JOURNAL OF FOOD BIOCHEMISTRY
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2024
·Vol. 2024
·期 1
·3900785
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IF 3.5
Wei Ren,Jian Xu,Yongping Zhang,Yanyan Miao,Yao Liu
The aim of this study is to investigate efficient, cost-effective, and high-quality drying technologies for Rosa roxburghii Tratt. Five drying methods—hot air drying (HAD), microwave drying (MD), vacuum drying (VD), microwave vacuum drying (MVD), and freeze vacuum drying (FVD), were employed to dry Rosa roxburghii Tratt. The study focused on evaluating drying characteristics, colors, texture and structure, and microstructure, as well as the content of active ingredients and antioxidant activity of Rosa roxburghii Tratt. The results of drying kinetics indicated that the Wang and Singh model was the most suitable for FVD, while the Page model was optimal for the other four drying methods. Rosa roxburghii Tratt subjected to HAD exhibited the highest energy consumption per unit but the lowest ΔE and the highest TFC. The microstructure of Rosa roxburghii Tratt under different drying methods was analyzed. Rosa roxburghii Tratt dried using MD experienced serious cell rupture, resulting in a large loss of active ingredients and the worst antioxidant ability, but it had the fastest drying rate. On the other hand, Rosa roxburghii Tratt dried under VD had the microstructure with the least pore space, leading to slower drying speed and the highest total polyphenol content. Rosa roxburghii Tratt dried using MVD had the least hardness and chewiness, with slightly better Δ E and active ingredient content compared to MD. FVD Rosa roxburghii Tratt took the longest time to dry, with the greatest Δ E difference, hardness, and chewiness, but it had the highest Vitamin C content and the most powerful antioxidant ability. Principal component analysis (PCA)–entropy weighting method was used to provide comprehensive scores for the different drying methods, with FVD, HAD, VD, MVD, and MD were 0.8107, 0.7037, 0.4499, 0.2746, and 0.0586 respectively. Through comprehensive analysis, we demonstrated that the quality of Rosa roxburghii Tratt obtained via FVD and HAD is satisfactory. Additionally, HAD is characterized by its economic efficiency and convenience, providing valuable insights for the industrial production of Rosa roxburghii Tratt drying.
研究领域:
食品科学
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农业工程
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采后技术
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植物科学
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产品关联
DOI
高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2025
·
IF 11.3
Yuling Ren,Pengfei Qi,Yujie Han,Yinhua Wan,Jiuyang Lin,Ming Xie,Xiangrong Chen,Shichao Feng,Jianquan Luo
The efficient removal of organic contaminants from high-salinity wastewater is crucial for resource recovery and achieving zero discharge. Nanofiltration (NF) membranes are effective in separating organic compounds and monovalent salts, but they typically exhibit an excessive rejection of divalent salts. Modifying the charge characteristics of NF membranes can improve salt permeation; however, the role of charge spatial distribution in governing salt transport behavior is not fully understood. In this study, we developed a mix-charged NF membrane with a horizontal charge distribution by employing interfacial polymerization combined with a polyester template etching and solvent-induced polyamine intercalation strategy. The ratio of positive to negative charge domains in the membrane can be precisely controlled by adjusting the aqueous monomer ratio and polyamine modifier type. X-ray photoelectron spectroscopy (XPS) depth profiling and separation layer thickness analysis confirmed the complete penetration of polyamines into the separation layer, providing direct evidence of the formation of horizontally distributed charge domains. This unique charge distribution results in a high charge density and a near-electroneutral surface, which facilitates the permeation of the divalent salts. The size-dependent “plug-in” modification and covalent cross-linking further reduce pore size, enhancing rejection of small organic molecules. Additionally, the membrane demonstrated exceptional antifouling performance against both negatively and positively charged pollutants, attributed to its unique charge distribution and smooth surface. Molecular dynamics (MD) simulations further revealed that weak electrostatic interactions and a tightly bound hydration layer contribute to the membrane’s superior antifouling properties. This work provides valuable insights into the design of NF membranes with tailored microstructures and charge distributions for improved water treatment performance.
研究领域:
环境工程
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水处理
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膜技术
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材料科学
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产品关联
DOI
PubMed
高影响因子
Food Science and Human Wellness
·
2023
·
IF 7
Hui Zou,Tingting Ben,Ping Wu,Geoffrey I.N. Waterhouse,Yilun Chen
This novel study identifies the effective anti-inflammatory phenolic compounds in dandelion and provides mechanistic insights into their interactions with receptor proteins (toll‐like receptor 4, TLR4; co‐receptor myeloid differentiation protein-2, MD-2) using UHPLC-ESI-MS/MS, lipopolysaccharide (LPS)-stimulated THP-1 cell line, fluorescence quenching and anisotropy, molecular docking (single ligand and multi-ligand docking) and molecular dynamics simulation. A 50 % aqueous methanol extract had a greater anti-inflammatory effect and higher chicoric acid content, compared with the 100 % water and 100 % methanol extracts. Chicoric acid, chlorogenic acid, methylophiopogonone A, caffeic acid, gallic acid monohydrate and 4'- O -demethylbroussonin A had relatively high binding energies and contents in all extracts. Chicoric acid competed with chlorogenic acid, 4'- O -demethylbroussonin A and quercetin for MD-2. Among dandelion’s phenolics, chicoric acid most effectively hindered TLR4-MD-2 complex formation, with a quenching constant of 0.62 × 10 6 L/mol for MD-2 or TLR4 at 320 K, and binding energies of –6.87 and –5.97 kcal/mol, respectively, for MD-2 and TLR4.
研究领域:
药理学
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生物化学
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分子生物学
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分析化学
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免疫学
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DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
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2018
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IF 6.578
Yujian Yao,Meng Li,Xingzhong Cao,Peng Zhang,Wen Zhang,Junfeng Zheng,Xuan Zhang,Lianjun Wang
A new sulfonated diamine monomer , 4,4′-((1,4-phenylenebis(methylene))bis(azanediyl))dibenzenesulfonic acid (PMABSA) was synthesized and used as the sole aqueous reactant to fabricate a novel reverse osmosis (RO) membrane with trimesoyl chloride (TMC), in place of conventional m -phenylene diamine (MPD). The separation performance of the PMABSA/TMC membrane was optimized by the response surface method (RSM) by means of evaluating the pure water permeability (PWP) and salt rejection (R) to NaCl, and optimal results of PWP of 1.18 ± 0.03 L m −2 h −1 bar −1 , and R of 98.2 ± 0.4%, respectively, were achieved at 1.55 MPa. Owing to the rigid benzene ring in the center of the molecule, which may have a blocking effect during the interfacial polymerization (IP) process, the resulting barrier layer was less compact and had low thickness. Both molecular dynamics (MD) simulation and positron annihilation spectroscopy (PAS) revealed the creation of sufficient free volumes in the sulfonated polyamide matrix. Regardless of the slightly lower water permeation, the PMABSA/TMC membrane exhibited a superior rejection ability to all the ions compared to that of commercial SW30HR (Dow Chemical) in a model seawater separating test. Overall, all the results indicated the great potential of the novel membrane as a new choice of non-MPD RO membrane for seawater desalination.
研究领域:
材料科学
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化学工程
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环境科学
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水处理
✓ 已验证
DOI
高影响因子
Journal of Evidence-Based Integrative Medicine
·
2024
·
IF 3.3
Shu Dong,MD,Panling Xu,MD,Peiwen Yang,MD,Juying Jiao,MD,Chien-shan Cheng,MD,PhD,Lianyu Chen,MD,PhD
BackgroundHuanglianjiedu decoction (HLJDD) is a classical Traditional Chinese Medicine (TCM) prescription with thousand years of clinical use against various malignancies, including pancreatic adenocarcinoma (PAAD). However, its potential bioactive component and molecular mechanism remains unclear.AimsThis study is to inspect the HLJDD mechanisms of action against PAAD via integrated computational and pharmacochemistry strategy, in vivo and in vitro experiments to validate associated targets and pathways.MethodsA PAAD xenograft model was established by subcutaneous injecting Panc02 cells into C57BL/6 mice. Ultra-high performance liquid chromatography with tandem mass spectrometry (UHPLC-MS/MS) was engaged to determine constituents of HLJDD and assessed for pharmacokinetic scheme using the TCM Systems Pharmacology Platform (TCM-SP). Differentially expressed genes (DEGs) of PAAD was retrieved from the transcriptome dataset GSE43795, followed by recognizing overlapping targets the oncogenes and target genes of PAAD and HLJDD, respectively. Putative signaling pathways of HLJDD in treating PAAD were enriched using KEGG and GO analyses. The anti-PAAD effects of HLJDD was assessed in vivo and in vitro, besides, the potential mechanism was validated using immunoblotting and immunohistochemical assays.ResultsHLJDD significantly suppressed the growth of transplanted PAAD tumors, constrained PAAD progression, and induced apoptosis and S-phase arrest. Seventy-five active components meeting the drug-likeness criteria and 278 target genes of HLJDD were identified. KEGG analysis indicated that the top three enriched pathways were cancer, AGE-RAGE signaling, and IL-17 signaling pathways. Disease enrichment analysis highlighted immune, pharmacological, and cancer-related diseases as the top three categories. A total of 47 potential target genes were identified. Immunoblotting revealed that HLJDD inhibited PI3K and MAPK-related signaling pathways, while immunohistochemical staining confirmed that HLJDD suppressed the expression of phosphorylated MAPK and ERK1/2.ConclusionHLJDD inhibited PAAD in vitro and in vivo via the modulation of multiple mechanisms, including regulation of PI3K/AKT/mTOR and MAPK/ERK1/2 signaling pathways.
研究领域:
肿瘤学
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中医药学
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药理学
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分子生物学
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系统生物学
✓ 已验证
DOI
PubMed
高影响因子
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