SEPARATION AND PURIFICATION TECHNOLOGY
·
2020
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IF 5.774
Xixian Huang,Nengwu Zhu,Fulin Mao,Yang Ding,Sihai Zhang,Fei Li,Huangrui Liu,Pingxiao Wu
Tailoring economical g-C 3 N 4 -based composites with efficient visible-light photocatalytic degradation ability have received great attention. In this study, a novel and efficient visible-light photocatalyst, Au nanoparticles doped porous carbon modified g-C 3 N 4 (Au@C/g-C 3 N 4 ), was synthesized using thermal polycondensation method. The crystal, morphological and photoelectrical characterizations verified the successful synthesis of Au@C/g-C 3 N 4 hybrid and it had larger specific area and narrower band gap than that of pure g-C 3 N 4 . The optimal Rhodamine B (RhB) photocatalytic oxidation performance (94.3%) and mineralization rate (50.7%) were obtained by Au@C/g-C 3 N 4 -2 composite at 1.0 g L −1 catalyst dosage and pH of 5.0, which was 3.23 and 2.96 times, respectively than that of g-C 3 N 4 at the same conditions. Au@C/g-C 3 N 4 -2 also maintained satisfactory RhB degradation efficiency (70.7%) after 4 consecutive photocatalytic cycles. Mechanism analyses indicated that the significantly improved photocatalytic activity of Au@C/g-C 3 N 4 composite mainly attributed to the rapid separation and migration of charge carriers via the interfacial interaction between the Au@C and g-C 3 N 4 , which resulted in the accelerated O 2 − generation for organic pollutants oxidation. In general, this study supplied a novel strategy for efficient g-C 3 N 4 visible-light photocatalysts construction, and further clarified its plausible visible-light photocatalytic mechanism.
研究领域:
环境科学
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材料科学
✓ 已验证
DOI
高影响因子
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2024
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IF 6
Yuxin Feng,Xuan Xuan,Yuemiao Hu,Jiaguo Lu,Zhiwen Dong,Ziqiang Sun,Hongying Yao,Lei Hu,Qikun Yin,Yi Liu,Hongbo Wang
Murine double minute 2 (MDM2) and homologous protein murine double minute X (MDMX) are p53 negative regulators that perform significant driving effects in tumorigenesis, and targeting these oncoproteins has became an efficient strategy in treating cancers. However, the definite antitumor activity and significance ordering of each protein in MDM family is still unclear due to the similar structure and complicated regulation. Herein, we identified two G-rich sequences ( G 1 and G 5 ) located in the promoter that could assemble the G-quadruplex to respectively inhibit and promote the transcription of the MDM2 and MDMX. Based on this target, we designed and synthesized a novel G-quadruplex ligand A3f and achieved the differentiated regulation of MDM protein. In triple-negative breast cancer (TNBC) cells, A3f could induce MDM2-dependent proliferation arrest and exhibit additive therapeutic effect with MDMX inhibitors. Overall, this study provided a novel strategy to regulate the transcription of MDM genes by targeting certain G-rich sequences, and discovered an active antitumor molecule for use in TNBC treatment.
研究领域:
肿瘤学
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分子生物学
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癌症治疗
✓ 已验证
DOI
PubMed
高影响因子
NANOTECHNOLOGY
·
2024
·Vol. 35
·期 19
·195605
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IF 2.9
Shuo Wang,Haotian Yin,Lei Wang,Jing Ding,Jinfeng Zhang,Hui Wan,Guofeng Guan
Photocatalytic reduction of carbon dioxide is a technology that effectively utilizes CO2 and solar energy. Sodium niobate (NaNbO3) has received much attention in the field of photocatalysis due to its excellent photocatalytic properties. However, the application of NaNbO3 in the field of photocatalysis is still limited by poor reaction to visible light and easy recombination of photo-generated carriers. Heterojunction with g-C3N4 to construct core–shell structure can effectively improve the above problems. Combining the two can design a core–shell composite material that is beneficial for photocatalytic reduction of CO2. Herein, we prepared a core–shell heterojunction g-C3N4/NaNbO3 by uniformly impregnating urea on the surface of NaNbO3 chromium nanofibers with NaNbO3 nanofibers prepared by electrospinning as a catalyst carrier, and urea as a precursor of g-C3N4. The core–shell structure of g-C3N4/NaNbO3 was verified by a series of characterization methods such as XPS, XRD, and TEM. It was found that under the same conditions, the methanol yield of core–shell g-C3N4/NaNbO3 was 12.86 μmol·g−1·h−1, which is twice that of pure NaNbO3 (6.67 μmol·g−1·h−1). This article highlights an impregnation method to build core–shell structures for improved photocatalytic reduction of CO2.
研究领域:
材料科学
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环境科学
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化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
·
IF 9.4
Xiaosong Zhou,Xiaoxing Yu,Lanzhen Peng,Jin Luo,Xiaomei Ning,Xuliang Fan,Xunfu Zhou,Xiaoqin Zhou
The photocatalytic H 2 production activity of polymer carbon nitride (g-C 3 N 4 ) is limited by the rapid recombination of photoelectron-hole pairs and slow surface reduction dynamic process. Here, a supramolecular complex (named R-TAP-Pd(II)) was fabricated via self-assembly of (R)-N-(1-phenylethyl)-4-(4-(pyridin-2-yl)-1H-1,2,3-triazol-1-yl)benzamide (R-TAP) with Pd(II) and used to modify g-C 3 N 4 . In the R-TAP-Pd(II)@g-C 3 N 4 composite photocatalyst, the spin polarization of R-TAP-Pd(II) can promote charge transfer and inhibit photogenerated carrier recombination, as confirmed by spectral tests and photoelectrochemical performance tests. Electrochemical tests and in situ X-ray photoelectron spectroscopy (XPS) tests proved that the Pd(II) ion in the R-TAP-Pd(II) molecule can serve as active sites to accelerate H 2 production. The R-TAP-Pd(II)@g-C 3 N 4 presented a photocatalytic H 2 generation rate of 1085 μmol g −1 h −1 when exposed to visible light, which was a about 278-fold increase compared with g-C 3 N 4 . This work finds a new approach to boost the photocatalytic efficiency of g-C 3 N 4 via supramolecular self-assembly.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
·
IF 8.5
Zhiqiang Guo,Mengdie Tian,Min Zhou,Zhuoer Li,Meijun Li
In this study, the formation of the immunoglobulin G-glabridin (IgG-GB) complex and nanocomplex was analyzed by assessing the structure, stability, solubility, and anticancer effects against the human epithelial ovarian cancer cell line SKOV3. The hydrodynamic sizes of the prepared IgG-GB nanocomplex were 190.1 ± 25.68 nm (PDI: 0.19 ± 0.02), and the solubility levels of GB in the free and nanoformulated forms were 97.28 μg/mL and 368.95 ± 59.63 μg/mL, respectively. Additionally, the IgG-GB nanocomplex exhibited a slower and more sustained release of GB in a pH-sensitive manner. Spectroscopic measurements indicated logKb values of 4.01 and 4.66 for the IgG-GB complex and the IgG-GB nanocomplex, respectively. Furthermore, the main reaction type between IgG and GB was found to be hydrophobic forces, which led to the partial folding of IgG and nanoformulated IgG. Cellular assays demonstrated that the IC50 concentrations of GB, the IgG-GB complex, and the IgG-GB nanocomplex in ovarian cancer SKOV3 cells were 10.74, 10.05, and 6.39 μM, respectively, while these amounts were > 77.84 μM in normal epithelial FHC cells. Moreover, the IgG-GB nanocomplex resulted in increased membrane leakage, mitochondrial dysfunction, and upregulation of Bax/Bcl-2 and caspase-3, along with caspase-3 activity determined by LDH, MP, real-time PCR, and enzyme activity assays. In conclusion, an efficient IgG-GB nanocomplex was potentially prepared and developed as a selective anticancer system against ovarian cancer cells.
研究领域:
药理学
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肿瘤学
·
生物化学
✓ 已验证
DOI
PubMed
高影响因子
Materials Today Chemistry
·
2024
·
IF 6.7
Junyu Chen,Yanqin Ma,Xinjian Cheng,Yufan Wu,Huizhi Chen,Cheng Liu
Natural polymer chitosan has many advantages, but the poor solubility limits its application. In this study, chitosan derivatives soluble in DCM, DMF, DMSO, H 2 O and other solvents were developed by introducing side chains into chitosan (CS). In addition, the fluorescent group on the side chain makes the chitosan derivative have the ability to detect 4-nitrophenol (4-NP). Firstly, a chain transfer agent containing C C (N3-NS) was synthesized with naphthalimide as the fluorescence unit. Then, using AIBN as initiator, an extensively soluble polymer with fluorescent moiety TP-NVP was synthesized by reversible addition-fragmentation chain transfer polymerization (RAFT) method using monomer N -vinyl pyrrolidone (NVP). Finally, the C C of TP-NVP was used to react with –NH 2 on CS to prepare PVP-g-chitosan, so that more CS was “pulled” by TP-NVP into the solvent. The solubility of the synthesized CS-PVP probe can be adjusted by adjusting the amount of NVP, up to 17.6 mg/mL. At the same time, the synthesized CS-PVP had a good detection effect on 4-NP, and the detection limit (LOD) was 0.054 μM. The HOMO-LUMO energy level of the probe was calculated by cyclic voltammetry (CV). In addition, CS-PVP was successfully loaded on a low background fluorescent test paper to achieve real-time visual intelligent determination of 4-NP in real samples with the help of a color scanning APP of a smartphone.
研究领域:
材料科学
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分析化学
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生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Surfaces and Interfaces
·
2025
·
IF 6.3
Jing Fan,Liang Guo,Fenhong Song
This study employed the hydrothermal method to dope Mn into Sn 3 O 4 , which was then combined with g-C 3 N 4 through calcination to prepare an II-type Mn-Sn 3 O 4 -x/CN composite photocatalyst. The impact of Mn-Sn 3 O 4 loading on the photocatalytic performance was discussed. The synthesized composite catalysts exhibited remarkable hydrogen production performance under visible light, with Mn-Sn 3 O 4 -10/CN demonstrating the highest performance. Characterization techniques confirmed the successful preparation of the catalysts, and the light absorption capacity, charge separation and transport efficiency of Mn-Sn 3 O 4 -10/CN are significantly improved compared to catalysts with other ratios. This study developed a Mn-Sn 3 O 4 -x/CN composite catalyst with high stability and good hydrogen production rate. It provides further directions for the research of g-C 3 N 4 -based composite catalysts.
研究领域:
材料科学
·
能源科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2020
·
IF 6.155
Miao-Miao Fang,Jun-Xia Shao,Xiang-Gang Huang,Jin-Yi Wang,Wei Chen
A direct Z-scheme CdFe 2 O 4 /g-C 3 N 4 hybrid systems with different weight ratios of CdFe 2 O 4 nanoparticles were successfully designed and constructed for ceftiofur sodium photodegradation. The as-obtained CdFe 2 O 4 /g-C 3 N 4 hybrid samples composed of CdFe 2 O 4 nanoparticles and g-C 3 N 4 nanosheets were systematically characterized by different techniques including X-ray diffraction, scanning electron microscope, transmission electron microscope, Fourier transform infrared spectroscopy , X-ray photoelectron spectroscopy, UV–vis DRS , chemical oxygen demand, inductively coupled plasma mass spectrometer, photochemical test and electron spin resonance spectrometer technique. The optimal photocatalytic activity for ceftiofur sodium photodegradation was achieved by modulating the weight ration between CdFe 2 O 4 nanoparticles and g-C 3 N 4 nanosheets. The result from photocatalytic tests indicate that CdFe 2 O 4 /g-C 3 N 4 -2 hybrid sample exhibit highly efficient photocatalytic activity towards ceftiofur sodium removal in comparison with pristine CdFe 2 O 4 nanoparticles and pure g-C 3 N 4 nanosheets. Meanwhile the excellent photocatalytic stability of CdFe 2 O 4 /g-C 3 N 4 -2 hybrid sample was also verified during recycling runs towards photocatalytic ceftiofur sodium degradation. The significant enhancement of photocatalytic activity was attributed to the Z-scheme charge separation and transfer based on the construction of tight heterogeneous interface and well-matched band potentials. We expect this research to provide a new insight into the design and preparation of direct Z-scheme hybrid photocatalysts for environmental remediation.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2020
·
IF 6.182
Jianmei Pan,Wei Shen,Yahai Zhang,Hua Tang,Haoyu Sun,Wenqiang Zhong,Xuehua Yan
Photocatalytic water splitting to product hydrogen (H 2 ) is a desired route to utilize solar energy into chemical energy. At present, most photocatalysts for H 2 generation contains metallic elements with high-cost, confined reserves, and environmentally unfriendly. The exploitation of metal-free and efficient photocatalysts becomes particularly important. Herein, a new metal-free g-C 3 N 4 -based heterojunction composites were facilely produced via the ultrasonic assisted deposition and subsequent calcination from g-C 3 N 4 layers embedded with SiOC with prominent conductivity and large surface area. Systematic investigates suggested that the SiOC/g-C 3 N 4 heterojunctions exhibited eminently meliorated photocatalytic H 2 production efficiency. The optimum H 2 production rate (1020 μmol h −1 g −1 ) of the SiOC/g-C 3 N 4 photocatalyst is 3.2 and 25.5 folds that of g-C 3 N 4 and SiOC , respectively. The boosted photocatalytic activity primarily originates from the increased absorptivity of light, the markedly expedited charge migration and the impeded recombination of charge carriers. This study offers a new perspective for the scientific contrive and fabrication of high-quality heterojunction photocatalysts for solar energy utilization.
研究领域:
材料科学
·
能源科学
✓ 已验证
DOI
高影响因子
Journal of Physical Chemistry C
·
2019
·
IF 4.309
Yongke Zhang,Zhiliang Jin
g-C3N4@ZIF-67 composite photocatalyst-supported NiSx are successfully prepared by a hydrothermal method using g-C3N4 and ZIF-67 as carriers. The synthesized composite catalyst has an efficient photocatalytic H2 production effect. Under visible light irradiation, the maximum H2 production within 5 h over the [g-C3N4@ZIF-67/(10%wt)NiSx] photocatalyst is 208 μmol, which is 8.32 times higher than that of pure g-C3N4. Based on the analysis of scanning electron microscopy and transmission electron microscopy, it is not only known that g-C3N4 and ZIF-67 provide space for the loading of NiSx nanoparticles but also that ZIF-67 as a carrier framework can effectively reduce the particle size of NiSx nanoparticles and increase the dispersion of NiSx. Further studies of photoluminescence (PL), time-resolved PL, i–t, linear scanning voltammetry, electrochemical impedance spectroscopy, and Mott–Schottky curves, we can not only know that the modification of NiSx nanoparticles do enhance the electron transfer ability but also that the matched conduction band position between g-C3N4 and ZIF-67 provides a feasible thermodynamic path for the transmission of electrons. Based on the DFT calculations, both NiS2 and Ni3S4 show the metallic characteristics, which means the outstanding electrical conductivity of them and implies the excellent capability to transport electrons. The work function of NiSx with metallic properties is more negative than that of the semiconductor, which indicates that the loading of NiSx can further promote the separation of electrons, thereby improving the H2 production efficiency.
研究领域:
材料科学
·
能源化学
·
催化科学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2019
·
IF 4.784
Lili Wang,Xun Zhang,Jin Xu,Qiang Wang,Xuerong Fan
The effect of starch-g-poly(acrylamide) (S-g-PAM) molecular structure on sizing properties has been investigated. S-g-PAMs were synthesized with the catalysis of horseradish peroxidase (HRP) and Fourier transform infrared (FT-IR) confirmed the acrylamide (AM) units had been successfully grafted on starch chains. Structural parameters, including degree of branching (DB), degree of substitution (DS) and grafting ratio (GR) were characterized by 1 H nuclear magnetic resonance ( 1 H NMR), and were correlated with sizing properties of apparent viscosity, adhesion to cotton yarns and film mechanical properties. The apparent viscosity of S-g-PAMs has no obvious correlation with DB and DS (or GR), as the amylose content of the native starch might have more influence on the viscosity of grafted starches. DS (or GR) values of grafted starches have a positive relationship with the tensile strength of sized cotton yarns and are negatively related with tensile strength of starch film. These results can provide guidance in the section of starch with improved sizing properties.
研究领域:
高分子化学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMOSPHERE
·
2018
·
IF 4.427
Xueming Lin,Yongwen Ma,Jinquan Wan,Yan Wang,Yongtao Li
In this study, FeMoO 4 was applied to activate persulfate (PS, S 2 O 8 2− ) for azo dye Orange G (OG) degradation. The catalyst was characterized by X-ray diffraction (XRD), scanning electron microscope (SEM), transmission electron microscope (TEM), X-ray photoelectron spectroscopy (XPS) and nitrogen adsorption-desorption isotherms. FeMoO 4 showed excellent efficiency in activating PS for OG removal. More than 95% could be removed after 40 min under reaction conditions of 4 mM PS, 0.3 g L −1 FeMoO 4 and 0.2 mM OG. The effect of different parameters (PS doses, FeMoO 4 doses and pH) were evaluated. The results showed that acid condition provided higher efficiency and overdosing FeMoO 4 and PS presented a scavenging effect. Major intermediates were identified and possible degradation pathway was proposed. Recycle tests presented that FeMoO 4 had excellent recyclable stability in activating PS for OG removal. Sulfate radicals and hydroxyl radicals all occurred in the oxidation reactions and the former came first. The oxidation reaction was involved in the translation of Fe 2+ /Fe 3+ occurred on the surface layer. This study revealed that the FeMoO 4 /PS system is a very promising method for degrading organic contaminants in the environment.
研究领域:
环境科学
·
催化化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）