MICROCHEMICAL JOURNAL
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2026
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IF 5.2
Wenxia Chen,Rui Yuan,Xianlong Lu,Jing Qi,Xiaomin Zuo,Rui Yang
A 3D μPAD featuring physical isolation has been designed for crosstalk-free triplex detection. • A ZIF-8/CuFe 2 O 4 nanozyme, which exhibits broad-spectrum POD-like activity and generates three distinct color signals, has been synthesized. • A low-cost POCT platform that integrates functional materials, devices, and intelligent readout for GSH, AA, and DA has been developed. This work addresses the challenge of synchronous and rapid on-site detection of multiple metabolic small molecules in serum, and has constructed a point-of-care testing (POCT) platform based on broad-spectrum catalytic nanoenzyme and anti-interference three-dimensional (3D) paper chip. The ZIF-8/CuFe 2 O 4 composite nanoenzyme, prepared by a simple method, utilizes its interface synergy effect and exhibits excellent broad-spectrum peroxidase-like (POD-like) activity, capable of simultaneously and efficiently catalyzing the production of three-color contrasting chromogenic signals with 3,3′,5,5′-tetramethylbenzidine (TMB), 4-aminoantipyrine (4-AAP)/phenol, and o -phenylenediamine (OPD). On this basis, a 3D microfluidic paper-based analytical device (μPAD) with vertically isolated flow channels is constructed, which fundamentally eliminates signal crosstalk in multi-channel detection from the physical architecture level. During the detection, the target substances glutathione (GSH), ascorbic acid (AA), and dopamine (DA) quantitatively regulate the chromogenic reaction through competitive inhibition mechanisms. Combined with smartphone imaging and image analysis, synchronous and rapid quantification of the three substances can be achieved. The limit of detection (LOD) of this platform for GSH, AA, and DA is 0.072 μM, 0.44 μM, and 0.29 μM, respectively. Additionally, it shows a good recovery rate and reliability in diluted human serum samples. The integrated strategy of “functional materials–device design–intelligent reading” proposed in this work offers a new solution that is low-cost, easy-to-operate, and resistant to interference for on-site immediate detection of multiple indicators. Download: Download high-res image (131KB) Download: Download full-size image
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DOI
高影响因子
Energetic Materials Frontiers
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2025
·
IF 3.9
Su-hang Chen,Jie Zhang,Kui Tang,Xi Chen,Jia Zhao,Tuan Zhao,Bin Zhang,Kang-zhen Xu
Microwave ignition (MWI) technology enables synchronized large-area multi-point ignition, multi-pulse operation, higher combustion temperature and efficiency, and dynamic thrust modulation through microwave field adjustments compared to conventional electric ignition methods. However, MWI application is still limited by the absence of a microwave-responsive ignition agent. Herein, A series of nano-titanium/copper ferrite/potassium perchlorate ( n- Ti-CFO/KP (0∼40%)) microwave-sensitive agents were successfully synthesized via electrostatic spraying, where KP enhances combustion, while CFO acts as both catalyst and microwave sensitizer. MWI results demonstrate that n- Ti-CFO/KP (10%) exhibits the shortest ignition delay time (IDT) by 6.34 ms, owing to its high chemical reactivity and the high microwave absorption of Ti, CFO. Combustion analysis suggests that n- Ti-CFO/KP (40%) composite achieves 10-fold combustion enhancement over KP-free ignition agents by a peak pressure of 552.2 kPa and combustion rate of 221.4 m·s -1 , while n- Ti-CFO/KP exhibits the combustion flame temperature of 1250 °C compared to n- Ti-CFO by 700 °C. This remarkable improvement is attributed to the synergistic catalytic activation and combustion - supporting effects of CFO. Furthermore, n- Ti-CFO/KP (10%) exhibits comparable combustion and sensitivity performance to conventional agents ( μ- Ti/KP and B/KNO 3 ). The n- Ti-CFO/KP (10%) shows its main exothermic peak at 310 °C, significantly lower than the 550 °C peak observed for μ- Ti/KP, as well as the excellent catalytic decomposition effect of CFO on KP was further confirmed, where the low reaction temperature can shorten the microwave dielectric heating time. The synergistic effect and combustion intensification result from the coupled interaction between the microwave thermal characteristics of n- Ti-CFO and low-temperature oxygen release kinetics of KP. This coupling achieves significantly reduced MWI delay and enhanced energy release rates, thereby overcoming traditional combustion's reliance on high-temperature conditions. This result provides a new insight into the design of pyrotechnics and propulsion for fast plasma generation and microwave combustion.
研究领域:
材料科学
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燃烧学
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能源化学
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推进技术
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功能材料
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物理化学
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产品关联
DOI
高影响因子
Energetic Materials Frontiers
·
2021
·
IF 0
Jinghua Wang,Jingjing Wang,Shaojie Wang,Hui Li,Qilong Yan,Kangzhen Xu
As part of our ongoing search for high-performance nanoenergetic materials, we herein used self-assembly guided by negatively charged graphene oxide (GO) to fabricate a high-energy Al/GO/CuFe 2 O 4 nanocomposite with a dense layered structure featuring evenly mixed Al and CuFe 2 O 4 nanoparticles uniformly loaded on the GO surface. Investigation of the effects of the equivalence ratio ( Φ = 1.00–1.75) showed that the heat release achieved at the optimal value of Φ = 1.50 (3175 ± 65 J·g −1 ) exceeded that of most known thermites, while the fierce ignition process of this composite was characterized by an ignition delay time of (0.025 ± 0.002) s, a flame propagation speed of (14.3 ± 3.8) m·s −1 , and a continuous reaction duration of (33 ± 0.58) ms. In addition, the nanocomposite with Φ = 1.00 effectively catalyzed the thermal decomposition of 1,3,5-trinitroperhydro-1,3,5-triazine (RDX) and ammonium perchlorate (AP), decreasing their decomposition temperatures by 7.4 and 64.8 °C, respectively, reducing their apparent activation energies of decomposition by 118.7 and 18 kJ·mol −1 , respectively. And the constant-volume combustion enthalpies of RDX and AP increase with the addition of Al/GO/CuFe 2 O 4 . The reason of this enhanced performance was probed by analyzing the nanocomposite assembly process, and a plausible assembly mechanism was proposed.
研究领域:
材料科学
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化学工程
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纳米技术
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DOI
Water
·
2020
·Vol. 12
·期 12
·3583
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IF 2.544
Junying Yang,Minye Huang,Shengsen Wang,Xiaoyun Mao,Yueming Hu,Xian Chen
In this study, a magnetic copper ferrite/montmorillonite-k10 nanocomposite (CuFe2O4/MMT-k10) was successfully fabricated by a simple sol-gel combustion method and was characterised by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), the Brunner–Emmett–Teller (BET) method, vibrating sample magnetometer (VSM), and X-ray photoelectron spectroscopy (XPS). For levofloxacin (LVF) degradation, CuFe2O4/MMT-k10 was utilized to activate persulfate (PS). Due to the relative high adsorption capacity of CuFe2O4/MMT-k10, the adsorption feature was considered an enhancement of LVF degradation. In addition, the response surface methodology (RSM) model was established with the parameters of pH, temperature, PS dosage, and CuFe2O4/MMT-k10 dosage as the independent variables to obtain the optimal response for LVF degradation. In cycle experiments, we identified the good stability and reusability of CuFe2O4/MMT-k10. We proposed a potential mechanism of CuFe2O4/MMT-k10 activating PS through free radical quenching tests and XPS analysis. These results reveal that CuFe2O4/MMT-k10 nanocomposite could activate the persulfate, which is an efficient technique for LVF degradation in water.Keywords:magnetic;copper ferrite;montmorillonite-k10;levofloxacin;persulfate;response surface methodology
研究领域:
环境科学
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材料科学
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化学工程
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产品关联
DOI
高影响因子
Advanced Science
·
2024
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IF 14.3
Xiangjun Wei,Renlu Han,Yun Gao,Pengxin Song,Zhen Guo,Yafei Hou,Jiancheng Yu,Keqi Tang
Bioenergetic therapy is emerging as a promising therapeutic approach. However, its therapeutic effectiveness is restricted by metabolic plasticity, as tumor cells switch metabolic phenotypes between glycolysis and oxidative phosphorylation (OXPHOS) to compensate for energy. Herein, Metformin (MET) and BAY-876 (BAY) co-loaded CuFe 2 O 4 (CF) nanoplatform (CFMB) is developed to boost energy deprivation by synchronous interventions of glycolysis and OXPHOS for bioenergetic therapy synergetic with chemodynamic/photothermal therapy (CDT/PTT). The MET can simultaneously restrain glycolysis and OXPHOS by inhibiting hexokinase 2 (HK2) activity and damaging mitochondrial function to deprive energy, respectively. Besides, BAY blocks glucose uptake by inhibiting glucose transporter 1 (GLUT1) expression, further potentiating the glycolysis repression and thus achieving much more depletion of tumorigenic energy sources. Interestingly, the upregulated antioxidant glutathione (GSH) in cancer cells triggers CFMB degradation to release Cu + /Fe 2+ catalyzing tumor-overexpressed H 2 O 2 to hydroxyl radical (∙OH), both impairing OXPHOS and achieving GSH-depletion amplified CDT. Furthermore, upon near-infrared (NIR) light irradiation, CFMB has a photothermal conversion capacity to kill cancer cells for PTT and improve ∙OH production for enhanced CDT. In vivo experiments have manifested that CFMB remarkably suppressed tumor growth in mice without systemic toxicity. This study provides a new therapeutic modality paradigm to boost bioenergetic-related therapies.
研究领域:
肿瘤学
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生物医学工程
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诊疗学
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材料科学
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产品关联
DOI
PubMed
高影响因子
Journal of Water Process Engineering
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2025
·
IF 6.7
Xiaoyang Wei,Jingyun Zang,Pengju Chen,Zhenhai Wang,Sen Wang,Yajun Zhao,Zhi Fang
Plasma synergized Fenton-like catalysts are regarded as a highly promising method for antibiotic degradation. However, further enhancement is required in terms of the energy utilization efficiency of the plasma and the performance of the Fenton-like catalyst. In this study, a synergistic system of pulsed gas-liquid discharge (PGLD), heterogeneous Fenton-like catalyst CuFe 2 O 4 (CFO), and persulfate (PS) is constructed for the efficient degradation of tetracycline. The degradation rate in the PGLD/CFO/PS system reached 96.9 % with a synergistic factor of 2.85 when 80 mg of CFO and 3 mM of PS were added. The initial solution pH, the dosage of CFO and PS, and the working gas can also exert a considerable influence on degradation. The higher concentrations of H 2 O 2 and O 3 may account for the higher degradation rates observed in the PGLD/CFO/PS system. ESR experiments demonstrated that the PGLD/CFO/PS system was more conducive to OH and SO 4 − formation, which are the key active species for degradation. Three potential degradation pathways were postulated according to the degradation intermediates. The PGLD/CFO/PS system has been demonstrated to significantly reduce the toxicity of the antibiotic solution following treatment. This research provides a prospective approach for the sustainable implementation of wastewater treatment.
研究领域:
环境科学
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化学工程
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废水处理
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产品关联
DOI
高影响因子
Sensors and Actuators Reports
·
2025
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IF 7.6
Yanli Sun,Hongying Li,Tao Wang,Kai Zhang,Xueliang Wang
MicroRNA-17 (miR-17) is a critical biomarker linked to various cancers and diseases, underscoring the need for sensitive and selective detection methods. Herein, an ultra-sensitive electrochemiluminescent (ECL) sensor for miR-17 detection utilizing MOF-derived porous CuFe 2 O 4 nanospheres and CRISPR/Cas13a trans-cleavage-triggered hybridization chain reaction (HCR) amplification was presented. The porous CuFe 2 O 4 nanospheres possessed a high surface area and excellent catalytic activity, significantly enhancing ECL emission. To the best of our knowledge, this is the first report demonstrating that MOF-derived CuFe 2 O 4 can effectively enhance the electrochemiluminescence of Ru(bpy) 3 2 ⁺ for miR-17 detection. The CRISPR/Cas13a system provided miR-17 recognition and trans-cleavage activity, triggering HCR for signal amplification. Under optimized conditions, the biosensor exhibited a wide linear detection range from 20 aM to 5000 aM, with a detection limit of 9.23 aM. The system discriminated miR-17 from closely related miRNAs with negligible cross-reactivity, which demonstrated its outstanding selectivity. Practical applicability was confirmed by successful quantification of miR-17 in diluted human serum which achieved recovery rates between 95.2% and 104.8%. The results validated the biosensor’s potential for early disease diagnosis and clinical monitoring of miR-17-associated disorders.
研究领域:
生物传感器
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分析化学
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纳米材料
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分子诊断
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癌症研究
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产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 7
·497
·
IF 5.4
Xie Zexing,Dou Xinkai,Wang Haitong,Liu Yu,Lv Peiwen,Xin Tao,Li Nianlu
At-home monitoring of key blood indicators, including cholesterol and glucose, is vital for point-of-care chronic condition management. In this work, portable kits based on L-arginine modified Cu-CuFe 2 O 4 nanoparticles (Cu-CuFe 2 O 4 @L-Arg NPs) were fabricated for colorimetric determination of glucose and cholesterol in human serum. Cu-CuFe 2 O 4 @L-Arg NPs with superior peroxidase-like activities were synthesized via a straightforward hydrothermal approach. The accelerated electron transfer process of Cu 0 and its role as an electron donor contributed to excellent catalytic activity of Cu-CuFe 2 O 4 @L-Arg toward 3,3’,5,5’-tetramethylbenzidine (TMB). Portable kits include glucose oxidase or cholesterol oxidase, phosphate buffer solution (PBS) pH 7.0, Cu-CuFe 2 O 4 @L-Arg, PBS pH 4.0 and TMB. Among the enzyme-like reactions, Cu-CuFe 2 O 4 @L-Arg catalyzes the conversion of H 2 O 2 into hydroxyl radicals (•OH), which subsequently oxidize the TMB substrate to yield a blue-colored product. The signal intensities of the blue products were proportional to H 2 O 2 , which was produced in the cholesterol or glucose systems. This method achieves linear detection of free cholesterol from 5 µM to 1.2 mM, exhibiting a low LOD of 1 µM, and was validated by obtaining recoveries of 97-103.5% for total cholesterol in human serum analyses. The method enabled the linear quantification of glucose from 50 to 1500 µM with a limit of detection (LOD) of 5 µM, and recoveries in human serum ranged from 96% to 102.8%. The portable kits, characterized by low cost, visual readout, high specificity, and long-term stability, demonstrate considerable potential for self-monitoring devices for key clinical biomarkers. Graphical
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2022
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IF 16.744
Haiqiang Qi,Guifang Pan,Xuelin Shi,Zhirong Sun
The heterogeneous electro-Fenton (hetero-EF) technology is an attractive but challenging method used to degrade organic pollutants . The development of a catalysts for the stable and efficient degradation of pollutants under neutral conditions remains a challenging task. In this study, a microsphere catalyst consisting of magnetic Cu–Fe–FeC 3 on nitrogen-doped biochar (Cu–Fe–Fe 3 C@NDB) was prepared using chitosan as the carrier material in a two-step process. A hetero-EF system using Cu–Fe–Fe 3 C@NDB as the catalyst was constructed to efficiently degrade amoxicillin. The catalyst exhibited a wide pH application range, a good stability, and a low metal ion leaching . The main reasons behind the remarkable catalytic performance and excellent stability of the Cu–Fe–Fe 3 C@NDB catalyst are: (i) The presence of a core–shell structure, in which Cu–Fe bimetallic particles are wrapped in the structure of biomass carbon to slow down the loss of the metal active component in the catalyst and maintain its stability; (ii) The uniform dispersion of nanoparticles on the surface of the Cu–Fe–Fe 3 C@NDB catalyst, N-doped carbon, and the combined effect of Cu and Fe, which are beneficial to improve the charge transfer efficiency and regulate the electronic structure, which in turns improve the activity of the catalyst. This work demonstrates that the efficient degradation of pollutants under neutral conditions can be achieved and provides useful information for the design and synthesis of efficient and stable catalysts in hetero-EF reaction systems.
研究领域:
环境科学
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材料科学
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Qiunan Sun,Xuejiang Wang,Yiyang Liu,Yanan Zhang,Siqing Xia,Jianfu Zhao
In this study, floating carbon nitride incorporating copper ferrite catalyst (CNCFEp) was synthesized by a simple coprecipitation-calcination method. The prepared catalyst was applied to the catalytic activation of peroxymonosulfate (PMS) for the degradation of antibiotics under visible light irradiation (Vis/CNCFEp/PMS system). In the presence of CNCFEp (2.0 g/L) and PMS (0.1 g/L), 97.6 % of sulfamethazine (SMT, 10 mg/L) was degraded in 30 min under neutral conditions, whereas negligible influence was observed accompanied by water matrixes. The floating composite catalyst showed excellent stability after 5 times recycling experiments. Singlet oxygen ( 1 O 2 ) and high-valent oxo-metal species were unveiled to be the major reactive oxygen species (ROS), rather than conventional hydroxyl radicals or sulfate radicals. These nonradical species were produced by direct oxidation or the transformation of superoxide ions and metastable metal composite at neutral pH. SMT was broken down by four degradation pathways in this system and a remarkable reduction in toxicity has been demonstrated by the quantitative structure–activity relationship (QSAR) prediction. Likewise, the nonradical species were capable of inactivating the bacteria ( E. coli) . This work was the first study dedicated to the mechanism of PMS activation by CNCFEp and provides a novel catalytic system for removal of organic contaminants and bacteria in environmental waters.
研究领域:
环境科学
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催化材料
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水处理技术
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产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 10
·1-11
·
IF 5.3
Chen Wenxia,Hu Shuangyi,Zhou Bingqian,Ren Yueran,Xue Yangyang,Yang Rui
Lung cancer, as one of the cancers with the highest morbidity and mortality rates in the world, requires accurate detection of its vital serum marker, neuron-specific enolase (NSE), which is a key challenge for early detection of lung cancer. However, traditional chemiluminescence immunoassay (CLIA) methods rely on labeled antibodies (Abs) and suffer from complex operations and high costs. In this work, a label-free CLIA based on CL-functionalized mesoporous magnetic nanoparticles (CuFe 2 O 4 @mSiO 2 -Cys-Luminol-Au NPs) is developed for the rapid and sensitive detection of NSE. The material combines the advantages of magnetic separation, mesoporous loading, catalytic enhancement, and biorecognition. CuFe 2 O 4 NPs offer efficient magnetic separation, while the mesoporous silica (mSiO 2 ) layer is effectively loaded with luminol to amplify CL signals. L-cysteine (L-Cys) ensures the uniform distribution of luminol and gold nanoparticles (Luminol-Au NPs), with these Au NPs immobilizing Abs through Au–S and Au–N bonds, achieving high-density biocoupling. The constructed label-free CLIA enables highly sensitive detection of NSE without Abs labeling. The results show that the NSE concentration is linearly correlated with the CL intensity in the range 1.0 × 10 −13 ~ 1.0 × 10 −8 g/mL, and the detection limit is as low as 2.3 × 10 −14 g/mL. The proposed method demonstrates excellent selectivity, stability, and anti-interference capability for the detection of NSE in human serum samples. Graphical
研究领域:
生物医学工程
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分析化学
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纳米技术
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癌症诊断
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生物传感器
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Shu-Ting Cheng,Jia-Xin Song,Xiao-Fang Shen,Yue-Hong Pang
Dimethyl phthalate (DMP) is widely used as a plasticizer in the plastics industry, posing a serious threat to environmental pollution and public health. In this work, CuFe 2 O 4 @AC was used as a coating to prepare a novel solid-phase microextraction (SPME) fiber. CuFe 2 O 4 @AC fiber exhibits a larger specific surface area and more active sites, significantly enhancing DMP enrichment efficiency. The SPME method was applied for DMP measurement in beverages. Under optimal conditions, the developed method demonstrates a low detection limit (0.07 ng mL −1 ), a wide linear range (0.5–1000 ng mL −1 ), and good repeatability. Subsequently, SPME method combined with electro-Fenton degradation was established. The degradation process of DMP was dynamically analyzed by combining DFT calculation with gas chromatography–mass spectrometry. We developed a dynamic analytical method for extracting and monitoring electro-Fenton degradation products. This approach demonstrates significant potential for monitoring the degradation process of trace environmental endocrine disruptors.
研究领域:
环境化学
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分析化学
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材料科学
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化学工程
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）