Reproductive and Developmental Medicine
·
2020
·
IF 0
Ya-Ling Wang,Min-Yan Liu,Yu-Hua Li,Yi-Ting Yang,Wei-Wei Wang,He-Guo Yu,Zhi-Yu Shao,Hua Diao
Objective: Amino acyl modification of lysine residues is an essential mechanism of nutrient sensing that regulates various biological functions including reproduction. At present, the lack of pan-specific antibodies for a recently identified lysine valylation hinders the characterization and detection of this modification. The objective of this study is to raise pan-specific antibodies that may facilitate the identification of novel expression patterns of lysine valylation. Methods: Chicken ovalbumin was valylated as an immunogen to raise polyclonal antibodies (PcAbs) in rabbits. The population of the pan-specific antibodies recognizing valylated lysine was purified using the chemically synthesized valylated peptides consisting of random amino acids. The specificity of the antibodies was evaluated using ELISA, dot blots, Western blots, and immunohistochemistry (IHC) staining in human epididymis as well. Results: A preliminary and simple strategy to make an anti-valylated lysine PcAb was developed. The recognition of the antibodies to valyllysine was evaluated as pan specific. This was useful for the detection of the newly identified valyl modification using ELISA, dot blots, and Western blots. The antibodies were also successfully utilized in IHC assays, which revealed novel valyllysine modification patterns in epididymis tissues of human. Conclusions: A new antibody tool was provided for the study of lysine valylation. The novel expression patterns of valyllysine in the epididymis suggest that this modification may be involved in sperm maturation.
研究领域:
生物化学
·
分子生物学
·
生殖生物学
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DOI
DESALINATION
·
2024
·
IF 8.3
Kun Wang,Zihao Ge,Mianliang Ji,Jian Li
Block copolymer-based porous materials have found extensive applications across a broad spectrum of industries. Their customized structures and scalable production capabilities have provided numerous possibilities to design membranes with precise separation properties. In this study, mPEGx-b-PAN block copolymers have been synthesized by incorporating mPEG of varying molecular weights in order to improve the selectivity and the antifouling properties of the resulting ultrafiltration membranes. Microphase separation within mPEG and PAN blocks was dependent on mPEG chain length and block concentration, ultimately leading to the controlled creation of pores in the mPEGx-b-PAN ultrafiltration membrane. Simultaneously, the surface layer thickness of the composite membrane was considerably reduced after adding the block copolymer. The optimized UF 2000 – 1.0 membrane, prepared by blending 1 % mPEG 2000 -b-PAN with PAN, exhibited a high permeability of 340.75 ± 22.17 L m −2 h −1 bar −1 and a BSA rejection rate of over 99 %, effectively separating organic pollutants such as HA, CR, and CB-G250. Furthermore, antifouling tests showed that the mPEG 2000 -b-PAN/PAN composite membranes exhibited a gradual degradation of permeability during the antifouling stage, with high permeability recovery after backwashing. Therefore, mPEGx-b-PAN block copolymers demonstrate promising potential for membrane separation applications and pave the way for significant advancements in filtration technology.
研究领域:
材料科学
·
环境工程
·
化学工程
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产品关联
DOI
高影响因子
Journal of Energy Storage
·
2025
·
IF 9.8
Qilong Hao,Jing Zhao,Qing Wen,Jinling Yin,Guiling Wang
Sodium metal is considered a potential candidate for the anode in next-generation cost-effective and high-energy-density metal batteries. However, its practical application in ether-based electrolytes is severely hindered by the uncontrolled proliferation of sodium dendrites and the instability of the solid electrolyte interphase (SEI) layer. To address these challenges, we developed a lightweight, multifunctional separator using electrospinning technology. This separator, composed of a polymer-metal-organic framework composite (PAN/ZIF-67), offers a novel alternative to conventional bulky glass fiber separators. The PAN/ZIF-67 separator features a unique ordered structure and open active metal sites, which significantly enhance electrolyte wettability and promote anion adsorption, effectively guiding the uniform deposition of Na + . Experimental results confirmed its superior electrochemical performance, including low polarization voltage and high cycling stability, under standard ether-based electrolyte conditions without additives. In symmetric Na || Na cells equipped with the PAN/ZIF-67 separator, exceptional cycling stability was achieved, with a low polarization voltage of ∼12 mV at 1 mA cm −2 sustained over 1000 h and ∼66 mV at 5 mA cm −2 for over 500 h. In a full cell with a Na₃V₂(PO₄)₃ cathode and Na anode, the separator demonstrated excellent rate capability and cycling stability, maintaining a capacity retention of 72.4 % after 800 cycles at 5C. This work offers a possible solution to address critical issues in sodium metal batteries and represents a notable advancement toward their practical applications.
研究领域:
材料科学
·
能源存储
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产品关联
DOI
高影响因子
POLYMER
·
2024
·
IF 4.1
Lulu He,Jinfen Lou,Xiang Nie,Min He,Qiao Fan,Jifei Yang,Yufei Liu,Shuhao Qin,Jie Yu
Polyamide 6 (PA6) is widely utilized, yet it confronts challenges such as susceptibility to thermal oxidative aging and high sensitivity to notch impact during usage. In addressing these issues, two novel toughening macromolecular antioxidants, 3-(3,5-di- tert -butyl-4-hydroxyphenyl) propionic acid 2-acrylamidoethyl ester styrene copolymer (PAS) and 3-(3,5-di- tert -butyl-4-hydroxyphenyl) propionic acid 2-acrylamidoethyl- N -phenylmaleimide copolymer (PAN), were synthesized via free radical copolymerization. Upon incorporation into PA6, their effects on PA6 performance were investigated. Relative to pure PA6, PA6/PAN and PA6/PAS exhibited significant improvements in fracture elongation, with increases of 136.91 % and 313.83 % respectively, along with notch impact strength enhancements of 18.55 % and 24.89 % respectively. This enhancement can be attributed to PAN and PAS reducing the hydrogen bond density between PA6 molecular chains. Subsequent long-term accelerated thermal aging tests conducted at 150 °C, as well as performance testing of samples before and after aging, revealed that the aging of PA6/PAN and PA6/PAS could be delayed by 4–12 days. The exceptional anti-thermal oxidative aging ability and toughening effect of these two macromolecular antioxidants in PA6 showcase promising prospects for its expanded applications.
研究领域:
材料科学
·
高分子化学
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产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2019
·
IF 3.45
Cheng Zhang,Runping Li,Jianhua Liu,Guo Chen,Shenghui Guo,Lei Xu,Shijie Xiao,Zhigang Shen
The effects of modification temperature and time on polyacrylonitrile (PAN) fibers under various concentrations of KMnO 4 were studied. Wettability , colouration, chemical structure (Fourier transform infrared spectroscopy), crystal structure (X-ray diffraction), stack domains (D), interlayer spacing (d), microscopic structure (Scanning electron microscopy) and elemental content (energy dispersive spectroscopy) were analysed. Aside from its good hydrophilicity, KMnO 4 at 2 and 4 wt% are beneficial to the modification of PAN fibers. The colouration of the fiber at 80 °C is the most obvious. The clear peak of the pre-oxidised fibers at 2340 cm −1 corresponds to the conjugated structure of MnO 4 –C N. At 4 wt%, the degree of pre-oxidation is too high and the main infrared peak disappears. M 2, 30 has a minimum D of 9.320 nm and 8.258 nm at 2θ = 16.883° and 2θ = 29.673°, respectively, and the fiber crystals are the finest. At a content of 4 wt%, the fibers are axially cracked and crystals appear on the surface. M 2, 30 and M 2, 60 have a close percentage of C element, whereas M 2, 30 has a lower percentage of Mn element. The best modification conditions of KMnO 4 are 2 wt%, 80 °C and 30 min.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
CHEMOSPHERE
·
2018
·
IF 4.427
Peng Liu,Xiangyu Wang,Jun Ma,Huiling Liu,Ping Ning
To provide superior substrates and determine the specific species of immobilized nano zero-valent iron (NZVI) system, polyacrylonitrile (PAN) membrane was functionalized by bio-inspired polydopamine (PDA) and poly( l -DOPA) (PDOPA) for efficient immobilization of NZVI. The synthesized composites were denoted as PAN/PDA-NZVI (PPN) and PAN/PDOPA-NZVI (PON), respectively. Analyses of XRD, SEM/EDS and XPS show that the aggregation and release of iron nanoparticles had been successfully controlled by improving membrane hydrophilcity and iron-chelating capacity via the graft of functionalized groups (i.e. OH and COOH) of PDA and PDOPA on PAN membrane. Both PPN and PON composites exhibited superior reactivity for Cr(VI) removal (Cr(VI) removal efficiency and reaction rate were 2.21–2.22 and 9.90–10.14 times higher than that of bare NZVI, respectively). The stability and recyclability of PPN and PON composites could be maintained over repeated cycles. Further analyses indicate that PON is more capable for Cr(VI) elimination than PPN due to the proprietary carboxyl of l -DOPA. With the addition of 1,10-phenanthroline, membrane-chelated Fe(II) was determined to be the major species in Cr(VI) removal system, accounting for 56.9% and 53.8% with regard to PPN and PON composites, and Fe 0 was responsible for the reduction of residual Cr(VI). Analyse of reacted composites revealed that Cr(VI) was completely converted into Cr(III), followed by formation of dominant Cr(III)/Fe(III) (oxy)hydroxides and partial desorption from NZVI reactive sites. This study suggested that both synthesized PPN and PON composites have potentials for Cr(VI)-contaminated wastewater treatment .
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
ELECTROCHIMICA ACTA
·
2026
·
IF 5.8
Bin Yao,Xudong Bu,Yurong Zhang,Xiaodong Chen,Yanshuang Meng,Kai Zhang,Xiaofeng Zhu,Sheng Wang,Xueyan Du
Ti 3 C 2 T x MXene holds great promise as an electrode material for electrochemical energy storage, but its practical application is often limited by the restacking of nanosheets, which impedes ion accessibility and rate capability. Herein, a simple in-situ carbonization strategy using polyacrylonitrile (PAN) is developed to fabricate MXene/C composite electrodes. During pyrolysis, PAN transforms into N-doped amorphous carbon, which not only spacers and bridges adjacent Ti 3 C 2 T x MXene lamellae but also introduces porosity, thereby enlarging the interlayer spacing and forming a permeable mesoporous network while maintaining efficient electron transport. Electrochemical evaluation identifies 600 °C as the optimal carbonization temperature, leading to surface-capacitive-dominated charge storage with enhanced ion diffusion kinetics. By optimizing the composition, the composite with 20 wt% PAN achieves a specific capacitance of 237.75 F g -1 at 1 A g -1 , along with significantly improved rate performance and cycling stability compared to the pristine MXene electrode. This polymer-derived carbon intercalation approach offers a straightforward and effective route for tailoring the MXene interlayer structure, facilitating the rational design of high-performance supercapacitor electrodes.
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产品关联
DOI
高影响因子
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
·
2026
·Vol. 132
·期 4
·289
·
IF 3
Wang Jiaming,Cao Ping,Ji Zhengyang,Shan Mingzhe,Yuan Yishan,Song Xiqing,Lu Yaozeng,Tan Surong,Li Zining,Jiang Junlai,Zhang Jing
Piezoresistive wearable electronic devices have great potential in fields such as health detection and human-computer interaction, but traditional devices often fail to recognize pressure changes while maintaining high sensitivity to temperature. In this study, we propose a temperature-recognized piezoresistive pressure sensor based on rGO/MWCNTs@PAN composite film, the strain layer of this sensor is synthesized through electrospinning, the substrate was a high-carbon low-polymer mixture of dimethylformamide (DMF), polyacrylonitrile (PAN), and doped with an excess of multiwalled carbon nanotubes (MWCNTs, 0.6 g), in a high MWCNTs environment, the material as a whole is strengthened, with a more resilient structure. Meanwhile, its unique tubular structure provides a conductive path for the reaction and offers support. Embedding PVA on the substrate surface enhances overall stability and is coated with rGO, under this high-carbon condition, the electrical conductivity is enhanced, making it sensitive to pressure while responding more precisely to temperature changes. Moreover, with the combination of rGO and MWCNTs, the original flexibility can be maintained. The sensitivities of the devices prepared by this method within the ranges of 0–18 kPa, 18–85 kPa and 85–140 kPa are 174.3 kPa − 1 , 32.2 kPa − 1 and 23.5 kPa − 1 respectively, it maintains a high sensitivity to pressure. In addition, the sensor also demonstrated a low detection limit (0.5 Pa), a fast response (200 ms), and maintained a 91% cycle retention rate after 5,000 cycles, and it can accurately identify the temperature within the range of 40 to 70℃. Based on these characteristics, this piezoresistive pressure sensor with temperature recognition can detect in real time a richer range of human health movement indicators, such as finger bending, elbow movement and knee bending, etc. This study indicates that this pressure-temperature sensor has broad application prospects in health monitoring.
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产品关联
DOI
高影响因子
NANOTECHNOLOGY
·
2020
·Vol. 31
·期 24
·24LT01
·
IF 3.551
Tingting Cai,Yun Yang,Ting Bi,Ernest Bi,Yanfang Li
Recently, polyacrylonitrile (PAN) fiber films have shown greater advantages over polyvinylidene fluoride (PVDF) in the field of energy harvesting. Adding other substances with high piezoelectric coefficient is worth exploring to further improve the output voltage of PAN. Here, we successfully dispersed high dielectric constant barium titanate in PAN nanofiber films with different dosages using an electrospinning technology. The X-ray diffraction and Fourier transform infrared spectroscopy results indicated that BaTiO3 nanoparticles aid in transforming PAN from a 31-helical conformation to a planar zigzag conformation, thus improving the output voltage of PAN nanofibers significantly and also promoting its mechanical properties. In addition, the human body function monitoring experiment showed a good response current to the rhythm of elbow bending, knee bending, running, and breathing. Besides, when a simple rectifier circuit was applied, the capacitor could be charged to 2 V in less than 2 min and light a commercial LED through repeated tapping.
研究领域:
材料科学
·
能源技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Physical Chemistry C
·
2017
·
IF 4.536
Ying Liu,Lingyang Liu,Yongtao Tan,Lingbin Kong,Long Kang,Fen Ran
Both vanadium nitride and carbon are the important negative materials for capacitors electrodes, while effectively dispersing vanadium nitride into the surface of carbon materials would highly enhance the utilization of active materials. In this article, we find out a valid dispersion method of vanadium nitride nanoparticles into the porous carbon networks, which is derived from a synthesized block copolymer of polyacrylonitrile-b-poly[2-(methacryloyloxy)ethyl]trimethylammonium chloride-b-polyacrylonitrile together with the absorbed ammonium metavanadate. With the superiority of the designed structure, the fabricated materials are used as negative materials for capacitors electrodes and show outstanding electrochemical performance with a specific capacitance of 195.7 F/g and a prior cycle stability of 75% retention. In addition, the effect of the ratio of copolymer to ammonium metavanadate on the electrochemical performance of the product is also investigated in detail.
研究领域:
材料科学
·
能源存储
✓ 已验证
DOI
高影响因子
ACS Applied Polymer Materials
·
2020
·
IF 0
Dan Lv,Guosheng Tang,Long Chen,Mengjie Zhang,Jiaxin Cui,Ranhua Xiong,Chaobo Huang
Today, poor water and air quality caused by fine particulate matters (PMs), toxic spills, and antibiotic-containing wastewater are posing serious threats and risks to the environment and human health. Although many contaminant materials can be effectively removed by the traditional membrane technology, the simultaneous multifunctional materials like PM removal, oily water separation, and antibiotic adsorption are rarely reported. In addition, most of the membranes are destroyed when working in the harsh environment such as high temperatures, high pressures, strong acids and bases, and so on. In this work, a multifunctional Fe3O4@polyacrylonitrile/chitosan (Fe3O4@PAN/CS) membrane with robust stability and repeatable usage was fabricated via a simple and environment-friendly gas-spinning method; the obtained functional membrane is supposed to be applied in both air and liquid contaminant remediation. In comparison with the reported membranes, the multifunctional Fe3O4@PAN/CS composite nanofiber membranes not only have excellent performance in air filtration, antibiotic adsorption, or oil–water separation but also show robust reusability and durability even in harsh environments. Our strategy would bring ideas to the design and fabrication of multifunctional membranes for simultaneous environmental remediation such as air purification and wastewater treatment.
研究领域:
环境科学
·
材料科学
·
纳米技术
✓ 已验证
产品关联
DOI
SYNTHETIC METALS
·
2025
·
IF 4.6
Yulu Chen,Huawei Rong,Rongzhi Zhao,Zhen Shi,Lingfeng Li,Hang Shentu,Xuefeng Zhang
With the rapid development of next-generation wireless communication technologies, electromagnetic pollution has become an issue that cannot be overlooked. Designing lightweight, flexible composite materials with excellent electromagnetic shielding properties has become a significant challenge. This study designed a double-layer core-shell structure to fabricate polymer-based PAN@PDA@Ag nanofiber membranes. Scanning electron microscopy (SEM) studies revealed that the nanofiber exhibits a distinct core-shell structure. PAN@PDA nanofiber adsorbs silver nanoparticles (AgNPs) via chemical reduction, forming a dense conductive network layer. The morphology of fibers is achieved by regulating the contents of PDA. The [email protected] @Ag-90 fiber membranes, with a thickness of 0.06 mm, show an impressive conductivity of 3601.76 S/m and a shielding effectiveness of 85.6 dB. This work demonstrates that the synergistic effect among the components endows the composite with outstanding electromagnetic shielding performance, offering promising prospects for applications in next-generation wireless technologies.
研究领域:
材料科学
·
电磁屏蔽
·
纳米技术
·
聚合物复合材料
·
无线通信
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）