MARINE POLLUTION BULLETIN
·
2023
·
IF 5.8
Minggu Zhang,Na Liu,Lei Hou,Chao Li,Chengliang Li
Both non-degradable and biodegradable plastics can act as vectors of diverse organic pollutants. In this study, two types of biodegradable microplastics [poly (butylene adipate- co -terephthalate) (PBAT) and polylactic acid (PLA)] and one type of non-degradable microplastics [polypropylene (PP)] were selected to investigate the impacts of ultraviolet (UV) irradiation for one month on microplastics surface modification and their adsorption behaviors for chlorpyrifos (CPF). The study revealed that PBAT held the largest adsorption capacity, and PLA held the fastest adsorption rate. The UV irradiation diminished the adsorption capacities on PLA and PP but enhanced the adsorption capacities on PBAT. The adsorption capacity normalized by specific surface area revealed that specific surface area was the dominant factor for affecting the adsorption capacities on PP and PLA after UV irradiation. These findings further clarify the interaction between CPF and microplastics, and provide a theoretical basis for assessing the ecological risk of microplastics in water.
研究领域:
环境科学
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生态学
·
污染研究
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DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2023
·Vol. 11
·期 19
·4191-4202
·
IF 7
Xin Zhang,Jing Guo,Yuanfa Liu,Xinmin Hao,Qiang Yao,Yi Xu,Yafei Guo
In this study, CNFs were provided by an efficient, unmodified, and clean biological method with enzymes and a small amount of alkali, compared to the CNCs with the chemical method involving a strong acid. To provide an accurate targeted selection for future applications, we made the following comparison by analyzing the differences in the preparation method, performance, and application performance of the two nanocelluloses. The result of this study indicated that CNFs and CNCs exhibited a crystallinity index of 58.2 and 83.5%, respectively. CNFs had a mean length (L) of 192.3 nm and a diameter (D) of 1.9 nm, and the average L and D of CNCs reached 123.6 nm and 3.7 nm, respectively. The solution viscosity of CNFs and CNCs reached 7.46 Pa s and 1.91 Pa s, respectively. CNFs and CNCs exhibited zeta potential values of −88.26 mV and −26.40 mV, respectively. The electrospun composite film of PLA–CNFs and PLA–CNCs achieved water contact angles of 138.7 and 34.5°, and the water–oil contact angle reached 24.7 and 30.5°, respectively. The breaking strength of PLA–CNFs and PLA–CNCs reached 96.07 cN and 163.23 cN, and the break elongation followed an order of PLA–CNCs (32.16%) < PLA–CNFs (34.70%). In brief, CNFs can make the composite membrane hydrophobic and with superior extension, and CNCs can make the composite membrane hydrophilic and enhance its strength. Both the composite films conformed to the non-toxic standard, and the PLA–CNFs film more significantly contributed to the cell growth, which is expected to serve as a medical material.
研究领域:
材料科学
·
生物学
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DOI
PubMed
高影响因子
Polymers
·
2020
·Vol. 13
·期 1
·108
·
IF 3.426
Vsevolod A. Zhuikov,Elizaveta A. Akoulina,Dariana V. Chesnokova,You Wenhao,Tatiana K. Makhina,Irina V. Demyanova,Yuliya V. Zhuikova,Vera V. Voinova,Nikita V. Belishev,Roman A. Surmenev,Maria A. Surmeneva,Garina A. Bonartseva,Konstantin V. Shaitan,Anton P. Bonartsev
Over the past century there was a significant development and extensive application of biodegradable and biocompatible polymers for their biomedical applications. This research investigates the dynamic change in properties of biodegradable polymers: poly(3-hydroxybutyrate (PHB), poly-l-lactide (PLA), and their 50:50 blend (PHB/PLA)) during their hydrolytic non-enzymatic (in phosphate buffered saline (PBS), at pH = 7.4, 37 °C) and enzymatic degradation (in PBS supplemented with 0.25 mg/mL pancreatic lipase). 3T3 fibroblast proliferation on the polymer films experiencing different degradation durations was also studied. Enzymatic degradation significantly accelerated the degradation rate of polymers compared to non-enzymatic hydrolytic degradation, whereas the seeding of 3T3 cells on the polymer films accelerated only the PLA molecular weight loss. Surprisingly, the immiscible nature of PHB/PLA blend (showed by differential scanning calorimetry) led to a slower and more uniform enzymatic degradation in comparison with pure polymers, PHB and PLA, which displayed a two-stage degradation process. PHB/PLA blend also displayed relatively stable cell viability on films upon exposure to degradation of different durations, which was associated with the uneven distribution of cells on polymer films. Thus, the obtained data are of great benefit for designing biodegradable scaffolds based on polymer blends for tissue engineering.Keywords:poly(3-hydroxybutyrate);poly-l-lactide;polymer blend;biodegradation;hydrolysis;pancreatic lipase;3T3 fibroblasts;nanoparticles
研究领域:
生物材料学
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组织工程学
·
生物医学工程
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DOI
PubMed
高影响因子
MATERIALS LETTERS
·
2025
·
IF 2.7
Lan Zhang,Zhicheng Ye,Pengliang Hou
In this paper, a polylactic acid (PLA)/thermoplastic polyurethane (TPU) composite material was developed to improve the tensile strength and flexibility of PLA, thereby improving its overall mechanical properties. SEM and FTIR analyses confirmed that the blending PLA with TPU did not induce chemical reactions. Results indicated that the modulus of the PLA 9/1 composite increased by 17% compared to PLA 10/0 , demonstrating TPU effectiveness in enhancing flexibility. Additionally, an optimal TPU amount acts as a particle reinforcement, improving the mechanical properties and expanding application potential of PLA.
研究领域:
材料科学
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生物医学工程
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DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2016
·
IF 3.485
Changyu He,Qinglai Yang,Lianjiang Tan,Bingya Liu,Zhenggang Zhu,Bing Gong,Yu-Mei Shen,Zhifeng Shao
The need for smart materials in the area of biotechnology has accelerated the development of stimuli-responsive copolymer micelles. Here, we reported a novel dual-stimuli-responsive block copolymer PEG-DMTK-SS-PLA with both dimethyl thioketal (DMTK) and disulfide linkage incorporated into the backbone, capable of triggering fast drug release properties upon both oxidative (H 2 O 2 ) and reductive (GSH) environment. The CMC values of these copolymer micelles ranging from 0.051 to 0.087 mg mL −1 , the average diameters are from 34 nm to 55 nm and 65 nm to 198 nm for blank and DOX-loaded micelles respectively. MTT assay conducted in NIH 3T3 cells showed the low cytotoxicity of these micelles even when the concentration reached up to 500 μg/mL. Considering tumor microenvironment’s diverse in kinds of tumor cells, fluorescence microscopy, flow cytometry and MTT activity analysis were conducted in several cancer cells (e.g., cervix, lung, gastric, and colon cancer cells), and further confirmed that the dual responsive PEG-DMTK-SS-PLA micelles were degraded much faster than that of non-responsive PEG-PLA and single responsive PEG-SS-PLA and PEG-DMTK-PLA micelles. These results indicate that the dual-responsive micelles are promising for efficient anticancer drug delivery.
研究领域:
生物技术
·
药剂学
·
肿瘤学
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DOI
高影响因子
JOURNAL OF FLUORESCENCE
·
2024
·
IF 2.6
Ge Jiahao,Zhang Kangjun,Hu Weijian,Zhou Haihua,Wu Xiaokang
Hepatocellular carcinoma (HCC) is a common malignant tumor originating from liver cells, characterized by complex pathogenesis and limited treatment options such as surgery, chemotherapy, and transplantation. Cisplatin, an effective chemotherapeutic agent, disrupts cancer cell DNA but is hindered by side effects and the need for controlled sustained release to optimize efficacy. Metal-organic frameworks (MOFs) have emerged as promising nanocarriers for precise local drug delivery, reducing required doses and mitigating side effects of chemotherapeutic drugs, thus offering a potential avenue for hepatocellular carcinoma (HCC) treatment. In this research, a rectangular channel MOF (Rumgay H, Ferlay J, Martel C, Georges D, Ibrahim AS, Zheng R, Wei W, Lemmens VEPP, Soerjomataram I (2022) Global, regional and national burden of primary liver cancer by subtype. Eur J Cancer 161:108–118) carrier was synthesized using ligand L as the organic linker coordinated with Cu(II) and I(I). The MOF’s structure and fluorescence properties were characterized. Additionally, to enhance substrate biocompatibility, composite carrier materials were prepared by incorporating polylactic acid (PLA) with 1 , utilized for cisplatin loading. To evaluate the inhibitory effect of PLA- 1 @cisplatin on HCC, HepG-2 and Huh-7 HCC cell lines were treated with varying concentrations of the drug for 48 h, and their cell viability was assessed. The results demonstrated a significant dose-dependent reduction in cell viability of both HepG-2 and Huh-7 cells. To explore the potential inhibitory mechanism of PLA- 1 @cisplatin on HCC, the mRNA levels of GADD45A and NACC1 in HepG-2 and Huh-7 cells post-treatment were measured. GADD45A expression, initially low in HCC cells, was significantly upregulated after drug treatment, while NACC1, typically highly expressed in HCC, showed a significant decrease in mRNA levels with increasing concentrations of PLA- 1 @cisplatin. These findings indicate that PLA- 1 @cisplatin effectively upregulates GADD45A expression and downregulates NACC1 expression. Overall, the developed cisplatin-loaded nanoparticle system holds promise for HCC treatment by reducing chemotherapy side effects and enhancing drug efficacy.
研究领域:
肿瘤学
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纳米医学
·
分子生物学
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DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2020
·Vol. 55
·期 35
·16730-16743
·
IF 3.553
Liu Mengzhu,Hao Xueyan,Wang Yongpeng,Jiang Zhenhua,Zhang Haibo
Abstract A sustained release system that composed of biodegradable core-sheath nanofibers in 3D hierarchy has been developed through electrospinning of water-in-oil precursor emulsion, in which theophylline dissolved in water was labeled as ‘aqueous phase’ and PLA solution was considered as ‘organic phase’. SEM images revealed that the fibers crossed and overlapped with each other, forming a 3D network-like structure. TEM indicated that the drug was well incorporated into PLA nanofibers, forming a core-sheath structure, which represented a reservoir-type delivery system. The fiber scaffolds were further characterized by FTIR, XRD, TGA, and DSC, which proved theophylline was successfully loaded into the fibers in an amorphous form. The release of drug consisted of three sequential stages, in which the release rate decreased successively. The changes on release rate were proved to be related to the drug diffusion and polymer degradation. At nearly 30 days, the drug still released continuously. This was accomplished by the gradually swelling and degradation of PLA. The successful preparation of the 3D core-sheath nanofibers can incorporate a water-soluble drug in a biodegradable polymer, which effectively protected the activity of the drug, inhibited a sudden release and accomplished sustained release. Graphic abstract
研究领域:
材料科学
·
药学
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DOI
高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2018
·
IF 1.911
Feng Su,Yuandou Wang,Xue Liu,Xin Shen,Xingjian Zhang,Quansheng Xing,Lihong Wang,Yangsheng Chen
Carboxymethyl chitosan-graft-polylactide (CMCS-PLA) and carboxymethyl chitosan (CMCS) hydrogels were prepared by using 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride/N-hydroxysuccinimide (EDC/NHS) as crosslinking agent and catalyst at room temperature. The biocompatibility of the hydrogels was evaluated with the aim of assessing their potential as drug carrier. Various aspects of biocompatibility were considered, including MTT assay, agar diffusion test, release of lactate dehydrogenase (LDH), hemolytic test, plasma recalcification time (PRT), and dynamic clotting time. MTT assay showed that the cytotoxicity level of both hydrogels to L-929 cells was 0 or 1. The LDH release of CMCS and CMCS-PLA was 26 and 29%, respectively, which is slightly higher than that of the negative control (21%) and much lower than that of the negative control (87%). The hemolysis ratio of CMCS and CMCS-PLA was 1.4 and 1.7%, respectively, suggesting outstanding anti-hemolysis properties of both materials. The PRT value of CMCS and CMCS-PLA was higher by 77 and 99% than the value of the positive control. All the results revealed that the hydrogels present good cytocompatibility and hemocompatibility in vitro. In vivo degradation and tissue compatibility were evaluated by subcutaneous injection in the dorsal area of rats. CMCS and CMCS-PLA hydrogels were completely degraded and the inflammatory response also completely disappeared around hydrogels after 19 days in vivo. It is thus concluded that hydrogels formed of CMCS and CMCS-PLA with outstanding biocompatibility are promising as potential drug carrier.
研究领域:
生物材料
·
药理学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Shun Chen,Fuwei Liang,Liping Jin,Chenpeng Ji,Nan Xu,Kun Qian,Wenwen Guo
With the increasing awareness of environmental protection, the demand for eco-friendly bio-derived flame-retardant for textiles has received increasing attention. In this work, a fully bio-derived phosphorylated furan-based flame retardant (FAP) was synthesized by the Schiff reaction of furan-based compounds (furfural and furfurylamine). To evaluate the application scope and flame retardant efficiency of FAP, cotton fabrics and PLA nonwovens were selected as biomass-based representatives of natural fiber materials and synthetic fiber materials, respectively. Significantly, based on the composition of furan ring, phosphorus and nitrogen containing components of FAP, excellent charring and flame retardant properties of coated cotton fabrics and PLA nonwovens can be expected. TGA results showed that the residual char of C-FAP-3 and P-FAP-3 were 39.7% (increased by 267.6%) and 16.7% (increased by 215.1%), respectively, higher than those of control cotton (10.8%) and PLA nonwoven (5.3%). Cone test results exhibited that the peak heat release rate (PHRR) and total heat release (THR) values of C-FAP-3 were sharply decreased by 69.4% and 37.8%, respectively. P-FAP-3 also displayed a significant reduction in PHRR, implying high flame retardancy of C-FAP-3 and P-FAP-3. Notably, through the weight gains of FAP coating on cotton and PLA as well as the final LOI and VBT results of the flame retardant treated fabrics, it can be preliminarily inferred that control cotton fabrics are more likely to achieve better flame retardant effects than PLA. Additionally, the facile synthetic strategy of fully bio-derived flame retardants is expected to promote the development of green flame retardant strategies for high-performance textiles.
研究领域:
材料科学
·
环境科学
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产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2013
·Vol. 38
·期 2
·490-494
·
IF 2.966
Tieshi Wang,Xinde Tang,Qun Zhang,Faqi Yu,Wenjuan Guo,Guangyou Zhang,Meishan Pei
Well-defined amphiphilic triblock copolymers PMAGP-b-PLA-b-PMAGP with varied compositions and molecular weights were obtained via a four-step procedure. The hydrophilicity and water absorption increase with an increase of the PMAGP chain length. The presence of active hydroxyl groups was confirmed by a dyeing procedure.
研究领域:
材料科学
·
生物医学工程
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产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2016
·Vol. 134
·期 8
·
IF 1.866
Tian Zhong,Yang Jiao,Lingling Guo,Jiamin Ding,Zhuping Nie,Lianjiang Tan,Ran Huang
To address concern of the dispersion property of hydrophilic drugs of excess dose loaded in a hydrophobic poly(lactic acid) (PLA) matrix, this work developed a PLA and PLA -b -polyethylene glycol (PEG) composite scaffold ( ) and studied its carrier properties for aspirin as a model hydrophilic drug. The porous functional scaffolds were prepared from PLA and PLA -b -PEG solutions with the dose of 5, 10, and 15 wt % aspirin preloaded. The products and control samples of pure PLA with the same loading amount for comparison were characterized by scanning electron microscopy and X-ray diffraction to examine the miscibility and porous structure. Rapid degradations in a strongly basic solution were performed to determine the actual loading amount and the encapsulation ratio. The in vitro release in phosphate buffer saline (PBS) at 37.5 °C indicated that the addition of amphiphilic block polymer may efficiently enhance the dispersion property and stabilize the release of hydrophilic drugs, especially with a high loading dose. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134 , 44489.
研究领域:
生物材料
·
药物递送
·
高分子科学
·
组织工程
·
制药技术
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DOI
高影响因子
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
·
2026
·Vol. 114
·期 4
·e70066
·
IF 3
Kebi Li,Xiaopei Wu,Peijun Xiong,Hanping He,Zinuo Xia,Yang Zhou,Liang Zhao,Jiaxin Li,Tao Liu,Hongwei Shi,Peihu Xu,Haixing Xu
Peripheral nerve injury (PNI) remains a major clinical challenge due to the limitations of autologous nerve grafting. Herein, a multifunctional composite nerve conduit was developed by integrating an oriented collagen-grafted polylactic acid (PLA) electrospun scaffold with a conductive and anti-inflammatory hydrogel to enhance peripheral nerve regeneration. The hydrogel was fabricated by chemically cross-linking carboxymethyl chitosan (CMCS) and sodium carboxymethyl cellulose (CMC-Na), incorporating polyaniline (PANI) to impart electrical conductivity and loading rhein (RH) for sustained anti-inflammatory release. The PLA conduit was further modified with collagen and loaded with nerve growth factor (NGF), forming a structurally guided dual-drug delivery system. The modified conduit exhibited improved hydrophilicity (water contact angle reduced from 107.7° to 68.9°) and enhanced mechanical properties (Young's modulus of 9.88 MPa). Sustained NGF and RH release reached 81.53% and 76.37% within 30 days, respectively, with stable degradation over 72 days. The conductive hydrogel displayed a uniform porous structure with high porosity (> 70%) and an electrical conductivity of 12.19 mS/cm. The electrical conductivity of the composite nerve conduit is 3.27 mS/cm. In vitro experiments demonstrated enhanced Schwann cell adhesion, neurite outgrowth, neuronal differentiation, anti-inflammatory activity, and responsiveness to electrical stimulation. In vivo studies using a rat sciatic nerve defect model confirmed significantly accelerated nerve regeneration. Overall, this electrically responsive, dual-drug-loaded hydrogel-filled nerve conduit represents a promising alternative to autologous nerve grafts for peripheral nerve repair.
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PubMed
高影响因子
危险品化学品经营许可证（带存储）