ACTA PHARMACOLOGICA SINICA
·
2024
·
IF 6.9
Xia Rui-xue,Zou Pei-chen,Xie Jun-ting,Tang Ya-bin,Gong Miao-miao,Fan Fu,Aihemaiti Ayinazhaer,Liu Yu-qing,Shen Ying,Zhou Bin-bing S.,Zhu Liang,Lei Hui-min
RAS is the most frequently mutated oncoprotein for cancer driving. Understanding of RAS biology and discovery of druggable lynchpins in RAS pathway is a prerequisite for targeted therapy of RAS-mutant cancers. The recent identification of KRAS G12C inhibitor breaks the “undruggable” curse on RAS and has changed the therapy paradigm of KRAS-mutant cancers. However, KRAS mutations, let alone KRAS G12C mutation, account for only part of RAS-mutated cancers. Targeted therapies for cancers harboring other RAS mutations remain the urgent need. In this study we explored the pivotal regulatory molecules that allow for broad inhibition of RAS mutants. By comparing the expression levels of nucleotide pyrophosphatase (NPPS) in a panel of cell lines and the functional consequence of increased NPPS expression in RAS-mutant cells, we demonstrated that cancer cells with various kinds of RAS mutations depended on NPPS for growth and survival, and that this dependence conferred a vulnerability of RAS-mutant cancer to treatment of NPPS inhibition. RAS-mutant cells, compared with RAS-wildtype cells, bored and required an upregulation of NPPS. Transcriptomics and metabolomics analyses revealed a NPPS-dependent hyperglycolysis in RAS-mutant cells. We demonstrated that NPPS promoted glucose-derived glycolytic intermediates in RAS-mutant cells by enhancing its interaction with hexokinase 1 (HK1), the enzyme catalyzing the first committed step of glycolysis. Pharmacological inhibition of NPPS-HK1 axis using NPPS inhibitor Enpp-1-IN-1 or HK1 inhibitor 2-deoxyglucose (2-DG), or genetic interfere with NPPS suppressed RAS-mutant cancers in vitro and in vivo. In conclusion, this study reveals an unrecognized mechanism and druggable lynchpin for modulation of pan-mutant-RAS pathway, proposing a new potential therapeutic approach for treating RAS-mutant cancers.
研究领域:
肿瘤学
·
分子生物学
·
癌症治疗
✓ 已验证
DOI
高影响因子
Advanced Optical Materials
·
2018
·Vol. 6
·期 10
·1701389
·
IF 7.43
Zhongyuan Guan,Aiwei Tang,Peiwen Lv,Zhenyang Liu,Xu Li,Zhan'ao Tan,Tasawar Hayat,Ahmed Alsaedi,Chunhe Yang,Feng Teng
A series of multinary Cu-In-Zn-Se-S nanocrystals (NCs) are synthesized via a phosphine-free and one-pot approach, in which the Se powder and 1-dodecanethiol (DDT) are used as chalcogenide sources, respectively. The X-ray photoelectron spectra are used to confirm the presence of lattice sulfur in the as-obtained products. The emission color and the relative photoluminescence quantum yields of the Cu-In-Zn-Se-S NCs can be tuned by varying the Cu contents, the amount of Se powder, as well as the DDT dosage. In addition, the formation process of the multinary Cu-In-Zn-Se-S NCs is different from that of quaternary Cu-In-Zn-S NCs, which is dominated by the doping of Cu ions into the In-deficient In-Zn-Se-S NCs but not the partial interdiffusion of Zn 2+ into the Cu-based NCs. This plausible deduction is based on the comparison of optical properties of the products synthesized using the hot-injection and one-pot methods. Furthermore, the performance of the solution-processed quantum-dot light-emitting diodes (QLEDs) using the Cu-In-Zn-Se-S NCs as emission layers is examined, and the QLEDs exhibit a high luminance over 1500 cd m −2 and a high peak current efficiency of ≈0.4 cd A −1 at 1000 cd m −2 .
研究领域:
材料科学
·
纳米技术
·
光电子学
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Wei Zhao,Mengru Yan,Xinran Yang,Xiaojun Zeng,Yantong Chen,Benlin Dai,Xiaozhong Chu,Xuekun Hong,Feihu Mu,Shijie Li,Dennis Y.C. Leung
Environmental pollution caused by the overusage and uncontrolled discharge of antibiotics such as amoxicillin will endanger public health and ecosystems. Herein, a novel Ag/MIL-68(In)-NH 2 /Bi 4 O 7 plasmonic heterojunction has been successfully prepared through a two-step route followed by photoreduction for environmentally friendly photocatalytic amoxicillin degradation. Ag/MIL-68(In)-NH 2 /Bi 4 O 7 displayed the most efficient photocatalytic performance, which was 3.7 and 3.2 times that of Bi 4 O 7 and MIL-68(In)-NH 2 , respectively. The superior photocatalytic activity was directly linked to its large surface area and localized surface plasmon resonance (LSPR) effect, which provides more active sites and effectively promotes visible light absorption. Moreover, the degradation path of amoxicillin was explored in detail by combining Gaussian software calculation with liquid chromatography-mass spectrometry (LC-MS) analysis. Finally, a series of characterizations and simulations were carried out to demonstrate the S-scheme photocatalytic mechanism.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Open Chemistry
·
2023
·Vol. 21
·期 1
·
IF 2.3
Hongmei Yu,Weiwei Liang,Yuan Sun
In this work, a novel In( iii ) coordination polymer, i.e., {[In(L)(im)(H 2 O)](H 2 O)}
n
( 1 ) was produced from the synthetic reactions in water and dimethylformamide mixed solvents and using methyl-3-hydroxy-5-carboxy-2-thiophenecarboxylic acid (H 2 L) and imidazole (Him) as the co-ligands, and then successfully loaded with dexamethasone. The injectable hydrogels were prepared from natural polysaccharide hyaluronic acid with good biocompatibility and successfully loaded with In( iii ) complex. The suppressive inhibitory effect of hydrogels toward U251 human glioma cell line viability was assessed using the Cell Counting Kit-8 assay kit, and the relatively expressed levels of the vascular endothelial growth factor signaling pathway were determined by real-time RT-PCR.
研究领域:
药学
·
肿瘤学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Brain and Behavior
·
2023
·Vol. 13
·期 5
·e2980
·
IF 3.1
Yunchao Shi,Ying Fang,Peng Shen,He Liu,Longsheng Xu,Liyan Wang,Maoxian Yang
Purpose Cognitive impairment is a critical complication of acute respiratory distress syndrome (ARDS). However, effective interventions are lacking. Growing evidence demonstrates that c-Jun N-terminal kinase (JNK)-mediated neuroinflammation is involved in the development of ARDS. Therefore, we hypothesized that the JNK pathway is involved in ARDS-induced cognitive impairment. Methods An in vivo rat model of ARDS was established by treating it with lipopolysaccharide. The cognitive function was assessed by behavioral tests. The levels of pro-inflammatory cytokines, JNK and NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) were analyzed by enzyme-linked immunosorbent assay, western blot, or immunohistochemical analysis. Results We found that JNK inhibitor 8 (JNK-IN-8) alleviated cognitive impairment, neuroinflammation, and NLRP3 inflammasome activation in the ARDS rat model. Additionally, an in vivo study showed that the protective effect of JNK-IN-8 on cognitive impairment was blocked by nigericin, an NLRP3 activator. Conclusions Our data suggest that JNK-IN-8 treatment improves ARDS-induced cognitive impairment by inhibiting the JNK/nuclear factor-κB-mediated NLRP3 inflammasome.
研究领域:
药理学
·
神经科学
·
免疫学
·
呼吸医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2025
·
IF 7.7
Ziwen Yao,Jing Li,Shuai Nie,Yuan Wang,Xitao Yin,Yunxia He
Utilizing p-n composite materials for the fabrication of metal-oxide semiconductor (MOS) gas sensors represents a promising strategy to achieve exceptional selectivity in detecting reducing gases such as hydrogen (H₂) and carbon monoxide (CO). However, previous studies have typically achieved this selectivity under fixed operating temperatures and single molar ratios. This study presents the successful synthesis of n-In₂O₃/p-Co₃O₄ nanoparticles, featuring a p-n heterojunction structure, using a simple composite preparation method. The gas-sensing properties, crystal structure, morphology, and chemical states were comprehensively characterized using an electrochemical workstation, XRD, TEM, HRTEM, and XPS. Experimental results show that the gas sensor responses of the n-In₂O₃/p-xCo₃O₄ composites (with x = 10.5, 15, 18, 21), annealed at 500°C within an operational temperature range of 350°C to 400°C, exhibit distinct behaviors for CO and H₂ gases. This addresses the challenge of achieving selective detection across varying conditions. Notably, the n-In₂O₃/p-18Co₃O₄ composites display opposing response characteristics for both gases across a broad temperature range of 200°C to 400°C. At 350°C, the n-In₂O₃/p-18Co₃O₄ sensor demonstrates optimal selectivity, significantly minimizing cross-sensitivity and improving detection accuracy and reliability. The sensor also shows excellent stability, with consistent responses under repetitive exposure conditions. By improving both sensor selectivity and stability, this research advances gas detection technologies, with potential applications in sustainable energy and public health monitoring.
研究领域:
材料科学
·
传感器技术
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Yi-Shan Ouyang,Yu Jiang,Shuang Ni,Run-Yuan Jiang,Jian Wang,Wen-Bin Wang,Wei Zhang,Qing-Yuan Yang
Although the engineering of visible-light-driven photocatalysts with appropriate bandgap structures is beneficial for generating hydrogen (H2), the construction of heterojunctions and energy band matching are extremely challenging. In this study, In2O3@Ni2P (IO@NP) heterojunctions are attained by annealing MIL-68(In) and combining the resulting material with NP via a simple hydrothermal method. Visible-light photocatalysis experiments validate that the optimized IO@NP heterojunction exhibits a dramatically improved H2 release rate of 2485.5 μmol g–1 h–1 of 92.4 times higher than that of IO. Optical characterization reveals that the doping of IO with an NP component promotes the rapid separation of photo-induced carriers and enables the capture of visible light. Moreover, the interfacial effects of the IO@NP heterojunction and synergistic interaction between IO and NP that arises through their close contact mean that plentiful active centers are available to reactants. Notably, eosin Y (EY) acts as a sacrificial photosensitizer and has a significant effect on the rate of H2 generation under visible light irradiation, which is an aspect that needs further improvement. Overall, this study describes a feasible approach for synthesizing promising IO-based heterojunctions for use in practical photocatalysis.
研究领域:
材料科学
·
光催化
·
能源转换
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Yue Wang,Wenjun Zhang,Yanjun Zhang,Meng Chen
Metal-organic frameworks (MOFs), with tunable morphologies and porous architectures, show great potential in photocatalysis. A variety of MOFs can be synthesized by changing the types of metal ions and organic ligands. However, fewer studies have explored the influence of the metal-to-ligand molar ratio on the catalytic performance of the resulting MOF-related products. In this work, capsule-shaped NH 2 -MIL-68(In)/InOOH composites were synthesized by adjusting molar ratios of In(NO 3 ) 3 to 2-aminoterephthalic acid. Time-dependent characterization revealed sequential crystallization: rod-shaped NH 2 -MIL-68(In) initially formed in the solution, followed by the in-situ growth of InOOH nanowires on its surfaces via excess indium ions, ultimately constructing a Z-scheme heterojunction. The optimized NM/InOOH (8:1) composite exhibited a larger specific surface area and extended light absorption. The Z-scheme configuration significantly promoted charge carrier separation efficiency while maintaining strong redox potentials of the photoinduced holes and electrons, thereby resulting in 5–8-fold improvement in degradation rates for four dyes (AOII, RhB, MB, and Rh6G), highlighting its broad photocatalytic applicability.
研究领域:
材料科学
·
纳米技术
·
环境科学
·
光催化
·
无机化学
✓ 已验证
产品关联
DOI
高影响因子
CRYSTENGCOMM
·
2025
·
IF 2.6
Yuting Luo,Yiwei Sun,Haoxiang Wang,yuyang He,Mengqi Lu,Ruoyu Wang,Dongpo Xu
Due to the wide application of tetracycline (TC), there will be residues in human daily food. It is important to develop sensitive and rapid detection methods for TC in food. In this study, a rod-like NH2-MIL-68 (In) material was developed as a DNA probe binding site for rapid detection of TC. The aptamer and NH2-MIL-68 (In) were tightly bound by glutaraldehyde. After the addition of TC, the aptamer specifically adsorbs TC in the test sample, resulting in increased impedance on the electrode and decreased electrical signal. Under optimized conditions, the sensor had a wide detection range (0.001-100 μM) and a low detection limit (0.36 nM). In addition, the NH2-MIL-68 (In)@Apta sensor was successfully applied to TC residues in milk samples with recoveries of 84.33 % -117.22 %. The results showed that our work can provide a new strategy for the direct detection of TC in food samples.
研究领域:
食品科学
·
分析化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2022
·Vol. 169
·期 12
·127509
·
IF 4.386
Rui Kuang,Ning Deng,Fuying Dong,Yongling Ding,Xuan Kuang
Electrochemical enantiorecognition of Tryptophan (Trp) isomers using Cys@In2S3/GCE prepared by two steps of sulfidation and chiralization from MIL-68(In) is reported. The Cys@In2S3/GCE electrode shows highly selective, sensitive and quantitative analysis towards Trp enantiomers. This proposed chiral sensors could be considered for practical applications in the field of Trp related medical recognition.
研究领域:
生物化学
·
分析化学
·
材料科学
✓ 已验证
DOI
高影响因子
ANALYST
·
2018
·Vol. 143
·期 14
·3390-3398
·
IF 3.864
Jiahong Guo,Zhiwei Bai,Yonglei Lyu,Jikui Wang,Qiang Wang
PDMS-PU (polydimethylsiloxane-polyurethane) sponge decorated with In(OH)3 (indium hydroxide) and BCP (bromocresol purple) particles is shown to be a room-temperature ammonia sensor with high sensitivity and excellent reproducibility; it can accomplish real-time detection and monitoring of ammonia in the surrounding environment. The superhydrophobic and yellowish In(OH)3-BCP-TiO2-based ammonia-responsive (IBT-AR) sponge changes to a purple superhydrophilic one when exposed to ammonia. Notably, after reacting with ammonia, the sponge can recover its original wettability and color after heating in air. The wettability, color and absorption signal of IBT-AR sponge have been measured for sensing ammonia using the water contact angle, macroscopic observation and UV-vis absorption spectrometry, respectively. The minimum ammonia concentrations that can be detected by the sponge wettability, color and absorption signal are 0.5%, 1.4 ppm and 50 ppb, respectively. This kind of sponge with smart wettability and color is a promising new ammonia detector.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMISTRY OF MATERIALS
·
2024
·
IF 7.2
Shi-Wei Fu,Jian Yang,Zong-Yan Zhao,Bao-Feng Shan,Jia-Xin Zhang,Jin Zhang,Qingju Liu,Jianyong Feng,Zhaosheng Li,Zhigang Zou
A profound understanding of the band-edge electronic structure is crucial for advancing the development of highly efficient photocatalytic materials and unraveling the underlying mechanisms. This study employs a unified and consistent assessment protocol, offering a systematic exploration of the inherent connections between the band-edge electronic structure and the photo(electro)catalytic performance of a series of delafossite ABO2 compounds (A = Cu, Ag; B = Al, Ga, In). These compounds exhibit characteristics of indirect bandgap semiconductors, with fundamental and optical bandgaps spanning from 1.45 to 3.57 eV. Notably, the Cu-based ABO2 compounds display a significantly larger fundamental bandgap and excel as photocathode materials when the B-site element is held constant. Among these, CuInO2 emerges as the most promising candidate, showcasing superior photo(electro)catalytic performance. Extensive density functional theory calculations unravel intricate insights into the interplay between the band-edge electronic structure and valence orbital hybridization of the A- and B-site elements, providing invaluable perspectives for comprehending and enhancing the photo(electro)catalytic performance of such compounds. The findings in this study not only establish robust theoretical foundations for integrating ABO2 compounds into the field of photo(electro)catalysis but also lay the groundwork for future material design and optimization.
研究领域:
材料科学
·
催化
·
光化学
·
理论化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）