39 μM for ascorbic acid (AA) evaluation. Applied in commercial fruit juice products, the fabricated Fe 3 O 4 @MnO 2 nanocatalysts showed a reliable and visual assessment for the accurate TAC analysis. In addition, the fabricated Fe 3 O 4 @MnO 2 nanocatalysts could be easily recycled due to their intrinsic superparamagnetic property. Together, an intellegent Fe 3 O 4 @MnO 2 nanocatalyst was well developed for visual TAC analysis in fruit juice with convenient applications in future.
研究领域:
纳米技术
·
分析化学
·
食品科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）