JOURNAL OF APPLIED POLYMER SCIENCE
·
2023
·
IF 3
Yuhan Chen,Nian Yin,Yunfei Wang,Shanjun Gao,Chunhui Shen
A novel bio-based carbon forming agent (Mg@PA-CS) containing P and N elements was were synthesized using the complexation characteristics of chitosan (CS) and phytate (PA). The flame retardant behavior of poly(lactic acid) (PLA)/Mg@PA-CS/APP composites (addition of 20 wt% of different ratios of Mg@PA-CS and APP to polylactic acid composites) were investigated by the limiting oxygen index (LOI), vertical burning test (UL-94), cone calorimetry test (CCT), and thermogravimetric analysis (TGA). Due to the biphasic flame retardant and synergistic effect, since the 20 wt% flame retardant system (Mg@PA-CS:APP = 1:2), PLA composites passed the UL-94 test V-0 rating, reached 34% LOI value. The peak heat release rate (PHRR) and total heat release rate (THR) were reduced to 1/2 of the pure PLA, char residue could be as high as 11.49% at 800°C. Moreover, the flame-retardant mechanism of PLA composites during thermal decomposition was analyzed using a scanning electron microscope (SEM) and the coupling techniques of TGA linked with FT-IR (TG-FTIR).
研究领域:
材料科学
·
高分子科学
·
消防安全工程
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Shuai Chen,Liang Wang,Shuang Rong,Yuyuan Duan,Huizhu Wang
This study aimed to optimize the extraction process of polysaccharides from Rosa laevigata Michx. (RLMP) using an ultrasound-microwave-assisted method and investigate its in vitro hypoglycemic activity. Key factors affecting RLMP yield were identified using a Plackett–Burman design, followed by a Box–Behnken design and response–surface methodology, to determine the optimal extraction conditions. RLMP was purified using DEAE-52 cellulose, yielding two homogeneous fractions: RLMP-1 and RLMP-2. Monosaccharide composition was analyzed by gas chromatography, and structural characterization of RLMP, RLMP-1, and RLMP-2 was performed using FT-IR, SEM, and TEM. Methylation analysis and NMR were used to elucidate the sugar-chain structure of RLMP-1. In vitro hypoglycemic activity analysis showed that RLMP improved the glucose consumption and glycogen synthesis and enhanced the activities of pyruvate kinase and hexokinase in IR-HepG2 cells. Moreover, RLMP significantly increased the activities of antioxidant enzymes, such as CAT, SOD, and GSH-Px and decreased those of ROS and MDA. Western blotting analysis confirmed that RLMP enhances glucose and lipid metabolism and reduces oxidative stress by activating the PI3K/Akt/GLUT-4 signaling pathway, thereby exerting its hypoglycemic effect. These findings suggest that RLMP is a promising candidate for developing novel antioxidant agents or hypoglycemic drugs.
研究领域:
药理学
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生物化学
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分子生物学
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食品科学
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药物化学
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产品关联
DOI
PubMed
高影响因子
ELECTROCHIMICA ACTA
·
2019
·
IF 5.383
Jiangxue An,Li Li,Yaping Ding,Weijuan Hu,Dingding Duan,Huan Lu,Daixin Ye,Xiaoli Zhu,Hongxia Chen
A novel electrochemical sensor based on molecularly imprinted polymer (MIP) and iron metal-organic frameworks was fabricated for highly sensitive detection of melamine (MEL) in this work. MIL-53(Fe), a kind of iron metal-organic frameworks, was prepared by a simple solvothermal method . The molecularly imprinted polymer films with specific recognition sites were synthesized by electropolymerization using methacrylic acid (MAA) as functional monomers interacted with MEL as templates. MIL-53(Fe) was characterized by XRD and FT-IR. The morphology of the MIP modified electrode was characterized by scanning electron microscopy. Under the optimal conditions, the molecularly imprinted electrochemical sensor (MIECS) shows a wide linear range of 10 −11 M to 10 −6 M for MEL with a detection limit (3σ) as low as 8.21 × 10 −12 M. Moreover, the MIP sensor shows high selectivity for melamine, good reproducibility and stability. The MIECS has been applied to the real detection of melamine in liquid milk samples with satisfying results.
研究领域:
分析化学
·
材料科学
·
电化学
·
食品安全
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产品关联
DOI
高影响因子
CARBON
·
2015
·
IF 6.196
Hao Wu,Wenyuan Yi,Zhe Chen,Haitao Wang,Qiangguo Du
Janus graphene oxide (GO) nanosheets functionalized by amino-containing chemicals were prepared via Pickering emulsion template. A wax-in-water Pickering emulsion was used to mask one side of GO nanosheets in order to achieve asymmetric chemical functionalization. Janus particles were obtained by removing the oil phase. The successful reaction of epoxy groups on the surface of GO with amino-containing chemicals was confirmed by Fourier transform infrared spectroscopy (FT-IR) and thermal gravimetric analysis (TGA). The asymmetric surface structure of Janus GO nanosheets was detected by atomic force microscope (AFM) and X-ray diffraction (XRD). The efficient stabilization of an oil-in-water Pickering emulsion by Janus GO was proved. Polymer microspheres fabricated by using Janus GO as Pickering stabilizer had a more hydrophilic surface compared with those stabilized by symmetrically modified GO.
研究领域:
材料科学
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化学
·
纳米技术
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胶体科学
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产品关联
DOI
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2018
·Vol. 26
·期 1
·215-226
·
IF 2.8
Zhang Juan,Khan Muhammad Asim,Xia Mingzhu,Abdo Abdelnasir Mahmoud,Lei Wu,Liao Chuan,Wang Fengyun
A highly resourceful, eco-friendly, and recyclable magnetic adsorbent based on montmorillonite (CoFe 2 O 4 /MMT) was fabricated via a facile hydrothermal method to harvest tetracycline (TC) and ciprofloxacin (CIP) from pollutant water. The prepared adsorbent was characterized by XRD, FT-IR, SEM, and VSM methods to comprehend its structure, morphology, and magnetism. Effects of experimental parameters including solution pH, adsorption time, initial concentration, and ion strength were studied in details. The experimental adsorption data of TC and CIP fitted into pseudo-second-order kinetic model and Langmuir isotherm, respectively. The maximum adsorptions of TC and CIP could reach up to 240.91 and 224.00 mg/g. The thermodynamic study indicates that the adsorption process is spontaneous. In addition, the antibiotics can be further degraded under visible light environment and the magnetic sorbent can also be thermally regenerated.
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研究领域:
环境科学
·
材料科学
·
化学工程
·
分析化学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2021
·
IF 5.875
Jiuheng Ruan,Chao Liu,Haoyuan Song,Ting Zhong,Peng Quan,Liang Fang
At present, how the release kinetics of permeation enhancers affected their enhancement efficacy on drug skin absorption and its molecular mechanisms remained unclear. Herein, the release kinetics of permeation enhancer (Plurol Oleique CC (POCC)) which involved release percent ( PR ), release duration ( RD ) and release kinetic constant ( k ) and its enhancement efficacy on drug skin absorption were investigated with in vitro skin retention study and in vitro skin permeation study, respectively. POCC released from the acidic-drug loading patches followed with the Higuchi release model and had short RD (8–16 h), resulting in its unsustainable enhancement efficiency for acidic drugs. However, POCC released from the basic-drug loading patches followed with zero-order model with long RD (12–24 h), inducing a sustainable and efficient enhancement efficiency for basic drugs. The lower variance of an innovative parameter permeation enhancement coefficient ( C PE ) represented the relatively sustainable and effective enhancement effect and was listed as followed: 0.20 (Zaltoprofen (ZPF)), 0.31 (Diclofenac (DCF)), 0.27 (Indomethacin (IMC)), 0.07 (Azasetron (AST)), 0.11 (Oxybutynin (OBN)) and 0.06 (Donepezil (DNP)). According to the results of FT-IR, MTDSC , 13 C NMR spectra, molecular dynamics simulation, SAXS and Raman imaging, the Higuchi release model was caused by strong interaction between the acid drugs and pressure sensitive adhesive (PSA). This strong interaction induced faster diffusion speed of POCC from acidic-drug loading patches and make the swell degree of long periodicity phase (LPP) of stratum corneum (SC) lipids reached plateau early. The zero-order release model was because the weak interaction between basic drugs and PSA making most of POCC was still bound to PSA, which in turn lead to LPP swelled at a slow but sustainable process. In conclusion, zero-order release kinetic of POCC lead to sustainable and efficient penetration enhancement efficiency on basic drug, while the Higuchi release kinetic showed opposite effect for acidic drugs. A deep understanding of release kinetics of enhancer and its enhancement efficiency may drive the ideal selection of permeation enhancers and rational optimization of transdermal patches .
研究领域:
药剂学
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药物递送系统
·
药物化学
·
生物物理学
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产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2022
·
IF 9.231
Bei Wang,Bin Huang,Bing Yang,Liang Ye,Jingqi Zeng,Zhiwei Xiong,Yaping Chen,Shuchen Guo,Yanjun Yang,Weikun Ma,Maomao Zhu,Xiaobin Jia,Liang Feng
Ophiopogonis Radix polysaccharides with various bioactivities have caught people's attention in the pharmaceutical and functional food industries. It is necessary to reveal their structures, chain conformations, and solvent behaviors. A neutral polysaccharide named ORP-1 with molecular weight of 3667 Da was obtained from Ophiopogonis Radix. It was composed of d -fructofuranose and d -glucopyranose in the ratio of 0.85:0.15. Methylation, FT-IR and NMR analysis indicated ORP-1 consisted of 2,6-linked-Fru f units as the main chain and 1-linked-Glc p residue at the end. Congo red assay showed ORP-1 had no triple-helix structure. The observation of TEM and AFM found ORP-1 could self-assemble to form colloidal aggregate in water. This phenomenon was verified using CMC determination and MD simulation. Furthermore, intermolecular hydrogen bonds and hydrophobic interactions would be the main forces driving the aggregate. These results provided reference for the study of the chain conformation and behavior of polysaccharides in aqueous solution.
研究领域:
药学
·
食品科学
·
生物物理学
·
分析化学
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产品关联
DOI
PubMed
高影响因子
CHEMOSPHERE
·
2023
·
IF 8.8
Xiangchu Zeng,Guanghua Zhang,Jia Wen,Xiuling Li,Junfeng Zhu,Zhe Wu
Heavy metals and azo dyes caused huge harm to the aqueous system and human health. A magnetic chitosan/polyethyleneimine embedded hydrophobic sodium alginate composite ( MCPS ) was designed and prepared to simultaneously remove aqueous same ionic type heavy metals and azo dyes. In mono-polluted system, the optimal pH for Cr(VI), MO (methyl orange), Cu(Ⅱ) and MB (methylene blue) were 3, 2, 6 and 12 with a saturated adsorption capacity of 87.53, 66.41, 351.03 and 286.54 mg/g, respectively. Pseudo-second-order was suitable to describe the adsorption kinetics of them and the adsorption isotherms were more consistent with the Langmuir isotherm model being a spontaneous, endothermic, and entropy-increasing process. In binary-polluted system, MCPS possessed simultaneous adsorption for Cr (Ⅵ)-MO and Cu(Ⅱ)-MB pollutants at their optimal pH, in addition, whether in anionic or cationic solution, the removal of heavy metals were promoted with the add of azo dyes but the removal of azo dyes were suppressed with the add of heavy metals. Both Cr (Ⅵ)-MO and Cu(Ⅱ)-MB pollutants could be effectively adsorbed and desorbed from MCPS by changing the pH of the aqueous solution to realize recyclability . Lastly, removal mechanism was revealed in detail by FT-IR, EDS and XPS .
研究领域:
环境科学
·
化学工程
·
材料科学
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2023
·
IF 5.8
Bingbing Zhu,Erna Jia,Qimeng Zhang,Yanyan Zhang,Hua Zhou,Ying Tan,Zhennan Deng
Zwitterionic polymers have attracted considerable attention because of their anti-adsorption and unique anti-polyelectrolyte effects and was widely used in surface modification. In this study, zwitterionic copolymers (poly (sulfobetaine methacrylate-co-butyl acrylate) (pSB) coating on the surface of a hydroxylated titanium sheet using surface-initiated atom transfer radical polymerization (SI-ATRP) was successfully constructed. X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FT-IR) and Water contact angle (WCA) analysis proved the successful preparation of the coating. The swelling effect caused by the anti-polyelectrolyte effect was reflected in the simulation experiment in vitro, and this coating can promote the proliferation and osteogenesis of MC3T3-E1. Therefore, this study provides a new strategy for designing multifunctional biomaterials for implant surface modifications.
研究领域:
生物材料
·
表面化学
·
生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2019
·
IF 3.131
Yankun Xie,Weiqu Liu,Liyan Liang,Chunhua Liu,Sha He,Fengyuan Zhang,Hongyi Shi,Maiping Yang
In this study, in order to improve the hydrophobicity and corrosion protection of epoxy coatings, a fluorinated polyacrylate polymer containing epoxy groups (PFEMA) was designed and used to modify epoxy resin . FT-IR, 1 H-NMR and GPC were employed to characterize the structure of PFEMA polymer. Contact angle (CA), X-ray photoelectron spectrum (XPS), scanning electron microscope , Tafel curves, electrochemical impedance spectroscopy (EIS) and salt spray test were carried out to investigate the performance of fluorinated polyacrylate modified epoxy coatings. The incorporation of PFEMA polymer changes the hydrophilic nature of epoxy resin to hydrophobicity, and the CA shifts from 67° to 98° with the content of fluorinated polyacrylate increases from 0 to 10 wt%. EIS measurements show that the impedance modulus value of fluorinated epoxy coatings is higher compared to pure epoxy resin. Additionally, the corrosion rate also decreases and its value shifts from 4.223×10 −8 mm/year to the lowest value of 9.696×10 -9 mm/year with the increasing of fluorinated polyacrylate in epoxy resin, demonstrating that the corrosion resistance of epoxy coatings has been significantly strengthened after introduction of fluorinated polyacrylate.
研究领域:
材料科学
·
腐蚀科学
·
表面化学
·
高分子科学
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产品关联
DOI
高影响因子
POLYMER BULLETIN
·
2022
·Vol. 80
·期 1
·725-738
·
IF 2.843
Zhang Huadong,Yan Zhongyi,Yang Zhizhou,Mu Qiuhong,Peng Dan,Zhao Hui
Two low melting point phthalonitrile monomers (EPN and EEPN) containing flexible glycidyl groups were synthesized using hydroxyl-containing phthalonitrile and epichlorohydrin as raw materials. The structures of the synthesized monomers were characterized by Fourier transform infrared (FT-IR), nuclear magnetic resonance ( 1 H-NMR and 13 C-NMR) spectra and elemental analysis. Then each of them was blended with 4-(4-aminophenoxy)-phthalonitrile (APPN) and cured to obtain two kinds of amine-catalytic phthalonitrile-based crosslinked polymers. DSC results showed that two blending systems underwent a two-stage polymerization process with the increase of curing temperature. Rheological measurements exhibited that the introduction of glycidyl groups to phthalonitrile resin could greatly improve its processability. Moreover, after thermal cured at 300 ℃, the resulting phthalonitrile resins exhibited excellent mechanical performance, thermal and thermo-oxidative stability.
研究领域:
材料科学
·
高分子化学
·
热能工程
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产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2023
·
IF 4.2
Weizhen Zhang,Zhilong Yang,Yuan Li,Qi Zhang,Shijun Zhang,Liqun Zhang
Epoxidized silicone rubber with an epoxy content of 5% (ESR-5) was introduced to improve the compatibility of the polyamide 6 (PA6)/poly(dimethylsiloxane) (PDMS) composite. The effects of the ESR-5 on the molecular structure, interfacial morphology, and toughness and thermal properties of the PA6/PDMS composite were investigated using nuclear magnetic resonance (NMR) spectroscopy, Fourier transform infrared (FT-IR) spectroscopy, differential scanning calorimetry (DSC), scanning electron microscopy (SEM), atomic force microscopy (AFM), and dynamic thermomechanical analysis (DMA). The FT-IR spectra and torque rheological testing confirmed the reaction between the epoxy group of ESR-5 and the carboxyl group at the end of PA6. The AFM and SEM images confirmed that the ESR-5 altered the interfacial thickness and remarkably decreased the average size of the dispersed rubber particles, which enhanced the interfacial compatibility. At a rubber content of 20% by weight in PA6/PDMS composites, the optimum impact strength at −60 °C, which is 469% higher than pure PA6, was obtained with an ESR-5 content of 50% in rubber phase.
研究领域:
材料科学
·
高分子科学
·
复合材料
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）