JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
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2020
·
IF 2.69
Jie Liu,Qin Zou,Bin Cai,Jiawei Wei,Chen Yuan,Yubao Li
A novel bilayer fibrous membrane for guided tissue regeneration (GTR) was prepared via two-step electrospinning process, subsequent crosslinking and surface conjugation with heparin. The bilayer membrane consists of upper layer polycaprolactone/gelatin (PCL/Gel) membrane for soft tissue regeneration and lower layer PCL/Gel/nano-hydroxyapatite (PCL/Gel/n-HA) membrane for hard tissue regeneration. The results indicated that the physicochemical and biological properties of the membrane were strongly influenced by the crosslinking time and by the heparin conjugation. Crosslinking effectively prolonged the degradation time while maintaining the membrane barrier function, and the surface heparin conjugation obviously improved the biological performance of the membrane. An enhanced cell adhesion and proliferation were observed on the heparin-conjugated fibrous membranes, which also showed good histocompatibility and favorable in vivo degradability. The electrospun bilayer fibrous membrane may have promising prospect for modulation of cell response and simultaneous regeneration of soft and hard tissues.
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DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Zhi Wang,Ruya Zhang,Chen Yang,Hui Yi,Wenge Yang,Yonghong Hu
Current smart cling films for pork preservation often face two key challenges: either they lack real-time freshness monitoring capabilities, or their antibacterial components rely on visible light—limiting penetration depth and easily inducing lipid oxidation in pork. To address these gaps, this work fabricated an electrospun bilayer smart cling film with integrated preservation and monitoring functions. The film comprises a hydrophilic outer layer (polycaprolactone [PCL]/polyvinyl alcohol [PVA]/chitosan [CS]/anthocyanin [ACN], for pH-responsive color indication) and a hydrophobic inner layer (PCL as the matrix, loaded with aluminum phthalocyanine [AlPc], for near-infrared-driven antibacterial activity). We systematically investigated the effect of AlPc loading (5 %–15 %) on film performance. Results showed that the film with 15 % AlPc exhibited the highest level of comprehensive properties among the tested groups: its antibacterial and antioxidant capacities were significantly enhanced, alongside improved physical characteristics—hydrophobicity of the inner antibacterial layer increased by 17 % (in terms of water contact angle), and water vapor transmission (WVT) was reduced by 19 %. Importantly, the film displayed distinct color changes (light red to dark red) in pH 3–11 buffer solutions and during pork storage, enabling real-time freshness monitoring. Moreover, it extended the freshness period of pork to 5 days. These findings demonstrate that the prepared bilayer film effectively addresses the limitations of existing cling films, offering significant potential for simultaneous pork shelf-life extension and freshness monitoring.
研究领域:
食品科学与技术
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材料科学
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活性包装
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纳米技术
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食品保鲜
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产品关联
DOI
PubMed
高影响因子
POLYMER
·
2024
·
IF 4.1
Yu Gu,Jiahao Liu,Wei Gao,Meichen Liu,Chunwang Yi
The preparation of polyesteramides (PEAs) with regular block structure has long been a challenge, owing to the occurrence of the ester-amide exchange during the polymerization at high tempereture. In this work, we report a simple and green method to prepare polyamide 6 (PA6) based triblock PEA whose structure is poly(ε-caprolactone)-block-PA6-block-poly(ε-caprolactone) (PCL- b -PA6- b -PCL) using tetraphenyl tin as catalyst without solvent. The first segment PA6 was synthesized via cationic ring-opening polymerization (ROP) of ε-caprolactam (CPL), later, ROP of ε-caprolactone (CL) was involved to extend polycaprolactone (PCL) segments by using tetraphenyl tin as catalyst. By varying the proportion of CPL and CL, series PA6-based PEAs was prepared and characterized by gel permeation chromatography, 1 H, DOSY, and 13 C NMR. The results showed that PEA containing more proportion of CL presented a higher molecular weight with narrow polydisperse index. In particular, the lower water absorption and lower oligomers content infers that the PEA could have a prospective application in processing precision electronic devices.
研究领域:
材料科学
·
高分子化学
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DOI
高影响因子
Scientific Reports
·
2024
·Vol. 14
·期 1
·1-14
·
IF 3.8
Kong Chenfan,Sun Jianrong,Hu Xinzi,Li Guangzhi,Wu Song
Immune checkpoint inhibitors (ICIs) are effective agents for tumor immunotherapy. However, their clinical effectiveness is unsatisfactory due to off-target effects and a suppressive immune microenvironment. This study developed a nanodrug delivery system for bladder cancer (BCa) using PCL-MPEG and PCL-PEG-CHO to synthesize internal hydrophobic and external hydrophilic micelles (PP) that encapsulated water-insoluble astragaloside IV (PPA). The aldehyde group on the surface of PPA reacted with the amino group of aPD-L1, allowing the decoration of this antibody on the surface of the micelles. The resultingPPA@aPD-L1effectively piggybacked astragaloside IV and aPD-L1 antibody. These findings suggest that PPA@aPD-L1 is relatively stable in circulation and efficiently binds to BCa cells with the aid of aPD-L1. Additionally, this strategy prolongs the drug’s retention time in tumors. Compared to PBS, PP, and PPA with PPA + aPD-L1 groups, PPA@aPD-L1significantly prolonged the survival of mice with BCa and reduced tumor volume. Mechanistic studies showed that PPA inhibited the NF-κB and STAT3 signaling pathways in tumor cells. Additionally, PPA@aPD-L1increased IFN-γ and decreased IL-10 expression in bladder tumors, affecting the number and type of intratumorally infiltrating T cells. Our study presents a simple and effective drug delivery system that combines herbal monomers with ICIs. It has demonstrated a potent ability to suppress tumor growth and holds potential for future applications.
研究领域:
癌症治疗
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纳米技术
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药学
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免疫学
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2018
·Vol. 6
·期 20
·3372-3386
·
IF 4.776
Longbao Feng,Shina Yan,Qiyu Zhu,Jie Chen,Lian Deng,Yanfang Zheng,Wei Xue,Rui Guo
Drug/gene co-delivery carriers are a promising strategy for cancer treatment. Thus, herein, T7-conjugated redox-sensitive amphiphilic polyethylene glycol–polyethyleneimine–poly(caprolactone)-SS-poly(caprolactone)–polyethyleneimine–polyethylene glycol (PEG–PEI–PCL-SS-PCL–PEG) (PPPT) is designed to realize the co-delivery of pORF-hTRAIL and DOX efficiently into tumor cells. PPPT is synthesized via the ring opening polymerization (ROP) of ε-caprolactone followed by Michael addition polymerization and atom transfer radical polymerization (ATRP) of the maleic imide group of MAL-PEG-NHS. The PPPT micelles present a spherical or ellipsoidal geometry with a mean diameter of approximately 100–120 nm. Meanwhile, they also exhibit a redox-responsive drug release profile in vitro. The blood compatibility and complement activation tests reveal that the PPPT micelles do not induce blood hemolysis, blood clotting, or complement activation. The T7-modified co-delivery system shows a higher cellular uptake efficiency than the unmodified co-delivery system in human breast cancer MCF-7 cells and is accumulated in tumor more efficiently in vivo. These results suggest that the T7-targeted codelivery system of DOX and pORF-hTRAIL is a combined delivery platform that can significantly improve the treatment of breast cancer.
研究领域:
癌症治疗
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药剂学
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纳米技术
·
分子生物学
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产品关联
DOI
PubMed
高影响因子
POLYMER
·
2026
·
IF 5.1
Rui-Dong Wang,Yi-Fei Zhang,Xiao-Long Han,Yu-Kun Gao,Ting-Ting You,Peng-Gang Yin
This study investigates the design of polyrotaxane-based solid polymer electrolytes (SPEs) by grafting polycaprolactone (PCL) onto hydroxypropylated polyrotaxane (HyPR) and examining the synergistic effects of cross-linking and polymer grafting on key material properties. Incorporation of long-chain PEG crosslinker resulted in SPEs with high ionic conductivity, achieving 5.6 × 10 −6 S/cm at 30 °C and 1.5 × 10 −4 S/cm at 60 °C. Comparative analysis of short-chain and long-chain crosslinkers revealed the trade-off between enhancing segmental mobility for ionic transport and maintaining sufficient thermal and mechanical stability, underscoring the need for further optimization to achieve a well-balanced network structure. Overall, this work demonstrates the potential of polyrotaxane-based cross-linked networks as a versatile platform for high-performance SPEs and offers insights for the rational design of next-generation solid-state electrolyte materials.
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高影响因子
POLYMER SCIENCE SERIES A
·
2016
·Vol. 58
·期 2
·196-205
·
IF 0.76
Luo Chunyan,Chen Weixing,Gao Ying
The crystallization behavior of poly(e-caprolactone)/poly(ethylene glycol) (PCL/PEG) blend was investigated by differential scanning calorimetry (DSC) and polarized microscopy (POM). Individual phase transition peaks in the DSC curves for both PEG and PCL in all the polymer blends with different PCL contents were observed. The crystallization and melting peak temperatures of PEG were at 41 and 65°C, respectively; while the crystallization and melting temperatures of PCL located at 28 and 56°C, respectively. In-situ POM results demonstrated that spherulites crystalline morphology was formed for both PCL and PEG homopolymers. In PEG/PCL blend, however, both the phase separation morphology and spherulitic morphology can be observed. In blends with 30 or 50 wt % PCL, the PCL component formed dispersed phase and crystallized at lower temperature. However, in blends with 70% PCL, the phase inversion behavior occurred. The continuous PCL phase crystallized at 35°C, while the PEG dispersed phase crystallized at a lower temperature. Fractional crystallization behavior of PEG and PCL was controlled by temperature. The spherulites growth rate of PEG was greatly influenced by temperature, instead of the content of PCL component in the PCL/PEG blends.
研究领域:
材料科学
·
高分子化学
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产品关联
DOI
高影响因子
International Journal of Nanomedicine
·
2022
·
IF 7.033
Zemin Hou,Wencheng Zhou,Xi Guo,Rui Zhong,Ao Wang,Jiehua Li,Ying Cen,Chao You,Hong Tan,Meng Tian
Background The main challenge of polymeric micelles as drug delivery systems is that the actual delivery efficiency is not as high as expected, which is closely related with the interactions with the complex biological environments such as blood components, phagocytosis, and biodistribution. Herein, we expect to understand these concerns for the clinically relevant micelles that composed of methoxypolyethylene glycol (MPEG) with identical chain length And poly(ε-caprolactone) (PCL) with tunable chain length (PCL n -MPEG) (n=20, 30, and 40) wherein doxorubicin was encapsulated as a model drug. Methods The doxorubicin-loaded PCL n -MPEG micelles were prepared by a dialysis method and characterized by dynamic light scattering and transmission electron microscopy. The surface PEG density and chain conformation were investigated by dissipative particle dynamics simulation. The stability of the micelles was detected by nanoparticle tracking analysis. The effects of PCL chain length on the blood components, phagocytosis, and biodistribution were assayed in vitro and in vivo. Results The micelles exhibited spherical morphology with a diameter about 30nm. The PEG chain conformation from "mushroom-like" to "brush-like" was evident. The micelles have no remarkable effect on the red blood cells, blood coagulation, and platelet activation. Interestingly, the protein adsorption was affected and dependent on the chain conformation, with lowest adsorption for PCL 30 -MPEG, which also has the loWest phagocytosis. The stability of the micelles was in the order of PCL 40 -MPEG>PCL 30 -MPEG>PCL 20 -MPEG which was dependent on the PCL chain length. The micelles mainly accumulated in liver, with the order consistent with their stability, indicating that, besides the phagocytosis, the stability of the micelle plays an important role in biodistribution as well. The related mechanisms were proposed and discussed. Conclusion Manipulating the PEG/PCL ratio of the micelle is an effective approach to modulate the protein adsorption, phagocytosis, and biodistribution, which may be a prerequisite for clinical applications.
研究领域:
药学
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纳米技术
·
生物医学工程
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药物递送系统
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产品关联
DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2017
·
IF 4.164
Manqing Yan,Mingchen Zhou,Jing Chen,Tianlei Zhao,Longxiang Tang,Hong Bi
In this paper, the environment-friendly, water-soluble carbon dots (CDs) with stable photoluminescence (PL) have been prepared via the one-step pyrolysis of lotus leaf. Then the as-prepared CDs containing abundant hydroxylic and carboxylic groups were employed as cocatalyst with tartaric acid (TA) in ring-opening polymerization (ROP) of ε-caprolactone (ε-CL). The low-toxic organic acid TA, as main catalyst, was used to catalyze the ROP of ε-CL efficiently. The fluorescent CDs@PCL hybrids were obviously hydrophobic and they exhibited an excellent biocompatibility, and biodegradability due to the existence of PCL. Therefore the hydrophobic, biodegradable and multi-color fluorescent CDs@PCL hybrids may have potential applications in biomedicine, photocatalyst, bioimaging, and environmental analysis. Furthermore the application of CDs in catalyzing and initiating polymerization reaction will exemplify the versatility of CDs in the most unexpected fields.
研究领域:
材料科学
·
生物医学
·
环境科学
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DOI
PubMed
高影响因子
Materials Today Communications
·
2026
·
IF 4.9
Erlong Li,Jiheng Shan,Chengzhi Zhang,Qingqing He,Junheng Zhang,Yilin Liu,Yiran Wang,Jianzhuang Ren,Kewei Ren,Xinwei Han,Yingjuan Zheng
Mechanical injury is the primary initiating cause of iatrogenic tracheal stenosis (TS), while bacterial infection and persistent inflammatory responses are crucial exacerbating factors driving fibrotic progression. In this study, we constructed a Tanshinone IIA / PCL nanofiber-covered airway stent (PCL@Tan-IIA) using electrospinning technology. Characterizations revealed that the PCL@Tan-IIA stent possessed hydrophobic surface characteristics, favorable mechanical strength, and desirable drug-release kinetics, coupled with potent antibacterial efficacy against planktonic methicillin-resistant Staphylococcus aureus (MRSA). Mechanistically, the stent exerted anti-inflammatory activity by downregulating the secretion of pro-inflammatory cytokine IL-6 and upregulating the expression of anti-inflammatory cytokine IL-10 in macrophages. Concurrently, it exhibited anti-fibrotic effects through inhibiting the migration and activation of human pulmonary fibroblasts. Moreover, the PCL@Tan-IIA stent implanted in New Zealand rabbits inhibited local airway bacterial proliferation, alleviated inflammation and reduced excessive fibrous tissue hyperplasia. This work provides a promising strategy to overcome stent-induced restenosis and has potential for clinical translation in the management of TS.
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DOI
高影响因子
JOURNAL OF PHYSICAL CHEMISTRY B
·
2016
·
IF 3.187
Yihuang Chen,Tiansheng Gan,Chunfeng Ma,Linge Wang,Guangzhao Zhang
Crystallization of polymer chains confined on a surface greatly influences surface properties. We have grafted comb-like copolymer, consisting of poly(2-hydroxyethyl methacrylate) (PHEMA) backbone and semicrystalline poly(ε-caprolactone) (PCL) side chains, on silicon surface and investigated the crystallization of such confined PCL chains upon solvent evaporation by using atomic force microscopy (AFM), grazing incidence wide-angle X-ray scattering (GI-WAXS), and polarized optical microscope (POM). Our studies reveal that the PCL chains align and form “flat-on” lamellae at a low PCL chain density. As the chain density increases, the comb-like polymer (PHEMA-g-PCL) chains undergo pancake-to-mushroom-to-brush transition, and the lamellae turn from “flat-on” to “edge-on” in orientation. Further increasing PCL chain density leads the “edge-on” lamellae to change from a quasi-two-dimensional (quasi-2D) to quasi-three-dimensional (quasi-3D). Because of the confinements of polymer chains, we can observe the evolution of spherulites at different stages during the mushroom-to-brush transition of PHEMA-g-PCL chains. The confinements also result in knobbly substructures in the edge-on lamellae.
研究领域:
材料科学
·
高分子化学
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DOI
高影响因子
ACS Applied Polymer Materials
·
2020
·
IF 0
Qing Luo,Jing Chen,Pitchaimari Gnanasekar,Xiaozhen Ma,Dongdong Qin,Haining Na,Jin Zhu,Ning Yan
Shape-memory biomaterials, especially those stable against degradation, are attractive for applications in the biomedical fields, such as artificial bone scaffold material, artificial blood vessel material, and so on. In this study, shape-memory polyurethanes (SMPUs) were synthesized based on poly(ε-caprolactone) (PCL) diol, dicyclohexylmethylmethane-4,4′-diisocyanate (HMDI), and planar ring chain extenders. Catechol (PCTE), 1,4,9,10-anthracenetetrol (ANTE), and 2,3,6,7,10,11-hexahydroxytriphenylene hydrate (HHTP) with different rigidities were used as the stationary phase to produce the SMPUs. Shape-memory and degradation properties of the SMPUs were characterized. It was found that poly(PCL & PCTE urethane) (PCPU), poly(PCL & ANTE urethane) (PCAU), and poly(PCL & HHTP urethane) (PCHU) showed outstanding shape-memory properties with the shape fixity rate of 90.9%, 90.4%, and 94.0% and shape recovery rate of 99.1%, 99.1%, and 98.7%, respectively, following the triple-shape-memory testing procedure. Moreover, during the 6 month hydrolysis process, all SMPUs had 90.6%–94.3% of weight remaining, demonstrating good hydrolysis resistance with highly stable thermomechanical performance. These SMPUs possess excellent shape-memory properties and are highly promising for applications as implant materials in vivo.
研究领域:
生物医学材料
·
高分子化学
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产品关联
DOI
危险品化学品经营许可证（带存储）