ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2024
·
IF 6.2
Xing Zhang,Yifei Kong,Zihan He,Wenbin Yu,Wenjing Shao,Chengliang Gong,Wenlin Zhou,Xiaolong Hu
Perfluorooctanoic acid (PFOA) and tetrabromobisphenol A (TBBP-A) are emerging environmental contaminants with recognized potential health and ecological risks. This study investigated the effects of PFOA and TBBP-A exposure on the global of metabolites of silkworm gut with GC-MS metabolomics. Our results revealed distinct metabolic alterations in silkworms exposed to PFOA and TBBP-A, highlighting their differential impacts on silkworm health and productivity. Exposure to these chemicals significantly altered metabolic profiles, leading to disruptions in pathways related to lipid, carbohydrate, and amino acid metabolism. These findings suggest that PFOA and TBBP-A disrupt crucial metabolic processes in silkworms, indicating potential toxicity and prompting further investigation into their effects on human health and the environment. Ongoing research is crucial to develop safer alternatives and mitigate the risks associated with these persistent contaminants.
研究领域:
环境科学
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昆虫学
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代谢生物学
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高影响因子
Environmental Technology & Innovation
·
2024
·
IF 6.7
Yongjia Lei,Hongyu Zeng,Ravi Naidu,Dong Tian,Li Zhao,Mei Huang,Jinsong He,Jianmei Zou,Shihuai Deng,Li Sun,Fei Shen
Due to the synergistic contribution, dual-frequency ultrasound can significantly enhance the degradation of organic contaminants, but the effects of different frequency combinations have not been clarified and need to be explored. In this study, several frequency combinations were designed firstly both in experimental exploration and numerical simulation within the dual-frequency ultrasound coupling persulfate (PS) system to investigate the effect of frequency combinations on the degradation of perfluorooctanoic acid (PFOA). The monitoring parameters included the defluorination percentage and the simulated maximum expansion ratio ( R max / R 0 ). The simulated maximum expansion ratios in different frequency combinations showed a high correlation with their defluorination results, indicating that the discrepancy in defluorination effects of different frequency combinations was mostly attributed to their various maximum expansion ratios. Additionally, various maximum expansion ratios could result in different maximum solution temperatures, and the increase in temperature was found positive for PFOA defluorination in this study. In addition, the synergistic parameters that affected the maximum expansion ratio were analyzed, including the phase difference, frequency ratio, and frequency value. The obtained results showed that the maximum expansion ratio varied with different phase differences, and the frequency ratio could affect the variation trend. For the same fundamental frequency, the larger the frequency ratio, the smaller the maximum expansion ratio. Under the same phase difference and frequency ratio, the larger the frequency value, the lower the cavitation.
研究领域:
环境科学
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化学工程
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CHEMOSPHERE
·
2023
·
IF 8.8
Zhilin Zhao,Xiaoying Zheng,Zongshuo Han,Shanshan Yang,Huijie Zhang,Tao Lin,Chao Zhou
Co-pollution of microplastics and per- and polyfluoroalkyl substances (PFAS) is prevailing in the aquatic environment. However, the risks of coexisting microplastics and PFAS on organisms remain unknown. This study investigated the response mechanisms of Chlorella sorokiniana ( C. sorokiniana ) under polystyrene microplastics (PS-MPs) and perfluorooctanoic acid (PFOA) stress, including toxicity and defense mechanisms. C. sorokiniana was exposed to PS-MPs (10 mg/L) and PFOA (0.05, 0.5, and 5 mg/L) and their mixtures for 96 h, respectively. We found that the dominant toxicity mechanism of PFOA and PS-MPs to C. sorokiniana was dissimilar. PS-MPs mainly inhibited photosynthesis through shading effect, while PFOA mainly induced oxidative stress by reactive oxygen species . The co-exposure of PFOA and PS-MPs aggravated biotoxicity (maximum inhibition rate: 27.27 ± 2.44%), such as photosynthesis inhibition, physical damage, and oxidative stress, compared with individuals. To alleviate toxicity, C. sorokiniana activated defense mechanisms. Extracellular polymeric substances were the first barrier to protect cells, the effect on its secretion was ordered PS-MPs+5PFOA > PS-MPs > 5PFOA, and IBRv2 values were 2.37, 1.35, 1.11, respectively. Antioxidant system was thought of second defense pathway, the influence order of treatment groups was PS-MPs+5PFOA > 5PFOA > PS-MPs, and its IBRv2 values were 2.89, 1.69, 0.25, respectively. Our findings provide valuable information on the complex impacts of PFOA and PS-MPs, which facilitate the ecological risk assessment of multiple pollutants.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Zhixiang Xu,Jinrui Xiong,Caiqing Li,Siyuan Hu,Zihui Li,Yitao Ma,Siyuan Li,Bin Huang,Xiaomin Ren,Xuejun Pan
Per/polyfluoroalkyl substances (PFAS) are widespread in aquatic environments and pose significant risks to human health. Their roles in the spread of antibiotic resistance genes through conjugation were investigated in the laboratory. Results showed that PFAS including Perfluorooctanoic acid (PFOA), 6:2Cl-PFAES and 8:2Cl-PFAES at concentrations up to 100 µg/L can significantly enhance the RP4 plasmid-mediated conjugative transfer of antibiotic resistance genes (ARGs) within and across genera as much as 3.38-fold. Perfluorooctanoic acid (PFOA), a representative PFAS, was then selected to investigate the related mechanisms within genera by which PFAS promoted the conjugative transfer of ARGs. The phenotypic experiments demonstrated that PFOA could induce oxidative stress, enhance cell membrane permeability and promote the excretion of extracellular polymeric substances in Escherichia coli , resulting in the elevation of intercellular contact and conjugative transfer of ARGs. Moreover, quantitative polymerase chain reaction revealed that PFOA exposure regulated the expression of conjugation-related genes. In addition, PFOA has also been shown to alter microbial metabolic pathways, including amino acid metabolism, nucleotide metabolism, and membrane translocation, thus altering cellular energy allocation to influence the conjugative transfer of ARGs. This study deepened the understanding of PFAS in promoting the propagation of ARGs, hence improving awareness of the ecological and health risks of PFAS.
研究领域:
环境科学
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微生物学
·
毒理学
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高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
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2023
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IF 22.1
Jingzhen Wang,Chun-Shuai Cao,Yinqing Zhang,Lingyan Zhu
Perfluorooctanoic acid (PFOA) is refractory owing to the strong C-F bonds and is extremely difficult to be degraded by traditional photocatalysts. In this study, an S-scheme heterojunction was successfully synthesized by incorporating BiOF with wide-bandgap Bi 7 O 5 F 11 . Theoretical calculations, in situ X-ray photoelectron spectroscopy and Kelvin probe force microscopy verified that a build-in electric field was created in the heterojunction, facilitating the separation of electron-hole pairs. Thus, the photoexcited electrons in the conduction-band (CB) of BiOF rapidly recombined with holes in the valence-band (VB) of Bi 7 O 5 F 11 , leading to enrichment of the highly reductive electrons in CB of Bi 7 O 5 F 11 and strongly oxidative holes in VB of BiOF. Additionally, the strong interaction between Bi 7 O 5 F 11 /BiOF and PFOA is conducive to electron transfer from catalyst surface to PFOA. Thus, BOF-2 displayed superbly-high photoactivity to decompose PFOA. PFOA (5 mg/L) was decomposed within 1 h, and 53% of total-organic-carbon was removed in 2 h of irradiation.
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Journal of Environmental Sciences
·
2022
·
IF 6.796
Wenjing Tang,Yunyi Meng,Bin Yang,Dongyu He,Yan Li,Bojun Li,Zheming Shi,Changwei Zhao
Nanofiltration (NF) process has become one of the most promising technologies to remove micro-organic combined water pollution . Developing a NF membrane material with efficient separation for perfluorooctanoic acid (PFOA) combined pollution is highly desired, this manuscript targets this unmet need specifically. In this work, hydrophilic SiO 2 nanoparticles with various contents blended with carboxylic multiwalled carbon nanotube were used to modify poly (m-phenylene isophthal amide) (SiO 2 /CMWCNT/PMIA) hollow fiber NF membrane. The modified membrane with 0.1 wt% SiO 2 doping exhibits way better fouling resistance with irreversible fouling ratio decreased dramatically from 18.7% to 2.3%, and the recovery rate of water flux increases significantly from 81.2% to 97.7%. The separation experiment results had confirmed that the modified membrane could improve the rejection from 97.2% to 98.6% for perfluorooctanoic acid (PFOA) and its combined pollution with bovine serum albumin (BSA). It is clear that this reported SiO 2 /CMWCNT/PMIA hollow fiber NF membrane potentially could be applied in water treatment . This research also provides a theoretical basis for efficiently removal of PFOA and its combined pollution by NF membrane.
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高影响因子
ENVIRONMENTAL POLLUTION
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2019
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IF 5.714
Da Lv,Yi Gu,Ming Guo,Ping Hou,Yan Li,Ronghui Wu
To better understand the toxicological activities of perfluorooctanoic acid (PFOA), we examined the effects of PFOA on apoptosis and its molecular mechanism in SMMC-7721 hepatoma cells. Cell viability was evaluated by MTT assay and apoptosis was determined by flow cytometry. Western blot and quantitative real-time PCR were used to examine the protein and gene expressions of Bax and Bcl-2. Our results showed that PFOA inhibited SMMC-7721 cell growth and induced apoptosis. PFOA treatment increased Bax expression and increased Bcl-2 expression at both gene and protein levels. Our study demonstrated that PFOA had toxic effects on SMMC-7721 cells, such as inhibiting cell proliferation and inducing apoptosis. Furthermore, we showed that PFOA-mediated induction of apoptosis involved inducing Bax and decreasing Bcl-2 expression as a molecular mechanism of its toxicological effects.
研究领域:
毒理学
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细胞生物学
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癌症研究
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SEPARATION AND PURIFICATION TECHNOLOGY
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2026
·
IF 9.1
Angzhan Li,Dayong Tian,Yao Guo,Xingling Zhang,Shaopeng Zhang,Liu Cheng,Li Wang,Yifeng Zhang,Ning Fu
Perfluorooctanoic acid (PFOA) is currently regarded as a refractory pollutant. The development efficient degradation technologies remains a critical challenge owing to the strong stability of C-F bond. However, current photocatalytic approaches for PFOA degradation suffer from slow reaction kinetics. Herein, a series of ultrathin BiOCl@g-C 3 N 4 (BiCN) was prepared using a hydrothermal method, and their PFOA degradation performance was evaluated. The most effective photocatalyst (BiCN-2) achieved a 92.3% PFOA removal rate within 30 min (rate constant k = 0.1059 min −1 ), with a corresponding defluorination efficiency of 24.8%. Specifically, the exposed (101) facets of BiOCl accelerate electron movement, whereas the BiOCl@g-C 3 N 4 heterojunction interface enhances the separation of photogenerated charges. Additionally, the metallic Bi nanoparticles acted as both electron bridges and sources of hot electrons via the surface plasmon resonance effect, further boosting the reaction. Superoxide radicals, photogenerated electrons, and photogenerated holes were identified as the main reactive species in the degradation reaction. Density functional theory was employed to determine the interaction mechanism between PFOA and the photocatalyst. This study provides insights into an efficient alternative for the photocatalytic degradation of PFOA.
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高影响因子
Journal of Environmental Sciences
·
2025
·
IF 6.3
Xiaotian Huang,Zuhong Lin,Denglong Lu,Haipu Li
Perfluorooctanoic acid (PFOA) is a persistent toxic chemical that enters the human body through the food chain and causes harm. In this study, human thyroid follicular epithelial cells (Nthy-ori3-1 cells) were used as a model. PFOA was shown to reduce cell viability through a cell activity assay. Notably, at a concentration of 100 μmol/L, PFOA enhanced the activity of antioxidant enzymes ((Total superoxide dismutase (T-SOD), catalase (CAT), glutathione (GSH), total Antioxidant Capacity (T-AOC)), while the level of intracellular reactive oxygen species (ROS) remained elevated. PFOA triggered oxidative stress by inducing abnormal ROS levels, which subsequently exacerbated the inflammatory response and affected cellular activity. Therefore, pretreatment with 10μmol/L EVP4593 (QNZ, an NF-κB inhibitor) increased the percentage of normal cells from 74.06 % to 83.74 % at 1 μmol/L PFOA. Molecular docking and molecular dynamics indicated that QNZ competitively inhibited the interaction between PFOA and nuclear factor kappa-B (NF-κB) proteins. Correspondingly, Western blotting and qPCR analyses confirmed that QNZ suppressed the expression of apoptosis-related proteins ((Tumor protein p53 (P53), tumor necrosis factor-alpha (TNF-α), Bcl2-associated X (BAX), B-cell lymphoma-2 (BCL-2), cysteine aspartate protease-3 (Caspase-3), NF-κB) and their related genes. Additionally, PFOA prompted cells to release T4 and T3. This study not only elucidates the toxic effects of PFOA on cells, but also reveals the defense mechanism by which QNZ effectively alleviates cell toxicity.
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ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2024
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IF 10.8
Yanei Xue,Wenjun Sun,Wenxin Shi,Ching-Hua Huang,Domenico Santoro
Research on the use of peracetic acid (PAA) activated by nonmetal solid catalysts for the removal of dissolved refractory organic compounds has gained attention recently due to its improved efficiency and suitability for advanced water treatment (AWT). Among these catalysts, nanocarbon (NC) stands out as an exceptional example. In the NC-based peroxide AWT studies, the focus on the mechanism involving multimedia coordination on the NC surface (reactive species (RS) path, electron reduction non-RS pathway, and singlet oxygen non-RS path) has been confined to the one-step electron reaction, leaving the mechanisms of multichannel or continuous electron transfer paths unexplored. Moreover, there are very few studies that have identified the nonfree radical pathway initiated by electron transfer within PAA AWT. In this study, the complete decomposition (kobs = 0.1995) and significant defluorination of perfluorooctanoic acid (PFOA, deF% = 72%) through PAA/NC has been confirmed. Through the use of multiple electrochemical monitors and the exploration of current diffusion effects, the process of electron reception and conduction stimulated by PAA activation was examined, leading to the discovery of the dynamic process from the PAA molecule → NC solid surface → target object. The vital role of prehydrated electrons (epre–) before the entry of resolvable electrons into the aqueous phase was also detailed. To the best of our knowledge, this is the first instance of identifying the nonradical mechanism of continuous electron transfer in PAA-based AWT, which deviates from the previously identified mechanisms of singlet oxygen, single-electron, or double-electron single-path transfer. The pathway, along with the strong reducibility of epre– initiated by this pathway, has been proven to be essential in reducing the need for catalysts and chemicals in AWT.
研究领域:
环境科学
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化学工程
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Environments
·
2026
·Vol. 13
·期 2
·91
·
IF 4.3
Zheng Tang,Naixing Kang,Dajun Ren,Yongyuan Yang
Perfluoroalkyl and polyfluoroalkyl substances (PFASs) have been identified as forever chemicals and pose a serious threat to the environment due to their stable C–F bond. The current methods are ineffective or costly for PFAS remediation. In response, this study develops a dielectric barrier discharge (DBD) air plasma system capable of simultaneously treating perfluorooctanoic acid (PFOA)-contaminated wastewater and enhancing waste-activated sludge (WAS) solubilization through the subsequent use of plasma-activated water (PAW). Air plasma achieved 94% PFOA degradation and 32% defluorination within 40 min—substantially outperforming Ar and N2plasma—due to the co-generation of hydrated electrons (eaq−),•OH, and reactive nitrogen species (RNS). Scavenging experiments confirmed that eaq−is the primary initiator of C–F bond cleavage, while H2O2and NO2−synergistically form peroxynitrous acid (ONOOH), further promoting chain-shortening reactions. UPLC-MS identified PFHpA, PFHxA, PFPeA, and PFBA as key intermediates. The air plasma effluent contained high concentrations of NO2−-N and H2O2under acidic conditions, enabling PAW to induce strong oxidative stress on WAS, resulting in significant extracellular polymeric substance (EPS) release (DOC up to 134 mg/L), improved sludge filterability (capillary suction time (CST) reduced by ~85%), and shifts in microbial community. This study presents a dual-functional air plasma approach that enables both PFAS degradation and sludge treatment, improving the overall competitiveness and applicability of plasma technology for advanced wastewater treatment.
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JOURNAL OF HAZARDOUS MATERIALS
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2026
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IF 11.3
Wantong Tang,Xin Xiao,Enhui Wu,Kun Wang,Xinfei Ge,Xiaoying Zhu,Chiheng Chu,Baoliang Chen
Per- and polyfluoroalkyl substances (PFAS) are persistent organic pollutants with exceptional stability and significant ecological risk. However, their distribution and accumulation in soil–crop systems, especially for the replacement compound GenX, remain poorly characterized. Here, rice ( Oryza sativa , Nipponbare) was cultivated for five months in paddy soils amended with PFOA, PFOS, and GenX to map fate, bioaccumulation, and toxic responses across the soil–crop system and to derive soil safety thresholds protective of human health. PFAS exposure (10–100 μg/g) altered plant morphology and development and induced dose-linear oxidative stress (SOD, POD, CAT, MDA, H 2 O 2 , protein). Compound-specific translocation emerged: short-chain GenX showed greater upward transport and endosperm accumulation, whereas long-chain PFOA/PFOS were more root-retained (endosperm accumulation in total plant: PFOA 8.973–10.440%, PFOS 9.951–12.800%, GenX 10.286–20.773%). Overall toxic potency ranked PFOA ≥ PFOS > GenX. Based on measured plant uptake, we propose provisional exposure safety thresholds for rice cultivation of 3.157 ng/g (PFOA), 2.327 ng/g (PFOS), and 21.220 ng/g (GenX). This growth-cycle assessment provides an integrated evidence base for PFAS ecological risk evaluation and delivers actionable guidance to safeguard food security.
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高影响因子
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