AICHE JOURNAL
·
2024
·
IF 3.5
Dong Lin,Xiuhui Zheng,Ze Zong,Yang Xu,Qiuming He,Zhe Ma,De Chen,Chaohe Yang,Xiang Feng
Comprehensive mechanistic explorations and profound understandings of the interactions between water molecules and active intermediates harbors tremendous significance in the field of zeolite catalysis. Herein, we envision a strategy to accelerate alkene epoxidation reactions (e.g., 1-pentene, 1-hexene, cyclohexene, cyclooctene) with preformed H 2 O 2 inside confined channels of Ti-beta by water molecules. Combined with in situ UV–vis, kinetic experiments, and DFT calculations, it is found that keen control of water molecules could effectively enhance H 2 O 2 adsorption and stabilize crucial oxygen intermediates (Ti-OOH) by hydrogen bonding interactions. As a result, the yields of corresponding epoxides increased up to 20.5%. However, excessive water clusters construct a dense and robust hydrogen-bond network, blocking the activation of reactants and further epoxidation over Ti sites. This finding not only sheds new light on the mechanism of water-accelerated reaction, but also opens up new opportunities to enhance the efficiency of industrial epoxidation reactions involving H 2 O 2 .
研究领域:
催化化学
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材料科学
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理论化学
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产品关联
DOI
高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
·
2022
·
IF 5.876
Shuang Wang,Lipeng Zhou,Beibei Gao,Yunlai Su,Xiaomei Yang
Sn-Beta is a good solid Lewis acid catalyst. Seed-assisted hydrothermal synthesis is a popular method for its preparation. However, the mechanism of seeds in the crystallization process is not clear. Here, the role of seeds in the growth of crystal and the influence on the properties of the corresponding products were studied. The seeds and gel was characterized by XRD , SEM, FT-IR and TG. During the crystallization, it was observed that the seeds were partially dissolved and formed seed fragments in the initial stage. Then the seed fragments acted as the core of the crystals and promoted the crystallization process. Seeds greatly decreased the crystal size of the products as compared with the direct hydrothermal method in absence of seeds. The acidity and catalytic performance of Sn-Beta synthesized via seeds route are similar with those of none-seeds method.
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DOI
高影响因子
Genes & Genomics
·
2022
·Vol. 44
·期 7
·867-878
·
IF 2.164
Li Mo,She Jiang,Ma Louyan,Ma Li,Ma Xiaorui,Zhai Jiajia
Background Destruction of pancreatic beta cells is the most typical characteristic of diabetes. Objective We aimed to evaluate the effect of berberine (BBR), a bioactive isoquinoline derivative alkaloid, on beta cell injury. Methods Rodent pancreatic beta cell line INS-1 was treated with 0.5 mM palmitate (PA) for 24 h to establish an in vitro beta cell injury model. Results BBR at 5 µM promoted cell viability, inhibited cell apoptosis and enhanced insulin secretion in PA-induced INS-1 cells. BBR treatment also suppressed PA-induced oxidative stress in INS-1 cells, as evidenced by the decreased ROS production and increased activities of antioxidant enzymes. In addition, suppressed ATP production and reduced mitochondrial membrane potential were restored by BBR in PA-treated INS-1 cells. It was further determined that BBR affected the expressions of mitophagy-associated proteins, suggesting that BBR promoted mitophagy in PA-exposed INS-1 cells. Meanwhile, we found that BBR facilitated nuclear expression and DNA-binding activity of Nrf2, an antioxidative protein that can regulate mitophagy. Finally, a rescue experiment was performed and the results demonstrated that the effect of BBR on cell viability, apoptosis and mitochondrial function in PA-induced INS-1 cells were cancelled by PINK1 knockdown. Conclusions BBR protects islet β cells from PA-induced injury, and this protective effect may be achieved by regulating mitophagy. The present study may provide a novel therapeutic strategy for β cell injury in diabetes mellitus.
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DOI
PubMed
高影响因子
Nanomaterials
·
2019
·Vol. 9
·期 10
·1429
·
IF 4.034
Yuehua Deng,Yani Li,Wenjie Nie,Xiang Gao,Shentan Liu,Xiaochun Tan,Mingming Chen,Dongzhuang Hou
As a nano-adsorbent, magnetic graphene oxide (GO/Fe3O4) was synthesized to potentially adsorb propranolol (PRO) from water. The synthetic material was characterized by SEM, TEM, VSM, FTIR, XRD, zeta potential, and XPS. The environmental factors, such as pH, humic acid concentration, PRO concentration, and contact time, were investigated regarding their effect on the adsorption process. The kinetics data fitted the pseudo first-order and second-order kinetics equations. The Langmuir equation, the Freundlich equation, and the Sips equation were used to analyze the adsorption isotherms. Electrostatic attraction, hydrogen bonding, and the π–π interaction all contributed to the adsorption process of PRO onto GO/Fe3O4. The discovery of this study emphasized the feasibility of GO/Fe3O4removal of PRO and expanded the scope of the application of GO.Keywords:magnetic graphene oxide;propranolol;Fe3O4;adsorption
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DOI
PubMed
高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
·
2019
·
IF 4.182
Kai Gao,Qing Wang,Xuexun Du,Qinglian Wei,Yongmin Huang
Dimethylamine (DMA), which is mostly generated in fine chemical industry, has enormously threatened the public health, therefore should be eliminated from water efficiently. Superior to any other methods to remove DMA, adsorbing it by sorbent could avoid the generation of secondary pollution. Among all the sorbents employed in this study, low Si/Al ratio Beta zeolite synthesized without organic template exhibits the highest performance of adsorbing DMA from water. When the transition-metal cations were introduced by ion-exchange, the adsorption of DMA was enhanced. Subsequently, the saturated adsorbent was heated in air condition, detection results of the off-gas indicated that nearly all of the DMA adsorbed was oxidized and negligible harmful by-product was produced. Beta zeolite adsorption coupled with catalytic oxidation could eliminate DMA efficiently and environmental friendly which has wide application prospects in waterworks.
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DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2014
·
IF 4.331
Saou-Hsing Liou,Gordon C.C. Yang,Chih-Lung Wang,Yu-Han Chiu
This 5-month study contains two parts: (1) to monitor the concentrations of 11 phthalate esters metabolites (PAEMs) and two beta-agonists in human urine samples collected from a small group of consented participants including 16 females and five males; and (2) to analyze the residues of phthalate esters (PAEs) and beta-agonists in various categories of drinking water consumed by the same group of subjects. Each category of human urine and drinking water had 183 samples of its own. The analytical results showed that nine PAEMs were detected in human urine and eight PAEs were detected in drinking water samples. It was found that average concentrations of PAEMs increased as the age increased, but no significant difference between sexes. Further, using the principal component analysis, the loadings of age effect were found to be two times greater than that of gender effect in terms of four DEHP metabolites. Regarding beta-agonists of concern (i.e., ractopamine and salbutamol), they were neither detected in human urine nor drinking water samples in this study.
研究领域:
环境科学
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毒理学
·
公共卫生
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DOI
PubMed
高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
·
2020
·
IF 4.551
Baoyu Wang,Ximing Yan,Haiyan Zhang
Zeolite/binder (beta/Al 2 O 3 ) was treated with different concentrations of phosphoric acid , and the samples pre- and post-treatment were characterized by several methods. It was found that the content of tetrahedral framework Al species in the beta zeolite increased after the sample was impregnated with phosphoric acid, and the generated aluminophosphate reduced the external surface area of the catalyst but had no effects on the catalytic ability of the beta zeolite. The realumination behavior of beta zeolite is proposed in this work. Polyphosphate reacted with hexa-coordinated aluminum , resulting in the formation of amorphous aluminophosphate species, which were then transferred to the silicon hydroxyl structure cavity on the zeolite to complete realumination. The influence of the sample before and after phosphoric acid modification on the activity of synthesized polyoxymethylene dimethyl ethers was discussed. When the phosphoric acid concentration was 0.5 M, the time to reach the same conversion of trioxane (about 94%) was shortened by 60 min compared to the parent sample.
研究领域:
化学工程
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催化科学
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DOI
高影响因子
Reaction Chemistry & Engineering
·
2022
·Vol. 7
·期 6
·1447-1460
·
IF 5.2
Jianchao Liu,Hong Xu,Jinxiang Dong,Ligong Zhou,Xuekuan Li,Hui Ge
The synthesis of alkylbenzenes produced from syngas and benzene over a ZnCrOx/beta bifunctional catalyst has been studied. Our characterization results showed that in the mixed catalyst the beta-zeolite crystallites were dispersed on the surface of the ZnCr oxides. The close contact facilitated the methanol intermediate formed on ZnCrOx to diffuse to the acidic sites of the beta-zeolite crystallites, reacting with benzene to produce alkylbenzenes. The competitive side reactions, which lead to by-products such as CO2 and hydrocarbons, were suppressed. The medium strong acidity and mesopores of the beta-zeolite crystallites contributed to the high activity and selectivity. The optimized ZnCrOx/beta-11 = 1 : 3 (w/w) afforded 40.72% benzene and 62.40% CO conversion with high alkylbenzene selectivity during the initial stage of the reaction, which then underwent quick deactivation, and maintained a benzene conversion of ∼27%. Coke formation on the beta-zeolite crystallites was proposed to be the main cause of deactivation.
研究领域:
催化化学
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材料科学
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DOI
高影响因子
PROSTAGLANDINS & OTHER LIPID MEDIATORS
·
2025
·
IF 2.5
Jindao Wang,Minghui Zhou,Qiuli Zhou,Guangyang Sun,Yu Zhang,Feng Tao,Minfeng Ye
Background Gastric cancer (GC) is the third leading culprit of cancer-related deaths around the world. Beta-sitosterol (BS) is an important phytosterol that has been proven to have anti-proliferative effects on GC and other tumors. However, mechanisms and targets of BS in cancer are rarely explored. Methods In this investigation, the targets of BS in the treatment of GC were analyzed by network pharmacology. Molecular docking and cellular thermal shift assay were introduced to validate the binding relationship between BS and PTGS1. The impacts of BS on GC cell viability, half maximal inhibitory concentration, proliferation ability, apoptosis level, and angiogenesis ability were detected by using Cell Counting Kit-8, clone formation assay, flow cytometry, and angiogenesis experiment, respectively. In addition, the expression levels of angiogenic factors (VEGF, FGF, PAI-1) were detected by using western blot. Results In this project, through cell experiments, PTGS1 was identified as a protein that directly binds to BS. In vitro cell experiments revealed that BS promoted apoptosis and inhibited GC cell proliferation and angiogenesis. Importantly, treatment with BS attenuated the promoting influence of PTGS1 overexpression on GC cell proliferation and angiogenesis. Conclusion This investigation highlighted PTGS1 as the target of BS in GC cells. BS can regulate PTGS1 to inhibit GC cell proliferation and angiogenesis, providing new evidence for the potential use of BS as a therapeutic agent for GC.
研究领域:
肿瘤学
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药理学
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分子生物学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF ENVIRONMENTAL MANAGEMENT
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2024
·
IF 8
Guangxia Xu,Xiaoyu Long,Junjie Zhai,Yunhao Liu,Chaowei Wang,Jinbu Li,Xing Wang
Widespread use of the pyrethroid insecticide beta-cypermethrin (beta-CYP) has led to adverse effects on nontarget populations within agroecosystems. Despite the efficacy of beta-CYP in pest control, its toxicological and defense mechanisms remain incompletely understood. In the present study, we explored the toxicological effects, antioxidant mechanisms and immune response against beta-CYP using Drosophila melanogaster , a well-established model organism for the study of insect biology, to represent the broader class of nontarget organisms. We exposed Drosophila larvae to 0.667 μg/mL beta-CYP and revealed that delayed development and caused intestinal epithelial damage in larvae. To gain insights into the molecular underpinnings of these effects, RNA sequencing analysis and quantitative polymerase chain reaction validation were performed. These analyses revealed that the messenger RNA levels of glutathione S-transferase were increased, third instar larvae exhibited an increase in reactive oxygen species content and a corresponding increase in antioxidant enzyme activity in response to beta-CYP exposure, indicating an upregulated response to oxidative stress. Beta-CYP also activated Hippo pathway to resist apoptosis and promote cell proliferation. Moreover, beta-CYP induced melanization and Toll immune pathways involved in immune response in Drosophila larvae, specifically the Toll pathway gene Drs . This activation suggests that Drosophila increases antioxidant defenses and promotes mitosis in damaged tissues as compensatory mechanisms to mitigate the cytotoxic effects of beta-CYP. These findings provide new insight into the mechanisms of beta-CYP–induced toxicity and the defense mechanisms in insects; they may also inform strategies for the sustainable use of insecticides and the development of mitigation measures to protect nontarget species in agroecosystems.
研究领域:
毒理学
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昆虫生物学
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分子生物学
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免疫学
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DOI
PubMed
高影响因子
JOURNAL OF POROUS MATERIALS
·
2018
·Vol. 26
·期 4
·1017-1025
·
IF 1.858
Liu Zhen,Zhao Liang,Zhang Tingting,Wang Yu,Xu Yanyan,Komarneni Sridhar,Wang Yi,Liu Xinmei,Yan Zifeng
The traditional silicon sources for beta zeolite synthesis are solid silica gel, carbon-white or tetraethyl orthosilicate (TEOS), which makes the material cost even higher. Herein, beta zeolite synthesis by hydrothermal method with industrial silica sol as silicon source was investigated. The effects of synthesis conditions on product property were investigated in detail, including template content, crystallization temperature, crystallization time and alkalinity of hydrothermal system. The products properties, such as crystallinity, pore structure, morphology and acid properties were thoroughly characterized by XRD, N 2 adsorption–desorption isotherm, SEM, TEM, Py-FTIR and NH 3 -TPD. The optimum condition for synthesis of beta zeolite using industrial silica sol as silicon source was finally determined. Compared with commercial beta zeolite, the as-synthesized beta zeolite had higher relative crystallinity, higher total and microporous specific surface area with higher total concentration and B/L ratio of acid sites.
研究领域:
材料科学
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化学工程
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2018
·
IF 3.909
Jingwei Wang,Zhiheng Guo,Jianxin Xiong,Datong Wu,Shan Li,Yongxin Tao,Yong Qin,Yong Kong
Modification of natural polysaccharides such as chitosan (CS), β‑cyclodextrin (β-CD), and alginic acid offers a promising strategy for the preparation of smart drug carriers, and latest innovations on such carriers are focused on stimuli-responsive biomaterials. In this study, highly hydrophilic three-demensional (3D) porous CS-grafted β-CD (CS-g-β-CD) was prepared through the Williamson ether synthesis reaction with epichlorohydrin (ECH) as the crosslinker and the consequent nucleophilic reaction between the epoxide ring of ECH and the primary amine of CS, which was then characterized by 1 H nuclear ( 1 H NMR), Fourier transform infrared (FT-IR) spectra, X-ray diffraction (XRD) analysis, scanning electron microscope (SEM), thermogravimetry (TG), and N 2 adsorption/desorption isotherms. When etoposide (VP16), an anti-cancer drug, was encapsulated in the CS-g-β-CD, the encapsulation ratio was up to 73.6%. Finally, the resultant CS-g-β-CD was successfully used as the responsive drug carrier for pH- and thermo-sensitive release of VP16. This work opens a new avenue for the preparation of stimuli-responsive drug carriers with modified natural polysaccharides.
研究领域:
生物材料学
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）