Contrast Media & Molecular Imaging
·
2019
·Vol. 2019
·期 1
·5215923
·
IF 1.984
Yapu Liu,Qi Liu,Zhou Yang,Junyu Lin,Xiuhua Wu,Zucheng Huang,Junhao Liu,Rong Li,Zhiping Huang,Xiaoliang Wu,Qingan Zhu
Purpose . Barium sulfate and lead oxide are commonly used for angiographic studies, but there is no report on the comparison of two contrast agents in angiography of cervical spinal cord. This study was aimed to compare the microvascular architecture of cervical spinal cord in rats after angiography with the barium sulfate agent to the lead oxide agent. Methods . Twelve adult Sprague-Dawley rats were randomly divided into the barium sulfate group ( n = 6) and the lead oxide group ( n = 6). Each rat was perfused under the same protocol using either two contrast agents. The angiography was evaluated with the vascular number at different ranks. The cervical spinal cord samples were scanned using micro-CT with low resolution and high resolution. The microvascular parameters, including ratio of vascular volume to tissue volume (VV/TV), vascular number (V.N), diameter (V.Dm), separation (V.Sp), connectivity density (Conn.D), structure model index (SMI), percentage, and volume of vessels at different diameters were measured. Results . The perfusion was better in the barium sulfate group, with more blood vessel trees of rank II and III visible compared to the lead oxide group. Low-resolution micro-CT analysis showed no difference in microvascular parameters except SMI between the two groups. High-resolution micro-CT analysis results showed that V.N and Conn.D of barium sulfate group were 60% and 290% more than those of the lead oxide group; however, V.Sp was 41% less than the lead oxide group. The percentage of vessels with diameter of 10 μ m and 20 μ m, and the volume of vessels with diameter of less than 100 μ m was higher in the barium sulfate group than in the lead oxide group. The SMI index in the barium sulfate group was higher than that in the lead oxide group at both low resolution and high resolution. Conclusions . Compared with lead oxide, barium sulfate is more suitable for perfusion of cervical spinal cord microvessels, and cheap and nontoxic with high resolution.
研究领域:
神经影像学
·
血管生物学
·
放射学
·
临床前研究
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DOI
高影响因子
Science Advances
·
2026
·Vol. 12
·期 22
·
IF 13.9
Jinbin Pan,Li Ma,Hua Ma,Yuanlin Zhang,Iris. Y. Zhou,Nicholas J. Rotile,Dong Li,Onofrio A. Catalano,Shao-Kai Sun,Peter Caravan
Early, noninvasive, and spatially resolved assessment of renal dysfunction is essential for theranostics of kidney diseases, yet clinical biomarkers are criticized for averaging whole-kidney function and missing focal or unilateral injury. Here, we present a contrast-sparing computed tomography (CT) approach that maps renal dysfunction at the compartment level using renal-clearable glutathione-gold nanoclusters (GSH-Au NCs). The merits of ultrasmall hydrodynamic size (2.8 nanometers) and high x-ray attenuation ability enable GSH-Au NCs with fast renal clearance and robust intrarenal CT contrast. In three mechanistically distinct mouse models of acute kidney injury, low-dose GSH-Au NCs produced mechanism-specific imaging signatures and distinct time-attenuation behaviors, even before biomarkers changed. Notably, at an ultralow dose (32.5 milligrams of Au per kilogram), early bilateral cisplatin injury can be easily detected with an obvious bright band at the outer medulla area on CT, consistent with tubular injury and a cast/debris-mediated mechanism. This work establishes a dose-efficient CT workflow for early, noninvasive, spatial mapping of renal dysfunction, supporting diagnosis, classification, and monitoring of kidney disease.
✓ 已验证
DOI
高影响因子
Materials Today Bio
·
2025
·
IF 10.2
Xiaohuan Guo,Bingbing Cai,Qi Fang,Yanyan Chen,Yuzhu Zhou,Zhixing Liang,Changchun Wen,Yan-Cheng Liu,Hong Liang
The high level of glutathione (GSH) in tumor cells can consume reactive oxygen species (ROS), seriously affecting the efficacy of chemodynamic therapy (CDT). Although it took a great deal of effort, developing a tumor-specific CDT that efficiently depletes GSH remains a formidable challenge. Herein, we propose a pH-responsive nanocatalyst containing the active molecule norcantharidin (NCTD) and Cu 2+ for dual GSH depletion, achieving efficient GSH depletion. Due to the weakly acidic tumor microenvironment (TME), the catalyst releases NCTD and Cu 2+ in a pH-responsive manner for the synergistic therapy of chemotherapy (CT) and CDT. Both components consume GSH and subsequently produce ROS, reducing the antioxidant capacity of cancer cells while increasing oxidative stress. This disrupts cellular redox homeostasis, leading to mitochondrial dysfunction and inducing tumor cell apoptosis. This work not only develops nanomaterials with dual GSH depletion capabilities for high-efficiency CDT but also achieves synergistic CT and CDT tumor therapy with the addition of NCTD, an active ingredient of traditional Chinese medicine.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOCONJUGATE CHEMISTRY
·
2026
·
IF 4.5
Shujie Li,Xingyu Gao,Shuo Li,Ruihan Liu,Xuejun Zhang,Xu Wang,Shao-Kai Sun,Guohe Wang
Accurate visualization of hepatic vasculature and tumor margins is critical for preoperative evaluation and intraoperative guidance in liver cancer. Here, we report a dual-contrast computed tomography (CT) strategy using a long-circulating hafnium oxide nanoprobe to enable concurrent visualization of hepatic vasculature and tumor boundaries. In an orthotopic hepatocellular carcinoma (HCC) mouse model, the nanoprobe provided sustained positive vascular contrast while simultaneously delineating tumor margins with negative contrast for over 120 min. Unlike conventional multiphase CT, this single-injection approach captures both vascular and tumor information in a single scan. This simple yet effective strategy offers new insights into the development of next-generation multifunctional diagnostic nanoprobes.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanoscale
·
2018
·Vol. 10
·期 8
·3631-3638
·
IF 7.233
Yu Liu,Xiaolin Lv,Heng Liu,Zijian Zhou,Jianpan Huang,Shenglan Lei,Shuhui Cai,Zhong Chen,Yanli Guo,Zhiwei Chen,Xi Zhou,Liming Nie
Stimuli-responsive nanoprobes that integrate multi-modal imaging capacities are highly desirable for precise tumor visualization. Herein, novel porous gold nanocluster-decorated manganese monoxide nanocomposites (MnO@Au NCs) were synthesized via a facile approach. The porous gold nanocluster layer was germinated on the surface of the as-prepared MnO@DMSA NPs through simple reduction of chloroauric acid in the presence of hydroxylamine hydrochloride. The MnO@Au NCs could be effectively internalized by tumor cells and slowly release Mn2+ ions within the acidic tumor microenvironment, improving the visualization of the tumor morphology. Benefitting from the porous architecture, the enhanced accessibility of Mn centers to proximal water molecules greatly augmented T1-weighted MRI contrast capacity. Compared with the conventional Mn-based contrast agents, the porous Au nanoclusters on MnO@Au NCs could delay the release of Mn2+ ions and thus effectively prolong the diagnostic time window. The broad near-infrared absorption of MnO@Au NCs features a high photoacoustic imaging depth than that of conventional gold nanospheres. Moreover, the Au nanoclusters exhibited desirable X-ray computed tomography contrast and rapid clearance from the living body. The as-prepared MnO@Au NCs hold great potential for accurate tumor imaging.
研究领域:
生物医学工程
·
纳米医学
·
影像医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Science of Advanced Materials
·
2021
·Vol. 13
·期 7
·1364-1373
·
IF 1.474
Zhang Yumei,Pei Ruina,Luo Tao
ABSTRACT
The development of nanomaterials, especially the development of multi-modality imaging nanoprobe technology has become a reality for tumor imaging diagnosis. In this study, the gadolinium ion chelating agent (2,2′,2′′-(10-(2-(2, 5-dioxopyrrolidin-1-oxyl)-2
oxoethyl)-1, 4, 7, 10-tetraazacyclododecane-1, 4, 7-tri)triacetic acid) (DOTA-NHS) and polyethylene glycol (PEG)-modified targeting ligand PEG-folic acid (FA) were grafted onto the PEG-modified fifth-generation polyamide-amine dendrimer (P5-NH2), which were undertaken as standards
to wrap gold nanoparticles. Then, remaining amino group was acetylated to acquire Gd–Au DENPS-FA nanoparticles. Biocompatibility and cytotoxicity of nanoparticles were analyzed while characterizing them. The cases with unidentified tumors (mass diameter >4.5 cm) of abdominal or pelvic
origin were selected and used for clinical study of computed tomography (CT)/magnetic resonance imaging (MRI) dual-modality abdominal tumors. In the test, average particle size of Gd-Au DENPs-FA nanoparticles was 4.2 nm, and they had good water solubility and stability in aqueous solution.
When concentration of Au+ nanoparticles increased, the cell morphology remained normal, only a small number of round cells appeared, and the cell activity remained above 80%. GD-Au DENPs-FA nanoparticles had a good targeting specificity for KB cells with high folate receptor expression.
During 6–24 hours of injection, the signal at the tumor site of the patient was enhanced markedly, namely the targeted gold nanoparticles were bound to the tumor tissue and the metabolic rate was slow. Based on this material, CT/MRI imaging could be performed in the patient’s body
and further used for the early diagnosis of abdominal tumors.
研究领域:
医学影像学
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纳米生物学
·
肿瘤学
✓ 已验证
DOI
高影响因子
MOLECULAR PHARMACEUTICS
·
2018
·
IF 4.556
Hui Liu,Yuxiang Han,Jiyuan Li,Ming Qin,Qunfeng Fu,Chunhong Wang,Zhibo Liu
Amino acids derivative are well established molecular probes for diagnosis of a variety of cancer using positron emission tomography (PET). Recently, boramino acid (BAAs) was found as a prospective molecular platform for developing PET tracer. The objective of this study was to develop a 18F-labeled alanine derivative through displacing its carboxylate by trifluoroborate as a selective ASCT2 marker for cancer imaging. 18F-Ala-BF3 was first evaluated in healthy FVB/N mice in vivo, exhibiting rapid renal clearance with almost negligible uptake in stomach (1.53 ± 0.31%ID/g). Notable uptake was observed in thyroid (3.71 ± 0.49%ID/g, 40 min post injection), of which the uptake was significantly inhibited by co-injection with natural L-alanine. In addition, we further established 18F-Ala-BF3 on a human gastric cancer cell (BGC-823) xenografts bearing mouse model. Dynamic PET-CT scan revealed the optimal time window for tumor imaging, it was between 40 and 60 min post injection, when the BGC-823 xenografts uptake was 5.49 ± 1.47%ID/g (n = 4), and the tumor-to-stomach, tumor-to-blood, tumor-to-muscle, and tumor-to-brain ratios were 3.27 ± 1.53, 3.80 ± 1.48, 3.47 ± 1.48, and 6.20 ± 1.47, respectively.
研究领域:
医学影像学
·
肿瘤学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Yanyan Cui,Jian Yang,Qunfang Zhou,Ping Liang,Yaling Wang,Xueyun Gao,Yongtian Wang
Albumin-stabilized Ag nanodots (ANDs) are prepared by a one-step biomineralization method. The highly crystallized nanodots have ultrasmall sizes (approximately 5.8 nm) and robust X-ray attenuation (5.7313 HU per mM Ag). The unlabeled ANDs are directly excreted from the body via the urine after in vivo X-ray computer tomography (CT) imaging application. ANDs could be used as CT imaging agents and effective photothermal therapy agents. Tumor growth inhibition reaches 90.2% after photothermal treatment with ANDs. ANDs are promising tools for in vivo CT imaging and clearable near-infrared-triggered theranostic agents.
研究领域:
医学影像学
·
纳米医学
·
生物材料学
✓ 已验证
DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2020
·
IF 3.83
Anzhe Wang,Ping Hu,Xinyuan Zhao,Zhizhi Wang,Cong Zhang,Yongzheng Wang
Although important, fracture strength in structural ceramics remains difficult to predict due to the inherent micropores, and there is a tremendous need for more precise modelling of pore-like flaw-strength relationship. In this study, classical crack problems were successfully transformed into pore-like flaw-strength models by adding a reasonable stress correction factor proposed by Gomez. Based on the accurate fracture toughness measurement and the precise laser introduction of flaws vs strength tests, the optimized Sato-Takahashi model, which is suitable for any cross-sectional shapes and sharpness flaws, was found to have fairly good prediction for fracture strength in five typical structural ceramics. The experimental error at very small-sized flaws was analyzed from the aspects of the critical flaw size and the inherent flaw size detected by nano-CT. Overall, the simple and user-friendly optimized Sato-Takahashi model could pave the way for quantitative assessments of reliability and failure causes for fine ceramics.
研究领域:
材料科学
·
工程力学
✓ 已验证
产品关联
DOI
高影响因子
BIOMATERIALS
·
2016
·
IF 8.387
Ang Li,Xiang Li,Xujiang Yu,Wei Li,Ruyi Zhao,Xiao An,Daxiang Cui,Xiaoyuan Chen,Wanwan Li
In this work, we report a successful synthesis of copper bismuth sulfide nanorods (NRs) with broad and strong photoabsorption ranging from ultraviolet (UV) to near-infrared (NIR) wavelengths, which can be used as a 1064 nm-laser-driven photothermal agent with the photothermal conversion efficiency of 40.7%, noticeably higher than most of the reported PTT agents working in NIR-II window. The as-prepared PEGylated Cu 3 BiS 3 NRs were used as photoacoustic imaging (PAI) and CT imaging agents due to their strong NIR absorption and large X-ray attenuation coefficient of bismuth. We are the first to demonstrate that a small quantity of PEGylated Cu 3 BiS 3 NRs in tumors can concentrate radiation energy and trigger mild PTT under NIR-II irradiation and thus, these particles could be used as a novel, synergistic thermoradiotheraputic agent that enhances the efficacy of radiotherapy .
研究领域:
生物医学工程
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NANOTECHNOLOGY
·
2018
·Vol. 30
·期 7
·075101
·
IF 3.404
Hongying Guo,Xiaoshuang Zhao,Hongmei Sun,Hongda Zhu,Honghao Sun
Development of a safe, efficient and inexpensive multifunctional nanoplatform using a facile approach for multimodal imaging and therapeutic functions becomes more and more practically relevant but challenging. In this work, we demonstrated a novel nanocomposites (Bi2S3-Gd) for computed tomography (CT)/magnetic resonance (MR) imaging-guided photothermal therapy (PTT) for cancer in vitro. It was achieved by modification of hydrophobic Bi2S3 with a smart amphiphilic gadolinium-chelated ligand. The as-prepared nanocomposites composed of low-cost Bi2S3 and gadolinium complexes, showed high stability, excellent biocompatibility and good photostability. It was observed that Bi2S3-Gd nanocomposites can efficiently convert the NIR light into heat, and then suppressed the growth of tumor cells under NIR laser irradiation. Apart from serving as an effective photothermal agent, the as-prepared nanomaterials could induce an efficient contrast enhancement for both CT and MR imaging at low concentrations of Bi and Gd, rendering more accurate diagnosis. This work suggests the potential of Bi2S3-Gd nanomaterials as a novel multifunctional nanoplatform for CT/MR imaging-guided PTT for cancer.
研究领域:
医学影像学
·
纳米医学
·
肿瘤学
✓ 已验证
DOI
高影响因子
Theranostics
·
2015
·
IF 8.022
Peiyu Qiu,Rongjin Sun,Guo Gao,Chunlei Zhang,Bin Chen,Naishun Yan,Ting Yin,Yanlei Liu,Jingjing Zhang,Yao Yang,Daxiang Cui
Rare-earth (RE)-doped upconversion nanocrystals (UCNCs) are deemed as the promising candidates of luminescent nanoprobe for biological imaging and labeling. A number of methods have been used for the fabrication of UCNCs, but their assembly into porous architectures with desired size, shape and crystallographic phase remains a long-term challenging task. Here we report a facile, anion-induced hydrothermal oriented-explosive method to simultaneously control size, shape and phase of porous UCNCs. Our results confirmed the anion-induced hydrothermal oriented-explosion porous structure, size and phase transition for the cubic/hexagonal phase of NaLuF 4 and NaGdF 4 nanocrystals with various sizes and shapes. This general method is very important not only for successfully preparing lanthanide doped porous UCNCs, but also for clarifying the formation process of porous UCNCs in the hydrothermal system. The synthesized UCNCs were used for in vitro and in vivo CT imaging, and could be acted as the potential CT contrast agents.
研究领域:
材料科学
·
生物医学工程
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）