CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Liping Liu,Tao Yang,Shaoru Wang,Wenyuan Jia,Yun Liu,Kun Jiao,Yongzheng Yan,Yuheng Yang,Xuanzuo Jiang,Chiyu Li,Zhiqiang Cheng,Guomin Liu,Yungang Luo
The healing process of diabetic wounds is characterized by a slow and arduous progression, making it challenging to achieve wound closure and complete healing through self-contraction, as observed in normal wounds. In this study, an intelligent multi-responsive composite of polytrimethylene carbonate (PTMC)/polyvinylpyrrolidone (PVP) nanofibrous dressing (C-PPZS) loaded with simvastatin-loaded ZIF-8 nanoparticles (ZIF-8@SIM NPs) was fabricated via electrospinning technology. The dressing exhibited liquid-triggered and temperature-controlled shrinkage characteristics, as well as pH-responsive drug release properties. When subjected to a temperature of 37 ℃ for 60 min, the area shrinkage rate of PPZS in PBS was determined to be 78.36 ± 1.14 %, and C-PPZS also reduced the area of isolated mouse skin defects to 38.01 ± 2.33 % of its original size. Furthermore, in vitro studies demonstrated that C-PPZS exhibited favorable biocompatibility and proangiogenic properties, along with significant inhibitory effects against S. aureus and E. coli . In vivo experiments conducted on diabetic mice revealed that C-PPZS facilitated wound closure and healing, attenuated scar formation, stimulated collagen fiber deposition, and promoted vascular regeneration. In conclusion, C-PPZS has great potential as an advanced dressing for the treatment of chronic wounds.
研究领域:
材料科学
·
生物医学工程
·
药学
·
伤口愈合
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
Nanomaterials
·
2020
·Vol. 10
·期 2
·322
·
IF 4.324
Lin-Fei Chen,Pei-Yao Xu,Chao-Ping Fu,Ranjith Kumar Kankala,Ai-Zheng Chen,Shi-Bin Wang
Due to its hydrophobicity, fisetin (FIS) often suffers from several limitations in terms of its applicability during the fabrication of pharmaceutical formulations. To overcome this intrinsic limitation of hydrophobicity, we demonstrate here the generation of poly (vinyl pyrrolidone) (PVP)-encapsulated FIS nanoparticles (FIS-PVP NPs) utilizing a supercritical antisolvent (SAS) method to enhance its aqueous solubility and substantial therapeutic effects. In this context, the effects of various processing and formulation parameters, including the solvent/antisolvent ratio, drug/polymer (FIS/PVP) mass ratio, and solution flow rate, on the eventual particle size as well as on distribution were investigated using a 23factorial experimental design. Notably, the FIS/PVP mass ratio significantly affected the morphological attributes of the resultant particles. Initially, the designed constructs were characterized systematically using various techniques (e.g., chemical functionalities were examined with Fourier-transform infrared (FTIR) spectroscopy, and physical states were examined with X-ray diffraction analysis (XRD) and differential scanning calorimetry (DSC) techniques). In addition, drug release as well as cytotoxicity evaluations in vitro indicated that the nanosized polymer-coated particles showed augmented performance efficiency compared to the free drug, which was attributable to the improvement in the dissolution rate of the FIS-PVP NPs due to their small size, facilitating a higher surface area over the raw form of FIS. Our findings show that the designed SAS process-assisted nanoconstructs with augmented bioavailability, have great potential for applications in pharmaceutics.Keywords:supercritical fluid technology;fisetin;nanofabrication;antitumor
研究领域:
药学
·
纳米技术
·
药物递送系统
·
癌症研究
·
超临界流体技术
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2024
·
IF 6.1
Dong Mo,Wei Cui,Linxin Chen,Juanjuan Meng,Yuting Sun,Kaiyong Cai,Jixi Zhang,Jianrong Zhang,Kui Wang,Xiaohe Luo
Hepatic ischemia-reperfusion injury (IRI) is a common pathological process during hepatectomy and liver transplantation and the two primary reasons for hepatic IRI are reactive oxygen species (ROS)-mediated oxidative stress and excessive inflammatory responses. Herein, a novel antioxidant nanodrug (A-MPDA@Fe3O4@PVP) is prepared by employing L-arginine-doped mesoporous polydopamine (A-MPDA) nanoparticles as the carrier for deposition of ultra-small ferric oxide (Fe3O4) nanoparticles and further surface modification with polyvinylpyrrolidone (PVP). A-MPDA@Fe3O4@PVP not only effectively reduces the aggregation of ultra-small Fe3O4, but also simultaneously replicates the catalytic activity of catalase (CAT) and superoxide dismutase (SOD). A-MPDA@Fe3O4@PVP with good antioxidant activity can rapidly remove various toxic reactive oxygen species (ROS) and effectively regulate macrophage polarization in vitro. In the treatment of hepatic IRI, A-MPDA@Fe3O4@PVP effectively alleviates ROS-induced oxidative stress, reduces the expression of inflammatory factors, and prevents apoptosis of hepatocytes through immune regulation. A-MPDA@Fe3O4@PVP can further protect liver tissue by activating the PPARγ/NF-κB pathway. This multiplex antioxidant enzyme therapy can provide new references for the treatment of IRI in organ transplantation and other ROS-related injuries such as fibrosis, cirrhosis, and bacterial and hepatic viral infection.
研究领域:
药理学
·
纳米技术
·
肝病学
·
免疫学
·
病理生理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENERGY & FUELS
·
2015
·
IF 2.79
Hui-Bo Qin,Zhen-Feng Sun,Xiao-Qin Wang,Jing-Li Yang,Chang-Yu Sun,Bei Liu,Lan-Ying Yang,Guang-Jin Chen
Two new kinetic hydrate inhibitors (KHIs) named PVP-B and PVP-BP were synthesized successfully and compared with commercial KHIs such as PVP and Inhibex 55W. PVP-B and PVP-BP are both the ramifications of PVP. They were obtained by introducing a t-butyl group and both t-butyl and phenyl groups into PVP molecules, respectively. The hydrate inhibition performances of KHIs were assessed in a sapphire cell through two kinds of onset times of hydrate formation: TVO, the time when hydrate crystals are initially observed by naked eyes, and TPD, the time when rapid and continuous dropping of system pressure begins. TVO was used to evaluate an KHI’s inhibition performance to hydrate nucleation. The length of time period from TVO to TPD was used to evaluate a KHI’s inhibition performance to hydrate growth. The results demonstrate that both PVP-B and PVP-BP are superior to PVP and Inhibex 55W; PVP-BP has better inhibition performance than PVP-B because of the stronger steric hindrance effects of the phenyl group in PVP-BP molecules than those of the t-butyl group in PVP-B molecules. Additionally, we found TVO does not always increase with the increasing dosage of KHI while TPD does. The most suitable dosage of PVP-BP was determined to 0.5 wt % or so, at which the nucleation of hydrate is inhibited most perfectly. Finally, we demonstrated glycol could be used as synergist to improve the performance of PVP-BP remarkably. The most suitable dosage of glycol was determined to be 0.9 wt % or so. Our work presents not only two new KHIs but also important insights into the inhibition mechanism of KHIs.
研究领域:
化学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2013
·Vol. 48
·期 15
·5140-5147
·
IF 2.163
Gai Guangqing,Wang Liyan,Dong Xiangting,Xu Shuzhi
Fe 3 O 4 /PVP//Tb(BA) 3 phen/PVP magnetic–photoluminescent bifunctional bistrand aligned composite nanofibers bundles based on Fe 3 O 4 nanoparticles (NPs) and terbium complex Tb(BA) 3 phen (BA = benzoic acid) were fabricated by employing a parallel axial electrospinning setup and were characterized by X-ray diffraction, field-emission scanning electron microscopy (FESEM), energy dispersive spectroscopy (EDS), transmission electron microscopy, fluorescence spectroscopy, and vibrating sample magnetometer. It is found that Fe 3 O 4 NPs were only dispersed into one strand of the bistrand aligned composite nanofibers bundles, but no nanoparticles in the other strand. And the average diameter of the individual strand fiber was 200 ± 25 nm. The bistrand aligned composite nanofibers bundles exhibit strong green emissions under the excitation of 275 nm ultraviolet light, and the 5
D
4 → 7
F
5 hypersensitive transition at 545 nm was the predominant emission peak of Tb 3+ ions. The newly obtained bifunctional nanofibers bundles exhibit excellent magnetism and high fluorescence intensity and are expected to apply in biology cell separation, magnetic resonance imaging, drug deliver, and fluorescence immunoassays/imaging.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Journal of Macromolecular Science Part B-Physics
·
2023
·
IF 1.4
Yueyue Rui,Bingyan Yu,Yun Liu,Lihu Fu,Jie Liu,Gang Lu
Hydrophilic coatings were prepared by dip-coating bare glass in polyvinylpyrrolidone (PVP)/silicon dioxide (SiO2) or polyvinylpyrrolidone (PVP)/carboxybetaine acrylamide (CBAA) suspensions. The effects of surface wettability on the anti-fogging and anti-icing properties of the two coatings were investigated. The surface morphologies of the coatings were characterized by polarized light microscopy and laser confocal microscopy, and the hydrophilicity of the coatings depended on the binding capacity of the hydrophilic functional groups in the fillers with water. The wettability of the coating surface was characterized by contact angle measurements, and it improved with increasing filler content. The coatings with the addition of more than 80 wt % of SiO2 or 1 wt % of CBAA showed superhydrophilic behavior. The anti-fogging and anti-frosting test results showed that the two coatings successfully prevented the development of fog and frost. The anti-icing properties of the coatings were also characterized. At three different temperatures, the anti-icing performance of the CBAA coating was better than that of the SiO2 coating. For, instance, at −15 °C, the icing delay time of PVP/SiO2 coating was 306.7 s and that of PVP/CBAA coating was 630.0s. Thus, the icing time of the CBAA coating was 323.3s longer than that of the SiO2 coating. When less than 80 wt% SiO2 or 10 wt% CBAA was added, the coating had good transparency.
研究领域:
材料科学
·
表面工程
·
高分子科学
·
纳米技术
·
涂层技术
✓ 已验证
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Meilin Yin,Zhen Li,LiPeng Wang,Shaokun Tang
The fabrication of structural stable metal organic frameworks (MOFs) with large pore size by facile, rapid and environmentally friendly synthetic method remains a serious challenge. Herein, it is the first time to develop a novel synthetic strategy that rapidly enlarges the pore size of microporous ZIF-8 by employing polyvinyl pyrrolidone (PVP) as a modulator to induce defect formation in environmentally friendly supercritical CO 2 (scCO 2 ). Notably, the high solubility and low mass transfer resistance of reactants in scCO 2 and low surface tension nature of scCO 2 are the key factors for the rapid preparation of structural stable PVP/ZIF-8 with hierarchically pores. And the PVP modulator as a weak ligand not only facilitates pore size but also perturbs coordination to form coordination defects, exposing more coordination metal sites. These characteristics are beneficial to fast diffusion and adsorption of CO 2 molecules. In addition, the influences of reaction conditions on the morphology, pore parameter and CO 2 adsorption performance of PVP/ZIF-8 are investigated. The result indicates that the PVP/ZIF-8 prepared with 1:1 of Zn/PVP mass ratio at 90 °C and 30 MPa in supercritical environment have the highest CO 2 adsorption equilibrium capacity (2.02 mmol CO 2 /g sorbent) and great cycle stability, which should be attributed to hierarchically porous structure with interconnected macropores and micropores.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
Polymers
·
2022
·Vol. 14
·期 13
·2704
·
IF 4.967
Xiangyu Jiao,Jiaxuan Xie,Mingda Hao,Yiping Li,Changtao Wang,Zhu Zhu,Yongqiang Wen
World hunger is on the rise, yet one-third of food is wasted. It is necessary to develop an effective food preservation method to reduce food waste. This article reports a composite film based on chitosan biguanidine hydrochloride(CBg) and poly (N-vinyl-2-pyrrolidone)(PVP) that can be used as a conformal coating for fresh produce. Due to the strong positive charge of CBg, the film has excellent antibacterial properties. Owing to the hydrogen bonds between CBg and PVP, the film has good flexibility and mechanical properties. In addition, the coating is washable, transparent, and can reduce the evaporation of water. The above characteristics mean the film has broad application prospects in the field of food preservation.Keywords:antimicrobial;chitosan derivative;coating;fruit
研究领域:
食品科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2020
·Vol. 10
·期 14
·8286-8290
·
IF 3.119
Xiaochuan Xu,Haipeng Zhang,Bin Liu,Jianhui Yang
In this work, corolla-shaped gold nanostructures with (110) planes were successfully synthesized using ethylenediaminetetraacetic acid (EDTA) and polyvinylpyrrolidone (PVP) as the co-reductants and shape-directing agents. The structure and the mechanism of the nanostructures were investigated by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and electrochemical characterization. On the basis that surface energies of different gold crystallographic planes are in the order γ(111) < γ(100) < γ(110), the (110) plane has the highest surface energy among the low-index planes. The gold nanocrystals with exposed high-energy planes are important in facilitating their potential applications such as highly efficient catalysts. This research is of great significance for the subsequent work on the synthesis of nanocrystals dominated by high-energy crystal planes.
研究领域:
材料科学
·
纳米技术
✓ 已验证
DOI
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2011
·Vol. 212
·期 17
·1900-1909
·
IF 2.437
Wenguang Leng,Shuxue Zhou,Limin Wu
Nail/spindle-shaped polyaniline is synthesized by chemically oxidizing aniline with ammonium persulfate in a near-neutral aqueous medium using PVP as the stabilizing agent. The type of dispersing agent, APS content and aniline concentration have obvious impacts on the morphology of the resulting polyaniline. Typically, in the concentration ranges of 1.5–6 × 10 −4 M PVP and 0.02–0.05 M aniline and for molar ratios [APS]:[aniline] of 0.4:1 to 0.8:1, nail/spindle-shaped polyaniline can be obtained. A possible mechanism is proposed to elucidate the formation process.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
NANOTECHNOLOGY
·
2022
·Vol. 33
·期 19
·195401
·
IF 3.953
Weiya Jiang,Bing Huang,Rongtao Hu,Yaqi Cui,Lunhui Guan
Rational design is essential in the synthesis of electrocatalysts for the oxygen reduction reaction (ORR). Herein, we introduced zeolitic imidazolate framework-8 (ZIF-8) and polyvinyl pyrrolidone (PVP) into the electrospinning process of the polyacrylonitrile (PAN) and hemin to increase the active site loading and exposed active area of the final product with empty bead-like structures. In this method, ZIF-8 acts as a carbon skeleton to provide a rich microporous structure that can support active sites, and as a nitrogen dopant to improve nitrogen contents. PVP changes the properties of the spinning solution, adjusts the fiber morphology, and to increase the exposed area of active sites as a pore former. The obtained Fe–N–C ORR catalyst delivered a half-wave potential (E1/2) of 0.924 V in a 0.1 M KOH solution and 0.77 V in a 0.1 M HClO4 solution. A homemade zinc air battery with power density of 236 mW cm−2 demonstrated the excellent performance of the catalyst under working conditions.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FIBERS AND POLYMERS
·
2019
·Vol. 20
·期 5
·961-965
·
IF 1.439
Song Kedong,Zhang Ping,Huang Yuting,Xu Fu,Ding Yanhuai
Polyurethane (PU) has been intensively studied as a promising separator material for Li-ion batteries (LIBs). However, poor dimensional stability and low liquid-electrolyte wettability of pure PU separator restrict its application in LIBs. Here polyvinyl pyrrolidone (PVP) and graphene oxide were employed to enhance the thermal stability, mechanical performance and liquid-electrolyte compatibility of PU separator. High anodic stability above 5.25 V was reached in PU/PVP/GO separator, fully compatible with the high-voltage cathode materials. The electrochemical characterization indicates PU/PVP/GO membrane is a promising separator for advanced LIBs.
研究领域:
材料科学
·
电化学
·
能源存储
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）