DRUG DELIVERY
·
2022
·
IF 6.819
Yujin Zhao,Chang Huang,Zhutian Zhang,Jiaxu Hong,Jianjiang Xu,Xinghuai Sun,Jianguo Sun
Glaucoma is the leading cause of irreversible vision loss worldwide, and reduction of intraocular pressure (IOP) is the only factor that can be interfered to delay disease progression. As the first line and preferred method to treat glaucoma, eye drops have many shortcomings, such as low bioavailability, poor patient compliance, and unsustainable therapeutic effect. In this study, a highly efficient brimonidine (BRI) silicone rubber implant (BRI@SR@TPU implant) has been designed, prepared, characterized, and administrated for sustained relief of IOP to treat glaucoma. The in vitro BRI release from BRI@SR@TPU implants shows a sustainable release profile for up to 35 d, with decreased burst release and increased immediate drug concentration. The carrier materials are not cytotoxic to human corneal epithelial cells and conjunctival epithelial cells, and show good biocompatibility, which can be safely administrated into rabbit’s conjunctival sac. The BRI@SR@TPU implant sustainably released BRI and effectively reduced IOP for 18 d (72 times) compared to the commercial BRI eye drops (6 h). The BRI@SR@TPU implant is thus a promising noninvasive platform product for long-term IOP-reducing in patients with glaucoma and ocular hypertension.
研究领域:
药剂学
·
眼科医学
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高影响因子
Advanced Healthcare Materials
·
2023
·
IF 10
Yuedan Xu,Dongni Shen,Zihuai Zhou,Yi Sun,Xinni Pan,Wei Liu,Chun Hung Chu,Ling Zhang,Matthias Hannig,Baiping Fu
Remineralized dentin with an antibacterial ability is still a significant challenge in dentistry. Previously, a polyelectrolyte-calcium complexes pre-precursor (PCCP) process is proposed for rapid collagen mineralization. In the present study, the expansion concept of the PCCP process is explored by replacing the calcium with other cations, such as strontium. The results of transmission electron microscopy (TEM), 3D stochastic optical reconstruction microscopy, energy-dispersive X-ray analysis, Fourier transform infrared spectroscopy, and high-resolution TEM with selected area electron diffraction demonstrate that biomimetic mineralization of collagen fibrils and demineralized dentin could be fulfilled with Sr&F-codoped hydroxyapatite (HAp) after they are treated with poly-aspartic acid-strontium (PAsp-Sr) suspension followed by a phosphate&fluoride solution. Moreover, dentin remineralized with Sr&F-codoped HAp exhibits in vitro and in vivo antibacterial ability against Streptococcus mutans . The cytotoxicity and oral mucosa irritation tests reveal excellent biocompatibility of mineralization mediums (PAsp-Sr suspension and phosphate&fluoride solution). The demineralized dentin's mechanical properties (elastic modulus and microhardness) could be restored almost to that of the intact dentin. Hence, the expansion concept of the PCCP process that replaces calcium ions with some cationic ions along with fluorine opens up new horizons for generating antibacterial remineralized dentin containing ions-doped HAp with excellent biocompatibility via biomimetic mineralization technology.
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CERAMICS INTERNATIONAL
·
2025
·Vol. 52
·期 1
·420-428
·
IF 5.6
Junjie Zang,Laijun Liu,Xiuyun Lei,Congling Yin
A series of Aurivillius-type Sr x Ba 1-x Bi 2 Ta 2 O 9 (SBBT, x = 0–1) ceramics were synthesized using a conventional solid-state reaction route and systematically investigated concerning their crystal structure and ferroelectric properties. High-resolution synchrotron XRD refinements indicate that BaBi 2 Ta 2 O 9 crystallizes in the polar A 2 1 am space group rather than I 4/ mmm , confirming the presence of local non-centrosymmetric distortions. A thermal-driven phase transition from orthorhombic to tetragonal is proposed for BBT. The disorder of Ba/Bi cations occurs in BaBi 2 Ta 2 O 9 . Increasing Sr-doping level tends to decrease the orthorhombic structural distortion of Sr x Ba 1-x Bi 2 Ta 2 O 9 . Raman spectroscopy reveals a redshift of the 840 cm −1 band with increasing Sr content x, consistent with the elongated minimum Ta-O distance within TaO 6 octahedra. The x = 0–0.4 compositions exhibit strong dielectric frequency dispersion, while the x = 0.8–1 samples display frequency-independent sharp dielectric peaks. Low-x compositions exhibit pinched P - E loops characteristic of relaxors, whereas high-x samples display squared P - E loops indicative of normal ferroelectrics. Vogel-Fulcher analysis and a phenomenological model reveal that Sr doping suppresses the dynamics of polar nano-region (PNRs) and increases their size across the x = 0–0.4 sample. These phenomena confirm a transition from relaxor to normal ferroelectricity in the SBBT system introduced by increasing Sr-doping level. This work provides new insights into the structure-property correlations in Aurivillius-phase relaxor ferroelectrics, offering guidance for the high-performance energy-storage materials design.
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CARBOHYDRATE POLYMERS
·
2021
·
IF 9.381
Zhengwei Liu,Xiaoqiong Mo,Fenbo Ma,Sijing Li,Guofeng Wu,Bin Tang,Lijun Lin
Osteoarthritis (OA) is an age-related joint disorder and one of the leading causes of physical disability. In this study, we designed and synthesized a new polysaccharide complex, carboxymethyl chitosan strontium (CMCS-Sr), which is believed to have positive effects on relieving OA. The synthesized CMCS-Sr was structurally verified by SEM, EDS, FTIR, etc. The therapeutic effects of CMCS-Sr were evaluated using various biological experiments. The cell viability and apoptosis results reveal that CMCS-Sr can significantly promote the proliferation and suppress OA chondrocytes apoptosis in vitro . The immunofluorescence staining results suggest that CMCS-Sr facilitates the promotion of the secretion of Type II collagen (Col-II). The transcriptomic results support the observed positive effects of CMCS-Sr on inhibiting chondrocytes apoptosis and alleviating inflammatory reactions. Moreover, animal study demonstrates that CMCS-Sr effectively reduced articular cartilage damage and subchondral bone degradation. Therefore, we propose the use of CMCS-Sr as a promising candidate for relieving OA.
研究领域:
药理学
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骨科
·
生物医学工程
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高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2025
·Vol. 37
·期 1
·5
·
IF 2.8
Yu Zhuoheng,Zhang Xinyang,Wu Yuhang,Chen Taihong,Wen Wei
Ba 2 TiSi 2 O 8 ceramics exhibit excellent thermal, electrical, and optical properties, offering great potential for functional applications. However, the dielectric properties of Ba 2 TiSi 2 O 8 ceramics have not been systematically investigated. This study explores the structural and dielectric evolution of Sr-doped Ba 2 TiSi 2 O 8 ceramics (0 ≤ x ≤ 1.6), with particular attention to phase composition, microstructure, and vibrational behavior. All compositions retained the tetragonal P4bm structure, while a gradual lattice contraction was observed with increasing Sr 2+ content. This structural evolution is further supported by Raman spectroscopy, which revealed systematic blue shifts in the TiO 5 and Si 2 O 7 vibrational modes, indicating enhanced bond strength and increased lattice rigidity. These structural modifications promoted densification and microstructural uniformity. At x = 0.4, the ceramic exhibited high relative density (> 97.8%), uniform grains, and phase purity, resulting in superior dielectric performance ( \({\varepsilon }_{r}{\prime}\) = 12.53, \(Q\times f\) = 2120 GHz, \({\tau }_{f}\) = − 23.63 ppm/°C). In contrast, excessive Sr 2+ content (x ≥ 0.8) induced abnormal grain growth and the emergence of secondary SrTiO 3 phases, accompanied by increased dielectric loss. These findings elucidate the delicate balance between lattice modification and dielectric response in Sr-doped Ba 2 TiSi 2 O 8 ceramics, offering valuable insight into the structural design of silicate-based microwave dielectric materials.
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MOLECULES
·
2024
·Vol. 29
·期 12
·2908
·
IF 4.2
Yudong Xie,Xiaowei Wang,Jinfeng Men,Min Zhu,Chengqiang Liang,Hao Ding,Zhihui Du,Ping Bao,Zhilin Hu
The efficient segregation of radioactive nuclides from low-level radioactive liquid waste (LLRW) is paramount for nuclear emergency protocols and waste minimization. Here, we synthesized Na3FePO4CO3(NFPC) via a one-pot hydrothermal method and applied it for the first time to the selective separation of Sr2+from simulated LLRW. Static adsorption experimental results indicated that the distribution coefficientKdremained above 5000 mL·g−1, even when the concentration of interfering ions was more than 40 times that of Sr2+. Furthermore, the removal efficiency of Sr2+showed no significant change within the pH range of 4 to 9. The adsorption of Sr2+fitted the pseudo-second-order kinetic model and the Langmuir isotherm model, with an equilibrium time of 36 min and a maximum adsorption capacity of 99.6 mg·g−1. Notably, the adsorption capacity was observed to increment marginally with an elevation in temperature. Characterization analyses and density functional theory (DFT) calculations elucidated the adsorption mechanism, demonstrating that Sr2+initially engaged in an ion exchange reaction with Na+. Subsequently, Sr2+coordinated with four oxygen atoms on the NFPC (100) facet, establishing a robust Sr-O bond via orbital hybridization.
研究领域:
环境科学
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核化学
·
理论化学
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Advanced Science
·
2026
·
IF 14.1
Yifan Wang,Yanjun Lv,Qilong Tang,Huaixin Hao,Jianfeng Jia,Gang Ye,Jing Chen,Chao Xu,Zhipeng Wang
Addressing the challenges of nuclear waste management and strategic resource recovery necessitates novel functional materials for the integrated and efficient capture of critical elements. This work reports a class of multifunctional eutectic mixtures (EMs) constructed from crown ether (hydrogen-bond acceptor, HBA) and partially esterified organophosphorus acids (hydrogen-bond donor, HBD). This design integrates the high selectivity of crown ether toward Sr(II) with the strong affinity of organophosphorus ligands for U(VI)/Pu(IV), achieving unprecedented single-step extraction efficiencies exceeding 99.9% for U(VI), 99.8% for Pu(IV), and 99% for Sr(II) under extreme and nearly realistic conditions. This exceptional performance originates from the differentiated metal coordination of crown ether and phosphoric esters, coupled with a synergistic “coordination-encapsulation” effect mediated by the formation of reverse micellar supramolecular structures. Our findings not only provide high-performance materials for the simultaneous recovery of critical radionuclides but also demonstrate the great potential of EMs as a sustainable platform for addressing complex separation scenarios.
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Materials Today Chemistry
·
2026
·
IF 7.4
Jin Chen,Naoyuki Hatada,Wenhao Li,Wenzhuo Chen,Donglin Han
Heavily acceptor-doped perovskite oxides have the potential to activate percolation conduction of protons at reduced temperatures, and the reported percolation proton conductors up to now are restricted to the systems containing high Sc content. However, larger trivalent rare earth elements (e.g., Y) are known to be better dopants for proton conducting zirconates, but their solubility is low. In this work, we propose a new strategy to design the percolation proton conducting perovskites, by introducing La and Y into the Sr and Zr-sites of SrZrO 3 , respectively, leading to the formation of (Sr 1.1- x La x -0.1 )(Zr 1- x Y x )O 2.95 (SLZY, x = 0.1 – 1.0), which takes Pnma and Pna 2 1 orthorhombic structures with x = 0.1 – 0.4 and 0.5 – 1.0, respectively. Interestingly, the conductivity decreases with the Y content increasing from 0.1 to around 0.7 and increases with the Y content further increasing to 1.0. Moreover, the activation energy of the bulk conduction shows the maximum value at x = 0.6. In addition to the expected monotonically increasing activation energy resulted from the enhanced structural asymmetry, these results imply that the trapping effect of protons plays an important role, which is enhanced with Y content increasing from 0.1 to around 0.6. Notably, higher Y content (e.g., x > 0.6) appears to activate the percolation conduction of protons, leading to the decreasing activation energy.
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JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
·
2025
·
IF 3.2
Alhalili Zahrah,Shariq Mohammad,Al-Qasmi Noha,Alqahtani Zahrah,Madkhali O.,Alathlawi Hussain J.,Ali Syed Kashif,Sharma Mukul,Hasan K. F.,Elhelali Thoraya M.
This study used a sol-gel method to prepare BiFeO 3 (BFO) and strontium-doped bismuth ferrite Bi 1-x Sr x FeO 3 (x = 0, 0.01, 0.03, 0.05 and 0.09) (Sr-doped BFO) photocatalysts. The microstructural analysis of the Sr-doped BFO photocatalysts revealed a rhombohedral perovskite structure in the samples. The optical study shows that doping with Sr ions reduced the energy band gap of the photocatalyst from 2.12 eV to 1.97 eV. Moreover, the calculated saturation magnetization (Ms) value was increased after doping with Sr ions, and for Sr (x = 0.05), the doped BFO sample exhibits the highest magnetization value of 0.481 emu/g. It was revealed that the Sr (x = 0.05) doped BFO photocatalyst exhibits 91.2% degradation of methylene blue (MB) dye under visible light radiation. In this study, the formation of trap levels due to the Sr ions, as well as the formation of superoxide anions ( \({O}_{2}^{-}\) ) and OH° radicals played a significant role in the degradation of MB. Graphical
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2026
·Vol. 37
·期 3
·242
·
IF 2.8
Zhang Jianhua,Li Lu,Hao Rong,Lei Zhipeng,Ma Yun,Li Yuanyuan,Kang Ailiang
CaCu 3 Ti 4 O 12 (CCTO) has been widely studied for capacitor applications due to its excellent giant dielectric constant and frequency stability, but its development is limited by its low breakdown field strength ( E b ). To promote E b and primarily clarify the intrinsic mechanism, a synergistic strategy combining Sr substitution for Ca in CCTO ceramics with the polymer pyrolysis method was adopted. With the increase of Sr substitution, the average grain size of the ceramics gradually decreased and E b was remarkably enhanced. In particular, an E b of 106.0 kV/cm at a current density of 0.05 mA/cm 2 was achieved for Ca 0.4 Sr 0.6 Cu 3 Ti 4 O 12 ceramics, which is mainly attributed to the tremendous increase in grain boundary resistance induced by the increase of grain boundary density and formation of the insulating secondary phase SrO resulting from Sr substitution. We hope this study will provide a potential solution for the fabrication of CCTO-based dielectric ceramics with excellent E b .
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ELECTROCHIMICA ACTA
·
2015
·
IF 4.504
Yi Cao,Baoping Lin,Ying Sun,Hong Yang,Xueqin Zhang
In this study, we synthesize the La x Sr 1−x CoO 3−δ (0.3≤x≤1) nanofibers (LNF-x) by Electrospun method to improve the energy density of supercapacitor. As well, the structure and electrochemical properties of LNF-x are investigated in detail. As a result, LNF-0.7 sample with high specific surface area possesses the maximum specific capacitance value of 747.75 F·g −1 at a current density of 2 A·g −1 in 1 M Na 2 SO 4 aqueous electrolyte. In addition, a symmetric supercapacitor and an asymmetric supercapacitor are constructed using the LNF-0.7 as the positive electrode, while the LNF-0.7 and activated carbon (AC) are applied to the negative electrode, respectively. The LNF-0.7//LNF-0.7 device with an extended operating voltage range of 0-1.6 V displays excellent electrochemical performance with a high energy density of 34.8 Wh·kg −1 at a low power density of 400 W·kg −1 . On the other hand, the LNF-0.7//AC supercapacitor is operated reversibly at a high cell voltage of 2.0 V and exhibits a high energy density of 27.7 Wh·kg −1 with a low power density of 500 W·kg −1 . Furthermore, the LNF-0.7//LNF-0.7 and LNF-0.7//AC devices have superior cycling stability with ∽97% and ∽80% specific capacitance retention after 2000 cycles, respectively.
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高影响因子
CERAMICS INTERNATIONAL
·
2023
·Vol. 49
·期 23
·39700-39706
·
IF 5.2
Xinkun Liu,Ying Dai,Xinmei Pei,Wen Chen
Ferroelectric thin films with giant room-temperature electrocaloric effect (ECE) could be very useful in design of solid-state refrigeration devices. Here, lead-free Ba 0.85 Ca 0.15-x Sr x Zr 0.1 Ti 0.9 O 3 (BCZT-xSr, 0.01 ≤ x ≤ 0.10) thin films are successfully prepared on the substrates (Pt/Ti/SiO 2 /Si) via sol-gel route, and the effect of the Sr substitution on the structure, electric properties and ECE of the films were investigated. The dielectric analyses show that the rhombohedral-tetragonal phase transition temperature (T R-T ) move to a higher temperature and the tetragonal-cubic phase transition temperature (T m ) shift to a lower temperature with increasing Sr content, and finally the T R-T peaks merge into the T m peaks at room temperature. The BCZT-0.05Sr film presents a giant ECE with ΔT = 27.1 K and ΔS = 30.6 J K −1 kg −1 at 800 kV cm -1 near room temperature (301 K). The giant ΔT benefits from a multiphase coexisting region with successive R-T and T-C phase transition character near room temperature. These results indicate that the lead-free Sr-doped BCZT thin film is an attractive material for application in ECE refrigeration devices.
研究领域:
材料科学
·
凝聚态物理
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功能材料
·
热电转换
·
固态制冷
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高影响因子
危险品化学品经营许可证（带存储）