Journal of the Taiwan Institute of Chemical Engineers
·
2017
·
IF 4.217
Long Huang,Weihua Luo,Meiying Liu,Jianwen Tian,Qiang Huang,Hongye Huang,Junfeng Hui,Yuanqing Wen,Xiaoyong Zhang,Yen Wei
The luminescent hydroxyapatite nanorods co-doped with Eu 3+ and F − (named as FAp:Eu 3+ ) were synthesized through liquid-solid-solution strategy to control their size and morphology as well as improve their fluorescence. However, these luminescent FAp:Eu 3+ nanorods are hydrophobic nature and cannot be directly used for biomedical applications. In this work, we developed a novel strategy for surface modification of FAp:Eu 3+ nanorods with the combination of the surface ligand exchange reaction and photo-initiated reversible addition-fragmentation chain transfer (photo-RAFT) polymerization using the biocompatible and hydrophilic poly(ethylene glycol) methacrylate (PEGMA) as the monomer. We demonstrated that the photo-RAFT polymerization is a facile and efficient route to fabricate hydrophilic FAp:Eu 3+ -polyPEGMA composites based on a series of characterization techniques. The FAp:Eu 3+ -polyPEGMA composites still well maintained the morphology and luminescent properties. Furthermore, the resultant FAp:Eu 3+ -polyPEGMA composites showed low cytotoxicity and desirable cell uptake behavior. These features suggested that the FAp:Eu 3+ -polyPEGMA composites are of great potential for biological imaging applications. More importantly, the photo-RAFT polymerization should be promising for preparation of many other luminescent nanocomposites owing to their advantages of photo-RAFT polymerization such as low polymerization temperature, high efficiency, absence of metal catalysts and good monomer applicability. It is therefore, the photo-RAFT could be extended for fabrication of many other multifunctional fluorescent composites for different biomedical applications.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED MATERIALS
·
2025
·
IF 26.8
Rubing Bai,Peihao Huo,Nanlong Zheng,Yujia Li,Wenchao Yan,Peiyu Fang,Xiaoyu Zhou,Zuqiang Bian,Zhiwei Liu
Light-emitting electrochemical cells (LECs) have good prospects in the solid-state lighting field due to their simple single-layer structure and low manufacturing cost. However, the lack of high-efficiency blue LECs limits their development and further application. To solve this problem, many luminescent materials with various mechanisms such as fluorescence, phosphorescence, and thermally-activated delayed fluorescence are studied as emitters in LECs. Besides these materials, herein lanthanide europium(II) (Eu(II)) complex with d-f transition is demonstrated as a new type of emitter for LECs. In detail, a blue emitting Eu(II) complex bis[hydrotris(3-tert-butylpyrazolyl)borate]europium(II) is dispersed into 9-(3-(triphenylsilyl)phenyl)-9H-3,9′-bicarbazole host and tetrahexylammonium tetrafluoroborate electrolyte to make a blend film, which attains a high photoluminescence quantum yield of ≈100%. The LEC using the blend film as an active layer achieves a blue emission with Commission Internationale de L'Eclairage coordinates of (0.12, 0.18) and a record-breaking external quantum efficiency of 19.8%, corresponding to an exciton utilization efficiency of ≈100%. This work reveals that Eu(II) complex with d-f transition is a promising emitter toward high-performance blue LECs, which can inspire further research on Eu(II) complex based LECs.
研究领域:
材料科学
·
光学
·
电子工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Discover Oncology
·
2025
·Vol. 16
·期 1
·1-13
·
IF 2.9
Huang Hai-yi,Lin Lisa Zong Yong,Lu Xin-yi,Jiang Ying
Triple negative breast cancer (TNBC) refers to a molecular subtype of breast cancers (BC) with high rate of distant metastases and poor prognosis. Epirubicin (EPI) is widely used for the therapy of TNBC but it’s limited in clinical use due to cardiotoxicity and chemotherapy resistance. We previously identified F-α-DDB-derivative, a novel synthetic of bifendate, as a potential agent to improve the therapeutic efficacy of TNBC in combination with EPI since F-α-DDB-derivative inhibited MDA-MB-468, but not as much as EPI. In this study, we investigated the antitumor activity of F-α-DDB-derivative in combination with EPI against TNBC in vitro and in vivo and whether co-treatment would induce additional cardiotoxicity. In human TNBC MDA-MB-468 cells, application of F-α-DDB-derivative (11.5, 23.0, 46.0 μg/ml) in combination with EPI (1.5, 3.0, 6.0 μg/ml) exhibited great inhibition on cell viability and cell proliferation. Additionally, F-α-DDB-derivative (5.75, 11.5, 23.0, 46.0 μg/ml) interacted with EPI (0.75, 1.5, 3.0, 6.0 μg/ml) synergistically to induce apoptosis in MDA-MB-468 cells. This suggests that F-α-DDB-derivative may be more sensitive to apoptotic pathways. Furthermore, we revealed that co-administration of EPI and F-α-DDB-derivative (ip, once every other day for 14 days) significantly increased the therapeutic efficacy of EPI (2.0 mg/kg) or F-α-DDB-derivative (20.0 mg/kg) in mice harboring MDA-MB-468 cell xenografts without additional cardiotoxicity compared to that in EPI monotherapy group. These results implicate that co-treatment of EPI and F-α-DDB-derivative may be a potential therapeutic approach for the treatment of TNBC.
研究领域:
肿瘤学
·
药理学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
·
2024
·
IF 3.1
Yanyang Wang,Shanshan Gao,Gege Yang,Wenyi Zhu,Ying Lu,Mengyuan Tan,Yuancheng Peng,Hua Yang,Chunxia Song
A portable platform for the visual determination of F− and Al3+ was developed by combining FeNPs@g-C3N4 nano-enzyme and a smartphone. The FeNPs@g-C3N4 nano-enzyme with excellent peroxidase activity was synthesized through the in situ growth of Fe nanoparticles (FeNPs) on graphite-phase carbon nitride nanosheets (g-C3N4), which could catalyze H2O2 to oxidize TMB to blue oxide (oxTMB). The peroxidase activity of the FeNPs@g-C3N4 nano-enzyme could be inhibited by F−, and then restored by Al3+ because of the coordination reaction between Fe3+/Al3+ and F−. Furthermore, the solution color could be dynamically manipulated by changing the concentrations of F− and Al3+. Under optimal conditions, the developed method gave low detection limits of 2.43 nM for F− and 7.66 μM for Al3+. The cooperation of nano-enzyme and smartphone has greatly shortened the detection time and reduced the cost of detection, providing a new strategy for the on-site and convenient detection of F− and Al3+ in tea, and showed significant application potential in food safety evaluation.
研究领域:
分析化学
·
食品安全
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2020
·
IF 3.99
Chao Feng,Shanshan Qiao,Yuan Guo,Yuehong Xie,Li Zhang,Naeem Akram,Shiang Li,Jide Wang
The development of a highly efficient renewable heterogeneous catalysts for the synthesis of cyclic carbonates by the cyclic esterification of epoxides and carbon dioxide under relatively mild reaction conditions is of great significance in the territory of chemical fixation of carbon dioxide (CO 2 ). This work comprises on a functional catalytic material F-Mn-MOF-74 using an effective competitive coordination strategy, adenine (Ad) as alkali source and competitive ligand, introduced onto the synthetic Mn-MOF-74. An F-Mn-MOF-74 crystal having a spherical structure and being functionalized is obtained, and lone pair of electrons on the nitrogen atom in the adenine can compete with 2,5-hydroxyterephthalic acid for coordination. The alkalinity exhibited by adenine is beneficial to enhance the catalytic properties of the crystal in the cycloaddition reaction of epoxide with carbon dioxide. Further catalytic experiments showed that the functionalized F-Mn-MOF-74 crystal combined with tetrabutylammonium bromide in the lacking of solvent showed excellent catalytic activity in the cycloaddition reaction of styrene oxide and carbon dioxide. Under the optimal reaction conditions after screening (100 °C and 10 bar CO 2 pressure), the yield of cyclic carbonate was as high as 99 %. The excellent catalytic performance for other epoxides also confirmed that F-Mn-MOF-74 catalytic material is universal in its application. The catalytic performance of the catalyst was not significantly decreased after being recycled seven times, attributed to its excellent stability. The possible mechanism for the synergistic effect of Lewis acid-base properties of functionalized F-Mn-MOF-74 catalytic material with cocatalyst is also proposed.
研究领域:
化学工程
·
催化材料
·
环境科学
✓ 已验证
DOI
高影响因子
CRYSTENGCOMM
·
2019
·Vol. 21
·期 34
·5059-5066
·
IF 3.382
Zenghui Yue,Huangjie Lu,Zijian Li,Shangyao Guo,Junze Song,Yiming Ren,Yu-Ying Huang,Jian Lin,Jian-Qiang Wang
The exploration of the family of f-element bearing single-molecule coordination polymers via solvothermal reactions yielded fourteen new rare-earth single-molecule complexes with three distinct phases, Ln(TPTZ)(NO3)3CH3CN (LnTPTZ-1, Ln = Pr and Nd), [Ln(TPTZ)(NO3)3(H2O)]·CH3CN (LnTPTZ-2, Ln = Pr–Er), and [Ln(TPTZ)(NO3)3(H2O)]·2CH3CN (LnTPTZ-3, Ln = Tm–Lu), as well as a uranyl coordination polymer UO2(TPTZ)(NO3)2 (UTPTZ). All of the structures exhibited zero-dimensional topologies due to the self-assembly of f-element cations with 2,4,6-tri-α-pyridyl-1,3,5-triazine (TPTZ), a tridentate semiaperture ligand featuring three ortho-N atoms on its pyridine and triazine rings. Due to the effect of lanthanide contraction, the structural evolution of the lanthanide complexes, including decrease in the unit cell dimensions and Ln–O/N bond lengths across the isomorphic structures, and more dramatically, transitions in the overall topology, was observed. In addition, a rather unusually bent OylUOyl unit with a highly distorted hexagonal bipyramid coordination environment was identified in UTPTZ. The homoleptic structures of EuTPTZ-2 and TbTPTZ-2 allowed the fine-tuning of the molar ratio Eu/Tb in a single EuxTb1−xTPTZ-2 complex, concomitantly giving rise to versatile photoluminescent colours in such materials. Explicitly, it exhibited multicolour photoluminescence ranging from green to red under the excitation of UV light, and an excellent linear relationship between chromacity coordinates and colour tunability could be obtained.
研究领域:
无机化学
·
材料化学
·
配位化学
·
光物理
·
稀土化学
✓ 已验证
DOI
高影响因子
Nature Communications
·
2023
·Vol. 14
·期 1
·1-14
·
IF 16.6
Liu Di,Song Yanling,Chen Hui,You Yuchan,Zhu Luwen,Zhang Jucong,Xu Xinyi,Hu Jiahao,Huang Xiajie,Wu Xiaochuan,Xu Xiaoling,Jiang Saiping,Du Yongzhong
Poor renal distribution of antibody-based drugs is the key factor contributing to low treatment efficiency for renal diseases and side effects. Here, we prepare F(ab′) 2 fragmented vascular endothelial growth factor receptor 2 antibody (anti-VEGFR2 (F(ab′) 2 ) to block VEGFR2 overactivation in diabetic nephropathy (DN). We find that the anti-VEGFR2 F(ab′) 2 has a higher accumulation in DN male mice kidneys than the intact VEGFR2 antibody, and simultaneously preserves the binding ability to VEGFR2. Furthermore, we develop an antibody fragment drug conjugate, anti-VEGFR2 F(ab′) 2 -SS31, comprising the anti-VEGFR2 F(ab′) 2 fragment linked to the mitochondria-targeted antioxidant peptide SS31. We find that introduction of SS31 potentiates the efficacy of anti-VEGFR2 F(ab′) 2 . These findings provide proof of concept for the premise that antibody fragment drug conjugate improves renal distribution and merits drug validation in renal disease therapy.
研究领域:
药理学
·
肾病学
·
糖尿病
✓ 已验证
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2018
·
IF 2.88
Yabo Shi,Min Liu,Hui Yan,Chang Cai,Qingying Guo,Wenxin Pei,Ruiyan Zhang,Zhengping Wang,Jun Han
The individual and combined interactions of bisphenol F and piceatannol with pepsin were investigated using spectroscopic methods (fluorescence, UV–vis absorption, and circular dichroism spectroscopy), combined with isothermal titration calorimetry and molecular docking. Thermodynamic data showed that hydrogen bonds and van der Waals forces might play a major role for the binding process. Site marking experiments and molecular docking confirmed the binding sites of these two ligands on pepsin. The discrepancy in the binding constant between the binary and ternary systems indicated the competitive binding of piceatannol and bisphenol F to pepsin. Circular dichroism spectra studies suggested that the binding of the two ligands led to a loosening of pepsin backbone. Enzyme activity assays indicated that the inhibition of pepsin activity by piceatannol and bisphenol F was competitive. These results will be helpful to understand the mechanism of piceatannol and bisphenol F affecting the activity of digestive proteases in the sight of the food security.
研究领域:
食品科学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Surfaces and Interfaces
·
2025
·
IF 6.3
Chuanjin Lin,Guoquan Suo,Jiarong Li,Rongrong Mu,Laraib Habib,Xiaojiang Hou,Shukai Ding,Jianfeng Zhu
Water-induced deterioration poses a significant threat to sandstone cultural heritage, necessitating effective protective measures. This research investigates a fluorine dual-modified nanocomposite coating composed of nanoplate-like TiO 2 and nanoparticle SiO 2 , utilizing 1H, 1H, 2H, 2H-perfluorodecyl triethoxysilane as the modifier. The study aims to optimize the modifier concentration for enhanced hydrophobicity , while also assessing the coating’s penetration depth and its effect on sandstone breathability. An optimal formulation, consisting of a TiO 2 -to-SiO 2 mass ratio of 75:25 combined with 80 µL of the perfluorodecyl triethoxysilane modifier, yielded exceptional water and oil contact angles of 150.1° and 139.3°, respectively. Even after 210 h of UV exposure, the coating exhibited remarkable stability, with only a minor decrease in contact angles. Furthermore, the treatment effectively preserved the air permeability of the sandstone. This F-modified nanoplate TiO 2 /nanoparticle SiO 2 composite coating demonstrates significant potential for the long-term protection of sandstone cultural relics against environmental weathering, offering a balance of high hydrophobicity and breathability.
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2021
·
IF 3.764
Zhicai Zhang,Heng Yuan,Fugang Qi,Nie Zhao,Biao Zhang,Xiaoping Ouyang
A high-performance BN@F-SiC filler was prepared by depositing hydrophobic nano-SiC grafted by γ-aminopropyltriethoxysilane (KH550) and 1H,1H,2H,2H-trifluoro-noctyltriethoxysilane (FAS) on h-BN grafted by glycidoxy-propyltrimethoxysilane (KH560). A coating containing 1 wt % composite was prepared by dispersing the composite material in epoxy resin (EP), and dispersion, wear resistance, corrosion resistance, electrochemical analysis, and other tests were performed. Also, the influence of h-BN and SiC quality ratios on these properties was systematically studied. The results showed that the BN@F-SiC (2:1) composite material had the best dispersibility in EP. The water contact angle for the coating reached 118°, which indicated that the coating is hydrophobic. The friction coefficient for the BN@F-SiC (2:1)/EP coating was reduced by 89.68% compared with that for the coating without any filler. The potential dynamic polarization test and the salt spray test showed that BN@F-SiC had excellent corrosion inhibition performance. In addition, an EIS test showed that the impedance value for the BN@F-SiC (2:1)/EP coating exceeded 1010 Ω·cm2 at a frequency of 10–2 Hz (|Z|0.01Hz) after 400 h of soaking, which is nearly 103 times higher than that obtained for the EP coating without a filler. This research helps establish a foundation for future research investigating the development of wear-resistant hydrophobic and anticorrosive coatings.
研究领域:
材料科学
·
表面工程
·
涂层技术
✓ 已验证
DOI
高影响因子
RARE METALS
·
2024
·Vol. 44
·期 3
·1577-1593
·
IF 9.6
Sun Gao-Xing,Zhu Bin,He Rui,Liang Qi-Dong,Jiang Sheng-Yu,Ren Yan,Pan Xiao-Xiao,Sun Yu-Qing,Lu Mi,Zhang Wen-Xian,Huang Cheng-Huan,Zhuang Shu-Xin
Although lithium-ion batteries are widely recognized as a new generation of energy storage devices, their large-scale application is severely hampered by their low energy density and restricted cyclic stability. Herein, an ingenious dual-modified interface, where the F-doping and fluorocarbon coating co-existed on Li[Ni 0.8 Co 0.1 Mn 0.1 ]O 2 surface, is rationally constructed to elevate its energy density and structural stability attributed to F − grafting between the bulk material and the coating utilizing a robust super-conformal fluorocarbon coating structural framework and more stable F-doped system under high charge/discharge cut-off voltage. In comparison with a single carbon-coated modified Li[Ni 0.8 Co 0.1 Mn 0.1 ]O 2 , the dual-modified sample overcomes the fatal disadvantage of carbon coating stripping during long-period cycles ascribed to the “TM-F-multifunctional coating” connector which firmly combines the bulk material with the coating with a strong interaction force, exhibiting a more stable-reversible structure and excellent comprehensive electrochemical performance under high cut-off voltage. Concomitantly, the F-transition metal bonds with stronger bond energies improve its structural reversibility during the processes of charge/discharge under high voltage. Furthermore, the fluorocarbon coating enhances its charge transfer ability and effectively restrains the interfacial side reactions. Additionally, the climbing nudged elastic band methodology is used to calculate the diffusion energy barrier of lithium-ions in the matrix material, which confirms the fundamental reason for its superior lithium-ion diffusion ability. The high pseudocapacitance contribution ratio is perfectly explained by calculating the adsorption capacity on the surface of the dual-modified sample. Consequently, experiments and theoretical calculations unequivocally confirm its distinguished electrochemical properties under high cut-off voltage. Graphical
研究领域:
材料科学
·
电化学
·
能源存储
·
锂离子电池
·
表面工程
·
固态化学
·
纳米材料
✓ 已验证
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2020
·
IF 6.182
Qi Wang,Baker Rhimi,Hui Wang,Chuanyi Wang
To solve the aggregation problem of TiO 2 nanomaterials and improve the catalytic efficiency, F-doped TiO 2 /exfoliated bentonite (TF/EB) composite was prepared by dispersing F-doped TiO 2 (TF) nanoparticles on an exfoliated bentonite (EB) using a facile sol–gel method. The exfoliated bentonite was prepared by liquid-exfoliation method from the natural bentonite (B). The prepared samples were applied for toluene degradation in gas phase under UV and visible light irradiation. The as-prepared TF/EB composite exhibited higher toluene degradation efficiency than that of pure TiO 2 , F-doped TiO 2 and TF/B composite. Results indicated that the calcination temperature and the initial F/Ti atom ratio of reaction precursors greatly affected the photocatalytic activity towards toluene degradation. The best photocatalytic performance was obtained by the sample calcinated at 400 °C with an initial F/Ti atom ratio of 5%. The improved photocatalytic performance is ascribed to a series of benefits introduced by F-doping and exfoliation process. The presence of F - ions increases the percentage of exposed reactive {0 0 1} facets on TiO 2 . Moreover, F - ions incorporated into the TiO 2 lattice generate oxygen vacancies and Ti 3+ defects, which influence the transfer and migration of the photoinduced charge carriers and induce a visible-light photocatalytic activity . Furthermore, the electrostatic interaction of negatively charged exfoliated bentonite surface leads to a more efficient separation of charge carriers.
研究领域:
环境科学
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）