JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2015
·Vol. 27
·期 2
·2022-2030
·
IF 1.569
Liu Hongli,Wang Shirong,Xiao Yin,Li Xianggao
This work aims at studying the structure of monomers on the dispersity of carbon black (CB) in a non-aqueous medium Isopar L. The polymethacrylate-grafted CB nanoparticles were prepared by a redox polymerization method. A series of methacrylate monomers containing alkyl side chain with different length and structure were employed for grafting. The structure and composition of polymethacrylate-grafted CB particles were characterized by a combination of FTIR, TGA and XPS. The particle size distribution, average diameter, contact angle to water and Isopar L and zeta potential of the prepared CB particles were investigated to provide insights into the effects of the monomer structure on the dispersity of modified CB particles in Isopar L. TEM images demonstrated that aggregation of modified CB particles reduced distinctly. The surface of CB particles changed from hydrophilic to hydrophobic after modification. Moreover, it is also found that the more branching or the longer the monomers used in the modification, the narrower the particle size distribution and the higher the zeta potential. The display prototype based on polymethacrylate-grafted carbon black particles showed an improved display performance under the electric field of 0.30 V μm −1 . Especially, the EPD based on ethylhexyl methacrylate modified CB particles displayed the highest contrast ratio of 8.36 and minimum response time (527 ms) compared with the ones prepared with other modified particles.
研究领域:
材料科学
·
聚合物化学
·
纳米技术
·
电泳显示技术
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2014
·
IF 5.9
Ze-Yong Li,Yun Liu,Jing-Jing Hu,Qi Xu,Li-Han Liu,Hui-Zhen Jia,Wei-Hai Chen,Qi Lei,Lei Rong,Xian-Zheng Zhang
In this paper, a novel stepwise-acid-active multifunctional mesoporous silica nanoparticle (MSN-SATAT&DMAK11) was developed as a drug carrier. The MSN-SATAT&DMAK11 is able to reverse its surface charge from negative to positive in the mildly acidic tumor extracellular environment. Then, the fast endo/lysosomal escape and subsequent nucleus targeting as well as intranuclear drug release can be realized after cellular internalization. Because of the difference in acidity between the tumor extracellular environment and that of endo/lysosomes, this multifunctional MSN-SATAT&DMAK11 exhibits a stepwise-acid-active drug delivery with a tumor-specific nucleus-targeted property.
研究领域:
纳米医学
·
生物材料
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small
·
2015
·Vol. 11
·期 21
·2543-2554
·
IF 8.368
Shi-Song Han,Ze-Yong Li,Jing-Yi Zhu,Kai Han,Zheng-Yang Zeng,Wei Hong,Wen-Xin Li,Hui-Zhen Jia,Yun Liu,Ren-Xi Zhuo,Xian-Zheng Zhang
A novel dual-pH sensitive charge-reversal strategy is designed to deliver antitumor drugs targeting to tumor cells and to further promote the nuclei internalization by a stepwise response to the mildly acidic extracellular pH (≈6.5) of a tumor and endo/lysosome pH (≈5.0). Poly( l -lysine)- block –poly( l -leucine) diblock copolymer is synthesized and the lysine amino residues are amidated by 2,3-dimethylmaleic anhydride to form β-carboxylic amide, making the polypeptides self-assemble into negatively charged micelles. The amide can be hydrolyzed when exposed to the mildly acidic tumor extracellular environment, which makes the micelles switch to positively charged and they are then readily internalized by tumor cells. A nuclear targeting Tat peptide is further conjugated to the polypeptide via a click reaction. The Tat is amidated by succinyl chloride to mask its positive charge and cell-penetrating function and thus to inhibit nonspecific cellular uptake. After the nanoparticles are internalized into the more acidic intracellular endo/lysosomes, the Tat succinyl amide is hydrolyzed to reactivate the Tat nuclear targeting function, promoting nanoparticle delivery into cell nuclei. This polypeptide nanocarrier facilitates tumor targeting and nuclear delivery simultaneously by simply modifying the lysine amino residues of polylysine and Tat into two different pH-sensitive β-carboxylic amides.
研究领域:
药学
·
纳米技术
·
癌症治疗
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2017
·
IF 3.671
Ting Liu,Enyong Ding,Feng Xue
Natural polymer flocculants for wastewater treatment have received close attention in recent years. Here we used two flocculants, polyacrylamide and poly( N , N -dimethylacrylamide) grafted cellulose nanocrystals synthesized by a “macro-RAFT assisted” strategy, for the flocculation of kaolin suspension. The flocculation performance of these two flocculants, including flocculants dosage, settling time and floc size, was carefully studied and compared. Results suggested that poly( N , N -dimethylacrylamide) grafted cellulose nanocrstyals showed better flocculation performance than polyacrylamide grafted ones. Meanwhile, their flocculation behavior was also compared with other cellulose-based flocculants in literature and we suggested polymer modified cellulose nanocrstals as flocculants might have higher flocculation performance, but this needs further verification.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2017
·Vol. 35
·期 10
·1222-1230
·
IF 1.692
Wu Qian,Xu Bing,Wei Jun-jie,Wang Qing,Wang Qi-gang,Liu Wen-guang
Over the past decades, the urgent need for high strength conductive hydrogels in diverse applications has motivated an unremitting effort to combine the improved mechanical properties of hydrogels with conductive performances. In this work, high strength conductive hydrogels intensified with intermolecular hydrogen bonding are fabricated by in situ mixing poly(2-vinyl-4,6-diamino-1,3,5-triazine- co -polyethylene glycol diacrylates) (PVDT-PEGDA) hydrogels with poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT/PSS). The conductive hydrogels in deionized water exhibit high mechanical performances with compressive strength and tensile strength in the range of 7.58−9.52 MPa and 0.48−1.20 MPa respectively, which are ascribed to the intermolecular hydrogen bonding interactions of diaminotriazine-diaminotriazine (DAT-DAT) in the network. Meanwhile, adding PEDOT/PSS can significantly increase both the specific conductivities and equilibrium water contents of the hydrogels. These cytocompatible conductive hydrogels may have a great potential to be used as electrical stimuli responsive soft biomaterials.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
CELLULOSE
·
2018
·Vol. 25
·期 3
·1705-1714
·
IF 3.809
Liu Ting,Ding Enyong,Xue Feng
Polymer grafting is an efficient way to obtain functional cellulose nanocrystals. In this work, we used a “macro-RAFT (macromolecular reversible addition–fragmentation chain transfer) agent-assisted” strategy, which adds extra amount of amphiphilic macro-RAFT agent with low molecular weight to graft poly(N,N-dimethylacrylamide) (PDMA) from cellulose nanocrystals. Successful grafting was evidenced by different characterization methods, and a high weight ratio of grafted PDMA was obtained (77.6%). The grafting process was studied through the weight ratio of grafted PDMA, monomer conversion, and the molecular weight of free and grafted PDMA at different reaction time. As a result, we have suggested that there were three types of grafted polymer chains on cellulose nanocrystals in this reaction system and discussed their evolution during the grafting reaction. Finally, we summarized several key factors for successful grafting in this macro-RAFT agent-assisted strategy.
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
MOLECULES
·
2017
·Vol. 22
·期 2
·152
·
IF 2.861
Jiachen Ma,Luqing Zhang,Bing Geng,Umair Azhar,Anhou Xu,Shuxiang Zhang
In this work, a thermo-responsive and cross-linked fluoropolymer poly(2,2,2-Trifluoroethyl) methacrylate (PTFEMA) was successfully prepared by reversible addition-fragmentation chain transfer (RAFT) mediated aqueous polymerization with a thermo-responsive diblock poly(dimethylacrylamide-b-N-isopropylacrylamide) (PDMA-b-PNIPAM) that performed a dual function as both a nanoreactor and macro-RAFT agent. The cross-linked polymer particles proved to be in a spherical-like structure of about 50 nm in diameter and with a relatively narrow particle size distribution.1H-NMR and19F-NMR spectra showed that thermo-responsive diblock P(DMA-b-NIPAM) and cross-linked PTFEMA particles were successfully synthesized. Influence of the amount of ammonium persulfate (APS), the molar ratio of monomers to RAFT agent, influence of the amount of cross-linker on aqueous polymerization and thermo-responsive characterization of the particles are investigated. Monomer conversion increased from 44% to 94% with increasing the molar ratio of APS and P(DMA-b-NIPAM) from 1:9 to1:3. As the reaction proceeded, the particle size increased from 29 to 49 nm due to the consumption of TFEMA monomer. The size of cross-linked nanoparticles sharply decreased from 50.3 to 40.5 nm over the temperature range 14–44 °C, suggesting good temperature sensitivity for these nanoparticles.Keywords:RAFT polymerization;nanoreactor;aqueous polymerization;cross-linking;temperature sensitivity
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2017
·Vol. 184
·期 4
·1185-1190
·
IF 4.58
Gong Lingling,Du Bibai,Pan Long,Liu Qingju,Yang Kunhao,Wang Wei,Zhao Hong,Wu Li,He Yujian
The authors describe a colorimetric assay for the determination of As(III) in aqueous solution using citrate capped gold nanoparticles (AuNPs) which, in the presence of As(III), undergo aggregation due to the interaction of citrate ion with As(III). This results in an easily detectable color change from wine-red to blue. The ratio of the absorbances at 661 and 519 nm is linearly related to the As(III) concentration in the 4 to 100 ppb range, with a detection limit as low as 1.8 ppb (at 3σ) which is below the guideline value of 10 ppb. The method is rather simple in that it does not require the surface of the AuNPs to be modified. It was successfully applied to the determination of As(III) in spiked drinking water where it gave adequate recoveries.
The ratio of the absorbances at 661 and 519 nm is linearly related to the As(III) concentration in the 4 to 100 ppb range, with a detection limit as low as 1.8 ppb (at 3σ) which is below the guideline value of 10 ppb.
研究领域:
分析化学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Meng-Yun Peng,Di-Wei Zheng,Shi-Bo Wang,Si-Xue Cheng,Xian-Zheng Zhang
A multifunctional nanosystem based on two-dimensional molybdenum disulfide (MoS2) was developed for synergistic tumor therapy. MoS2 was stabilized with lipoic acid (LA)-modified poly(ethylene glycol) and modified with a pH-responsive charge-convertible peptide (LA-K11(DMA)). Then, a positively charged photosensitizer, toluidine blue O (TBO), was loaded on MoS2 via physical absorption. The negatively charged LA-K11(DMA) peptide was converted into a positively charged one under acidic conditions. Charge conversion of the peptide could reduce the binding force between positively charged TBO and MoS2, leading to TBO release. Furthermore, the positively charged nanosystem was easily endocytosed by cells. Photo-induced hyperthermia of MoS2 in the tumor areas could promote TBO release and exhibited photothermal therapy. In vitro and in vivo results demonstrated that fluorescence and photo-induced reactive oxygen species (ROS) generation of TBO were severely decreased by MoS2 under normal conditions. While in the acidic condition, the pH-responsive nanosystem exhibited a highly specific and efficient antitumor effect with TBO release and photo-induced ROS generation, suggesting to be a promising accessory for synergistic tumor therapy.
研究领域:
纳米医学
·
癌症治疗
·
材料科学
·
生物材料
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2017
·
IF 6.32
Huixia Di,Huiqiao Liu,Mingmin Li,Jin Li,Dingbin Liu
Precise profiling of the sialic acid (SA) expression on the membrane of cancer cells is critical for early identification of cancers and assessment of cancer metastasis. However, the complex physiological environments often result in false positives with currently available imaging technologies. Herein, we have established a background-free surface-enhanced Raman scattering (SERS) imaging platform that allows high-precision profiling of SA expression in cancer cells and differentiation of clinically relevant cancer tissues with various metastasis degrees. Three-dimensional Raman imaging technique provided a deeper insight into visualizing the probe distribution and thus the SA expression at the single-cell level, without destructing the cells. This noninvasive, high-precision imaging technique could favor early diagnosis, staging, and monitoring therapeutic responses of cancers that are highly essential in clinical settings.
研究领域:
生物医学
·
分子影像学
·
癌症研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2018
·Vol. 28
·期 47
·1804609
·
IF 13.325
Xinxin Dai,Kai Han,Zhaoyu Ma,Heyou Han
The precise recognition of tumor tissue is the key challenge that hinders successful clinical translation of drug delivery systems. Herein, a tumor extracellular matrix orthogonal stimuli-responsive chimeric peptide is developed for logic gate controlled tumor recognition and photodynamic therapy. In vitro studies show that the negatively charged chimeric peptide is sensitive to two typical tumor hallmarks, i.e., mild acidity and matrix metalloproteinase 2 (MMP-2) simultaneously. Consequently, the chimeric peptide can undergo charge reversal from negative charge to positive charge in tumor, accelerating the cellular uptake. Specifically, the enhanced cellular uptake of chimeric peptide can be activated efficiently only in the presence of both acidity and MMP-2, endowing chimeric peptide with highly specific tumor therapy both in vitro and in vivo. This chimeric peptide based “AND” logic gate should show great potential in precise tumor therapy.
研究领域:
生物医学工程
·
肿瘤学
·
药剂学
✓ 已验证
产品关联
DOI
高影响因子
International Journal of Nanomedicine
·
2018
·
IF 4.37
Yanqiu Zhang,Lianjun Peng,Jiahui Chu,Ming Zhang,Lizhu Sun,Bin Zhong,Qiyong Wu
Background Co-delivery all-trans-retinoic acid (ATRA) and paclitaxel (PTX) is an effective strategy for cancer therapy. However, in many previous reported ATRA conjugated co-delivery systems, the ATRA was released slower than PTX, and the total drug release of ATRA far lower than that of PTX.Purpose We designed and prepared a pH and redox dual responsive drug delivery system (DA-ss-NPs) co-delivery ATRA and PTX for cancer therapy. The surface charge of DA-ss-NPs could change from negative to positive under tumor slightly acidic microenvironment, and both drugs could be quickly released from DA-ss-NPs under intracellular high concentration of glutathione (GSH).Methods The DA-ss-NPs were constructed by encapsulating PTX into the hydrophobic core of the polymer micelles, in which the polymer was synthesized by conjugating ATRA and 2,3-Dimethylmalefic anhydride (DMA) on side chains of Cystamine dihydrochloride (Cys) modified PEG-b-PAsp (named DA-ss-NPs). The surface charge of DA-ss-NPs under different pH conditions were detected. And the drug release was also measured under different concentration of GSH. The therapeutic effect of DA-ss-NPs were investigated in Human lung cancer A549 cells and A549 tumor-bearing mice.Results The zeta potential of DA-ss-NPs was -16.3 mV at pH 7.4, and which changed to 16 mV at pH 6.5. Cell uptake experiment showed that more DA-ss-NPs were internalized by A549 cells at pH 6.5 than that at pH 7.4. In addition, in presence of 10 mM GSH at pH 7.4, about 75%-85% ATRA was released from DA-ss-NPs within 48 h; but less than 20% ATRA was released without GSH. In vivo antitumor efficiency showed that the DA-ss-NPs could affectively inhibite the tumor in compared with control groups.Conclusion The charge-reversal and GSH-responsive DA-ss-NPs provide an excellent platform for potential tumor therapy.
研究领域:
药剂学
·
肿瘤学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）