Advanced Healthcare Materials
·
2021
·Vol. 10
·期 23
·2101316
·
IF 9.933
Zhuojia Xu,Aihua Qu,Weiwei Wang,Meiru Lu,Baimei Shi,Chen Chen,Changlong Hao,Liguang Xu,Maozhong Sun,Chuanlai Xu,Hua Kuang
Parkinson's disease (PD) is a common neurodegeneration disease. Unfortunately, there are no effective measures to prevent or inhibit this disease. In this study, biodegradable Mn 3 O 4 nanoparticles (NPs) in different shapes are prepared and enclosed them by {100}, {200} and {103} facets that exhibit facet-dependent protection against neurotoxicity induced by oxidative damage in a cell model of PD. Notably, Mn 3 O 4 nanorods enclosed by {103} facets exhibit high levels of enzyme-like activity to eliminate reactive oxygen specie in vitro. It is also determined that the uptake pathway of Mn 3 O 4 NPs into MN9D cells is mediated by caveolin. The data demonstrate that Mn 3 O 4 nanorods can be taken up by cells effectively and confer excellent levels of neuroprotection while the biodegradation of Mn 3 O 4 NPs in vivo is confirmed by photoacoustic image of Mn 3 O 4 NPs in brain at 60 d. Furthermore, the oxygen scavenging effect created by Mn 3 O 4 nanorods is successfully applied to a mouse model of PD; the amount of α -synuclein in the cerebrospinal fluid of PD mice is reduced by 61.2% in two weeks, thus demonstrating the potential application of facet-directed Mn 3 O 4 NPs for the clinical therapy of neurodegenerative disease.
研究领域:
生物医学工程
·
神经科学
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PubMed
高影响因子
Chemistry-Switzerland
·
2026
·Vol. 8
·期 9
·115
·
IF 2.6
Xinli Liu,Yingyi Luo
Radiation-induced salivary gland injury (RISGI) is an inevitable and serious complication for patients with head and neck cancer. Reactive oxygen species (ROS) generated during radiotherapy are the primary cause. Hyposalivation is the most obvious symptom of RISGI. Currently, clinical interventions have not achieved the desired efficacy. Inspired by the radioprotective properties of Mn3O4and PDA nanozymes and the robust bioadhesive properties of PDA hydrogels, we designed a Mn3O4–polydopamine hybrid hydrogel (termed MP hydrogel) capable of alleviating radiation-induced hyposalivation. MP hydrogel effectively scavenges ROS and increases the viability of salivary gland cells under ionizing radiation (IR). As a proof of concept, we applied MP hydrogel to the submandibular glands (SMGs) of male Sprague–Dawley (SD) rats, one of the three major salivary glands of rats. We demonstrated that MP hydrogel effectively mitigated radiation-triggered hyposalivation after in situ gelation in rats.
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Materials Today Chemistry
·
2025
·
IF 6.7
Yinyin Chen,Nana Liu,Qiuju Wu,Wei Wu,Wei Fan,Aimin Wu,Xianxiang Wang
To overcome the problem of poor water solubility of curcumin used for antibacterial purposes and the limitation that a single treatment method is difficult to achieve the expected therapeutic effect for drug-resistant bacteria, this study has developed a new type of composite material, Cur-PEI-Mn 3 O 4 (MPC). During the preparation of the composite material, the water solubility of curcumin (Cur) has been enhanced by modifying it with polyethyleneimine (PEI), and it has been combined with Mn 3 O 4 nanocylinders to improve the therapeutic effect. The experiment has proved that MPC can catalyze the production of reactive oxygen species (∙OH) from H 2 O 2 under slightly acidic conditions and consume glutathione (GSH). While in neutral conditions, when the concentration of MPC is 160 μg mL −1 , the clearance rate of ∙O 2 − can reach 80 %. The in vitro antibacterial experiments have shown that 1 mg/mL MPC + H 2 O 2 could significantly inhibit methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli (with a survival rate of 20 %). The mechanism includes damaging the bacterial membrane structure, causing protein leakage, depleting GSH and generating ∙OH. In the MRSA-infected wound model, MPC, under the acidic microenvironment of the wound in the early stage, can catalyze the production of ∙OH from H 2 O 2 and consume GSH to destroy the bacterial biofilm. In the neutral environment during the later stage of wound healing, MPC can exert antioxidant effects, significantly promoting epithelial regeneration (increased expression of Masson and CD31, decreased expression of IL-6 and TNF-α), and accelerating wound healing. Therefore, the improved solubility component Cur in this complex, along with the Mn 3 O 4 component with multiple catalytic activities, can work together to resist drug-resistant bacteria and thereby heal wounds infected by MRSA.
研究领域:
材料科学
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纳米技术
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抗菌治疗
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伤口愈合
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活性氧催化
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高影响因子
DESALINATION
·
2026
·
IF 9.9
Yubiao Xia,Yongjun Xue,Dongdong Zhang,Yuan Li,Wenjie Wu,Xingtao Xu
Mn₃O₄ electrodes were synthesized via a facile amino acid-assisted method. • The optimized electrode delivers ultrahigh electrosorption capacity and rate. • The system demonstrates a low energy consumption with negligible manganese leaching, ensuring safe and sustainable operation. To address the limitations in ion adsorption capacity and kinetics of conventional capacitive deionization (CDI) systems, this study proposes the utilization of Mn 3 O 4 electrodes featuring tailored oxygen vacancy to enhance desalination performance. Mn 3 O 4 materials with tunable oxygen vacancy concentrations were synthesized via an amino acid-assisted method and employed as CDI anodes. The introduced oxygen vacancies significantly improved the electrode's electrosorption capacity and reaction kinetics. The optimized electrode exhibited an electrosorption capacity of 110 mg/g at 1.2 V and an average salt removal rate of 29.26 mg/g/min. Compared with conventional electro-driven desalination technologies, the developed system demonstrates lower energy consumption while maintaining operational flexibility, offering a promising material and process strategy toward efficient and sustainable desalination.
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RSC Advances
·
2026
·Vol. 16
·期 22
·19752-19762
·
IF 6.1
Liang Chen,Lulu Fang,Haitao Lin,Yanzhe Ge,Yuan Cheng,Jianquan Wang
The global prevalence of gingivitis has raised the cost considerably for extensive healthcare and refractory management, which is often accompanied by excessive accumulation of reactive oxygen species (ROS) that are considered to play a pivotal role in the development of gingivitis and other inflammatory diseases. Ordinary medications for the treatment of gingivitis, such as chemical anti-inflammatory or antimicrobial agents, are sometimes unsatisfactory due to rapid pathogen consumption and metabolism. To this end, new strategies and platforms are thus needed for the treatment of such ROS-related diseases. Herein, Mn3O4@SiO2 NPs were designed and prepared through an in situ templating method and were found to possess over 2.5 times the in vivo antioxidant removal capacity and a 3-fold TNF (tumor necrosis factor)-α sequestration efficacy when compared with Mn3O4 NPs at the same concentration of Mn3O4. This was achieved through efficient catalytic ROS scavenging, thanks to the enlargement of the surface area and the enhanced dispersity and stabilization of the mesoporous SiO2-supported Mn3O4 NPs. Furthermore, 65% of the IL (interleukin)-1β was down-regulated by the Mn3O4@SiO2 NPs compared with an untreated gingivitis mouse model group, and in contrast, the IL-1β suppression rate for the iso-stoichiometric Mn3O4 NPs was about 85%. The multi-enzyme mimicking Mn3O4@SiO2 NPs provided satisfactory biosafety and therapeutic effects in a gingivitis mouse model and thus represent a promising therapeutic platform for treating gingivitis and other inflammatory diseases.
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PubMed
高影响因子
CRYSTENGCOMM
·
2024
·
IF 2.6
Shilong Li,Ming Zhao,Weichao Zhang,Xiang Wu
Aqueous zinc ion batteries (AZIBs) possess significant application potential in energy storage field due to their large capacity, low redox potential and high safety. Among various materials, Mn3O4 electrode has been widely investigated featuring its mixed Mn valence states (Mn2+, Mn3+ and Mn4+). However, it still suffers from the challenges of poor electrical conductivity and unstable structures. Herein, we coat a layer of polypyrrole (PPy) film on the surface of Mn3O4 microspheres by a simple one-step hydrothermal route. The assembled Zn//Mn3O4@PPy cells show a reversible capacity of 491.5 mAh/g at 0.1 A/g and a capacity retention of 96% at 2 A/g after 1200 times cycling. They also possess an energy density of 295 Wh/kg at a power density of 60 W/kg.
研究领域:
材料科学
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能源存储
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高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2020
·
IF 5.88
Yuanyuan Li,Li Tang,Dongmei Deng,Haibo He,Xiaoxia Yan,Jinhua Wang,Liqiang Luo
The construction of metal-oxide heterojunction architecture has greatly widened applications in the fields of optoelectronics, energy conversions and electrochemical sensors. In this study, olive-like hetero-structured MnO-Mn 3 O 4 microparticles wrapped by reduced graphene oxide (MnO-Mn 3 O 4 @rGO) were synthesized through a facile solvothermal-calcination treatment. The morphology and structure of MnO-Mn 3 O 4 @rGO were characterized by scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, Raman spectroscopy, and X-ray diffraction. The as-synthesized MnO-Mn 3 O 4 @rGO exhibited prominent catalyzing effect on the electroreduction of H 2 O 2 , due to the combination of good electrical conductivity of rGO and the synergistic effect of MnO and Mn 3 O 4 . The MnO-Mn 3 O 4 @rGO modified glassy carbon electrode provided a wide linear response from 0.004 to 17 mM, a low detection limit of 0.1 μM, and high sensitivity of 274.15 μA mM −1 cm −2 . The proposed sensor displayed noticeable selectivity and long-term stability. In addition, the biosensor has been successfully applied for detecting H 2 O 2 in tomato sauce with good recovery, revealing its promising potential applications for practical electrochemical sensors.
研究领域:
材料科学
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分析化学
·
生物医学工程
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PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2016
·
IF 3.014
Yuqin Wang,Zhenyuan Ji,Xiaoping Shen,Keqiang Xu,Aihua Yuan
In this study, a facile refluxing approach has been developed to load Mn 3 O 4 nanocrystals onto reduced graphene oxide (RGO) sheets. The microstructure and morphology of the resulting Mn 3 O 4 /RGO nanocomposites were systematically investigated by X-ray diffraction (XRD), Raman spectroscopy and transmission electron microscopy (TEM). The results reveal that Mn 3 O 4 nanocrystals with particle size of several nanometers were uniformly dispersed on the surface of RGO sheets. The electrochemical properties of the resulting Mn 3 O 4 /RGO nanocomposites were investigated by using them as electrode materials for a supercapacitor . It is found that the Mn 3 O 4 /RGO nanocomposites exhibit enhanced specific capacitance and long-term stability. The enhanced capacitive performance can be attributed to the synergistic effect among Mn 3 O 4 and RGO. The facile synthesis and the enhanced capacitive performance demonstrate the promising application of the Mn 3 O 4 /RGO nanocomposites as supercapacitor electrode materials.
研究领域:
材料科学
·
电化学
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高影响因子
Frontiers in Oncology
·
2020
·
IF 4.848
Li Ke,Li Peng,Wang Yang,Han Shuang
Postoperative recurrence is a common and severe problem in the treatment of gastric cancer; consequently, a prolonged course of chemotherapy treatment is inevitable. Monitoring by imaging could provide an accurate evaluation of the therapeutic effects, which would be beneficial to guide a treatment strategy adjustment over time. However, current imaging technologies remain insufficient for the continuous postoperative monitoring of gastric cancer. In this case, molecular imaging offers an efficient strategy. Targetable contrast agents are an essential part of molecular imaging, which could greatly enhance the accuracy and quality of monitoring. Herein, we synthesized a Mn-based contrast agent for magnetic resonance imaging (MRI) of gastric cancer monitoring. Initially, small-sized Mn3O4 nanoparticles (NPs) were synthesized. Then, a functionalized polyethylene glycol (PEG) lipid was attached to the surface of the Mn3O4 NPs, to improve biocompatibility. The targetable MRI contrast agent (Mn3O4@PEG-RGD NPs) was further prepared by the conjugation of the arginine-glycine-aspartic acid (RGD) peptides. The completed Mn3O4@PEG-RGD NPs had the small size of 7.3 ± 2.7 nm and exhibited superior colloidal stability in different solution environments. In addition, Mn3O4@PEG-RGD NPs exhibited reliable biotolerance and low toxicity both in vitro and in vivo. Imaging experiments amply demonstrated that Mn3O4@PEG-RGD NPs could efficiently accumulate in gastric cancer tissues and cells via RGD mediation, and immediately significantly increased the MRI effects. Through this study, we can conclude that Mn3O4@PEG-RGD NPs have the potential to be a novel MRI contrast agent for the postoperative monitoring of gastric cancer.
研究领域:
生物医学工程
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癌症研究
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医学影像
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纳米技术
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DOI
PubMed
高影响因子
TALANTA
·
2021
·
IF 6.057
Kun Ye,Mingliang Zhang,Peng Liu,Bangxiang Liu,Xuechao Xu,Xin Li,Hengjia Zhu,Linjie Wang,Mengzhu Wang,Xiangheng Niu
As a biomarker of several diseases, the activity of acid phosphatase (ACP) is generally used to assistantly diagnose these diseases. Thus, developing reliable ACP activity analytical methods becomes quite significant. Herein, we recommend a one-step sampling filtration-free electrochemical method for ACP activity determination based on the target-induced synergetic modulation of tag concentration and surface passivation . Mn 3 O 4 microspheres with favorable oxidase-mimicking activity are synthesized to catalyze the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) to its product TMBox, resulting in a remarkable re-reduction signal of TMBox to TMB recorded by an integrated electrochemical system consisting of screen-printed electrode (SPE) and 3D-printed holder. When hexametaphosphate ions (HMPi) with rich negative charges are employed to interact positively charged TMBox, the formed flocculent precipitate TMBox-HMPi automatically sedimentates onto SPE surface, and both the decreased concentration of free TMBox in solution and the increased electrode surface passivation triggered by TMBox-HMPi sedimentation synergistically reduce the re-reduction signal of TMBox. When ACP is present, it hydrolyzes the HMPi substrate, greatly relieving the formation of the TMBox-HMPi precipitate and its sedimentation onto SPE surface. As a result, the electrochemical re-reduction signal of TMBox becomes remarkable again. With the strategy of using one stimulus to generate two-fold signal change, highly sensitive ACP activity detection was realized, with a wide linear range from 0.05 to 50 U/L and a limit of detection down to 0.024 U/L. Reliable monitoring of ACP activity in clinical serum was also demonstrated.
研究领域:
生物医学
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分析化学
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DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2025
·Vol. 37
·期 1
·7
·
IF 2.8
Meng Weili,Dong Chao,Zhou Jiafeng,Cheng Hongwei,Wang Qingqing
Exploring eco-friendly, low-cost, and chemically stable electron acceptor material is of great significance for the hybrid polymer-based solar cells (HPSCs). In this paper, Manganese tetroxide (Mn 3 O 4 ) nanoparticles with a unique tetragonal and hexagonal lamellar structure (4–8 nm) were successfully synthesized by solvothermal method, exhibiting an optical bandgap of 2.39 eV. The as-prepared Mn 3 O 4 nanoparticles were used as electron acceptors for HPSCs blended with a conjugated polymer poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylene vinylene](MEH-PPV) , and delivered a power conversion efficiency ( η ) of 0.73%. Notably, decorating Mn 3 O 4 with the reduced graphene oxide (rGO) to form rGO–Mn 3 O 4 composites significantly improved device efficiency by 38.4%, reaching a η of 1.01%. This enhancement is attributed to the extended electron lifetime facilitated by the formation of rGO–Mn 3 O 4 composite, which provides abundant exciton separation interfaces, thereby promoting efficient exciton separation and charge transfer. These findings offer a new strategy for designing high-performance, sustainable electron acceptor materials for HPSCs.
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JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2022
·Vol. 26
·期 6
·1359-1368
·
IF 2.747
Chen Renhong,Mei Jie,Xu Jin,Xu Wanjie,Wang Laisen,Chen Yuanzhi,Peng Dong-Liang
High-voltage LiNi 0.5 Mn 1.5 O 4 with a spinel structure is considered as important cathode materials for high-energy density Li-ion batteries (LIBs). In this study, we investigate the size, structure, and the electrochemical performance of LiNi 0.5 Mn 1.5 O 4 electrodes prepared by using two different-sized Mn 3 O 4 nanocrystal precursors under different calcination conditions. As the calcination temperature rises, the particle sizes of the acquired LiNi 0.5 Mn 1.5 O 4 cathode materials can vary from ~ 100 nm to ~ 1 µm, and the morphology changes from nano round shape to truncated octahedral shape. The content of Mn 3+ is closely related to the calcination temperature and is affected by the size of Mn precursor. It is found that the LiNi 0.5 Mn 1.5 O 4 sample prepared by using 50-nm-sized Mn 3 O 4 nanocrystals under a calcination temperature of 800 C exhibits good cycling performance with a capacity retention ratio of 96.1% at 1 C after 200 cycles, while the LiNi 0.5 Mn 1.5 O 4 sample prepared by using 7-nm-sized Mn 3 O 4 nanocrystals under a calcination temperature of 800 °C shows an excellent rate performance with a capacity retention ratio of 98% after 500 cycles at 10 C. The results show that the size of Mn 3 O 4 precursor is an important parameter that governs the final size and electrochemical performances of LiNi 0.5 Mn 1.5 O 4 cathode materials.
研究领域:
材料科学
·
能源科学
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高影响因子
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