Scientific Reports
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2017
·Vol. 7
·期 1
·1-9
·
IF 4.259
Hua Yongquan,Pu Guojuan,Ou Caiwen,Zhang Xiaoli,Wang Ling,Sun Jiangtao,Yang Zhimou,Chen Minsheng
Here we report a supramolecular hydrogel based on Gd(III)-peptide complexes with dramatically enhanced magnetic resonance (MR) performance. The hydrogelations were formed by adding Gd(III) ion to the nanofiber dispersion of self-assembling peptides naphthalene-Gly-Phe-Phe-Tyr-Gly-Arg-Gly-Asp (Nap-GFFYGRGD) or naphthalene-Gly-Phe-Phe-Tyr-Gly-Arg-Gly-Glu (Nap-GFFYGRGE). We further showed that, by adjusting the molar ratio between Gd(III) and the corresponding peptide, the mechanical property of resulting gels could be fine-tuned. The longitudinal relaxivity (r 1 ) of the Nap-GFFYGRGE-Gd(III) was 58.9 mM −1 S −1 , which to our knowledge is the highest value for such peptide-Gd(III) complexes so far. Such an enhancement of r 1 value could be applied for enzyme detection in aqueous solutions and cell lysates.
研究领域:
生物材料学
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医学影像学
·
生物化学
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DOI
高影响因子
CERAMICS INTERNATIONAL
·
2021
·
IF 4.527
Chunling Yang,Qianhong Ren,Xiaomei Liu,Yi Liu,Botao Zhang,Ping Zhou,Hua Li
Artificial bone fillers are essentially required for repairing bone defects, and developing the fillers with synergistic biocompatibility and anti-bacterial activity persists as one of the critical challenges. In this work, a new agarose/gadolinium-doped hydroxyapatite filler with three-dimensional porous structures was fabricated. For the composite filler, agarose provides three-dimensional skeleton and endows porosity, workability, and high specific surface area, hydroxyapatite (HA) offers the biocompatibility, and the rare earth element gadolinium (Gd) acts as the antibacterial agent. X-ray photoelectron spectroscopy detection showed the doping of Gd in HA lattice with the formation of Gd-HA interstitial solid solution. Attenuated total reflection Fourier transform infrared spectroscopy imaging suggested chemical interactions between agarose and Gd-HA, and the physical structure of agarose was tuned by the Gd-doped HA. Cytotoxicity testing and alizarin red staining experiments using mouse pro-osteoblasts (MC3T3-E1) revealed remarkable bioactivity and osteogenic properties of the composite fillers, and proliferation and growth rates of the cells increased in proportion to Gd content in the composites. Antibacterial testing using the gram-positive bacteria S. aureus and the gram-negative bacteria E. coli indicated promising antibacterial properties of the fillers. Meanwhile, the antibacterial properties of composite filles were enhanced with the increase of Gd content. The antibacterial fillers with porous structure and excellent physicomechanical properties show inspiring potential for bone defect repair.
研究领域:
生物材料
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组织工程
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生物医学工程
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DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
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2015
·Vol. 39
·期 11
·8999-9005
·
IF 3.086
Yingda Du,Ming Xing,Zhiman Li,Wei Guo
Along with the rapid development of modern medicine, the creation and evaluation of nanoparticulate contrast agents have attracted considerable attention of scientists worldwide. Herein, we designed and synthesized a metabolizable nano-sized contrast agent based on rod-like PEGylated gadolinium hydroxide (defined as PEG-Gd(OH)3) via a facile and economic route. Due to the high amount of gadolinium in these nanorods, these well-prepared PEG-Gd(OH)3 could provide more enhanced contrast than clinical iodine-based agents under the usual voltages in computed tomography (CT) imaging. Different from other small molecule-based contrast agents, our PEG-Gd(OH)3 exhibited an obvious liver-targeted property based on our in vivo experiments, indicating their expected usage in the detection of hepatic metastases. Long-term toxicity and possible metabolic pathway demonstrated that these nanorods exhibit overall safety and could not cause gadolinium-associated nephrogenic systemic fibrosis (NSF). With its high biocompatibility and superior contrast efficacy, PEG-Gd(OH)3 could bring more opportunities to a new generation of nanoparticulate CT contrast agents in biomedicine.
研究领域:
医学影像学
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纳米医学
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生物材料学
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产品关联
DOI
高影响因子
JOURNAL OF LUMINESCENCE
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2017
·
IF 2.686
Huimin Zhao,Lixin Zang,Qinyu Liu,Bingjie Ma,Meng Kou,Jinhua Lv,Chengshan Guo
The enhancement of the room-temperature phosphorescence (RTP) emissions of phosphorescent metalloporphyrins is critical toward extending their applications in many fields. Imidazole is widely used as a molten solvent in the synthesis of metalloporphyrins and can influence their RTP emissions. Here, the effects of imidazole on the RTP emissions of a series of metalloporphyrins (hematoporphyrin monomethyl ether coordinated to gadolinium (Gd-HMME), lutetium (Lu-HMME), and palladium (Pd-HMME) ions) were studied. It was found that imidazole effectively enhanced the RTP emissions of these metalloporphyrins both on a solid matrix and in solution. For metalloporphyrins on a solid matrix (filter paper), the RTP intensities of samples immersed in an imidazole solution were much higher than those immersed in methanol. Imidazole enhanced the phosphorescence quantum yields ( Φ P ) of Gd-, Lu- and Pd-HMME on filter paper by 23-, 5.0-, and 3.5-fold, respectively. For metalloporphyrins in solution (methanol), the RTP intensities increased gradually with the concentration of imidazole. These results indicate that imidazole has potential as an RTP enhancer by protecting the triplet states of phosphorescent metalloporphyrins.
研究领域:
化学
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材料科学
·
光学
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产品关联
DOI
高影响因子
International Journal of Nanomedicine
·
2023
·
IF 8
Jianmin Li,Wenyi Zhang,Shuang Liu,Fan Yang,Yupeng Zhou,Lin Cao,Yiming Li,Yunfei Guo,Xiang Qi,Guoping Xu,Jing Peng,Yang Zhao
Purpose BSA-biomineralized Gd nanoparticles (Gd@BSA NPs) have been recognized as promising nanoscale MR contrast agents. The aim of this study was to carry out a preclinical evaluation of these NPs in a middle-sized animal model (rabbits).Methods New Zealand white rabbits were treated intravenously with Gd@BSA NPs (0.02 mmol Gd/kg) via a clinically-used high-pressure injector, with commercial Gd-diethylene triamine pentaacetate (Gd-DTPA)-injected group as control. Then MR angiography was performed according to the standard clinical protocol with a 3.0-T MR scanner. The SNR and CNR of the main arteries and branches were monitored. Pharmacokinetics and bioclearance were continuously evaluated in blood, urine, and feces. Gd deposition in vital organs was measured by ICP‒MS. Weight monitoring, HE staining, and blood biochemical analysis were also performed to comprehensively estimate systemic toxicity.Results The ultrasmall Gd@BSA NPs (<6 nm) exhibited high stability and T1 relaxivity. Compared to Gd-DTPA, Gd@BSA NPs demonstrated superior vascular system imaging performance at ultralow doses, especially of the cardiac artery and other main branches, and exhibited a significantly higher SNR and CNR. Notably, the Gd@BSA NPs showed a shorter half-life in blood, less retention in organs, and improved biocompatibility.Conclusion The preclinical evaluations here demonstrated that Gd@BSA NPs are promising and advantageous MR CA candidates that can be used at a low dose with excellent MR imaging performance, thus suggesting its further clinical trials and applications.
研究领域:
医学成像
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纳米技术
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药理学
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产品关联
DOI
PubMed
高影响因子
COLLOID AND POLYMER SCIENCE
·
2014
·Vol. 292
·期 9
·2173-2183
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IF 2.41
Guo Fengying,Li Ruiqing,Xu Jijing,Zou Lianchun,Gan Shucai
The Gd-, Tb-, and Ho-doped W-type hexagonal ferrite Ba 0.85 RE 0.15 Co 2 Fe 16 O 27 was fabricated by a facile route of low-temperature sol–gel self-propagating combustion. Furthermore, a combination of dielectric loss phase polyaniline and magnetic loss phase Ba 0.85 RE 0.15 Co 2 Fe 16 O 27 as the microwave absorber in a core-shell architecture has been synthesized. The effect of different lanthanide ions Gd, Tb, and Ho on their microstructure, static magnetic properties, electromagnetic properties, and microwave reflection loss have been systematically studied. Our results show that the Ho-doped ferrite has the low microstructure parameters ( a , c , and V ) and high saturation magnetization ( Ms ) attributed to its ionic radius and magnetic moment. Moreover, it was found that the Ho-doped composite exhibited excellent microwave absorbing property with a minimum reflection loss (RL) of about −15.1 dB at 9.4 GHz. The reflection loss of composite increases up to almost triple upon the combination of polyaniline and doped ferrite. Such lightweight and highly effective absorbers via combining the organic and inorganic phase into a core-shell architecture are highly desirable for microwave absorber in various applications.
The synthesis and properties of the PANI/REBF composites
研究领域:
材料科学
·
电磁学
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DOI
高影响因子
Science Advances
·
2026
·Vol. 12
·期 18
·
IF 13.9
Chunping Mao,Jie Yi,Fuan Deng,Wanning Zhu,Jiaru Zhao,Hualing Li,Luoxing Xia,Jianing Ji,Yuxiang Xiong,Jiayao Cai,Lingdong Jiang,Jun Shen,Guobin Hong,Lu Zhang
Accurate detection of microhepatocellular carcinoma (HCC) remains a major clinical challenge owing to the limited specificity and sensitivity of current imaging modalities. Herein, we present a dual-injection magnetic resonance imaging (MRI) peptidic probe based on in vivo membrane engineering, achieving in situ signal amplification and molecularly precise imaging. The first injection of programmable nanoparticles coassembled from two peptide monomers, incorporating a GPC3-targeting ligand, a β sheet–forming motif, a dibenzocyclooctyne (DBCO) handle, and porphyrin IX (PpIX) for fluorescence tracking. Following systemic administration, the nanoparticles high-specifically bind to GPC3-overexpressing tumor membranes and transform into surface-anchored nanofibrils, exposing confined DBCO groups. A second injection of azide-modified Gd-DOTA enables rapid copper-free click conjugation on the nanofibrillar scaffold, yielding a nearly fourfold increase in longitudinal relaxivity. MRI demonstrated strong T 1 -weighted signal enhancement and high tumor-to-liver contrast in Hepa1-6 tumor-bearing mice. In vivo membrane engineering strategy establishes a generalizable platform for receptor-guided molecular imaging and early cancer detection.
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DOI
PubMed
高影响因子
AIP Advances
·
2024
·Vol. 14
·期 5
·
IF 1.4
Liu Peng,Ren Weijun,Guo Qing,Zhang Zhao,Zhao Xueting,Zhang Zhidong,Dai Wei,Li Bing
Cryogenic refrigeration technology based on magnetocaloric effects plays a critical role in a variety of technological applications. In this paper, we report the cryogenic magnetocaloric effects of a series of sodium-rare earth fluoride samples (Ln = Gd, Tb, Dy, Ho, Er, Tm, Yb) synthesized by the solid-state reaction method. These compounds all crystallize in a hexagonal crystal structure. Down to 2 K, no magnetic ordering was detected, while all compounds show negative Curie–Weiss temperatures indicative of strong antiferromagnetic coupling. Magnetic fields effectively suppress the magnetic fluctuations, leading to a maximum magnetic entropy change of −56 J kg −1 K −1 in NaGdF 4 at the magnetic field change from 0 to 50 kOe. These series of compounds are potentially excellent magnetic refrigerants at low temperatures.
研究领域:
物理学
·
材料科学
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产品关联
DOI
高影响因子
Nanomaterials
·
2025
·Vol. 15
·期 11
·792
·
IF 4.3
Xuan Liu,Jie Chao,Feifei Guo,Liangliang Chang,Xinyang Zhang,Wei Long,Zengzhe Xi
Addressing the limitations of poor piezoelectric photocatalytic activity and insufficient magnetic recovery in pure BiFeO 3 nanoparticles, Gd and Zr co-doped BiFeO 3 nanoparticles were synthesized via the sol-gel method. The structural characterization revealed a rhombohedral-to-orthorhombic phase transition with reduced grain size (~35 nm) and lattice distortion due to dopant incorporation. An XPS analysis confirmed Fe 3+ dominance and oxygen vacancy enrichment, while optimized BGFZ9 exhibited enhanced remanent magnetization (0.1753 emu/g, 14.14 increase) compared to undoped BFO. The synergistic piezo-photocatalytic system achieved 81.08% Ofloxacin degradation within 120 min (rate constant: 0.0136 min −1 , 1.26 higher than BFO) through stress-induced piezoelectric fields that promoted electron transfer for ·O 2 − /·OH radical generation via O 2 reduction. The Ofloxacin degradation efficiency decreased to 24.36% after four cycles, with structural integrity confirmed by XRD phase stability. This work demonstrates a triple-optimization mechanism (crystal phase engineering, defect modulation, and magnetic enhancement) for designing magnetically recoverable multiferroic catalysts in pharmaceutical wastewater treatment.
研究领域:
材料科学
·
环境科学
·
化学工程
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产品关联
DOI
PubMed
高影响因子
BIOMACROMOLECULES
·
2023
·
IF 6.2
Shengxiang Fu,Zhongyuan Cai,Li Liu,Xiaomin Fu,Chunchao Xia,Su Lui,Qiyong Gong,Bin Song,Hua Ai
MRI contrast agents with high kinetic stability and relaxivity are the key objectives in the field. We previously reported that Gd-DOTA backboned-bound branched polymers possess high kinetic stability and significantly increased T1 relaxivity than traditional branched polymer contrast agents. In this work, non-PEGylated and PEGylated amphiphilic Gd-DOTA backboned-bound branched polymers [P(GdDOTA-C6), P(GdDOTA-C10), mPEG-P(GdDOTA-C6), and mPEG-P(GdDOTA-C10)] were obtained by sequential introduction of rigid carbon chains (1,6-hexamethylenediamine or 1,10-diaminodecane) and mPEG into the structure of Gd-DOTA backboned-bound branched polymers. It is found that the introduction of both rigid carbon chains, especially the longer one, and mPEG can increase the kinetic stability and T1 relaxivity of Gd-DOTA backboned-bound branched polymers. Among them, mPEG-P(GdDOTA-C10) possesses the highest kinetic stability (significantly higher than those of linear Gd-DTPA and cyclic Gd-DOTA-butrol) and T1 relaxivity (42.9 mM–1 s–1, 1.5 T), 11 times that of Gd-DOTA and 1.4 times that of previously reported Gd-DOTA backboned-bound branched polymers. In addition, mPEG-P(GdDOTA-C10) showed excellent MRA effect in cardiovascular and hepatic vessels at a dose (0.025 or 0.05 mmol Gd/kg BW) far below the clinical range (0.1–0.3 mmol Gd/kg BW). Overall, effective branched-polymer-based contrast agents can be obtained by a strategy in which rigid carbon chains and PEG were introduced into the structure of Gd-DOTA backbone-bound branched polymers, resulting in excellent kinetic stability and enhanced T1 relaxivity.
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2023
·
IF 10.9
Lili Hao,Haoyang Ding,Xiangchuan Xu,Hongli Mao,Zhongwei Gu
Magnetic resonance imaging (MRI) is a non-invasive medical imaging technique that has been widely applied in the clinical diagnosis of diseases across various fields. Currently, there is a dearth of high-performance dual-mode contrast agents that provide precise diagnostic information for complex diseases. In this study, iron oxide-gadolinium nanoparticles (IO-Gd NPs) bridged by hydrophilic ligand ethylenediamine tetramethylenephosphonic acid (EDTMP) are designed inspired by Solomon-Bloembergen–Morgan (SBM) theory, where T 1 and T 2 relaxivity increase with a reduction in Gd content. In particular, the NPs with minimum Gd content exhibit excellent dual-mode contrast performance ( r 1 = 94.42 mM −1 s −1 , r 2 = 343.62 mM −1 s −1 ). The underlying mechanism is that the bridged EDTMP coordinate limits Gd tumbling and forces Gd 3+ to expose itself to the surface of the NPs. This provides more opportunities for water molecules to coordinate with Gd 3+ and significantly enhances proton relaxivity. Moreover, the hydrophilicity of the ligand enhances the water dispersion stability of the NPs and increases the exchange rate of water protons near the NPs, further enhancing the dual-mode contrast effect. Finally, the biocompatibility and in vitro / vivo imaging performances of the IO@EDTMP-Gd NPs are systematically evaluated, and the results demonstrate their potential as dual-mode contrast agents. This study provides a new strategy for developing dual-mode MRI contrast agents that can further improve the accuracy of MRI in the diagnosis of complex diseases.
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DOI
高影响因子
Chinese Physics B
·
2023
·Vol. 32
·期 9
·097501
·
IF 1.7
Jian Wu,Bing Lu,Ying Zhang,Yixin Chen,Kai Sun,Daming Chen,Qiang Li,Yingli Liu,Jie Li
Magneto–dielectric properties of Co2Z ferrite materials are tuned via Gd doping for applications in high-frequency antennas and filters in the present work. Ba3Co2Fe24−xGdxO41 (x = 0.00, 0.05, 0.10, 0.15, and 0.20) materials are successfully prepared by using solid-state method at 925 °C for 4 h with 2.5-wt% Bi2O3 sintering aids. The content of Gd3+ ion can affect micromorphology, grain size, bulk density, and magneto–dielectric properties of the ferrite. With Gd3+ ion content increasing, saturation magnetization (Ms) first increases and then decreases. The maximum value of Ms is 44.86 emu/g at x = 0.15. Additionally, sites occupied by Gd3+ ions can change magnetic anisotropy constant of the ferrite. Magnetocrystalline anisotropy constant (K1) is derived from initial magnetization curve, and found to be related to spin–orbit coupling and intersublattice interactions between metal ions. The real part of magnetic permeability (μʹ) and real part of dielectric permittivity (εʹ) are measured in a frequency range of 10 MHz–1 GHz. When x = 0.15, material has excellent magneto–dielectric properties (μ' ≈ 12.2 and ε' ≈ 17.61), low magnetic loss (tan δμ ≈ 0.03 at 500 MHz), and dielectric loss (tan δε ≈ 0.04 at 500 MHz). The results show that Gd-doped Co2Z ferrite has broad application prospects in multilayer filters and high-frequency antennas.
研究领域:
材料科学
·
电磁学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）