CERAMICS INTERNATIONAL
·
2026
·
IF 6
Haiyang Chen,Jiale Wang,Ke Zhang,Mengyuan Du,Gaoxiang Ye,Mingjie Guo,Cong Gao,Weisu Weng,Bin Li,Junhong Chen
A novel spatial confined micro-domains method based on the polyacrylamide (PAM) gel carbonization for the synthesis of highly dispersed nano α-Al 2 O 3 was proposed. By optimizing the gel concentration and cross-linking degree, a carbon network featuring confined micro-domains was constructed to effectively inhibit the migration of alumina precursors during phase transformation. Under the influence of spatial confinement, well-dispersed α-Al 2 O 3 nanoparticles with high purity and an average size of approximately 98.3 nm were obtained at an Al 3+ concentration of 0.1 mol/L. FTIR, XPS analyses and first-principles calculations further revealed that the formation of Al-C bonds at the surface of α-Al 2 O 3 contributed to reducing surface energy and enhanced interfacial stability, which further restrained the growth and agglomeration of nano α-Al 2 O 3 . Notably, the alumina ceramics sintered from these nanoparticles exhibited a higher density and superior mechanical properties than commercial counterparts. This study offers a feasible confined-domain strategy for the controllable synthesis of high-performance nano α-Al 2 O 3 .
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高影响因子
POLYMER TESTING
·
2025
·
IF 6
Yingying Zhang,Cancan Yang,Chongyue Bai,Xuanye Wang,Chao Feng,Huige Wei
Polyacrylamide (PAM) based hydrogels are promising for soft strain sensor applications, while the incorporation of vinylimidazole (VI) endows the hydrogels with unique ion responsiveness and good biocompatibility. In this study, a high-performance PAM-co-VI/Ni/Co hydrogel was successfully fabricated through copolymerization of PAM with VI followed by modification with bimetallic nickel-cobalt ions. Experimental results demonstrate that when the VI content is 30% with a Ni/Co ion ratio of 3:1, the hydrogel exhibits remarkable comprehensive properties, with a tensile fracture strength of 0.46 MPa, an ultrahigh fracture strain of 1800%, a tensile sensitivity of 4.62, and long-term durability exceeding 1000 cycles. Furthermore, the hydrogel shows high pressure sensitivity (0.059 kPa -1 in the 0-5 kPa range), enabling precise detection of various mechanical signals from acoustic vibrations to complex human motions. Owing to its superior conductivity and biocompatibility, the PAM-co-VI/Ni/Co hydrogel also functions as a flexible electrode for electrocardiogram (ECG) monitoring, achieving conformal skin contact while stably acquiring high signal-to-noise ratio ECG waveforms with accurate identification of P-waves, Q, R, and S waves (QRS complexes), and other key features, demonstrating great potential for wearable health monitoring applications.
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高影响因子
Frontiers in Cellular and Infection Microbiology
·
2025
·
IF 4.8
Yizhuo Zhang,Luqin Lv,Su Xu,Yijian Chen
Introduction: Clostridioides difficile (C. difficile), a human pathogen that causes diarrhea and colon lesions, has garnered widespread attention. Rapid and accurate detection of bacterial virulence factors is essential for the diagnosis of C. difficile infection (CDI). To date, numerous laboratory tests have been developed; however, none fully meet the combined requirements of speed, cost-effectiveness, portability, sensitivity, and specificity. Molecular diagnostic technologies based on CRISPR-Cas systems have provided a promising solution to this challenge. Nonetheless, the limited compatibility between pre-amplification and CRISPR cleavage, coupled with the inherent selectivity of CRISPR systems for protospacer adjacent motif (PAM) sequences near the target site, poses additional constraints on the broader adoption of this approach.Methods: Here, we developed PAM-unconventional, One-step LAMP/CRISPR-Cas12b (POLC) detection platforms for the toxin-encoding genes tcdA and tcdB of C. difficile.Results: The POLC platforms operated at 60 °C, enabling result interpretation either through fluorescence intensity measurements or direct visualization under UV light. The limits of detection (LoDs) ranged from 3 to 14 copies/μL using a fluorescence reader and from 6 to 18 copies/μL via direct observation. Compared to qPCR, which typically requires over an hour, the POLC platforms reduced the detection time to approximately 40 minutes. Each reaction cost approximately USD 6.5, offering a substantial cost saving compared to qPCR-based commercial kits (over USD 10 per test). In clinical validation with 55 fecal samples, the tcdA POLC assay achieved 86.4% sensitivity and 84.8% specificity, while the tcdB POLC assay demonstrated 96.6% sensitivity and 100% specificity, using qPCR as the reference standard.Discussion: Our research presents innovative CRISPR-based one-step nucleic acid detection platforms that eliminate canonical PAM sequence requirements. These platforms exhibit high sensitivity and specificity while achieving rapid detection under simple conditions, making them promising candidates for clinical diagnostics and point-of-care testing (POCT).
研究领域:
医学诊断
·
分子生物学
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Jiaojiao Li,Lei Chen,Boliang Zhou,Xin Yang,Xingyu Chen,Zhiwei Lu,Jiangling Wan,Qing Du,Chuansheng Zheng,Yanbing Zhao,Xiangliang Yang
A significant challenge in comprehensive interventional liver cancer therapy based on radiofrequency ablation and multifunctional microsphere embolization lies in enhancing therapeutic efficacy. Addressing this challenge, an innovative coaxial electrospray technology has been developed. This technology distinguishes between the processes of droplet dispersion and microsphere solidification by utilizing the stability of Pickering emulsions. Consequently, it broadens the range of materials that can be synthesized via the electrospray method and enables the incorporation of diverse functional substances to prepare multifunctional embolic microspheres. This process successfully constructs Au@PAM microspheres that combine embolization, radiopaque imaging, and radiofrequency thermal response functions. The radiopacity of the Au@PAM was comparable to the 41 mg I/mL iohexol, indicating its potential as a radiopaque embolic agent. In vitro embolization simulation experiments have indicated that the Au@PAM microspheres exhibit excellent elasticity, deformation, filling capacity, and thermal response adhesion characteristics. Furthermore, in vitro radiofrequency response experiments have demonstrated that the Au@PAM microspheres exhibit significant radiofrequency thermal effects. The integration of embolization with radiofrequency treatment in VX2 tumor-bearing rabbits suggests that Au@PAM microspheres substantially enhance the synergistic anti-tumor effects of transcatheter arterial embolization and radiofrequency ablation on liver cancer. Additionally, they positively influence the regulation of the postoperative tumor microenvironment.
研究领域:
生物医学工程
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纳米技术
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肿瘤学
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放射学
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材料科学
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介入治疗
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Jinjin Lin,Qiannian Yang,Jiahao Huang,Zhiyi Wu,Yuanyu Wang
The CLZPP hydrogel with zwitterionic surfactant has high conductivity (16.19 S/m) and large tensile strain of 1083.76%. • CLZPP hydrogel electrodes show higher signal-to-noise ratios than commercial ones in EMG, ECG, and EOG monitoring. • The integrated device fabricated via layered pouring and stepwise cross-linking shows stable output over 1000 cycles. Flexible self-powered devices can operate without external power supplies and are therefore attractive for wearable health monitoring. Here, cocamidopropyl betaine (CAPB), LiCl, and ZnO nanoparticles were incorporated into a poly(vinyl alcohol)/polyacrylamide (PVA/PAM) double-network matrix to form a highly conductive and stretchable hydrogel. The optimized CAPB/LiCl/ZnO/PVA/PAM (CLZPP) hydrogel achieved a tensile stress of 116.41 kPa and a tensile strain of 1083.76%. Its toughness and ionic conductivity reached 0.66 MJ/m 3 and 16.19 S/m, respectively. It also exhibited sensitive strain responses and reliable cycling stability. As a wearable sensor, the hydrogel detected motions of the finger, wrist, knee, and neck, together with weak physiological signals associated with speech. As a bioelectrode, it recorded electromyographic (EMG), electrocardiographic (ECG), and electrooculographic (EOG) signals with performance comparable to commercial electrodes and higher signal-to-noise ratios. An all-hydrogel, fully flexible integrated piezoelectric sensor was then fabricated by sequential casting and stepwise crosslinking. The integrated piezoelectric sensor generated stable voltage through the piezoelectric response of ZnO, converting deformation-induced mechanical energy into electrical energy for self-powered sensing. Piezoelectric signatures produced by contact with different materials were further combined with machine learning to enable rapid material classification. This work provides a strategy for jointly optimizing the mechanical, electrical, and piezoelectric properties of hydrogels and supports their use in self-powered wearable health monitoring and intelligent human-machine interfaces. Download: Download high-res image (208KB) Download: Download full-size image
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JOURNAL OF ALLOYS AND COMPOUNDS
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2025
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IF 6.3
Yuqi Sun,Amatjan Sawut,Rena Simayi,Xixi Huang
Though advanced oxidation technologies show promise for water purification, they face challenges. Photocatalysts struggle with recoverability and environmental adaptability, while the Fenton process is limited by the finite cycling of Fe species, low H 2 O 2 utilization, and strict acidic pH requirements. Based on the above issues, this paper developed a novel FeOCl-loaded hydroxypropyl methylcellulose/polyacrylamide (HPMC/PAM) composite hydrogel (FeOCl/HPMC/PAM) is developed as an efficient photo-Fenton-like catalyst. The FeOCl/HPMC/PAM composite system exhibits complex degradation kinetics (zero-order reaction with 5–50 μL hydrogen peroxide solution, first-order reaction with 100 μL hydrogen peroxide solution) and demonstrates highly efficient degradation performance across a broad pH range (1–7). Under pH= 7, it achieves 93.47 % methylene blue (MB) degradation within 60 min via an adsorption-degradation synergistic mechanism. After six cycles, it retains 75 % activity, showing favorable reusability. The cyclic stability test shows that it still retains 75 % of the degradation efficiency after 6 consecutive cycles, confirming its reliable reusability. Meanwhile, the iron leaching rate of the composite material during the reaction is only 0.061 mg/L, confirming its structural stability and environmental safety. With low cost, easy recovery, and wide pH adaptability, this composite hydrogel exhibits potential as a commercially viable system for organic pollutant removal from real water matrices.
研究领域:
环境科学
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材料化学
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水处理技术
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催化化学
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高分子科学
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DOI
高影响因子
EUROPEAN POLYMER JOURNAL
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2023
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IF 6
Xiang Wang,Tianwen Dai,Zhixi Zhao,Xinyue Jiang,Chuxiang Zhou,Huawei Zou,Pengbo Liu
Polyacrylamide (PAM) hydrogel is easy to prepare and has been widely used in industrial and biomedical fields. But its mechanical properties and environmental adaptability are very poor. In this work, by introducing carboxymethyl cellulose (CMC) into the PAM crosslink network, a semi-interpenetrating (semi-IPN) network structure was constructed to improve the mechanical properties of PAM hydrogels. PAM/CMC hydrogel microspheres (HMPs) with semi-IPN structure were successfully prepared by in-situ precipitation droplet crosslinking polymerization (PDIC). On this basis, a double locking water strategy was proposed and achieved: firstly, lithium chloride (LiCl) was introduced into PAM/CMC hydrogel to retain the internal water; secondly, the PAM/CMC HMPs were coated with single layer graphene oxide (GO) to restrain the loss of free water on the HMPs surfaces. The morphology, the state of water in HMPs, the compression performance, phase transition behavior and heat transfer performance of the GO coated PAM/CMC/LiCl HMPs (GO@HMPs) were further studied. The experimental results showed that the CMC could effectively improve the compression performance of PAM HMPs, and the PAM/CMC HMPs had also good compression recovery performance. The anti-dehydration performance of PAM/CMC HMPs was effectively improved by the double locking water strategy. The latent heat of GO@HMPs was higher than that of the current commercial phase change microsphere materials. The GO@HMPs had excellent heat absorption ability and were expected to be used in infrared stealth and thermal camouflage fields.
研究领域:
材料科学
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生物医学工程
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高影响因子
BIOMACROMOLECULES
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2022
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IF 6.978
Xiaoli Zhao,Ya-feng Huang,Xuan Tian,Jinni Luo,Huanxia Wang,Jinfei Wang,Yuan Chen,Pengxiang Jia
Adhesive hydrogels have been considered as one of the most ideal materials for wound dressing. However, most existing adhesive hydrogels still have disadvantages such as low mechanical properties, poor biological activity (antibacterial and hemostatic ability), and low biocompatibility, which largely limit their application. Thus, it is highly desired to prepare a hydrogel-based wound dressing with good self-healing, ideal adhesive properties, rapid hemostasis, and excellent wound infection prevention activity. In this study, a simple method was presented to prepare a PAM-Lignin-CS-Laponite-SA hydrogel for wound dressing. The obtained hydrogel displayed excellent self-healing ability and repeatable adhesive performance, benefiting from the introduction of hydrogen bonding and electrostatic interactions inside the hydrogel network. In addition, the PAM-Lignin-CS-Laponite-SA hydrogel also exhibited low cell cytotoxicity, good antibacterial activity, and outstanding hemostatic properties. In conclusion, the PAM-Lignin-CS-Laponite-SA hydrogel demonstrated good tissue adhesion, excellent self-healing ability, effective bleeding control, and good antibacterial activity to prevent wound infection, which provides a new idea for developing a multifunctional hydrogel-based tissue adhesive hemostatic dressing.
研究领域:
材料科学
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生物医学工程
·
生物材料
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DOI
PubMed
高影响因子
CURRENT BIOLOGY
·
2025
·
IF 7.5
Mingmin Zhou,Meijun Zheng,Xiaohang Zhang,Xin Liu,Jing Guo,Xichu Cao,Aike Guo,Yan Li
Animals display rhythmic foraging behavior synchronized with the Earth’s 24-h cycle. However, the underlying neural mechanism remains poorly understood. In this study, we found that one group of olfactory inhibitory projection neurons (iPNs) in Drosophila , called mlPN3, exhibits circadian responses to food odor and plays an essential role in promoting rhythmic foraging. We show that this circadian activity of mlPN3 neurons is driven by a rhythmic inhibition from a group of dopaminergic neurons (DANs), PAM-β'2. Furthermore, PAM-β'2 DANs are activated in the early morning by a group of circadian neurons, called morning cells, through pigment-dispersing factor (PDF) neuropeptide. Suppressing either PAM-β'2 DANs or morning cells impairs morning foraging, which is fully rescued by inhibiting mlPN3 neurons. Together, our findings show that the constant inhibition on foraging behavior of these iPNs is lifted by the circadian signal through dopaminergic suppression, providing critical insights into the function of the disinhibition circuit in circadian regulation.
研究领域:
神经科学
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时间生物学
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行为遗传学
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DOI
PubMed
高影响因子
SENSORS AND ACTUATORS A-PHYSICAL
·
2023
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IF 4.6
Ruxue Yang,Hailong Cheng,Xinchun Luo,Xiyue Chen,Qing-Yun Wu,Xin Wu
Conductive hydrogels have attracted extensive attention in the application of wearable devices due to their excellent flexibility, biocompatibility, and stability. However, it is still a significant challenge to facilely fabricate the conductive hydrogels with high strength, high sensitivity and stable conductivity for wearable strain sensors. Herein, carbon nanoparticles based conductive hydrogels were prepared by a facile one-pot method of combining dispersant-free carbon nanocolloids with PVA/TA/PAM. When a small amount of carbon nanoparticles (0.45 wt%) were added into the hydrogel, the conductivity was significantly enhanced. Due to the synergetic effects from the PVA/TA/PAM polymers and carbon nanoparticles, the as-synthesized composites exhibited large mechanical strength (11.9 MPa) and failure strain (476 %), good sensitivity (GF max = 1.41), great stability (over 500 cycles). In addition, the strain sensor made from the conductive hydrogel could sensitively detect human movements such as finger bending, arm bending, wrist bending, and leg bending. This hydrogel preparation strategy exhibits potential applications in low-cost wearable devices with high mechanical strength and sensitivity.
研究领域:
材料科学
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纳米技术
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可穿戴技术
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生物医学工程
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高影响因子
Green Chemical Engineering
·
2024
·
IF 9.1
Enze Li,Jing Dong,Yongsheng Jia,Zihe Pan,Hongzhou Lv,Zhiping Du,Guandao Gao,Fangqin Cheng
Sufficient treatment of industrial organic wastewater with high salt and large amounts of suspended particulate matter remains a challenge worldwide. In this work, a novel coagulation-flotation combined process was developed to treat the suspended particles as well as significantly reduce organic pollutants content in the actual high-salt organic wastewater. Four typical inorganic and organic flocculants (poly aluminum chloride (PAC), poly ferric sulfate (PFS), polyacrylamide (PAM), and modified cationic starch (CS)) were selected for compounding to obtain an optimized flocculation system for high-salt wastewater. The results showed that the PAC-PAM with a 10:1 ratio in mass exhibited the best coagulation behaviors with the removal efficiency of turbidity and chemical oxygen demand (COD) being 95.33% and 9.21%, respectively, under the optimal operation conditions, and the sedimentation process of coagulant conformed to the quasi-second-order kinetics. The PAC-PAM flocs exhibited stronger netting, sweeping, and adsorption bridging capabilities, which were conducive to removing suspended particles. When the flotation was conducted after coagulation, the COD decreased significantly by 20.82%. In addition, this combined process could reduce the treatment time by 50% compared to the process with only coagulation treatment. During the flotation process, floc particles companies with hydrophobic polycyclic aromatic hydrocarbons could collide and adhere to microbubbles and be floated to the surface, resulting in an effective reduction of COD. This work could provide a novel strategy and step forward to design and optimize the pretreatment process engineering for organic high-salt wastewater.
研究领域:
环境工程
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废水处理
·
化学工程
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高影响因子
RSC Advances
·
2016
·Vol. 6
·期 89
·85885-85890
·
IF 3.289
Dongjian Shi,Xiaodong Zhang,Zhaokun Yang,Shirong Liu,Mingqing Chen
This paper presents fabrication of polyacrylamide (PAM) and PAM/poly(methacrylic acid) (PMAA) inverse opal photonic crystal hydrogels (IOHs) based on poly(styrene-acrylic acid) (PSA) template by a “Sandwich” method. SEM images showed the obtained IOHs had a three-dimensional ordered structure and extremely uniform pore size without over-layers and defects. The IOHs exhibited brilliant structural color by controlling the PSA particle size, MAA and cross-linker compositions. The color and Bragg diffraction peak of the IOHs responded to external stimuli such as pH, methanol and ethanol. The reflectance was red-shifted in low pH and blue-shifted in high pH and in the presence of methanol and ethanol. The effects of the MAA and cross-linker composition on the response properties of the IOHs were investigated. The PMAA in the IOHs provided –COOH groups that are apt to form hydrogen bonds with water, enhancing the response sensitivity.
研究领域:
材料科学
·
化学工程
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DOI
高影响因子
危险品化学品经营许可证（带存储）