JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
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2017
·Vol. 106
·期 5
·1827-1841
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IF 3.189
Yikun Yang,Chunyi Tong,Juchang Zhong,Ruiying Huang,Weihong Tan,Zhikai Tan
Magnetic hyperthermia has been rapidly developed as a potential cancer treatment in recent years. Artificially induced hyperthermia close to a tumor can raise the temperature to 45°C causing tumor cell death. Herein, we introduce a novel method for rapid preparation of anti-cancer magnetocaloric PCL/Fe 3 O 4 mats capable of high-performance hyperthermia using E-jet 3D printing technology. Our 3D printed mats not only maintained the heating efficiency of traditional techniques for magnetic hyperthermia but also prolonged the effective therapy in vivo . When Fe 3 O 4 nanoparticles (NPs) were used in mats at a concentration of 6 mmol/L, 0.07 g PCL/Fe 3 O 4 mats were able to increase the temperature peripherally to 45°C under an alternating magnetic field (AMF) within 45 min. Moreover, the reproducibility experiment indicated that the maximum temperature was achieved following repeated heating and cooling cycles. Cell toxicity tests showed a high cell death rate during one treatment cycle. In vivo experiments indicated clear signs of tumor growth inhibitory and prolonged survival time of tumor-bearing mice after 4 weeks of treatment. The present magnetic mats may be a potential candidate for a novel heat-generating substrate for localized hyperthermia cancer therapy. Furthermore, the main advantage of such implantable magnetic mats is the local and precise delivery of Fe 3 O 4 NPs, ideal for the hyperthermia treatment of easily accessible tumors. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1827–1841, 2018.
研究领域:
生物医学工程
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材料科学
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肿瘤学
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产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
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2021
·
IF 4.821
Xiaojing Si,Luchen Deng,Yingzi Wang,Mei Han,Yaping Ding
A novel poly alizarin red (AR) film incorporating carboxylic acid group functionalized multiwall carbon nanotube (f-MWCNT) modified glassy carbon electrode (GCE) was first prepared for the determination of luteolin (Lut). Scanning and transmission electron microscopy were applied for characterization of the surface morphology of the modified electrodes and cyclic voltammetry was used to investigate the electrochemical properties of the proposed electrode towards the oxidation of Lut. Optimization of the experimental parameters was performed with regard to pH, drop-coating volume of f-MWCNT, electro-polymerization cycles of alizarin red, and different potentials of i-t. And the mechanism for Lut detection based on AR/f-MWCNT/GCE was investigated by electrochemical methods. The linearity between the oxidation peak current and the Lut concentration was obtained in the range of 0.5 to 45 μM with a detection limit of 0.17 μM (S/N = 3). In addition, the AR/f-MWCNT/GCE electrode displayed high selectivity, good stability and reproducibility, and also successfully determined Lut in drug samples.
研究领域:
分析化学
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电化学
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纳米技术
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药物分析
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产品关联
DOI
高影响因子
JOURNAL OF POWER SOURCES
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2020
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IF 8.247
Leicheng Zhang,Chen Zhao,Maochun Wu,T.S. Zhao
We demonstrate an energy-dense, flowable electroactive material by suspending solid sulfur hosted in hollow carbon nanoshells (HCSs) in a liquid electrolyte without extra conductive additives for the pursuit of high-energy-density semi-solid flow batteries . Compared to conventionally used Ketjen Black (KB) additives, the conductive HCSs can confine the insulating active materials within their void space, while maintaining the electroactivity of the outer surface. More importantly, the liquid suspension of well-dispersed HCS/S nanoparticles shows much lower viscosity than that formed by aggregated KB particles with a hyperbranched structure. The cell with the liquid suspension paired with Li metal achieves an average volumetric capacity of ~80 Ah L −1 over 50 stable cycles in the static test and an energy density of 230 Wh L −1 in the intermittent flow test. Our energy-dense HCS/S suspension with high flowability shows great potential for high-energy-density energy storage systems .
研究领域:
材料科学
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电化学
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产品关联
DOI
高影响因子
MICROCHIMICA ACTA
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2017
·Vol. 184
·期 10
·3817-3823
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IF 4.58
Li Jingjing,Wang Yuxian,Jiao Yunfei,Jia Ru,Chen Zhengbo
Under normal circumstances, chromate ions cannot oxidize core-shell Cu-Au nanoparticles (NPs) because the standard redox potential of the Cr(VI)/Cr(III) system is lower than that of Au(I)/Au. However, in the presence of a certain concentration of hydrogen bromide, the Nernst potential becomes higher than that of Au(I)/Au and Cu(II)/Cu (as calculated by the Nernst equation). Based on this finding, a colorimetric method was developed that is based on oxidative etching of Cu@Au NPs by chromate. The Cu-Au NPs have a light red color in the presence of 5 mM HBr. On addition of Cr(VI), the gold shell is rapidly etched from the surface of the Cu-Au NPs, and this is accompanied by a color change to blue. The color changes were characterized by UV-vis spectroscopy. The absorbance at 526 nm changes in the 0.4 nM to 1 μM chromate concentration range, and the detection limit is 0.21 nM.
Schematic of a highly sensitive and selective colorimetric method for detection of chromate based on the redox etching of Cu@Au nanoparticles induced by Cr(VI). The presence of HBr enables Cu@Au NPs to be oxidized by Cr 6+ .
研究领域:
分析化学
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环境科学
✓ 已验证
DOI
高影响因子
ACS Sustainable Chemistry & Engineering
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2021
·
IF 8.198
Jiehan Lin,Wei Lu,Xiaoyu Shi,Qin Lu,Lei Wang,Hui He
Solid amine adsorbents cannot typically maintain desirable CO2 capture capacity while having ultralow regeneration temperatures. To address this issue, a novel thermoresponsive nanofiber-based solid amine adsorbent (TRCNF/PEIA) with high amino density and high content of thermoresponsive intelligent groups was designed and prepared using epichlorohydrin to rapidly cross-link polyethyleneimine (PEI) and a thermoresponsive cellulose nanofiber (TRCNF). The latter was obtained by grafting N-isopropylacrylamide (NIPAm) on the cellulose nanofiber (CNF) through Ce (IV)-initiated free radical polymerization. The as-prepared TRCNF/PEIA simultaneously showed high capture capacity (6.74 mmol/g) with water at 25 °C and a low regeneration temperature (60 °C). A comparison of the adsorption–desorption properties of TRCNF/PEIA with those of the PEIA, which was prepared using a procedure similar to that of TRCNF/PEIA but without TRCNF, showed that the thermoresponsive property of PNIPAm and the synergy of the hydroxyl groups of TRCNF/PEIA could facilitate CO2 complete desorption from the adsorbent at 60 °C, which was the lowest regeneration temperature to maintain the high adsorption capacity (≥6 mmol/g) of the adsorbents, based on the literature reports.
研究领域:
材料科学
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环境科学
✓ 已验证
DOI
高影响因子
JOURNAL OF HYDROLOGY
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2025
·
IF 6.3
Haixu Duan,Jiajun Chen,Zhipeng Du,Zhenquan Wang,Hongbo Zhou
Hydraulic conductivity exhibits dynamic circular and annular distributions within the porous media of the sweeping zone and surrounding contaminated groundwater. Investigating the equivalent hydraulic conductivity in annular effective heterogeneous media is essential for simplifying the calculation of hydraulic parameters. This study generalized the flow of a polymer mixture and contaminated plume in an aquifer as radial flow with differing hydraulic conductivities: K P (with respect to the polymer mixture) and K W (with respect to water). A theoretical formula for the equivalent hydraulic conductivity of annular effective heterogeneous media and corresponding methods for calculating key hydraulic parameters were developed. Radial transport experiments demonstrated that the experimental results for equivalent hydraulic conductivity, actual average radial velocity, and the time required to reach the influence radius were in good agreement with the theoretical predictions. As the radial advancement radius increased, the equivalent hydraulic conductivity gradually decreased, transitioning from the hydraulic conductivity of a medium with respect to water ( K W ) to that with respect to a polymer mixture ( K P ). Higher concentrations of the polymer mixture reduced the hydraulic conductivity contrast ( K P / K W ), thereby further decreasing the equivalent hydraulic conductivity of the aquifer layer. The actual average radial velocity and the time required to reach the influence radius were controlled by the radial advancement radius, the polymer mixture concentration, and the hydraulic head difference. These three factors influenced the change in displacement resistance during single-well injection. Finally, the reliability and simplicity of the theoretical formula and hydraulic calculation method were confirmed. This work facilitates the design of single-well injection remediation schemes for in situ chemical remediation of groundwater contamination.
研究领域:
环境科学
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水文学
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产品关联
DOI
高影响因子
Materials Today Communications
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2025
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IF 4.5
G.D. Lai,H. Niu,K. Li,L. Lu,Y. Cai,Y.L. Bian,H.W. Chai
The deformation and damage mechanisms of aluminum/polytetrafluoroethylene (Al/PTFE) composites under quasi-static compression are critical for aerospace, defense and structural applications, yet their mesoscale behavior remains insufficiently understood. This study combines in situ synchrotron X-ray micro computed tomography (CT) with CT-based finite element method (FEM) simulations to dynamically resolve the interplay between microstructure evolution and mechanical response. Real-time 3D imaging reveals negligible contributions of initial voids to bulk deformation, while catastrophic failure is governed by shear-induced interfacial debonding between Al particles and progressive void coalescence. Mesoscale FEM simulations quantify stress localization on Al particles, demonstrating its dependence on particle alignment relative to the loading direction. Damage initiates exclusively when adjacent particles deviate from the loading direction, underscoring the pivotal role of microstructural heterogeneity. These findings provide new insights into mesoscale structure–property relations in Al/PTFE composites, and the combined methodology of in situ CT experiments and CT image-based FEM simulations offers potential for advancing mechanistic studies of multiphase composites under complex mechanical conditions.
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DOI
高影响因子
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2024
·Vol. 26
·期 9
·7855-7864
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IF 2.9
Yao Wang,Ziqi Wang,Lujuan Yang,Wenkai Zhang,Gang Ma
Understanding the amyloid nucleation mechanism is fundamentally important for the development of diagnostics and therapeutics of amyloid-related diseases and for the design and application of amyloid-based materials. To this end, we here explore the use of atomic force microscopy (AFM) and a side-chain-based infrared (IR) probe technique to investigate the amyloid nanosheet formation mechanism of an Aβ16–22 variant, KLVFXAK, where X is p-cyanophenylalanine with its side-chain cyano group being an infrared probe. Using AFM, we reveal that the formation of KLVFXAK amyloid nanosheets follows a two-step non-classical nucleation mechanism. The first step is the rapid formation of a metastable fibrillar intermediate and the second step is slow transformation to the final nanosheet. Using the side-chain-based IR probe technique, we obtain spectroscopic evidence for the proposed nucleation mechanism of the amyloid nanosheet as well as the structural details for the intermediate and amyloid nanosheet. By using the structural constraints set by the two techniques, we propose the structural models for both the fibrillar intermediate and the amyloid nanosheet. In addition, we further investigated the amyloid nanosheet formation mechanism of a similar Aβ16–22 variant, KLVFXAE, and showed the impact of mutation on the amyloid nucleation mechanism. Our work also provides a nice example of how to use the combined approach of AFM and a side-chain-based IR probe technique to unravel the complex nucleation mechanism of amyloid formation.
研究领域:
生物物理学
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结构生物学
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材料科学
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蛋白质化学
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产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2022
·Vol. 32
·期 18
·2111662
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IF 19.924
Huaifang Qin,Liang Xu,Shiquan Lin,Fei Zhan,Kai Dong,Kai Han,Huamei Wang,Yawei Feng,Zhong Lin Wang
As an emerging technology for energy harvesting and distributed power supply, triboelectric nanogenerators are mainly based on a dielectric capacitive structure. Here, a new mechanism by introducing an oil phase into a water–solid interface is demonstrated for energy harvesting based on electric double layer (EDL) capacitance. Through squeezing and releasing oil droplets on a dielectric surface in water environment, charge transfer is observed in the back electrode accompanying the movement of the oil–water–solid three-phase line. The charge transfer is mainly attributed to the effect that the oil phase sweeps away ions near the dielectric surface in the EDL due to the discrepancy of EDL between water–solid and oil–solid interfaces. Under the water environment, the device is shown to be capable of direct energy harvesting and self-powered sensing without costly packaging. As a new working mode relying on EDL, it allows developing nanogenerators adaptive to severe environments even underwater with low friction and wear, and narrowing the gap between energy harvesting devices and electro-chemical devices. Through further enhanced EDL, it is reasonable to anticipate devices with an ultrahigh charge density comparable with EDL super capacitors, opening up an avenue toward new nanogenerators with overwhelming performance for practical applications ranging from blue energy harvesting to electro-catalysis.
研究领域:
纳米技术
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能量收集
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电化学
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传感器与传感系统
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可再生能源
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DOI
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2020
·Vol. 412
·期 28
·7811-7817
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IF 3.637
Hu Yinhua,Cao Xiuping,Guo Yingshu,Zheng Xiaofei,Li Dongjiao,Chen Si-Kai,Chen Guang,You Jinmao
The fluorescent nanoprobes for reduced thiol compounds (represented by glutathione, GSH) are constructed based on the aggregation-induced emission (AIE) luminescence mechanism and endosome escape technology. First, a DNA sequence was designed with the decoration of biotin at the 5′-end, disulfide bound in the internal portion, and amino at the 3′-end. The aptamer of the MCF-7 cell was also one of the most important structures in our DNA sequence for the selectivity of MCF-7 cells. We modified streptavidin-modified magnetic beads (MB) with biotin-modified influenza virus hemagglutinin peptide (HA) and biotin-DNA-amino to form MB/DNA/HA. Carboxyl-modified tetraphenylethylene (TPE), an iconic AIE fluorogen, was bonded with amino-modified DNA by covalent interactions (TPE/DNA). Then, the TPE molecule was attached on the outer layer of MB via biotin-modified TPE/DNA to form MB/DNA/HA/TPE. Compared with traditional AIE/biomolecule conjugates, the nanoprobe had an enhanced endosome escape function, due to the assembly of HA. This construction made the intracellular fluorescence response more accurate. In the presence of reduced thiol compounds (take GSH, for example), the disulfide bond on the DNA was reduced by thiol-disulfide exchange reactions and the TPE molecule was released into the solution. The shedding TPE molecule was more hydrophobic than TPE/DNA and the conversion of TPE/DNA to shedding TPE could lead to the aggregation of the TPE fluorogen. Thus, its fluorescence was enhanced. Under the optimized condition, the fluorescence intensity increased with the increase in concentration of GSH‚ ranging from 1.0 × 10 −9 M to 1.0 × 10 −5 M‚ and the detection limit was 1.0 × 10 −9 M. The relative standard deviation (RSD) was calculated to be 3.6%. The recovery in cell homogenate was from 94.5 to 102.7%. The nanoprobe provided a way for the detection of reduced thiol compounds in MCF-7 cells. We envision that, in the near future, our strategy of DNA-instructed AIE could be widely applied for biosensing and bioimaging in vitro and even in vivo with dramatically enhanced sensitivity.
Graphical Abstract
研究领域:
生物技术
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纳米技术
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分析化学
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细胞生物学
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分子生物学
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生物化学
✓ 已验证
DOI
PubMed
高影响因子
LANGMUIR
·
2010
·
IF 3.898
Yao Zhou,Wenshuang Lin,Huixuan Wang,Qingbiao Li,Jiale Huang,Mingming Du,Liqin Lin,Yixian Gao,Ling Lin,Ning He
Biosynthesized gold nanoparticles (GNPs) were transferred from water to a hydrophobic ionic liquid (IL), [Bmim]PF6, with the assistance of alkyl trimethyl ammonium bromide. The phase transfer mechanism was illustrated through the exemplification of cetyltrimethyl ammonium bromide (CTAB). Interaction between GNPs and CTAB was demonstrated through zeta potential analysis. Moreover, an anion-exchange process was discovered between CTAB and IL. During the process, the hydrophobic CTAPF6 formed in situ on the GNPs led to the hydrophobization and thus phase transfer of the GNPs. The phase transfer efficiency was found to be size-dependent.
研究领域:
纳米生物学
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材料科学
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry A
·
2018
·Vol. 6
·期 48
·24920-24927
·
IF 9.931
Dong-Cheng Liu,Li-Ming Cao,Zhi-Mei Luo,Di-Chang Zhong,Jing-Bo Tan,Tong-Bu Lu
Engineering efficient and cost-effective electrocatalysts for the oxygen evolution reaction (OER) is an essential part of electrochemical water splitting. Herein, we report the in situ preparation of an efficient OER electrocatalyst CoFePi/Ni(PO3)2 on carbon cloth (CC) by decorating amorphous CoFe phosphate (CoFePi) on crystalline nickel phosphate (Ni(PO3)2). The as-synthesized hierarchically heterogeneous electrocatalyst can be directly used as a working electrode for the OER without extra substrates or binders. Electrocatalytic studies showed that the CoFePi/Ni(PO3)2/CC electrode displays excellent OER catalytic activity and stability. A current density of 10 mA cm−2 during the OER process can be achieved at a low overpotential of 213 mV in 1.0 M KOH solution, comparable to the results reported for the most efficient OER electrocatalysts. The ultrahigh oxygen evolution activity and high durability are ascribed to the unique 3D hierarchical heterogeneous nanostructure and in situ generated amorphous–crystalline composite, as well as the highly conductive substrate of CC, which endows the composite catalyst with sufficient active sites, strong structural stability and good electrical conductivity. This strategy offers a new direction to fabricate high-performance electrocatalysts for the oxygen evolution reaction.
研究领域:
电化学
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材料科学
·
能量转换
·
催化
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）