TALANTA
·
2023
·
IF 6.1
Jing Xu,Yinbing Liu,Ke-Jing Huang,Renjie Wang,Xiaoxuan Sun
We report here for the first time a self-powered biosensing platform based on graphene/graphdiyne/graphene (GDY-Gr) heterostructure substrate material for ultrasensitive hepatocarcinoma marker (microRNA-21) detection in both electrochemical and colorimetric test modes. The dual-mode signal intuitively displayed on a smartphone fundamentally improves the detection accuracy. In electrochemical mode, the calibration curve is established in the linear range of 0.1–10000 fM, and the detection limit is as low as 0.333 fM (S/N = 3). Simultaneously, colorimetric analysis of the miRNA-21 is realized by using ABTS as an indicator. The detection limit is confirmed as 32 fM (S/N = 3), and miRNA-21 of concentration from 0.1 pM to 1 nM exhibit a linear relationship with R2 = 0.9968. Overall, the combination of GDY-Gr and multiple signal amplification strategy significantly improved the sensitivity by 310 times compared with traditional enzymatic biofuel cells (EBFCs) based detection platform, showing broad application prospects for on-site analysis and future mobile medical services.
研究领域:
生物传感器
·
癌症诊断
·
纳米材料
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电化学
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即时检测
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产品关联
DOI
PubMed
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2023
·
IF 12.6
Shiyu Liu,Jinyue Shi,Yu Lin,Hu Luo,Yeyu Wu,Jun Yan,Xuecai Tan,Ke-Jing Huang
Thalassemia is a globally prevalent single-gene blood disorder, with nearly 7% of the world's population being carriers. Therefore, the development of specific and sensitive methods for thalassemia detection holds significant importance. Herein, a sandwich-type electrochemical/colorimetric dual-mode biosensor is developed based on gold nanoparticles (AuNPs)/graphdiyne (GDY) and DNA nanoframeworks for ultra-sensitive detection of CD142 gene associated with sickle cell anemia. Utilizing AuNPs/GDY as the substrate electrode, the fabricated sandwiched DNA nanoframework not only improves selectivity but also introduces numerous signal probes to further amplify the output signal. In the electrochemical mode, glucose oxidase catalyzes the oxidation of glucose, generating electrons that are transferred to the biocathode for a reduction reaction, resulting in an electric signal proportional to the target concentration. In the colorimetric mode, glucose oxidase catalyzes the generation of H 2 O 2 from glucose, and with the aid of horseradish peroxidase , H 2 O 2 oxidizes 3,3′,5,5′-tetramethylbenzidine to produce a colored product, enabling colorimetric detection of the target. The dual-mode biosensor demonstrates a detection range of 0.0001–100 pM in the electrochemical mode and a detection range of 0.0001–10,000 pM in the colorimetric mode. The detection limit in the electrochemical mode is determined to be 30.4 aM ( S/N=3 ), while in the colorimetric mode is of 35.6 aM ( S/N=3 ). This dual-mode detection achieves ultra-sensitive detection of CD142, demonstrating broad prospects for application.
研究领域:
生物传感技术
·
医学遗传学
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纳米生物学
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产品关联
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 7
·1-10
·
IF 5.3
Chen Fei,Wang Xiang,Yan Lei,Lin Zhixiong,Zheng Weijun,Wu Dianming,Qiu Bin,Fang Yifan,Liu Mingkun
By preparing gold nanoparticles-graphdiyne (Au-GDY) as sensing substrate and [Ru(NH 3 ) 6 ] 3+ -UiO-66-NH 2 MOFs (Ru-UiO-66) as signaling probe as well as linking the as-prepared Au-GDY and Ru-UiO-66 with the specific peptide (PT) of MMP-7 to form Ru-UiO-66/PT/Au-GDY, a cost-effective and sensitive electrochemical sensor was designed for the detection of matrix metalloproteinase-7 (MMP-7) which is an important biomarker for tumor and biliary atresia. The superior electrical properties, easy preparation, large surface area, and high stability of Au-GDY make it be a desirable substrate to immobilize PT. The unique structure of UiO-66-NH 2 is beneficial to assemble [Ru(NH 3 ) 6 ] 3+ probe and link PT. In the absence of MMP-7, the Ru-UiO-66/PT/Au-GDY modified electrode exhibited a prominent peak current of [Ru(NH 3 ) 6 ] 3+ , which is decreased after the addition of target MMP-7 since it can specifically recognize and cleave PT to induce the Ru-UiO-66 leave the electrode. The experimental results showed that the decrease of the [Ru(NH 3 ) 6 ] 3+ signal has a linear relation with the concentrations of MMP-7 in the range 0.01 pg mL −1 –10.0 ng mL −1 . By optimizing experimental conditions, the achieved detection limit (LOD) for MMP-7 is 5.0 fg mL −1 . The analysis of real serum samples has excellent accuracy. The simplicity of preparation and sensitivity make the Ru-UiO-66/PT/Au-GDY sensor a considerable promising analysis tool for MMP-7 detection. Graphical abstract
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PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Jing Xu,Yinbing liu,Xinqi Luo,Yujin Li,Yiqing Xing,Ke-Jing Huang
Self-powered electrochemical biosensors based on enzyme biofuel cells (EBFC) are uniquely valuable in developing real-time and on-site detection of heavy metal ions. This work combines graphdiyne/graphene (GDY/GR) heterojunction with Deoxyribozyme (DNAzyme) trigger catalytic hairpin self-assembly (CHA) circuit. In addition, the smartphone is introduced to obtain the detection signals. The results show that the designed sensor platform can be used for single-tube ultrasensitive and visual lead ion detection with a wide linear range of 0.003–5000 nM and a low detection limit (LOD) of 0.005 nM. This design enriches the routine screening methods for heavy metal ions in food and environmental samples and introduces new idea for the development and application of self-powered electrochemical biosensors.
研究领域:
生物传感技术
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环境科学
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材料科学
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分析化学
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产品关联
DOI
高影响因子
Nano-Micro Letters
·
2025
·Vol. 17
·期 1
·1-20
·
IF 36.3
Jiang Chao,Wang Kaihang,Zhang Luwei,Zhang Chunfang,Wang Ning
Low ionic conductivity is a major obstacle for polymer solid-state electrolytes. In response to this issue, a design concept of enhanced regional electric potential difference (EREPD) is proposed to modulate the interaction of nanofillers with other components in the composite polymer solid-state electrolytes (CPSEs). While ensuring the periodic structure of the graphdiyne (GDY) backbone, methoxy-substituted GDY (OGDY) is prepared by an asymmetric substitution strategy, which increases the electric potential differences within each repeating unit of GDY. The staggered distributed electron-rich regions and electron-deficient regions on the two-dimensional plane of OGDY increase the free Li + concentration through Lewis acid–base pair interaction. The adjacent ERRs and EDRs form uniformly distributed EREPDs, creating a continuous potential gradient that synergistically facilitates the efficient migration of Li + . Impressively, the OGDY/poly(ethylene oxide) (PEO) exhibits a high ionic conductivity (1.1 × 10 –3 S cm −1 ) and ion mobility number (0.71). In addition, the accelerated Li + migration promotes the formation of uniform and dense SEI layers and inhibits the growth of lithium dendrites. As a proof of concept, Li||Li symmetric cell and Li||LiFePO 4 full cell and pouch cell assembled with OGDY/PEO exhibit good performance, highlighting the effectiveness of our EREPD design strategy for improving CPSEs performance.
研究领域:
材料科学
·
电化学
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产品关联
DOI
PubMed
高影响因子
CARBON
·
2026
·
IF 11.6
Wenjun Zhang,Youhai Huang,Sifan Zhang,Sanqiang Zhang,Zhaohua Fang,Meng Chen
As a rising new member of carbon allotropes, graphdiyne has shown great potential in various fields due to its fascinating properties. Herein, a controlled two-step hydrothermal route was employed to convert hydrogen-substituted γ-graphdiyne into two functional derivatives: graphdiyne oxides (OGDY) and graphdiyne oxide quantum dots (OGDYQD). Systematic characterization revealed distinct differences in morphology, chemical structure, and optical properties between precursors and derivatives. Especially, the existence of alkyne bonds was demonstrated through evidence from Fourier transform infrared spectroscopy (FTIR), photoluminescence spectroscopy (PL), and selective oxidation experiments, which provides new insights for the characterization of graphdiyne materials. Moreover, we identified an oxidation-locking phenomenon governing selective alkyne oxidation at specific sites during synthesis. The oxidation-locking feature endowed significant application potential upon both derivatives: OGDY exhibited excellent photocatalytic ability in the degradation of cationic dyes, achieving efficiency ∼5–200 higher than those of other carbon-based materials; while OGDYQD could achieve ultrasensitive electrochemical detection of methyl orange with a limit of detection (LOD) as low as 0.032 μM, as well as serve as an excellent catalyst, which was comparable to metal catalysts, for the hydrogenation of 4-nitrophenol. This work provides fundamental insights into sp-carbon reactivity while delivering practical platforms for multiple applications.
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DOI
高影响因子
Nano Today
·
2022
·
IF 18.962
Jiancheng Zhang,Qiang Bai,Xuelong Bi,Chaohui Zhang,Mingyu Shi,William W. Yu,Fanglin Du,Lina Wang,Zhaobo Wang,Zhiling Zhu,Ning Sui
Carbon based nanozyme is gaining increasingly attentions due to its high stability and tailorable architecture. However, the practical applications are largely restricted by its moderate catalytic activity . External field stimulation and heteroatom doping are two effective strategies for improving enzyme mimic activities. Here, sulfur doped graphdiyne (SGDY) nanosheets were synthesized using a straightforward one-pot hydrothermal approach and reveals impressive peroxidase-like activities as well as piezoelectric properties . Kinetic investigations show that ultrasound irradiation boosts the peroxidase-like activities of SGDY. DFT calculations explicate the mechanism of piezoelectric effect on promoting peroxidase-like activity. The degradation of dyes and antibiotics, as well as antibacterial studies, demonstrate that SGDY has the great potential to be utilized in wastewater treatment. In addition, a laboratory scale device for continuous wastewater treatment was developed as a proof of concept for the practical applications of piezoelectric enhanced nanozymes. This work not only sheds light on the mechanism of nanozyme-/piezocatalysis coupling process, but also opens up a new avenue for the rational design of nanozymes with high activity for wastewater treatment and bacterial disinfection .
研究领域:
材料科学
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环境科学
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纳米技术
·
催化
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产品关联
DOI
高影响因子
ACS Catalysis
·
2023
·
IF 12.9
Chao Zhang,Yingqiang Li,Yue Xie,Zhanjiang Yu,Xin Wan,Xinzhi Wang,Jiaan He,Junlang Li,Zhenguo Chen,Xiaoyong Li,Xiaohui Yi,Zhaoli Wang,Guang-Guo Ying,Dionysios D. Dionysiou,Mingzhi Huang
Selective hydrodehalogenation and hydrodearomatization of toxic chlorophenols into value-added chemicals represents a grand challenge for their efficient reutilization. For this purpose, single-atom catalysts (SACs) could be a strategy with relatively high catalytic selectivity and atom utilization but suffer from the catalytic limitation caused by low metal loading densities. Graphdiyne and γ-graphyne are considered promising substrates of SACs with excellent catalytic properties. Additionally, their quantum dots with nanometer size are expected to supply numerous surface anchoring sites and large atom spacing to confine metal cations to synthesize high-loading SACs. Here we report a synthesis approach for high-loading Ru SACs anchored on graphdiyne/γ-graphyne quantum dots (GDQD-Ru/GNQD-Ru), which exhibit remarkably higher turnover frequency (TOF) and selectivity (>99%) of hydrodehalogenation and hydrodearomatization of chlorophenols than graphdiyne/γ-graphyne nanosheet-based Ru SACs and nanoparticles. There is no significant selectivity decrease in chlorophenol transformation by GDQD-Ru/GNQD-Ru observed in 5 catalyst reuse cycles. GDQD-Ru/GNQD-Ru contribute to nearly exclusive hydrodehalogenation and hydrodearomatization without altering any other bonds in chlorophenols. Experimental results and theoretical calculations reveal that GDQD-Ru is more prone to lower energies of rate-limiting steps in H2-driven chlorophenol transformation than GNQD-Ru. The results confirm that graphdiyne/γ-graphyne quantum dots play crucial roles in facilitating the metal atom loading of SACs. Ru loadings are 27.6 and 16.0 wt % in GDQD-Ru/GNQD-Ru, approximately 7-fold and 4-fold higher than reported Ru SACs, respectively. This study provides mechanistic insights toward the roles of high-loading Ru SACs on sp- and sp2-hybridized carbonaceous substrates in selective hydrodehalogenation and hydrodearomatization.
研究领域:
化学
·
催化科学
·
环境科学
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DOI
高影响因子
JOURNAL OF POWER SOURCES
·
2024
·
IF 8.1
Qiankun Zhou,Hui Dong,Lingli Liu,Chunxiang Wei,Xin Liang,Heng Zhang,Lili Wang,Hongdian Lu,Shibin Nie,Liangji Xu,Wei Yang,Wenjie Yang,Anthony Chun Yin Yuen
Two-dimensional (2D) heterostructured electrodes, combining graphdiyne (GDY) and MXenes, have exhibited substantial promise in augmenting the mobility of both ionic and electron movement. However, the widespread advancement and industrial utilization have been impeded by intricate manufacturing procedures and insufficient stability. This study introduces a more streamlined, in-situ growth approach for preparing MXene@GDY electrodes, presenting a novel heterostructure. The method simplifies the manufacturing process while enhancing the specific capacity of the electrode and the more stable cycle life of lithium-ion batteries (LIBs). The resulting electrode exhibited an impressive initial specific capacity of 464.4 mA h g −1 , maintaining a high capacity of 492.9 mA h g −1 after 100 cycles at 100 mA current density. More importantly, after 1200 cycles, MXene@GDY showed a capacity of 340.7 mA h g −1 , significantly outperforming pure MXene, which only reached 122.3 mA h g −1 at a current density of 1.0 A g −1 . The proposed in-situ construction of heterojunction on the MXene surface has demonstrated immense potential for designing high-performance electrode materials which are applicable to LIBs.
研究领域:
材料科学
·
能源存储
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产品关联
DOI
高影响因子
Journal of Materials Chemistry A
·
2020
·Vol. 9
·期 7
·4066-4074
·
IF 11.301
Hanzhuo Zhang,Yaseen Muhammad,Xinfang Cui,Zhengsheng Zhang,Long Liu,Zhe Chu,Jing Li,Yanjuan Zhang,Syed Jalil Shah,Zhenxia Zhao
Carboxymethyl cellulose-foam-supported HKUST-1@graphdiyne (HK@GDY/CMC-B) was constructed with high thermal conductivity and directional channels to enhance the ad-/de-sorption efficiency of acetaldehyde. Characterization results showed that (1) HKUST-1 grew within CMC and GDY via an in situ tri-phase cross-linking strategy, forming a special “alkynyl|Cu|COOH” interface, which maintained the high BET surface area (945.1 m2 g−1) of the HK@GDY/CMC-B foam and established a tight connection among the different components of the composite; (2) the π-conjugated carbon structure of GDY and the unique “alkynyl|Cu|COOH” interface within HK@GDY/CMC-B accelerated the phonon conduction and significantly enhanced the thermal conductivity of HK@GDY/CMC-B (336 mW m−1 K−1); (3) the directional channels and the hierarchical pore structure with a unique interface in the HK@GDY/CMC-B foam facilitated the diffusion and adsorption of VOCs; (4) the compact “alkynyl|Cu|COOH” interface generated more unsaturated Cu(II) and Cu(I) sites and increased adsorbent surface polarity to capture acetaldehyde. Consequently, the obtained HK@GDY/CMC-B exhibited an excellent acetaldehyde adsorption capacity of up to 11.0 mmol g−1, which was 1.3–3.4 times higher than that of many state-of-the-art adsorbents. Kinetics performance data revealed that the diffusivity of acetaldehyde on the HK@GDY/CMC-B foam increased by 60% compared to that of the pristine HKUST-1. Similarly, the desorption rate of HK@GDY/CMC-B was 2.2–6.5 times faster than that of several state-of-the-art adsorbents under similar temperature programmed desorption. This greatly realized an energy-conserving approach for adsorbent regeneration. Based on these findings, the current tri-phase cross-linking strategy can be deemed as an efficient tactic to further improve the adsorption efficiency of MOFs for fast adsorption of VOCs on the commercial level.
研究领域:
材料科学
·
环境工程
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DOI
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2025
·Vol. 172
·期 3
·036503
·
IF 3.3
Xiaoyan Wang,Hao Zheng,Huiling Chen,Bin Qiu,Yunliang Liu,Qing Ye
Interleukin-6 (IL-6) is a common proinflammatory cytokine and can be adopted as an important biomarker for several diseases including nasopharynx cancer, pancreatitis, infections, and cardiovascular. It is thus necessary to design an effective method for monitoring IL-6. Herein, by preparing gold nanoparticles/graphdiyne (Au/GRD) nanohybrid with simple electroless deposition as the sensing substrate and UiO-66 metal–organic frameworks/ferrocene (UiO/Fc) as the signaling-amplifier, a highly efficient sandwich-type electrochemical immunosensing (SEI) platform was proposed for IL-6 determination. The superior electrical properties, easy preparation, high surface area, and stability of Au/GRD make it a desirable substrate to immobilize the primary antibody of IL-6. Meanwhile, the unique structure of UiO-66 is beneficial to immobilizing the Fc probe and the secondary antibody. By optimizing experimental conditions, the Fc current obtained at the as-designed SEI platform increases along with IL-6 increase, and the related linearity is 0.5 pg ml−1–1200.0 pg ml−1 coupled with a low detection limit of 0.2 pg ml−1. It is expected the as-designed SEI platform based on Au/GRD and UiO/Fc shows potential applications for IL-6 analysis.
研究领域:
生物医学工程
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分析化学
·
纳米技术
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产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 5
·1-9
·
IF 5.3
Li Yunpeng,Shi Zhuanzhuan,Wu Xiaoshuai,Miao Wenting,Yang Zhengyi,Lou Xinyu,Sun Wei,Guo Chunxian,Li Chang Ming
PEDOT:PSS has been used as a biomimetic uric acid (UA) sensor but suffers from unfortunate low detection limit (LOD), narrow detection range and poor stability. Herein, we get graphdiyne (GDY) marry PEDOT:PSS to create a very stable GDY@PEDOT:PSS heterostructure for a biomimetic UA sensor, which accomplishes the lowest LOD (6 nM), the widest detection range (0.03 μM-7 mM) and the longest stability (98.1% for 35 days) among the related UA sensors. The sensor was successfully used to in situ real-time detection of UA in sweat. The enhancement mechanisms of the sensor were investigated, and results discover that C≡C of GDY and C = C of PEDOT:PSS can cross-link each other by π–π interactions, making not only the former strongly resistant against oxidation deterioration, but also causes the latter to efficiently prevent water swelling of polymer for poor conductivity, thereby leading to high stability from both components. While the stabilized heterostructure can also offer more active sites by enhanced absorption of UA via π-π interactions for highly sensitive detection of UA. This work holds great promise for a practical sweat UA sensor while providing scientific insight to design a stable and electrocatalytically active structure from two unstable components. Graphical abstract
研究领域:
材料科学
·
生物医学工程
·
分析化学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）