POLYMER DEGRADATION AND STABILITY
·
2026
·
IF 8.1
Lunhe Wang,Pengcheng Zhang,Jun Lu,Juanjuan Su,Jian Han
To simultaneously overcome the low heat resistance and insufficient barrier properties of biaxially oriented polylactic acid (BO-PLA) film, this study concurrently incorporates polypropylene carbonate (PPC) and epoxidized soybean oil (ESO) to regulate the crystalline structure and phase morphology of PLLA/PDLA (LD) mixtures. ESO enhances compatibility between PPC dispersed phase and the LD matrix through reactive compatibilization while also establishing a branched topological molecular structure. This reinforces molecular chain entanglement and increases melt strength of LD-PG blend. During biaxial stretching, PPC and ESO synergistically elevate the alternative folding and stacking of enantiomeric PLA chains, through joint plasticization, enhanced intermolecular interactions, and reinforced entanglement. BO-LD-PG 4 × 4 film achieves a total crystallinity of 47.6% and SC crystallinity of 27.2%. Larger HC lamellas and smaller SC lamellas form highly oriented and interlocked fibrous structures, creating a dense crystalline network with shish-kebab-like crystalline distributed throughout, which significantly improves the heat resistance of BO-LD-PG 4 × 4 film with a shrinkage rate as low as 6.3% at 150 °C. Concurrently, the PPC nanophase and SC/HC crystalline network structure jointly enhance the barrier properties of BO-LD-PG 4 × 4 films, achieving as pH ₂O of 2.96 × 10⁻¹⁴ g · cm/cm² · s · Pa and P O₂ of 1.4 × 10⁻² cm³ · cm/m² · h · 0.1 MPa. This work not only provides an effective strategy for preparing high-performance fully biodegradable packaging materials but also sheds light on the structural evolution mechanisms of LD blends during biaxially stretching.
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高影响因子
ACS Applied Polymer Materials
·
2026
·
IF 5.2
Wang Libin,Li Minghao,Chen Yao,Zhang Xiaomei,Hu Lupeng,Jiang Jinhua,Zhang Peihua,Fu Shaoju
Piezoelectric fabrics are urgently required by flexible
wearable
electronics applications for their advantages, such as high sensitivity,
wearer comfort, and environmental compatibility. However, existing
piezoelectric materials are often limited by poor comfort and a lack
of multifunctionality, making it difficult to reconcile sweat management
on the skin-contacting side with efficient mechanical energy harvesting.
Herein, a biodegradable poly( l -lactic acid) (PLLA) matrix
integrated with MXene and hydrogen-bonded organic frameworks (HOFs)
was employed to fabricate a PLLA/Mxene/HOFs self-powered nanofiber
membrane, serving as the basis for a flexible piezoelectric fabric
(PHMF) sensor with unidirectional moisture-guiding functionality.
The integration of HOFs and MXene into electrospun PLLA nanofibers
through hydrogen-bonding interactions elevated the glass transition
and melting temperatures. The PHMF sensor exhibited a tensile strength
of 5.61 MPa, and it consisted of Coolmax yarn and a hydrophobic layer
and allowed sweat to move from the inner layer near the skin to the
outer layer in 0.06 s. When sweat was applied to the inner layer,
the moisture content of the inner layer quickly increased to 650%
within 10 s before gradually decreasing to around 264%, while the
moisture content of the outer layer accumulated to 470%. The PHMF
sensor exhibited strong piezoelectric performance, with an open-circuit
voltage of 26 V measured at 3 Hz under dry conditions, response and
recovery times of 122.25 and 80.15 ms, respectively, and favorable
stability after 5000 cycles. This work demonstrates the potential
of eco-friendly and multifunctional PHMF sensors for flexible, wearable
electronics.
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高影响因子
Biomaterials Research
·
2022
·Vol. 26
·期 1
·
IF 15.863
Pei Feng,Jiye Jia,Shuping Peng,Yang Shuai,Hao Pan,Xinna Bai,Cijun Shuai
Background The reinforcement effect of fiber-reinforced polymer composites is usually limited because of the poor interfacial interaction between fiber and polymer, though fiber reinforcement is regarded as an effective method to enhance the mechanical properties of polymer. Methods In this study, nano-SiO 2 particles grafted by 3-Glycidoxypropyltrimethoxysilane (KH560) were introduced onto the surface of 3-Aminopropyltriethoxysilane (KH550) modified carbon fiber (CF) by a self-assembly strategy to improve the interfacial bonding between CF and biopolymer poly (lactic acid) (PLLA). Results The results indicated that PLLA chains preferred to anchor at the surface of nano-SiO 2 particles and then formed high order crystalline structures. Subsequently, PLLA spherulites could epitaxially grow on the surface of functionalized CF, forming a transcrystalline structure at the CF/PLLA interface. Meanwhile, the nano-SiO 2 particles were fixed in the transcrystalline structure, which induced a stronger mechanical locking effect between CF and PLLA matrix. The results of tensile experiments indicated that the PLLA/CF-SiO 2 scaffold with a ratio of CF to SiO 2 of 9:3 possessed the optimal strength and modulus of 10.11 MPa and 1.18 GPa, respectively. In addition, in vitro tests including cell adhesion and fluorescence indicated that the scaffold had no toxicity and could provide a suitable microenvironment for the growth and proliferation of cell. Conclusion In short, the PLLA/CF-SiO 2 scaffold with good mechanical properties and cytocompatibility had great potential in the application of bone tissue engineering.
研究领域:
材料科学
·
生物医学工程
·
组织工程
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高影响因子
COLLOID AND POLYMER SCIENCE
·
2012
·Vol. 291
·期 4
·789-803
·
IF 2.331
Zhang Xiaojing,Wang Chaojun,Fang Shaoming,Sun Jiashu,Li Chong,Hu Yuelei
In this paper, a series of hybrid star PLLA (sPLLA) with different arm lengths was synthesized via the hydrosilylation between octakis(dimethylsiloxy) silsesquioxane (Q 8 M 8 ) and functionalized PLLA macromolecules with vinyl end groups (mPLLA). mPLLA was synthesized by ring-opening polymerization of l -lactide using 2-hydroxyethylmethacryl as an initiator in the presence of stannous 2-ethylhexanoate as a catalyst. The obtained sPLLA has low polydispersity with polydispersity index values from 1.29 to 1.30. The arm numbers of sPLLA vary from 5 to 7 and decrease with the increase in the length of the mPLLA arm due to the steric hindrance, which are estimated by 1 H NMR analysis. The branched structure of sPLLA is also evidenced by the lower intrinsic viscosity when compared with the linear mPLLA with similar molecular weight. Both the glass transition temperatures ( T
g ’s) and melting temperatures ( T
m ’s) of sPLLAs are higher than those of the mPLLA arms. The incorporation of polyhedral oligomeric silsesquioxane (POSS) does not change the crystalline structure of PLLA, while the crystallinity of sPLLA is enhanced as the result that the POSS core acts as a heterogeneous nucleating agent in the matrix to promote the crystallization ability of PLLA. High-resolution transmission electron microscopy observation suggests that POSS disperses in the crystalline PLLA matrix as 5–20 nm aggregates. Microspheres of sPLLA with mean diameter 1 to 2 μm were prepared via emulsion solvent evaporation method. The sPLLA microspheres have higher loading capacity and encapsulation efficiency and lower drug release rate than mPLLA microspheres.
研究领域:
材料科学
·
药物递送
·
高分子化学
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高影响因子
COLLOID AND POLYMER SCIENCE
·
2017
·Vol. 295
·期 9
·1609-1619
·
IF 1.723
Ding Amin,Zhou Yifeng,Chen Pengpeng,Nie Wangyan
Amphiphilic star-shaped copolymers based on star-shaped poly(L-lactide) (s-PLLA) and poly(ethylene glycol) (PEG) (s-PLLA-PEG) were synthesized with variable molecular weights (M w ) of PEG, and the relationship between the PEG block molecular weight of s-PLLA-PEG copolymers and their micelle properties were investigated. The structure and M w of s-PLLA-PEG were characterized with 1 H NMR, GPC, DSC, and XRD. The ibuprofen (IBU)-loaded s-PLLA-PEG micelles were prepared by dialysis method. The effects of PEG block molecular weight on the morphology, particle size, zeta potential, drug loading content (LC), drug encapsulation efficiency (EE), and in vitro drug release behavior of prepared micelles were investigated. Results indicated that the average diameters, LC, and EE of IBU-loaded s-PLLA-PEG micelles increased with increasing the M w of PEG in s-PLLA-PEG copolymers. The in vitro study showed that the IBU accumulative release can be depressed by increasing the M w of the s-PLLA-PEG, and the release profiles of IBU from s-PLLA-PEG followed the Baker-Lonsdale model equation. The results suggest that structural tailoring of PEG length from s-PLLA-PEG copolymers could provide a new strategy for designing drug carriers of high efficiency.
研究领域:
材料科学
·
药剂学
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高影响因子
ACS Applied Bio Materials
·
2025
·
IF 4.7
Yanxia Zhang,Nazakaiti Imamaimaiti,Xiaohui Tang,Jua Kim,Tao Jiang,Huiting Fu,Haobo Pan,Yingbo Wang
Poly(L-lactic acid) (PLLA) is a promising material for bone substitutes due to its biodegradability and biocompatibility. However, its limited osteogenic activity and antibacterial properties restrict its applications. To address these challenges, this study develops PLLA/SiO2@ZnO/PDA/PLL composite fibrous materials using an approach that integrates electrospinning with ultrasonic techniques. The composite exhibits photothermal antibacterial functionality and osteoinductive properties. The material demonstrates excellent hydrophilicity, sustained-release capability, and antibacterial activity. Upon near-infrared light exposure, Zn2+ ions are released, disrupting bacterial membranes via electrostatic interactions and lipid peroxidation induced by reactive oxygen species. This dual mechanism leads to bacterial membrane rupture and biofilm degradation. Zn2+ ions also interfere with bacterial respiratory enzymes, disrupting the electron transfer process and achieving efficient antibacterial effects. The composite further shows outstanding biocompatibility and osteoinductivity, promoting vascular endothelial cell and osteoblast adhesion and enhancing calcium-phosphate salt deposition. In vivo studies confirm its safety with no significant toxicity or adverse effects on tissues and organs. This PLLA/SiO2@ZnO/PDA/PLL composite offers significant potential for repairing infected bone tissue and provides a strong foundation for future applications in bone tissue engineering.
研究领域:
生物医学工程
·
材料科学
·
骨组织工程
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DOI
PubMed
高影响因子
Additive Manufacturing
·
2022
·
IF 11.632
Fangwei Qi,Ruobing Liao,Yang Shuai,Hao Pan,Guowen Qian,Shuping Peng,Cijun Shuai
Nerve guidance conduits with favorable electrical conductivity were highly desired in peripheral nerve repair since nerve was natural electro-active tissue. MXene was an appealing candidate in endowing polymeric guidance conduits with electrical conductivity, yet its superiority was extremely constrained by its discrete distribution, incapable forming contiguous conduction channels in matrix. Herein, an efficient conductive nerve guidance conduit with three-dimensional continuous conductive network structure was constructed by prior powder design and laser additive manufacturing . Specifically, MXene was coated on poly- L -lactic acid (PLLA) particle surface by ultrasonic-assisted solution mixing and thus MXene was enriched at interfacial regions among adjacent polymer particles to form continuous MXene conductive network. More ingeniously, benefiting from the unique shearing-free and confined-flowing forming characteristic of laser additive manufacturing, not only network structure was retained as well as MXene contact became more tightly, which provided a continuous channel for rapid charge transfer. Results demonstrated that the conduits with 3.5 vol% MXene exhibited a continuous conductive network structure, resulting in an excellent electrical conductivity of 4.53 S/m, which was in appropriate conductive range of nerve growth (1–10 S/m). Cell evaluation confirmed the conduits significantly promoted cell proliferation , differential and neurite outgrowth. Therefore, this work not only illustrated the feasibility of additive manufacturing in constructing conduits with three-dimensional continuous conductive network structure, but also created a powerful strategy for fabricating desirable conductive nerve guidance conduits.
研究领域:
生物医学工程
·
材料科学
·
组织工程
·
神经科学
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高影响因子
Surfaces and Interfaces
·
2024
·
IF 5.7
Cijun Shuai,Gao Pan,Qi Zhong,Shuping Peng
Bacterial infections considerably limit the success of scaffold transplantation. CuO 2 may generate hydroxyl radicals through a self-cascade catalytic process, which is effective for sterilization. However, reducing CuO 2 -derived Cu + ions to Cu° can lead to a decline in catalytic activity. To overcome these limitations, we anchored CuO 2 onto MoS 2 to establish stable Cu-S-Mo interfacial sites. The CuO 2 /MoS 2 nanozyme was fabricated using a low-temperature co-precipitation technique and introduced into poly- l -lactic acid scaffolds using selective laser sintering. The Cu-S-Mo interfacial sites showed a triad of functions that synergistically enhanced catalytic performance. These sites stabilized the Cu atoms, augmented catalytic activity by facilitating efficient electron transfer through the Mo 4+ /Mo 6+ redox couple, and improved the conduction of heat derived from the photothermal response of MoS 2 to the Cu catalyst. The synergistic action of chemodynamic and photothermal therapy, mediated by the Cu-S-Mo sites, resulted in remarkable antibacterial efficacy, with 92.3 % and 93.5 % inhibition rates against Staphylococcus aureus and Escherichia coli , respectively. Experimental evidence and simulations demonstrated that Cu-S-Mo structure stabilized the Cu atoms and improved electron transfer via interatomic charge transfer. These results highlight the potential of the CuO 2 @MoS 2 /PLLA scaffold in eliminating bacterial infections.
研究领域:
材料科学
·
生物医学工程
·
微生物学
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高影响因子
Polymers
·
2026
·Vol. 18
·期 3
·398
·
IF 5.8
Wanqing Zhan,Qiqi Wen,Haiyan Yao,Junchao Wei
Insufficient osteogenic activity and mechanical properties of poly-L-lactic acid (PLLA) are urgent problems to be solved in deepening their application in bone tissue engineering. In this work, PLLA/mesoporous bioactive glass (PLLA/MBG) scaffolds and PLLA/simvastatin-loaded mesoporous bioactive glass (PLLA/MBG@SIM) scaffolds with filler content of 5, 10, and 15 wt% MBG and MBG@SIM were fabricated via electrospinning technology. At 10 wt% MBG loading, the tensile strength and tensile modulus were 3.23 ± 0.26 MPa and 124.47 ± 8.68 MPa, respectively, over 50% higher than those of PLLA scaffolds, demonstrating a significant enhancement in mechanical properties. Moreover, the incorporation of MBG improved the bioactivity of the PLLA scaffold, promoting the formation of apatite on the surface of the scaffolds. All composite scaffolds were non-toxic with good biocompatibility. Furthermore, PLLA/MBG@SIM composite scaffolds displayed superior osteogenic effects, better than the pure PLLA scaffolds and PLLA/MBG scaffolds. This work presents a multifunctional scaffold system combining enhanced mechanical strength with potent osteogenic activity, showing great promise for bone tissue engineering applications.
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PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2020
·
IF 5.88
Guochang Liu,Ming Fu,Feng Li,Wen Fu,Zhang Zhao,Huimin Xia,Yuqing Niu
The repair and regeneration of tissues using tissue-engineered scaffolds represent the ultimate goal of regenerative medicine. Despite rapid developments in the field, urethral tissue engineering methods are still insufficient to replicate natural urethral tissue because the bioactivity of existing scaffolds is inefficient, especially for large tissue defects, which require large tissue-engineered scaffolds. Here, we describe the efficiency of gelatine-functionalized, tubular nanofibrous scaffolds of poly( l -lactic acid) (PLLA) in regulating the phenotypic expression of epithelial cells (ECs) and smooth muscle cells (SMCs) for urethral reconstruction. Flexible PLLA/gelatine tubular nanofibrous scaffolds with hierarchical architecture were fabricated by electrospinning. The PLLA/gelatine nanofibrous scaffold exhibited enhanced hydrophilicity and significantly promoted the adhesion, oriented elongation, and proliferation of New Zealand rabbit autologous ECs and SMCs simultaneously. Compared with pure PLLA nanofibrous scaffold, PLLA/gelatine nanofibrous scaffolds upregulated the expression of keratin (AE1/AE3) in ECs and actin (α-SMA) in SMCs as well as the synthesis of elastin. Three months of in vivo scaffold replacement of New Zealand rabbit urethras indicated that a tubular cellularized PLLA/gelatine nanofibrous scaffold maintained urethral patency and facilitated oriented SMC remodeling, lumen epithelialization, and angiogenesis. Our observations showed the synergistic effects of nano-morphology and biochemical clues in the design of biomimetic scaffolds, which can effectively promote urethral regeneration.
研究领域:
再生医学
·
组织工程学
·
生物材料科学
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.5
Xinkai Sun,Xinying Jiang,Fei Xie,Pengju Yao,Yi Zhang,Hui Yang,Carla Bittencourt,Wenjiang Li
In the context of sustainable development, the exploration of renewable, biodegradable, and environmentally friendly polymer aerogels have emerged as a significant area of research. Herein, we report a facile synthesis of fully degradable polylactic acid (PLLA)/poly (butylene adipate- co -terephthalate) (PBAT) composite aerogels via 1,4-dioxane-assisted co-dissolution, followed by freeze-drying and phase separation techniques. The resulting aerogels feature a hierarchically porous structure with 98.6% porosity and vertically aligned channels, formed by controlled solvent crystallization during the freezing process. This unique architectural configuration integrates PLLA's oil-retention capability with PBAT's elasticity, yielding adsorption capacities of 13.6 g/g for n-hexane and 31.5 g/g for carbon tetrachloride. Notably, the aerogel retains ~97.5% stress and height recovery after 100 cycles of 50% strain compression, overcoming pure PLLA's inherent brittleness. It also maintains 96.5% the oil-water separation efficiency after 20 c centrifugal desorption cycles. 1,4-Dioxane promotes the compatibility of PLLA and PBAT, improving the interfacial compatibility and effectively avoiding the structural defects usually caused by phase separation. This research provides a scalable, filler-free approach to fabricate the high-performance biodegradable aerogels, bridging environmental sustainability and practical functionality for oily wastewater remediation.
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PubMed
高影响因子
POLYMER
·
2026
·
IF 4.5
He Meng,Li Jiang,Yuan-Ming Zhai,Cong Yan,Fei Luo,Kai Zhang,Ming-Bo Yang
Poly(lactic acid) (PLA) is regarded as one of the most promising biodegradable polymers. However, PLA has inherent limitations, including low crystallinity, low melt strength, and inadequate thermal resistance, which limit its use in blown films and disposable containers. In this study, the poly(vinyl alcohol)-graft-poly(D-lactic acid) (PVA-g-PDLA) graft copolymer was synthesized via the "graft-onto" strategy and incorporated into the poly(vinyl alcohol)/poly(L-lactic acid) (PLLA/PVA) blend. By varying the PVA-g-PDLA content, a physical crosslinked network of stereocomplex crystals was formed, significantly enhancing the blend's crystallization rate, melt strength, and thermal resistance. Compared with the blend without PVA-g-PDLA (PLA7PVA3), the blend PLA7PVA3-g-20 exhibited a 289% increase in crystallization rate at 110 °C, a nearly four orders of magnitude increase in complex viscosity, around 1030% increase in strain-hardening ratio, a 1263% increase in the maximum elongation viscosity, and a 130% increase in Vicat softening temperature. These improvements make PLLA/PVA/PVA-g-PDLA blends promising for applications in blown films, disposable containers, and sustainable packaging solutions.
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高影响因子
危险品化学品经营许可证（带存储）