Journal of Environmental Chemical Engineering
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2025
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IF 7.2
Panpan Wang,Meiyu Shi,Yuan Shu,Qiang Niu,Pengfei Zhang
Daily discarded egg residues such as eggshells reach an astronomical figure around the world, causing severe environmental pollution and waste of Ca-based sources. CaCO 3 , especially these porous CaCO 3 nanoparticles, could role as an effective plastic stuffing, filler, ink filler, and adsorbent, having a great prospect for industrial application. Herein, based on a solid-state reaction between strong and weak acids, we successfully prepared a porous CaCO 3 -es with the BET specific surface area (SSA) up to 97.4 m 2 /g, and meanwhile with abundant mesopores and tiny small CaCO 3 primary nanoparticles about 7.4 nm. Notably, the prepared CaCO 3 -es showed significantly improved CO 2 adsorption capacity than the contrast CaCO 3 samples in both static and breakthrough tests. According to the characterization such as FTIR, Raman, XPS, TEM, and DFT calculations, the high CO 2 adsorption of CaCO 3 -es originated from its high porous structure, small nanoparticle size, and rich defective sites.
研究领域:
材料科学
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环境科学
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化学工程
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DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
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IF 5.4
Xue Chen,Jiemei Bi,Haoyang Zhang,Mengtong Yuan,Jianjiao Wang,Narisu Hu
Periodontitis is a chronic inflammatory disease caused by dental plaque biofilm. To prevent disease progression and achieve successful periodontal tissue repair, it is necessary to simultaneously address the need for antibacterial, anti-inflammatory, and osteogenic effects within deep lesions. This study proposes a novel approach using a NIR light-responsive nanocomposite for enhanced ossification and combating bacterial biofilm infections in periodontitis. The nanocomposite incorporates polydopamine-coated calcium carbonate nanoparticles and BMP-2, which exhibits excellent photothermal conversion efficiency for bacterial eradication. Additionally, polydopamine also serves as an efficient ROS scavenger, thereby reducing the inflammatory response associated with periodontal disease. The core CaCO 3 interacts with BMP-2 to promote bone regeneration. This strategy demonstrates a synergistic effect by integrating PTT, ROS therapy, and osteogenic therapy in treating biofilm-induced periodontitis. Moreover, the CaCO 3 @BMP-2/PDA NPs reduced the protein expression levels of pro-inflammatory cytokines TNF-α and IL-1β and mitigated LPS-induced inflammation. This combination not only achieved critical protective effects but also fostered the promotion of osteoblast differentiation.
研究领域:
生物医学工程
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口腔医学
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材料科学
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DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
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2019
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IF 3.973
Li Li,Yang Yang,Yirui Lv,Ping Yin,Ting Lei
Porous CaCO 3 microspheres are nowadays extensively used as a drug delivery system due to their excellent biocompatibility and degradability. However, the stability of vaterite CaCO 3 microspheres is a major problem as a drug carrier. In this work, porous calcite CaCO 3 microspheres are fabricated by calcination of gelatin-CaCO 3 composite microspheres at 550 °C in air. The size and morphology of CaCO 3 microspheres could be well regulated by the addition of gelatin. The structure of the as-prepared porous calcite CaCO 3 microspheres is characterized by scanning electron microscope (SEM), transmission electron microscope (TEM), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR). Compared with vaterite CaCO 3 microspheres, porous calcite CaCO 3 microspheres are more stable and exhibit good drug-loading and drug release properties for doxorubicin (DOX), an effective anticancer agent. This study provides an easy and novel approach to prepare stable porous calcite CaCO 3 microspheres, which show promising potential as a carrier for DOX.
研究领域:
材料科学
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药学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
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IF 8.025
Xiaochun Ma,Zhaodong Zhu,Haichuan Zhang,Shenglong Tian,Xiaohong Li,Huiming Fan,Shiyu Fu
Deacidification and surface self-cleaning are of great significance for the long-term preservation of historic literature. Herein, a superhydrophobic self-cleaning coating, derived from nanocellulose coated with CaCO 3 particles is constructed via chemical vapor deposition (CVD) for the first time for the preservation of historic paper. The static contact angle of superhydrophobic paper reached more than 150° and the minimum sliding angle was 6.4°. Deacidification effect was achieved with a desired pH value in the range from 7.50 to 7.77 and the maximum alkali storage was up to 1.235 mol/kg. It is found that the low-cost CaCO 3 nanoparticles can not only remove the acid substances, but also gave the paper function of self-cleaning, which is very great significant for the protection of paper-based relics.
研究领域:
材料科学
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文物保护科学
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化学工程
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产品关联
DOI
PubMed
高影响因子
Materials Today Chemistry
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2022
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IF 7.613
Zongqi Feng,Tingyu Yang,Shichao Dong,Ting Wu,Wen Jin,Zhouying Wu,Bingping Wang,Tiantian Liang,Lei Cao,Lan Yu
Calcium carbonate (CaCO 3 ) has been widely studied as a drug delivery system (DDS), but it still has some limitations in its clinical application in tumor chemotherapy, such as difficult industrialization, complex synthesis methods, time-consuming and labor-intensive, and low drug loading. Here, we developed an industrialized method for the simple, rapid and controllable synthesis of high drug-loaded vaterite hollow CaCO 3 (VHC). The VHC was successfully prepared by adding L-Leucine (Leu) in the process of preparing CaCO 3 in an industrial method. The effects of different reaction conditions on VHC were studied in detail, and a possible formation mechanism of VHC was proposed. As an industrially synthesized DDS, the VHC had low cytotoxicity and good biocompatibility, and had higher loading capacity (39.68%) and encapsulation efficiency (90.17%) for doxorubicin hydrochloride (DOX) due to the existence of hollow nano-cavity. Meanwhile, DOX@VHC showed good pH responsiveness, which can achieve sustained release of DOX. And, DOX@VHC could significantly inhibit tumor cells (cell inhibitory rate: 91.73%) and reduce the toxicity to normal cells. The high drug-loaded VHC synthesized rapidly by industrial methods can achieve controllable drug delivery and high-efficiency inhibition of tumor cells, and has a good application prospect in tumor therapy.
研究领域:
药学
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材料科学
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生物医学工程
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肿瘤学
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产品关联
DOI
高影响因子
BIOMATERIALS
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2022
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IF 15.304
Mengqing Xu,Jin Zhang,Yongli Mu,Mohamed Frahat Foda,Heyou Han
Capsaicin is a natural non-toxic small molecular organic substance, which is often used clinically to reduce inflammation and pain. Here, we report an acid-responsive CaCO 3 nanoparticle loaded with capsaicin that can specifically activate TRPV1 channels and trigger tumor calcium ion therapy. The excellent acid responsiveness of calcium carbonate enables it to precisely target the tumor sites. The released capsaicin can specifically activate TRPV1 channel, overloading the intracellular calcium ion concentration and causing cell apoptosis, which provides a new safer and cheaper treatment. We proved that the naturalness and non-toxicity of capsaicin make the CaCO 3 @CAP nanoparticles have excellent biocompatibility, which has good development prospects and clinical application potential.
研究领域:
药理学
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肿瘤学
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纳米医学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
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2022
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IF 10.383
Yuqi Ma,Anhe Wang,Jieling Li,Qi Li,Qingquan Han,Yafeng Jing,Xuefang Zheng,Hongyu Cao,Xuehai Yan,Shuo Bai
The self-assembling behavior of peptides and derivatives is crucial in the natural process to construct various architectures and achieve specific functions. However, the surface or interfacial self-assembly, in particular, on the surface of micro- or nanoparticles is even less systematically investigated. Here, uniform porous CaCO3 microparticles were prepared with different charged, hydrophobic and hydrophilic surfaces to assess the self-assembling behavior of dipeptides composed of various sequences. Experimental results indicate that dipeptides with a negative charge in an aqueous solution preferred to self-assemble on the hydrophobic and positively charged surface of CaCO3 particles, which can be ascribed to the electrostatic and hydrophobic interaction between dipeptides and CaCO3 particles. Meanwhile, the Log p (lipid–water partition coefficient) of dipeptides has a significant effect on the self-assembling behavior of dipeptides on the surface of porous CaCO3; dipeptides with high Log p preferred to self-assemble on the surface of CaCO3 particles, resulting in the improved cell internalization efficiency of particles with low cytotoxicity. After loading with a model drug (doxorubicin), the particles show obvious antitumor activity in animal experiments and can reduce Dox side effects effectively.
研究领域:
生物材料学
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细胞生物学
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药理学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
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IF 9.4
Zihan Xing,Linwei Li,Tao Liao,Jinyu Wang,Yuhao Guo,Ziqiang Xu,Wenqian Yu,Ying Kuang,Cao Li
Starvation therapy has shown promise as a cancer treatment, but its efficacy is often limited when used alone. In this work, a multifunctional nanoscale cascade enzyme system, named CaCO 3 @MnO 2 -NH 2 @GOx@PVP (CMGP), was fabricated for enhanced starvation/chemodynamic combination cancer therapy. CMGP is composed of CaCO 3 nanoparticles wrapped in a MnO 2 shell, with glucose oxidase (GOx) adsorbed and modified with polyvinylpyrrolidone (PVP). MnO 2 decomposes H 2 O 2 in cancer cells into O 2 , which enhances the efficiency of GOx-mediated starvation therapy. CaCO 3 can be decomposed in the acidic cancer cell environment, causing Ca 2+ overload in cancer cells and inhibiting mitochondrial metabolism. This synergizes with GOx to achieve more efficient starvation therapy. Additionally, the H 2 O 2 and gluconic acid produced during glucose consumption by GOx are utilized by MnO 2 with catalase-like activity to enhance O 2 production and Mn 2+ release. This process accelerates glucose consumption, reactive oxygen species (ROS) generation, and CaCO 3 decomposition, promoting the Ca 2+ release. CMGP can alleviate tumor hypoxia by cycling the enzymatic cascade reaction, which increases enzyme activity and combines with Ca 2+ overload to achieve enhanced combined starvation/chemodynamic therapy. In vitro and in vivo studies demonstrate that CMGP has effective anticancer abilities and good biosafety. It represents a new strategy with great potential for combined cancer therapy.
研究领域:
肿瘤学
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生物医学工程
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纳米医学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Bio Materials
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2021
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IF 0
Pengzhong Shi,Daozhen Zhou,Yaxin Zhu,Bo Peng,Nannan Shao,Xingjie Zan
Fast hemostasis, biosecurity, and adaptation of different bleeding sites are the major challenges for hemostatic materials. In this work, an easy-to-make, rapid hemostatic, tannic acid doped calcium carbonate microsphere with a low concentration of thrombin (Thr@TA-CaCO3) was developed. In an in vitro blood clotting assay, the hemostatic effect of Thr@TA-CaCO3 varied with the change of thrombin amount. Furthermore, the average hemostatic time can be reduced from 205 to 20 s as the thrombin levels are elevated. When applied in different hemorrhage models, the Thr@TA-CaCO3-treated group had a lower blood loss than the tannic acid modified CaCO3 (TA-CaCO3) groups. Especially in the rabbit artery injury model, the total bleeding amount in the Thr@TA-CaCO3-treated group was only 11.97% of that in the TA-CaCO3 groups, proving that Thr@TA-CaCO3 had an excellent hemostatic effect even in the case of rapidly flowing blood. Based on the above, Thr@TA-CaCO3 is a promising hemostatic agent and can be applied in more extensive clinical applications.
研究领域:
生物医学工程
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材料科学
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血液学
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DOI
SEPARATION AND PURIFICATION TECHNOLOGY
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2026
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IF 9
Haiying Xiao,Mingdong Li,Ying Qin,Zhangfa TONG,Lishuo Li
A sustainable and integrated strategy is developed for the synthesis of nitrogen-doped porous carbons (HNPCs) using organically modified CaCO₃ nanofluids as multifunctional precursors, and their CO₂ separation performance is systematically evaluated. Cubic and spherical CaCO 3 nanofluids were prepared using M2070 and KH560 as organic modifiers to form an organic crown-like structure, followed by programmed pyrolysis at 800 °C to obtain HNPCs. The obtained HNPCs exhibit well-developed porous structures with a high BET surface area of 777.3 m 2 ·g −1 , a micropore volume of 0.0928 cm 3 ·g −1 , and a nitrogen content of 2.79 wt% (elemental analysis). XPS analysis reveals that pyrrolic N (48.98%) and pyridinic N (26.47%) are the dominant nitrogen species, contributing to enhanced CO₂ adsorption affinity. The spherical CaCO₃-derived sample (SNPC(II)) shows superior CO₂ uptake capacities of 2.85 mmol·g −1 at 25 °C and 3.98 mmol·g −1 at 0 °C under 1 bar. The isosteric heat of adsorption ranges from 17.3 to 36.5 kJ·mol −1 , indicating a physisorption-dominated and energy-efficient process. Ideal Adsorbed Solution Theory predicts a CO 2 /N 2 selectivity of 34.19 at 298 K and 1 bar. Fixed-bed breakthrough experiments using simulated flue gas (15 vol% CO₂/85 vol% N₂) demonstrate a CO₂ breakthrough time of 4631 s·g −1 , markedly longer than that of N₂ (342 s·g −1 ). Moreover, SNPC(II) retains 98.7% of its initial CO₂ capacity after eight adsorption–desorption cycles, highlighting excellent cyclic stability.
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产品关联
DOI
高影响因子
FOOD HYDROCOLLOIDS
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2022
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IF 11.504
Hao Zhang,Tuo Zhang,Jiachen Zang,Chenyan Lv,Guanghua Zhao
CO 2 is a greenhouse gas and a major contributor to global warming . Efficient conversion of CO 2 into high value-added food materials represents a promising strategy to decrease CO 2 concentration. In this study, we reported that Ca 2+ -crosslinked alginate beads loaded with carbonic anhydrase (CA) can efficiently catalyze conversion of CO 2 into porous vaterite CaCO 3 particles via a carboxymethyl cellulose (CMC) inducing process. CA encapsulated within the Ca 2+ -crosslinked alginate beads maintained around 100% activity of its original activity after 10 assay cycles. Functionally, the CA-loaded alginate beads facilitated conversion of CO 2 into porous vaterite CaCO 3 particles with high CO 2 removal efficiency in the presence of carboxymethyl cellulose. Notably, such vaterite CaCO 3 particles can be explored for adsorption of astaxanthin with higher loading capacity (2.0 wt %), consequently improving the photo- and thermal-stability of this pigment.
研究领域:
环境科学
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生物化学
✓ 已验证
DOI
高影响因子
CHINESE JOURNAL OF CHEMICAL ENGINEERING
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2026
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IF 3.5
Hao Ding,Zhongjie Shen,Rubin Zeng,Haifeng Liu
The structural evolution and mass transport of calcium carbonate (CaCO 3 ) particles during high-temperature decarbonization are critical for thermochemical energy storage. Experimental characterization and molecular dynamics (MD) simulations were employed to investigate the decomposition mechanisms and morphological transformations of CaCO 3 . The results indicated that a temperature of 1000 °C represents a critical threshold for accelerated decomposition. Scanning electron microscopy (SEM) revealed the development of pores and carbon-depletion zones, while sintering-induced pore closure was observed at 1200 °C. The introduction of pulse residence time promoted particle cracking and enhanced the decomposition kinetics. MD simulations further demonstrated that CaO shell thickness controls CO 2 release: a 4 Å shell partially inhibited desorption, whereas a 6 Å shell completely blocked gas escape. The diffusion coefficient of calcium atoms in dual-particle systems increased by 3.6 times at 1473 K. Correspondingly, the diffusion activation energy decreased to 42.8 kJ·mol –1 in dual-particle systems, which facilitated the rapid formation of sintering necks. The combined effects of temperature, pulse duration, and shell confinement were consistently demonstrated, establishing a mechanistic framework for optimizing decarbonization and material synthesis.
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DOI
高影响因子
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