DESALINATION
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2024
·
IF 8.3
Jinsong He,Wenjie Liu,Fan Ni,Dong Tian,Yongjia Lei,Jianmei Zou,Yanzong Zhang,Fei Shen,Xiaochan An
Sacrificed template strategy has become a promising pathway to construct high performance loose nanofiltration (LNF) membranes for dye-containing wastewater treatment. However, few studies have been conducted on the recycling of templates in the LNF membrane preparation. In this study, lignin nanoparticles (LNPs) with abundant biomass sources, low cost, renewable ability, were attempted to be used as a recycled sacrificed template for the first time. The LNPs were easily renewed by concentration and NaOH dialysis with smaller nano-size and more hydrophilic surface. The optimized P-LNF-50 membrane prepared by pristine LNPs templates exhibited high water permeability of 146.24 LMH·bar −1 , excellent separation of dye/salt (i.e. rejection: 97.79 % for CR, 0.48 % for Na 2 SO 4 , 0.25 % for NaCl), and superior long-term stability. Interestingly, the R1-LNF-70 membrane prepared by 1 st recycled LNPs templates can still maintain high water permeability of 132.97 LMH·bar −1 and excellent separation of dye/salt (i.e. rejection rate: 98.31 % for CR, and 1.27 % for Na 2 SO 4 ). While the 2 nd recycled LNPs can not produce satisfied LNF membranes due to its poor figuration and easy aggregation. The inherent relationships between LNPs templates and selective layers were deeply explored. Importantly, the Sankey chart of recycling LNPs template technique and cost analysis indicated that the LNPs could be used as green templates for two cycles with comparable permeability and selectivity of dye/salts. Overall, our study paves the way for recycling of sacrificed templates for the scalable fabrication of high performance LNF membranes.
研究领域:
环境科学
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材料科学
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化学工程
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产品关联
DOI
高影响因子
Journal of Inflammation Research
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2024
·
IF 4.2
Yang Yang,Yuanji Zhao,Huan Lei,Xiaohong Tan
Purpose When consumed in appropriate quantities, probiotics, which are live microorganisms, are good for health. In this study, a mouse model of antibiotic-induced dyskinesia was established using a sterile mixed antibiotic solution to investigate the preventive impact of Limosilactobacillus fermentum ZS09 (LFZS09) on this condition in mice.Methods Following modeling, alterations in the serum and brain tissue of mice were assessed for motor measures such as running and swimming, malondialdehyde (MDA), superoxide dismutase, reduced glutathione, interleukin (IL-6, IL-10), and tumor necrosis factor (TNF)-α. The mouse cecum was used to evaluate the relative mRNA expression levels of the intestinal barrier genes, namely occludin-1, zona occludens-1 (ZO-1), and claudin-1. The relative mRNA expression levels of cAMP-response element binding protein (CREB), extracellular signal-regulated kinase (ERK), and brain-derived neurotrophic factor (BDNF) genes in the mouse brain tissue were also evaluated.Results Compared with the model group, LFZS09 considerably increased the swimming and running duration of mice, significantly decreased the levels of the inflammatory factors TNF-α and IL-6 and increased SOD expression in the mouse brain, and decreased MDA accumulation in the mouse brain and serum. Furthermore, LFZS09 upregulated occludin-1 gene expression in the cecal tissue to maintain the intestinal barrier, which in turn maintained the normal physiological function of the body. LFZS09 also enhanced the effect of BDNF and increased the expression of BDNF metabolic pathway-related genes, namely CREB, ERK1/2, and BDNF, in the mouse brain tissue. LFZS09 increased the number of Lactobacillus and Bifidobacterium in the gut of mice with motor dysregulation, and decreased the number of Enterococcus and Clostridium perfringens.Conclusion The findings indicate that LFZS09 regulates antibiotic-induced motor impairment in mice, thereby offering a theoretical foundation for future studies and probiotic or parabiotics production aimed at augmenting motor function.
研究领域:
微生物学
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神经科学
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药理学
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分子生物学
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产品关联
DOI
PubMed
高影响因子
ACS Biomaterials Science & Engineering
·
2024
·
IF 5.4
Yuying Hu,Xiangjian Liu,Wenqian Zhang,Jiangming Chen,Xiaoxiao Chen,Songwen Tan
In transfusion medicine, the cryopreservation of red blood cells (RBCs) is of major importance. The organic solvent glycerol (Gly) is considered the current gold-standard cryoprotectant (CPA) for RBC cryopreservation, but the deglycerolization procedure is complex and time-consuming, resulting in severe hemolysis. Therefore, it remains a research hotspot to find biocompatible and effective novel CPAs. Herein, the natural and biocompatible inulin, a polysaccharide, was first employed as a CPA for RBC cryopreservation. The presence of inulin could improve the thawed RBC recovery from 11.83 ± 1.40 to 81.86 ± 0.37%. It was found that inulin could promote vitrification because of its relatively high viscosity and glass transition temperature (Tg′), thus reducing the damage during cryopreservation. Inulin possessed membrane stability, which also had beneficial effects on RBC recovery. Moreover, inulin could inhibit the mechanical damage induced by ice recrystallization during thawing. After cryopreservation, the RBC properties were maintained normally. Mathematical modeling analysis was adopted to compare the performance of inulin, Gly, and hydroxyethyl starch (HES) in cryopreservation, and inulin presented the best efficiency. This work provides a promising CPA for RBC cryopreservation and may be beneficial for transfusion therapy in the clinic.
研究领域:
生物技术
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输血医学
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低温生物学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2020
·
IF 9.038
Longqian Xu,Chao Yu,Yunfeng Mao,Yang Zong,Bing Zhang,Huaqiang Chu,Deli Wu
In this study, we present a novel soil electrochemical remediation technology (called S-FCDI), which is based on flow-electrode capacitive deionization (FCDI), for Cd removal from kaolin while under continuous operation mode. The results demonstrated that Cd can be effectively removed from kaolin with reasonable energy consumption and minimal macroelement loss. The carboxylic ( OOH) functional groups on the surface of activated carbon (AC) facilitated the transfer of Cd from kaolin onto carbon surface. A stable acidic environment, which is advantageous for continuous Cd desorption, was achieved as a result of the balance between H + generation and transmembrane migration. Once these net negative charges on the particle were eliminated or reversed, the adsorbed Cd could be released easily and driven in concentrated stream by electrostatic repulsion. Under the optimal operating conditions (i.e., carbon =50 g/L, j = 3.47 A/m 2 , pH i = 3.2, [NaCl] a =8.6 mmol/L), more than 80 % Cd was removed from (200 g) kaolin after continuous 19 h operation at a relatively low electricity consumption of 22.7 kW h/kg Cd and a limited Al loss of 0.06 wt‰. These results from this work demonstrated that S-FCDI could be an alternative soil electrochemical remediation technology for heavy metal removal with low soil damage.
研究领域:
环境科学
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土壤学
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产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
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2019
·
IF 7.149
Shunke Ding,Yang Deng,Hongwei Li,Chao Fang,Naiyun Gao,Wenhai Chu
Iodinated disinfection byproducts (I-DBPs) are of particular concern in drinking water due to the more cytotoxic and genotoxic properties than their chlorinated and brominated analogs. Formation of I-DBP primarily results from the oxidation of iodide-containing waters with various oxidants and the chlor(am)ination of iodinated organic compounds in drinking water. This study first reports that ferric chloride (FeCl3) can lead to the formation of iodinated coagulation byproducts (I-CBPs) from iodide-containing resorcinol solution or natural waters. The unwanted I-CBP formation involved the oxidation of iodide by ferric ions to generate various reactive iodine species, which further oxidize organic compounds. Although the oxidation rate of iodide by FeCl3 was several orders of magnitude slower than that by chlorine or chloramine, most of the converted iodide under the ferric/iodide system was transformed into iodine and iodinated organic compounds rather than iodate. Formation of four aliphatic I-CBPs was observed, and four aromatic I-CBPs were identified by gas chromatography mass-spectrometry and theoretical calculation. Coagulation of iodide-containing waters with FeCl3 also produced I-CBPs ranging from 12.5 ± 0.8 to 32.5 ± 0.2 μg/L as I. These findings call for careful consideration of the formation of I-CBPs from coagulation of iodide-containing waters with ferric salts.
研究领域:
环境科学
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公共卫生
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产品关联
DOI
PubMed
高影响因子
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
·
2020
·Vol. 84
·期 2
·411-420
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IF 1.516
Miao Zhonghua,Cheng Ruyue,Zhang Yujie,Liang Huijing,Jiang Fengling,Shen Xi,Chen Gong,Zhang Qisheng,He Fang,Li Ming
This study assessed whether antibiotics could alter gut microbiota to affect host growth and the possibility of alleviation by lactobacilli. We divided four-week-old BABL/c mice into control (Ctrl), antibiotic exposure (Abx), Lactobacillus plantarum PC-170 (PC), and Lactobacillus rhamnosus GG (LGG) group and the Abx, LGG, and PC group received an one-week antibiotic/antibiotic + probiotic treatment. The fecal microbiota and the expression of splenic cytokines were determined. Following the ceftriaxone treatment, the body weight gain of Abx was delayed compared with others. The ceftriaxone treatment significantly decreased the alpha-diversity of the fecal microbiota and altered the fecal microbiota but LGG and PC can partly alleviate the effect. At the end of the study, the microbial community of LGG and PC group were more similar to Ctrl compared with Abx group. The results indicated that ceftriaxone could significantly alter intestinal microbiota. Lactobacilli might alleviate the side effects of antibiotics by stabilizing the intestinal microbiota.
研究领域:
微生物学
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免疫学
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药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
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2014
·Vol. 4
·期 14
·7124-7131
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IF 3.708
Jun Peng,Kai Xu,Hualun Cai,Jiancheng Wu,Weihong Lin,Zhiwei Yu,Mingcai Chen
We explore in detail what exactly the structure of octakis(methacryloxypropyl) silsesquioxane is. The study was performed by carrying out a modified hydrolysis-condensation of (3-methacryloxypropyl)trimethoxysilane. And pure cube-like octakis(methacryloxypropyl) silsesquioxane (CMSQ-T8) has been synthesized and isolated with high yields (up to 85%), which is a great improvement on other literature routes. Octakis(methacryloxypropyl) silsesquioxane is a colorless, crystalline solid with a melting point of 69–69.5 °C. The precise structure of the octakis(methacryloxypropyl) silsesquioxane, characterized by 1H NMR, 29Si NMR, Maldi-Tof MS and WAXD is completely reported. Then, the polymerization behaviors of CMSQ-T8 and T10–12 analogues (CMSQ-T10–12) were studied by DSC, UV-vis, and FT-IR. CMSQ-T8 showed a better thermal stability. Due to the high reactivity of methacryloxypropyl, the octakis(methacryloxypropyl) silsesquioxane could be further functionalized to introduce other functionalities, which offers an alternative way to the formation of novel functional cube-like silsesquioxanes.
研究领域:
材料科学
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有机化学
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产品关联
DOI
高影响因子
Journal of Cancer
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2017
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IF 2.916
Mingtong Ye,Sufan Wang,Ting Wan,Rui Jiang,Yun Qiu,Lei Pei,Nengzhi Pang,Yuanling Huang,Yufeng Huang,Zhenfeng Zhang,Lili Yang
Efficacy of EGFR-targeted tyrosine kinase inhibitors (TKIs), such as erlotinib, to treat human non-small cell lung cancers (NSCLCs) with activating mutations in EGFR is not persistent due to drug resistance. Reprogramming in energy (especially glucose) metabolism plays an important role in development and progression of acquired resistance in cancer cells. We hypothesize that glucose metabolism in EGFR-TKI sensitive HCC827 cells and erlotinib-resistant sub-line of HCC827 (which we name it as erlotinib-resistant 6, ER6 cells in this study) is different and targeting glucose metabolism might be a treatment strategy for erlotinib-resistant NSCLCs. In this study, we found increased glucose uptakes, significant increase in glycolysis rate and overexpression of glucose transporter 1 in ER6 cells compared to its parental cells HCC827. We also found AKT and autophagy of ER6 cells were more activated than HCC827 cells after glucose starvation. Combining glucose deprivation and AKT or autophagy inhibitor could synergize and overcome the acquired resistance against EGFR-targeted therapy for NSCLCs. Our data suggest that the combinations of inhibitors of AKT or autophagy together with glucose deprivation could be novel treatment strategies for NSCLC with acquired resistance to targeted therapy.
研究领域:
肿瘤学
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分子生物学
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药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CRYSTAL RESEARCH AND TECHNOLOGY
·
2022
·Vol. 57
·期 8
·2100200
·
IF 1.599
Mingyang Gao,Qinzhe Cao,Ao Yang,Qianyi Gao,Wen Zhang,Mingjia Zhang,Zhiyong Zhang
Numerous ingenious top-down methods have opened a new door to the extensive research of 2D crystals. In this paper, a novel “differential-temperature exfoliation technology” is proposed to synthesize 2D few-layer MoS 2 . Several characterizations are conducted for discussion. The spectroscopic, optical, and purification capacity of the as-exfoliated layered structures is further studied systematically. This research provides insights into the novel top-down production and the related potential for environmental protection of few-layer MoS 2 .
研究领域:
材料科学
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环境科学
✓ 已验证
产品关联
DOI
高影响因子
Wood Material Science & Engineering
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2023
·
IF 2.2
Weihua Zou,Zimu Li,Zhangheng Wang,Delin Sun
A blue thermochromic dye (B-TD) was prepared by mixing crystal violet lactone (CVL), hydroxyethyl acrylate (HEA) and myristic acid myristyl ester (MME). B-TD is a phase-changing material and can change colour at above 32°C about 5 s. The B-TD can permeate into pre-treated pinewood samples about 8–10 mm from the surface of samples after immersed pre-treated pinewood samples in B-TD for about 10 min at 70 °C. A blue thermochromic pinewood (B-TP) was prepared by filled the B-TD into pre-treated pinewood and covered polypropylene wax that can prevent B-TD overflowing from wood-based material when at phase-changing temperature. The B-TP can change colour from dark blue to light blue at 38–48°C, and can recover dark blue at below 38°C after about 5 h. B-TP can be used in a kind of pinewood woodwork that can indicate the temperature of woodwork surface to users by its colour-change phenomenon at 38–48°C, covering the lowest temperature of cryogenic burns (42°C), so this kind of pinewood woodwork can warn the temperature of cryogenic burns for avoiding cryogenic burns by its colour-change phenomenon.
研究领域:
材料科学
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林业工程
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生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2022
·
IF 14.224
Lirong Huang,Kun Jia,Haibin Xiong,Guiyou Tian,Jiaxin Xu,Wei Yuan,Chen Lu,Xiaoping Xiao,Huiqiang Lu
Nephrotoxicity of oxyfluorfen to vertebrates remains unclear despite its wide use as a herbicide. In order to further study its nephrotoxicity and its underlying mechanism, we used human embryonic kidney cells and zebrafish to explore. HEK293T cells were exposed to 2, 4, 6 μg/mL oxyfluorfen for 24 h in vitro, and zebrafish were exposed to 0.4, 0.8, 1.2 mg/L oxyfluorfen for 72 h in vivo. We found that oxyfluorfen inhibits cell migration and induces oxidative stress and apoptosis, causing kidney damage or nephrotoxicity in embryonic and adult zebrafish. Oxyfluorfen triggered inflammation in zebrafish and causing severe periorbital and body edema in embryos. Oxyfluorfen induced the secretion of kidney injury markers, including urea nitrogen (BUN), creatinine (CR), and β-n-acetyl-glucosaminidase (NAG) in zebrafish. Additionally, oxyfluorfen affected the homeostasis of oxidant and antioxidant systems, leading to reactive oxygen species (ROS) overload. Oxyfluorfen also damaged the glomerular podocytes and induced apoptosis of proximal tubules, which is harmful to normal body function and the renal filtration system. These results indicate that oxyfluorfen is a potential environmental hazard that can cause severe kidney injury and affect the health of organisms.
研究领域:
毒理学
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环境科学
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细胞生物学
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动物学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF SOILS AND SEDIMENTS
·
2023
·Vol. 23
·期 8
·3006-3017
·
IF 3.6
Dong Yibo,Liu Xudong,Wu Xiaomao
Purpose In this study, the adsorption behavior of diuron in a typical black soil and its bioavailability to crops and earthworms were investigated by adsorption and incubation experiments, combined with biochar amendment and aging time. Methods In this study, the adsorption of diuron, and its uptake by corn and earthworms were investigated in black soil with 0.1–5% (w/w) bamboo charcoal. Results Uptake of diuron by corns was reduced by 45% in black soil aged for 0 day in 0.1–5% biochar-amended soil, the concentration of diuron in both roots and stems of corn plants tended to decrease with the increase of aging time, and the enrichment coefficient of diuron in corn also tended to decrease in 0.1–5% biochar-amended soil. When aging time was 0 day and the biochar amendment in black soil was 0.1–5%, the accumulation concentration of diuron in earthworms decreased by 63%; the bioconcentration coefficient of diuron in earthworms in black soil with different levels of biochar decreased continuously with the increase of aging time. Conclusion Biochar is an efficient adsorbent for diuron and could significantly reduce the uptake of diuron by plants and earthworms from contaminated soil. Significant correlations indicated that regression analyses could be constructed between the bioconcentration factor and sorption coefficients to predict the bioavailability of diuron residues in soil to corns and earthworms. Biochar amendment could be used as an option to immobilize diuron in soil and protect non-target organisms from diuron contamination.
研究领域:
环境科学
·
土壤学
·
生态毒理学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）