JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2020
·Vol. 31
·期 24
·22375-22384
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IF 2.22
Wang Li,He Lin,Li Ji,Yu Yongsheng,Li Haibo
M-type strontium ferrite is a kind of magnetic functional material with wide application prospect. In this work, SrFe 12− x Al x O 19 (0 ≤ x ≤ 1) and Sr 1− y Ca y Fe 8 Al 4 O 19 (0 ≤ y ≤ 0.4) have been prepared by a hydrothermal method, and the effects of Al 3+ doping and Al 3+ and Ca 2+ co-doping on the magnetic properties have been investigated. X-ray diffraction analysis indicates all the samples are a hexagonal structure, and the shift of the diffraction peaks suggests that Al 3+ and Ca 2+ are successfully doped in SrFe 12 O 19 . Field emission scanning electron microscope images show the particles have the hexagonal shape with the size of 1.1–2.9 µm. Vibrating sample magnetometer reveals that the doping of Al 3+ and the co-doping Al 3+ and Ca 2+ can enhance magnetic properties of strontium ferrite. For example, the values of coercivity and the saturation magnetization of SrFe 8 Al 4 O 19 are 914.1 Oe and 44.0 emu/g, which are 3% and 117% enhancement compared with SrFe 12 O 19 , respectively. For Sr 1− y Ca y Fe 8 Al 4 O 19 , coercivity and saturation magnetization increase from 914.1 Oe and 41.8 emu/g to 1047.2 Oe and 50.2 emu/g when the Ca 2+ doping concentration increases from 0 to 0.4. Moreover, the effects of acid washing also on phase composition, morphology and magnetism are researched. The as-synthesized doping strontium ferrite will be useful for the applications in security switching and recording media.
研究领域:
材料科学
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磁学
✓ 已验证
产品关联
DOI
高影响因子
HYDROMETALLURGY
·
2019
·
IF 3.465
Shuainan Ni,Caibin Wu,Yanliang Wang,Xiangguang Guo,Zeyuan Zhao,Xiaoqi Sun
Softening ammonia sulfate wastewater is one of the vital issues in the rare earth industry. In this article, a novel softening process using [4,4′-isopropylidenebis (phenoxyacetate)] (H 2 IPOAA) for Ca 2+ and Mg 2+ (M 2+ ) is developed. The effect factors, i.e., equilibrium time, pH value of aqueous phase and saponification degree are investigated. The extraction mechanism is proposed to be cation exchange. With a saponification degree of 85%, H 2 IPOAA is successfully used for the precipitation of Ca 2+ and Mg 2+ from ammonia sulfate wastewater within 10 min. The process can form precipitated particles with an average size of 35 μm, which are much larger than the precipitates formed by H 2 C 2 O 4 , Na 2 C 2 O 4 and Na 2 CO 3 . The precipitated particles can be easily separated from the raffinate. In addition, H 2 IPOAA is repeatedly used for five times with a little loss. To a considerable extent, the reuse of H 2 IPOAA contributes to lowering the cost and reducing the pollution. The concentrations of Ca 2+ and Mg 2+ in the raffinate extracted by H 2 IPOAA are up to the MVR standard for wastewater treatment . The economical and efficient softening process meets the need of green chemistry, which is expected to replace traditional industrial processes for water softening based on H 2 C 2 O 4 , Na 2 C 2 O 4 and Na 2 CO 3 .
研究领域:
环境科学
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化学工程
✓ 已验证
产品关联
DOI
高影响因子
LUMINESCENCE
·
2019
·Vol. 34
·期 7
·707-714
·
IF 1.691
Li Wang,Yuanjun Yao,Jiao Wang,Chuan Dong,Hui Han
Spiropyran (SP) and its derivatives operate between their ring opening and closing forms as a versatile molecular platform for the fluorescence detection of cations and anions, using a colour change for signalling. A functionalized SP fluorescence probe, L , was prepared and characterized. Probe L can detect Ca 2+ with a fluorescence ‘turn-on’ response in ethanol solution. It selectively binds Ca 2+ to form a 1:1 ligand/metal complex, which produced a new emission band centred at 604 nm. The sensing result was clearly observed by the solution colour change from colourless to pink under visible light, and from blue to red under ultraviolet light. The detection limit was calculated to be 4.53 × 10 −8 M for Ca 2+ . The probe provides another possibility that SP-based derivatives could be used for the development and detection of metal ions in environmental and physiological systems.
研究领域:
分析化学
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生物化学
✓ 已验证
DOI
PubMed
高影响因子
FITOTERAPIA
·
2025
·
IF 2.6
Xuan Zhang,Jie Weng,Yi Luo,Hongcun Liu,Jing Yan,Zhiqiang Gong,Chaonan Kong,Xue Li,Lifang Yang,Mingguo Jiang
To elucidate the efficacy and potential molecular mechanisms underlying the therapeutic effects of Spatholobi Caulis flavonoids (SCF) in the treatment of primary dysmenorrhea (PD). The present study established oxytocin-induced uterine contractions in vitro and a model of PD in rats evoked by estradiol benzoate and oxytocin. The uterine contraction experiments demonstrated that SCF significantly inhibited uterine smooth muscle tone by 62.07 %. SCF effectively attenuated the torsional response in PD rats, normalised the PGF2α/PGE2 ratio, and reduced NO and Ca 2+ levels. The constituents of SCF were evaluated by using a Liquid Chromatograph Mass Spectrometer(LC-MS) method, and 11 flavonoid components were preliminarily deduced. Network pharmacology and molecular docking (MD) techniques were used to predict therapeutic targets, with the former suggesting key targets such as RhoA, VEGFA, and PIK3CA, while the latter indicated that 10 compounds had a strong binding affinity for RhoA. The expression of CALM, RhoA, ROCK1, PIK3CA, and AKT was down-regulated at both the protein and mRNA levels. Additionally, the expression levels of genes associated with VEGFA, IP3R, MLCK and NOS3 were found to be regulated. The collective evidence from this study suggests that SCF may attenuate uterine spasm by inhibiting the RhoA/ROCK signaling pathway, decreasing the levels of PGF2α, NO and Ca 2+ , and increasing the content of PGE2. This study provides a theoretical basis for the application of SCF in the treatment of PD.
研究领域:
药理学
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分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ORGANIC & BIOMOLECULAR CHEMISTRY
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2012
·Vol. 11
·期 3
·503-508
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IF 3.696
Qiaoling Liu,Wei Bian,Heping Shi,Li Fan,Shaomin Shuang,Chuan Dong,Martin M. F. Choi
A ratiometric fluorescent probe for Ca2+ based on 1,3,4-oxadiazole derivative has been designed and developed. The probe exhibits a large Stokes shift of 202 nm and a highly selective ratiometric emission response (490/582 nm) to Ca2+ over other metal cations. Additionally, the probe can readily reveal the changes of intracellular Ca2+ concentration in living human umbilical vein endothelial cells.
研究领域:
分析化学
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细胞生物学
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荧光探针
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生物成像
✓ 已验证
DOI
高影响因子
Theranostics
·
2025
·Vol. 15
·期 17
·8873
·
IF 13.3
Ningning Wang,Weizhen Li,Tuo Yang,Baolong Li,Chuikai Meng,Xiongyao Zhou,Jialu Sun,Kaiming Yu,Shusen Cui,Rangjuan Cao
Background: Ion homeostasis is disrupted following nerve injury, and elevated Ca 2+ levels have been reported to induce Schwann cell (SC) death. Notably, clinical interventions such as electrical stimulation enhance Ca 2+ influx and facilitate nerve regeneration. These findings highlight the need to clarify the precise role of Ca 2+ signaling in nerve regeneration. Methods: We assessed extracellular Ca 2+ concentrations in both human and murine peripheral nerve tissues after injury. Transcriptomic profiling identified CB1R as a key Ca 2+ -related gene and in vitro validation was performed with primary cultured SC and nerve explants. A sciatic nerve crush model was established in SC-specific CB1R knockout mice. Mitophagy, cellular metabolic homeostasis, and axonal regeneration were systematically assessed using proteomics, calcium imaging, and in vivo analyses. Additionally, the CB1R antagonist JD5037 was administered in both sciatic and optic nerve injury models to evaluate its translational potential. Results: Peripheral nerve injury (PNI) leads to elevated extracellular Ca 2+ levels at the injury site, where a moderate increase (~1.5-fold) favors SC survival. PNI also induces upregulation of CB1R, genetic ablation of CB1R enhances Ca 2+ influx, promotes SC survival, and maintains metabolic homeostasis. Mechanistically, CB1R interference upregulates adenine nucleotide translocase 2 (ANT2) expression, promotes mitochondrial permeability transition pore (mPTP) opening and mitochondrial membrane depolarization, thereby activating PINK1/Parkin-mediated mitophagy. This process improves mitochondrial quality and enhances energy metabolic efficiency, ultimately promoting axonal regeneration and functional recovery. Furthermore, systemic administration of the CB1R antagonist JD5037 similarly enhances regeneration of both peripheral and optic nerves in vivo . Conclusion: Moderate extracellular Ca 2+ elevation establishes a pro-regenerative microenvironment after nerve injury. Targeting CB1R facilitates Ca 2+ influx, enhances mitophagy via the PINK1/Parkin pathway, and promotes nerve regeneration. These findings identify CB1R as a viable therapeutic target and support the translational potential of JD5037 for nerve injury treatment.
研究领域:
神经科学
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分子生物学
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再生医学
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细胞信号转导
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线粒体生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CRYSTAL GROWTH & DESIGN
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2020
·
IF 4.089
Hong He,Li Chen,Zhijun Wang,Lingjun Zhang,Tingting Ge,Xiao Xiang,Shuxia Wang,Yingzhou Huang,Shunbo Li
The effects of organic and inorganic additives on crystal morphology have been extensively studied in various materials. However, the basic fundamentals behind the morphology control are still under debate due to the differences in experimental observations and lack of technical means to control the microenvironments where the crystal grows. Microfluidic technology with convenient operation and precise control of related parameters provides a unique tool for the investigation of crystallization processes on the micrometer and even nanometer scale. A concentration-gradient microfluidic chip was designed to screen the ion compositions to investigate the factors influencing the crystal morphology, and calcium carbonate was chosen for this study. Unexpectedly, the CO32–:Ca2+ ratio is discovered to induce a calcite morphology transition from regular rhombohedral to irregular rhombohedral and nanoparticle aggregations. In contrast, the morphology transition is believed to be caused by variations of the Mg:Ca ratio and supersaturation. The incorporation of different mole ratios of magnesium ions is also found to give different morphologies. The experimentally observed crystal morphology transition indicates that the crystal morphology is influenced by the CO32–:Ca2+ ratio when magnesium ions are present in the system. The proposed microfluidic method, providing an exquisite control of microenvironments during crystallization, can be applied in other materials to analyze the origin of unique morphologies. In addition, the discovery extends our understanding of the morphology control of biominerals.
研究领域:
材料科学
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化学
✓ 已验证
产品关联
DOI
高影响因子
Catalysts
·
2018
·Vol. 8
·期 9
·351
·
IF 3.465
Bolin Wang,Huixia Lai,Yuxue Yue,Gangfeng Sheng,Yaqin Deng,Haihua He,Lingling Guo,Jia Zhao,Xiaonian Li
An efficient and stable heterogeneous Zeolite Supported Ionic Liquid Catalyst (IL/CaX) has been explored in acetylene hydrochlorination reaction. The IL/CaX catalyst exhibits excellent space time yields of vinyl chloride (VCM), when compared to the benchmark of Au/C systems. Through characterization and kinetic studies, the reaction follows a two-site mechanism, which is described as the adsorbed hydrogen chloride on the Ca2+in zeolite, reacting with the adsorbed acetylene on the cation of ionic liquid to form vinyl chloride. The catalytic reaction takes place at the IL/CaX interface, whilst the upper interphase IL/CaX is not active. The deactivation of the catalyst is caused by the dissolving byproducts in the ionic liquid layer, which can be reactivated by a simple vacuum procedure. It is of great significance to study and develop green non-mercury catalysts, in acetylene hydrochlorination.Keywords:zeolite supported ionic liquid catalyst;IL/CaX;Ca2+;acetylene hydrochlorination
研究领域:
催化
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化学工程
·
环境化学
✓ 已验证
DOI
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2020
·
IF 4.872
Xiaoyong Huang,Xiaole Zhao,Kui Zhu,Shuangyang Ding,Bing Shao
The environmental effects of additives have attracted increasing attention. Sodium dehydroacetate (DHA-S), as an approved preservative, is widely added in processed foods, cosmetics and personal care products. However, DHA-S has been recently reported to induce hemorrhage and coagulation aberration in rats. Yet little is known about the ecotoxicological effect and underlying mechanisms of DHA-S. Here, we utilized the advantage of zebrafish model to evaluate such effects. DHA-S induced cerebral hemorrhage, mandibular dysplasia and pericardial edema in zebrafish after 24 h exposure (48–72 hpf) at 50 mg/L. We also observed the defective heart looping and apoptosis in DHA-S-treated zebrafish through o-dianisidine and acridine orange staining. Meanwhile, DHA-S induced the deficiency of Ca 2+ and vitamin D3 in zebrafish. We further demonstrated that DHA-S stimulated Ca 2+ influx resulting in Ca 2+ -dependent mitochondrial damage in cardiomyocytes. Additionally, DHA-S inhibited glucose uptake and repressed the biosynthesis of amino acids. Finally, we identified that sodium bicarbonate could rescue zebrafish from DHA-S induced cardiovascular toxicity. Altogether, our results suggest that DHA-S is a potential risk for cardiovascular system.
研究领域:
毒理学
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环境科学
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药理学
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发育生物学
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Ying Wang,Wanying Xiong,Yiyan Xu,Nan Yang,Huige Zheng,Qian Zhao,Xiaojing Liang,Huishuang Yin,Yunyan Zhang,Wenhu Zhou,Liangsheng Fan
Acid-responsive aPD-L1@CaP/A23187 enhances PD-L1 checkpoint blockade. • CaP nanoparticles encapsulate aPD-L1 and release it selectively in acidic TME. • Ca²⁺ from CaP synergizes with A23187 to boost Ca²⁺ influx and immune signaling. • The formulation elevates intracellular Ca²⁺, promotes DC maturation, and M1 polarization. • In vivo, it increases tumor accumulation, inhibits growth, reverses TME, and induces immune memory. Immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis have revolutionized cancer therapy, but their efficacy is restricted by the highly immunosuppressive tumor microenvironment and is often accompanied by systemic toxicities.To overcome these limitations, we developed a novel acid-responsive nanoplatform, aPD-L1@CaP/A23187, integrating anti–PD-L1 antibodies (aPD-L1) with calcium phosphate (CaP) nanoparticles and the Ca 2+ ionophore A23187. CaP nanoparticles encapsulated aPD-L1 with high efficiency and stability, enabling tumor-specific release under acidic conditions while minimizing systemic distribution. Simultaneously, Ca 2+ released from CaP synergized with A23187 to promote transmembrane Ca 2+ influx, thereby activating downstream Ca 2+ signaling pathways in immune cells. In vitro, this formulation increased intracellular Ca 2+ levels, induced dendritic cell maturation, and polarized macrophages toward the pro-inflammatory M1 phenotype. In vivo, aPD-L1@CaP/A23187 achieved ∼7.4-fold higher tumor enrichment than free antibody, exhibited potent tumor suppression in TC-1 tumor–bearing mice. Mechanistic studies revealed enhanced dendritic cell activation, robust CD8 + T cell infiltration and granzyme B secretion, reduced Treg proportions, and M1 macrophage polarization, collectively reversing the immunosuppressive tumor microenvironment. Importantly, treatment also induced durable effector memory T cell responses in a distant tumor model, providing protection against tumor recurrence and metastasis. These findings highlight the Ca 2+ -assisted nanoplatform offers a broadly applicable strategy for next-generation cancer immunotherapy.
✓ 已验证
DOI
高影响因子
APPLIED THERMAL ENGINEERING
·
2024
·
IF 6.1
Qing-Kai Zhu,Hong-Bei He,Chao-Chen Cai,Ting-Ting Li,Ching-Wen Lou,Jia-Horng Lin,Hai-Tao Ren
Evaporative cooling and radiative cooling are considered to be energy-saving and environmentally friendly cooling technologies. However, the evaporative cooling system requires complex external water supply equipment, and the radiative cooling is susceptible to weather, which hinder the practical application. Herein, TiO 2 was used as the photo-initiator and spectral regulator, and a hydrogel integrating radiative cooling and evaporative cooling was prepared by combining photopolymerization with semi-acidification sol–gel transition method. The obtained hydrogel shows good mechanical strength (elongation at break > 600 %, and fracture stress > 200 kPa), high visible reflectance (>80.0 %) and emissivity in atmospheric window band (>90.0 %). At the same time, due to the introduction of hygroscopic agent CaCl 2 , it can replenish water itself at night. In outdoor experiment, the hydrogel showed a cooling effect of up to 12.5 °C, showing a significant potential for reducing energy consumption in cooling applications. In addition, the synthesis process of hydrogel is green, which aligns with environmental safety and sustainability goals. This study provides a new strategy for developing efficient, environmentally friendly, and low-cost passive coolers to reduce the global energy burden.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2021
·
IF 5.302
Mingxin Liu,Jie Li,Ying Tang,Junqi Chen,Laiyuan Ao,Alin Cao,Liang Fang
The τ f of Y 3 Ga 5 O 12 ceramics was adjusted by Ca 2+ /Ti 4+ co-doping for Y 3+ at A-site and Ga 3+ at C-site to form Ca x Y 3- x Ti x Ga 5- x O 12 (0 ≤ x ≤ 2.0) ceramics by the solid-state reaction. When 0 ≤ x ≤ 1.7, all the samples remained as single garnet-structured with Ia- 3 d space group. The ε r increased from 10.4 ± 0.1 to 15.9 ± 0.1, and τ f optimized from −54.7 ± 1.0 to −8.3 ± 1.0 ppm/℃, attributing to the increase in polarizability per volume and “rattling” effect. Meanwhile, the Q × f slightly decreased from 98,200 ± 500 GHz to 65,300 ± 500 GHz due to the decrease in packing fraction. As x increased to 2.0, the properties dramatically deteriorated owing to the second phase CaTiO 3 . Optimal properties were obtained at x = 1.7, with ε r = 15.9 ± 0.1, Q × f = 65,300 ± 500 GHz and τ f = −8.3 ± 1.0 ppm/℃.
研究领域:
材料科学
·
电子材料
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）