NEW PHYTOLOGIST
·
2023
·
IF 9.4
Ling-Yan Wang,Jian Li,Benqiang Gong,Rui-Hua Wang,Yi-Li Chen,Jian Yin,Chang Yang,Jia-Ting Lin,Hao-Zhuo Liu,Yubing Yang,Jianfeng Li,Chunyu Li,Nan Yao
Summary Sphingolipids are cell membrane components and signaling molecules that induce endoplasmic reticulum (ER) stress responses, but the underlying mechanism is unknown. Orosomucoid proteins (ORMs) negatively regulate serine palmitoyltransferase activity, thus helping maintain proper sphingolipid levels in humans, yeast, and plants. In this report, we explored the roles of ORMs in regulating ER stress in Arabidopsis thaliana . Loss of ORM1 and ORM2 function caused constitutive activation of the unfolded protein response (UPR), as did treatment with the ceramide synthase inhibitor Fumonisin B1 (FB1) or ceramides. FB1 treatment induced the transcription factor bZIP28 to relocate from the ER membrane to the nucleus. The transcription factor WRKY75 positively regulates the UPR and physically interacted with bZIP28. We also found that the orm mutants showed impaired ER-associated degradation (ERAD), blocking the degradation of misfolded MILDEW RESISTANCE LOCUS-O 12 (MLO-12). ORM1 and ORM2 bind to EMS-MUTAGENIZED BRI1 SUPPRESSOR 7 (EBS7), a plant-specific component of the Arabidopsis ERAD complex, and regulate its stability. These data strongly suggest that ORMs in the ER membrane play vital roles in the UPR and ERAD pathways to prevent ER stress in Arabidopsis. Our results reveal that ORMs coordinate sphingolipid homeostasis with ER quality control and play a role in stress responses.
研究领域:
植物学
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分子生物学
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细胞生物学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MODERN OPTICS
·
2024
·
IF 1.2
Hui Ying Zhang,Wan Ying Xie,Peng Zhang,Xiao Hui Li,Zian Cheak Tiu
In this work, NaGdF4: 20%Yb, 2%Er microcrystals with varying contents of Cr3+ doping were obtained by conventional hydrothermal process. The microcrystal phase structure, morphology, upconversion luminescence mechanism, as well as temperature sensing behaviour under different treatment methods were researched. Based on the thermally coupled 2H11/2 and 4S3/2 levels of Er3+ and the dependence of fluorescence intensity ratio (FIR) on temperature, the optical temperature sensing behaviour of micrometer crystals were experimentally demonstrated. The NaGdF4: 20%Yb, 2%Er, 7%Cr microcrystals treated with high-temperature annealing show the best temperature sensing behaviour within the temperature span of 298–498 K. NaGdF4: 20%Yb, 2%Er, 7%Cr microcrystals with high temperature annealing presented the feasibility and promising properties for optical temperature sensing. The endeavour of emerging materials could lay the groundwork for future sustainable photonics engineering industrial growth.
研究领域:
材料科学
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光学工程
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产品关联
DOI
高影响因子
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
·
2021
·Vol. 101
·期 1
·215-226
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IF 2.326
Li Ping,Zhao Liuyong,Wang Song,Zhang Xiaohui,Jiang Huaiyuan,Liu Ruizhen,Zhao Nengchuang,Cheng Jian,Xu Caili,Zhao He,Lyu Renliang
Known as one efficient upconversion luminescent material, Rare-earth ions doped natrium yttrium fluoride NaYF 4 :Yb/Re has broad application prospects. However, due to the limitation of the existing preparation methods, it is difficult to realize industrial production. In this paper, the upconversion luminescence microparticles, rare earth ions doped Natrium Yttrium Fluoride NaYF 4 :Yb/Er, were synthesized productively by impinging stream method. Synthesis conditions were optimized as EDTA: Ln to 0.5 and NaF: Ln to 6 (Ln represents the sum of moles of Y, Yb, and Er), reacting temperature and time to 50 °C and 3 h to obtain a high yield of 99.92% and particle with good monodispersity. To get strong upconversion luminescence, the effect of the calcination temperature and the amount of EDTA were investigated. The bright upconversion emissions by excited with laser radiation at 975 nm were found at 510–690 nm. The higher the calcination temperature, the stronger the luminescence and the strongest luminescence occurs when calcined at 600 °C. And the adding of EDTA will decrease the luminescence intensity. However, the sintering of particles at high temperatures and aggregation of particles without EDTA are unfavorable for the application of the products. Based on the above considerations, the optimal calcination temperature was determined at 450 °C, and the ratio of EDTA: Ln is preferred at 0.5. The impinging stream method to prepare upconversion material has the advantages of being simple in the process and equipment, high in output, low in investment, and convenient to be applied and popularized.
研究领域:
材料科学
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化学工程
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产品关联
DOI
高影响因子
Nature Communications
·
2019
·Vol. 10
·期 1
·1-11
·
IF 11.878
Mei Qingsong,Bansal Akshaya,Jayakumar Muthu Kumara Gnanasammandhan,Zhang Zhiming,Zhang Jing,Huang Hua,Yu Dejie,Ramachandra Chrishan J. A.,Hausenloy Derek J.,Soong Tuck Wah,Zhang Yong
Reliance on low tissue penetrating UV or visible light limits clinical applicability of phototherapy, necessitating use of deep tissue penetrating near-infrared (NIR) to visible light transducers like upconversion nanoparticles (UCNPs). While typical UCNPs produce multiple simultaneous emissions for unidirectional control of biological processes, programmable control requires orthogonal non-overlapping light emissions. These can be obtained through doping nanocrystals with multiple activator ions. However, this requires tedious synthesis and produces complicated multi-shell nanoparticles with a lack of control over emission profiles due to activator crosstalk. Herein, we explore cross-relaxation (CR), a non-radiative recombination pathway typically perceived as deleterious, to manipulate energy migration within the same lanthanide activator ion (Er 3+ ) towards orthogonal red and green emissions, simply by adjusting excitation wavelength from 980 to 808 nm. These UCNPs allow programmable activation of two synergistic light-gated ion channels VChR1 and Jaws in the same cell to manipulate membrane polarization, demonstrated here for cardiac pacing.
研究领域:
材料科学
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生物物理学
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纳米技术
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光遗传学
✓ 已验证
DOI
PubMed
高影响因子
Nanomaterials
·
2018
·Vol. 8
·期 12
·1023
·
IF 3.504
Dandan Ju,Feng Song,Adnan Khan,Feifei Song,Aihua Zhou,Xiaoli Gao,Huimin Hu,Xu Sang,Victor Zadkov
The dual-mode emission and multicolor outputs in the time domain from core-shell microcrystals are presented. The core-shell microcrystals, with NaYF4:Yb/Er as the core and NaYF4:Ce/Tb/Eu as the shell, were successfully fabricated by employing the hydrothermal method, which confines the activator ions into a separate region and minimizes the effect of surface quenching. The material is capable of both upconversion and downshifting emission, and their multicolor outputs in response to 980 nm near-infrared (NIR) excitation laser and 252 nm, and 395 nm ultraviolet (UV) excitation light have been investigated. Furthermore, the tunable color emissions by controlling the Tb3+-Eu3+ratio in shells and the energy transfer of Ce3+→Tb3+→Eu3+were discussed in details. In addition, color tuning of core-shell-structured microrods from green to red region in the time domain could be obtained by setting suitable delay time. Due to downshifting multicolor outputs (time-resolved and pump-wavelength-induced downshifting) coupled with the upconversion mode, the core-shell microrods can be potentially applied to displays and high-level security.Keywords:NaYF4:Yb/Er@NaYF4:Ce/Tb/Eu microrods;dual-mode emission;time-resolved emission spectra;multicolor emission
研究领域:
材料科学
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光学
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产品关联
DOI
PubMed
高影响因子
OPTICAL MATERIALS
·
2024
·
IF 3.8
Hui Wang,Hui Hu,Kevin Homewood,Yun Gao
Double perovskites have shown great potential in addressing the toxicity and instability concerns of lead halide perovskites for practical applications. However, the fabrication of high-quality double perovskite single crystals has remained challenging. Here, large Er-doped Cs 2 AgBiCl 6 single crystals (SCs) with a maximum dimension of 8 mm were successfully prepared using a solution temperature-lowering (STL) method. The photoluminescence (PL) spectra were excited by the lasers with energies below and above the band gap, and the origin of the abnormal PL peaks changing with temperature is explored. The photodetector made from the Er-doped Cs 2 AgBiCl 6 SCs shows a significantly enhanced light responsivity and detectivity in the wavelength range from 370 nm to 660 nm compared with the undoped one, with excellent environmental and radiation stability. It reveals that the Er ions can be successfully doped into double perovskite single crystal, benefiting the application to optoelectronic devices.
研究领域:
材料科学
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光学工程
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产品关联
DOI
高影响因子
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
·
2025
·Vol. 122
·期 34
·e2512154122
·
IF 9.1
Yang Bai,Chao Zhang,Hao Liu,Fan Deng,Zeyu Wu,Wanyan Deng,Zengzhang Zheng,Rui Min,Shenglin Mei,He Kang,Huiqing Yu,Youdong Pan,Judy Lieberman,Jingxia Zhao,Xing Liu
Toll-like receptor 4 (TLR4), a pattern-recognition receptor located on the plasma membrane, senses extracellular danger signals to initiate inflammatory immune responses. It is initially synthesized in the endoplasmic reticulum (ER), undergoes N-linked glycosylation, and is subsequently transported to the Golgi before ultimately reaching the plasma membrane. However, the mechanisms underlying the processing and maturation of TLR4 in the ER remain elusive. Through whole genome-wide CRISPR screening, CCDC134 was identified as a critical and essential factor for TLR4-dependent inflammatory response. Localization of CCDC134 in the ER lumen rather than its exosome-mediated secretion is required for its role in TLR4 signaling. Loss of CCDC134 results in the retention of TLR4 in the ER for subsequent ER-associated degradation, and thus blockade of TLR4 maturation and plasma membrane trafficking. Defects in TLR4 processing and maturation in the ER in CCDC134-depleted cells are caused by aberrant hyperglycosylation and destabilization of glycoprotein 96 (gp96), a key chaperone of TLR4. These results suggest that CCDC134 controls gp96 glycosylation to facilitate TLR4 maturation in the ER.
研究领域:
免疫学
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细胞生物学
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分子生物学
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产品关联
DOI
PubMed
高影响因子
CURRENT APPLIED PHYSICS
·
2024
·
IF 2.4
Weiqiang Cai,Zijian Sun,Jiaying Xu,Jingyun Zou,Xiying Ma,Xiaoyu Zhang
Two-dimensional (2D) MoS 2 has attracted considerable attention for their significant potential application in high-frequency electronic devices. In this work, erbium doped MoS 2 (Er:MoS 2 ) film is prepared by chemical vapor deposition . The structures and binding energy are studied by X-ray photoelectron spectroscopy indicating the substitution of Er atoms into MoS 2 lattices. The complex permittivity of the film is measured by the microstrip line up to the frequency of 4 GHz. The high frequency permittivity ε′ of MoS 2 film is 4.11 and ε′ increases about 28% when the Er doping amount is 0.83 at% (atomic percentage). The permittivity of Er:MoS 2 film is higher than that of MoS 2 film, which is mainly due to the enhanced polarization of Er:MoS 2 film. The permittivity ε′ of Er:MoS 2 film increases with the increase of Er doping (0∼0.83 at%). It is believed that Er:MoS 2 film has great potential application in tunable electromagnetic devices.
研究领域:
材料科学
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电子工程
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DOI
高影响因子
ACS Applied Electronic Materials
·
2022
·
IF 4.494
Kai Feng,Bin Lu,Liangbin Hu
Cubic binary transparent (Er1–xYbx)2O3 (x = 0.005 and 0.01) ceramics with a high transmittance of ∼78.1% at 600 nm (∼95.6% of the theoretical transmittance of the Er2O3 single crystal) were successfully fabricated by vacuum sintering. Upon 980 nm laser pumping, the (Er1–xYbx)2O3 ceramics emit characteristic near-infrared downconversion radiation at 1450–1600 nm arising from the 4I13/2 → 4I15/2 transition of Er3+. The upconversion spectra of (Er,Yb)2O3 ceramics present typical red emission at 650–670 nm and green emission at 520–555 nm corresponding to 4F9/2 → 4I15/2 and 2H11/2/4S3/2 → 4I15/2 transitions of Er3+, respectively. A 0.5 at. % Yb3+ dopant dramatically improves the upconversion luminescence intensity by ∼13 times relative to the pure Er2O3 counterpart. The luminescence intensity gradually increases with the rising laser output power, and the upconversion mechanism ascribes to two-phonon processes. The fluorescence lifetimes of the (Er0.995Yb0.005)2O3 ceramic are determined to be ∼19.26 μs for the 540 nm green emission and ∼26.60 μs for the 668 nm red emission. The noncontact optical thermometric ability of the (Er0.995Yb0.005)2O3 ceramic in the temperature range of 298–473 K is assessed using the thermoresponsive fluorescence intensity ratio technique, and the maximum absolute sensitivity is ∼0.0045 K–1.
研究领域:
材料科学
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光学工程
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF ENERGY RESEARCH
·
2021
·Vol. 45
·期 10
·14870-14878
·
IF 5.164
Ruyue Bai,Pengpeng Chen,Shaohua Zeng,Yifeng Zhou,Wangyan Nie,Ying Xu
Summary A new method to improve the performance of Prussian blue sodium ion supercapacitors by polyaniline coating is presented. The conducting mechanism of polyaniline film facilitates small water molecules transforming between benzene structure and quinone structure of polyaniline, which minimizes lattice water content of NiCo–Prussian blue analogues materials. The polyaniline-coated NiCo–Prussian blue analogues are loaded on carbon sponge material to assemble flexible supercapacitors. The specific capacity of 118.2 F g −1 , energy density of 32 Wh kg −1 , and power density of 6.23 kW kg −1 are obtained on NiCoPBA@PANI-1@CS//AC device, which are much greater than those of NiCoPBA@CS//AC without polyaniline coating.
研究领域:
材料科学
·
电化学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF ENERGY RESEARCH
·
2021
·Vol. 45
·期 14
·19883-19894
·
IF 5.164
Shilin Luo,Zhitong Xu,Jian Liu,Baoliang Xu,Shiyin Ji,Yi Ding,Shengtai Zhang,Ling Zhang,Tao Duan,Jiehong Lei
Summary Yttrium iron garnet (YIG) is a potential matrix for immobilizing high-level radioactive waste (HLW) due to its high actinide solubility and chemical flexibility. In this study, Ce was employed as a surrogate of Pu. A series of Y 3- x Ce x Fe 5 O 12 (0 ≤ x ≤ 1) samples were prepared by solid-state sintering at 1400°C to investigate the solubility, microstructure, and chemical durability of Ce-doped YIG. The X-ray diffraction (XRD) and scanning electron microscopy (SEM) results showed that the solubility of the Ce in a single garnet was 32 mol% at synthesis temperature of 1400°C. The SEM analysis indicated the YIG ceramic grain growth and compactness as Ce concentrations increased. The XPS analysis indicated that the amount of Ce 4+ out of the total Ce increased as the CeO 2 doping increased, and the maximum value was more than 75.9% in the sample synthesis at 1400°C. Static leaching experiments were also conducted on the single Ce-doped garnet synthesized at 1400°C. The normalized LR Ce and LR Y release rates were approximately 10 −4 and 10 −5 g m −2 d −1 after 42 days, respectively. The chemical durability was comparable to other ceramic matrices (such as pyrochlore and zircon, among others). These results demonstrated that YIG ceramics are suitable for immobilizing HLW, such as Pu or U. Highlights The solubility of Ce in single-phase YIG was 32 mol% at 1400°C. Grain size and compactness increased Ce content. The concentration of Ce 4+ in total Ce of sample could be over 75.9%. The obtained YIG ceramics exhibit excellent chemical stability. Novelty Statement Y 3-x Ce x Fe 5 O 12 ceramics were prepared by solid-state sintering and the solubility, microstructure, and chemical durability were investigated. The solubility of Ce was 32 mol% at 1400°C. The obtained YIG ceramics exhibit excellent chemical stability.
研究领域:
材料科学
·
核废物管理
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DOI
高影响因子
INTERNATIONAL JOURNAL OF ENERGY RESEARCH
·
2019
·Vol. 44
·期 1
·448-459
·
IF 3.343
Nan Zhang,Yaoge Jing,Yanlin Song,Yanxia Du,Yanping Yuan
Summary Solid-solid phase change materials (SSPCMs) used in thermal energy storage (TES) system attract much attention in recent days. Here, graphene nanoplatelets (GnPs) were introduced into pentaglycerine (PG) with mass ratios of 1 wt%, 2 wt%, and 4 wt% to obtain PG/GnPs PCMs. The structure and thermal property of PG/GnPs PCMs were characterized by SEM, XPS, FT-IR, POM, DSC, thermal conductivity tester, and heat transfer performance test system. The effect of GnPs on the crystallization kinetic of PG was investigated by isoconversional method. The results indicated that PG and GnPs were uniformly mixed together by physical reaction. GnPs reduced the subcooling and enhanced the thermal conductivity of the PG/GnPs. The heat transfer rate of PG/GnPs was improved during to the high thermal conductivity. Crystallization kinetic results presented that the activation energy increases with the GnP content. In summary, GnPs improved the thermal behaviors of PG.
研究领域:
材料科学
·
能源存储
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）