ANALYTICAL CHEMISTRY
·
2024
·
IF 6.7
Fan Chen,Jinhao Wang,Lijuan Chen,Haoliang Lin,Dongxue Han,Yu Bao,Wei Wang,Li Niu
Wearable, noninvasive sensors enable the continuous monitoring of metabolites in sweat and provide clinical information related to an individual’s health and disease states. Uric acid (UA) is a key indicator highly associated with gout, hyperuricaemia, hypertension, kidney disease, and Lesch–Nyhan syndrome. However, the detection of UA levels typically relies on invasive blood tests. Therefore, developing a wearable device for noninvasive monitoring of UA concentrations in sweat could facilitate real-time personalized disease prevention. Here, we introduce 1,3,6,8-pyrene tetrasulfonic acid sodium salt (PyTS) as a bifunctional molecule functionalized with Ti3C2Tx via π–π conjugation to design nonenzymatic wearable sensors for sensitive and selective detection of UA concentration in human sweat. PyTS@Ti3C2Tx provides many oxidation–reduction active groups to enhance the electrocatalytic ability of the UA oxidation reaction. The PyTS@Ti3C2Tx-based electrochemical sensor demonstrates highly sensitive detection of UA in the concentration range of 5 μM–100 μM, exhibiting a lower detection limit of 0.48 μM compared to the uricase-based sensor (0.84 μM). In volunteers, the PyTS@Ti3C2Tx-based wearable sensor is integrated with flexible microfluidic sweat sampling and wireless electronics to enable real-time monitoring of UA levels during aerobic exercise. Simultaneously, it allows for comparison of blood UA levels via a commercial UA analyzer. Herein, this study provides a promising electrocatalyst strategy for nonenzymatic electrochemical UA sensor, enabling noninvasive real-time monitoring of UA levels in human sweat and personalized disease prevention.
研究领域:
生物传感器
·
材料科学
·
电化学
·
健康监测
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产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2021
·Vol. 31
·期 35
·2103210
·
IF 18.808
Xue Wang,Yuanming Wang,Yunpeng Jiang,Xiaolong Li,Yang Liu,Huanhao Xiao,Yu Ma,You-yuan Huang,Guohui Yuan
Exploiting Zn metal-free anode materials would be an effective strategy to resolve the problems of Zn metal dendrites that severely hinder the development of Zn ion batteries (ZIBs). However, the study of Zn metal-free anode materials is still in their infancy, and more importantly, the low energy density severely limits their practical implementations. Herein, a novel (NH 4 ) 2 V 10 O 25 · 8H 2 O@Ti 3 C 2 T x (NHVO@Ti 3 C 2 T x ) film anode is proposed and investigated for constructing “rocking-chair” ZIBs. The NHVO@Ti 3 C 2 T x electrode shows a capacity of 514.7 mAh g −1 and presents low potential which is 0.59 V (vs Zn 2+ /Zn) at 0.1 A g −1 . The introduction of Ti 3 C 2 T x not only affords an interconnected conductive network, but also stabilizes the NHVO nanobelts structure for a long cycle life (84.2% retention at 5.0 A g −1 over 6000 cycles). As a proof-of-concept, a zinc metal-free full battery is successfully demonstrated, which delivers the highest capacity of 131.7 mAh g −1 (mass containing anodic and cathodic) and energy density of 97.1 Wh kg −1 compared to all reported aqueous “rocking-chair” ZIBs. Furthermore, a long cycling span of 6000 cycles is obtained with capacity retention reaching up to 92.1%, which is impressive. This work is expected to provide new moment toward V-based materials for “rocking-chair” ZIBs.
研究领域:
材料科学
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电化学
·
能源存储
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DOI
高影响因子
Materials Today Chemistry
·
2024
·
IF 6.7
Linwei Li,Zihan Xing,Tao Liao,Jinyu Wang,Ziqiang Xu,Ying Kuang,Cao Li
Chemodynamic therapy (CDT) is a new cancer treatment that uses low-valence transition metal ions to catalyze intracellular Fenton/Fenton-like reactions, producing hydroxyl radicals (•OH) to eliminate cancer cells. However, achieving satisfactory therapeutic outcomes with CDT alone can be challenging. In this work, we reported an anticancer drug delivery DOX@HMDN-TQDs@PEI-PEG (DMTP) based on hollow mesoporous manganese dioxide nanoparticle (HMDN), which has the potential to improve cancer therapy by combining synergistic therapeutic and tumor magnetic resonance imaging (MRI) capability. After loading the anticancer drug doxorubicin hydrochloride (DOX), the pores of HMDN were sealed with polyethyleneimine (PEI) modified Ti 3 C 2 T x MXene quantum dots (TQDs) and finally modified with polyethylene glycol (PEG) to obtain the final system. HMDN depletes glutathione (GSH), which is harmful to CDT, in cancer cells, and generates Mn 2+ that can be used for both CDT and MRI. TQDs can also be used for highly effective photothermal therapy (PTT) that enhances CDT. The combination of DOX with chemotherapy can significantly inhibit tumor growth. In addition, DMTP combines the capability of tumor MRI as Mn 2+ is also a T 1 -weighted contrast agent . This multifunctional delivery system provides new ideas for research related to tumor diagnosis and treatment.
研究领域:
生物医学工程
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纳米医学
·
癌症治疗
·
分子影像
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产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2025
·
IF 7.7
Lin Chen,Xi Chen,Fei Wang,Yu Tong,Kewei Zhang,Zhengbo Han,Mingzhe Zhang
Metal-organic frameworks (MOFs) are regarded as potential candidate materials with great application prospects in the field of gas sensing. In this study, MOF derivatives were anchored onto MXene sheets through self-assembly technology to prepare a heterojunction material ZnO/Ti 3 C 2 T x MXene with high specific surface area, achieving ultrafast dual gas sensing behavior for H 2 /NO 2 . At a low temperature of 80°C, the ZnO/ Ti 3 C 2 T x MXene heterojunction sensor exhibited an ultrafast response (23.17%) to 500 ppb H 2 within 3.2 s. After a moderate temperature increase to 180°C, it also demonstrated significant sensing performance (46.3%) to 500 ppb NO 2 within 4 s. The electronic interaction mechanism of ZnO/ Ti 3 C 2 T x MXene heterostructures in H 2 and NO 2 detection was revealed through density functional theory calculations and in-situ Raman spectroscopy, clarifying the influence of interfacial charge transfer on sensing performance. Heterogeneous structures achieve the regulation of gas adsorption-induced electron rearrangement and carrier modulation by constructing interface charge-regulating channels, significantly enhancing the response rate, selectivity and reversibility in the detection of H 2 and NO 2 , thereby enabling highly sensitive and trace detection of the two gases.
研究领域:
材料科学
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气体传感技术
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纳米材料
·
电子器件
·
环境监测
·
能源安全
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF THE ENERGY INSTITUTE
·
2024
·
IF 5.6
Zheng Bo,Mengyu Cao,Yaolin Wang,Jianhua Yan,Kefa Cen,Xin Tu
Plasma catalytic CO 2 hydrogenation has emerged as a promising approach for converting CO 2 into valuable chemicals such as CO, offering a potential solution to mitigate greenhouse gas emissions. In this study, we investigate the synergistic effect between plasma and a Cu/Ti 3 C 2 T x MXene catalyst for CO 2 hydrogenation via the reverse water gas shift (RWGS) reaction in a dielectric barrier discharge (DBD) reactor. Our findings reveal a significant enhancement in CO 2 conversion (33.1%) and CO yield (31.9%) when using the Cu/Ti 3 C 2 T x catalyst compared to plasma alone or with a Ti 3 C 2 T x foam. Plasma treatment creates unsaturated Ti sites on the Ti 3 C 2 T x surface, dramatically improving CO 2 adsorption and activation, while Cu nanoparticles significantly enhances the activation and dissociation of H 2 molecules on the catalyst surface. These surface adsorbed hydrogen species readily hydrogenate adsorbed CO 2 molecules through the Langmuir-Hinshelwood mechanism. Furthermore, these surface hydrogen species can also participate in the conversion of gas-phase CO 2 molecules through the Eley-Rideal pathway. This work sheds light on the synergistic plasma catalytic mechanism and provide insights for optimizing CO 2 hydrogenation processes using MXene catalysts.
研究领域:
化学工程
·
催化
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环境科学
·
等离子体化学
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产品关联
DOI
高影响因子
Analytical Methods
·
2024
·
IF 2.7
Jing Li,Xun Zhou,Guanghua Mao,Gangbing Zhu,Yinhui Yi
In recent years, numerous colorimetric methods have been developed for the detection of silver ions (Ag+), yet there remains a need for a simple, sensitive, real-time and quantitative sensing platform. Herein, Ti3C2Tx MXene nanoribbons (Ti3C2TxNRs) were utilized as the carrier material, and gold@platinum (Au@Pt) bimetallic nanoparticles were decorated onto the Ti3C2TxNR surface, for the first time, via a facile self-reduction method. The resulting Au@Pt–Ti3C2TxNR nanohybrid exhibited excellent catalytic activity, facilitating the oxidation of 3,3′,5,5′-tetramethylbenzidine, a colorless substrate, to generate a blue product (oxTMB), displaying prominent peroxidase-like activity. In the presence of Ag+, a remarkable inhibiting effect was observed on the catalytic activity of the Au@Pt–Ti3C2TxNR nanohybrids, effectively halting the generation of oxTMB. Based on this, the as-obtained Au@Pt–Ti3C2TxNR nanozyme was then utilized to develop a novel colorimetric sensing platform for Ag+ detection, with a low detection limit of 1.57 nM and a wide linear detection range from 5.0 nM to 9.0 μM. In addition, by combining the unique advantages of hydrogel materials and smartphone technology, a simple, real-time and quantitative platform for Ag+ monitoring was constructed, highlighting its potential for practical applications in Ag+ detection.
研究领域:
纳米材料科学
·
分析化学
·
环境监测
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Hao Xu,Shuai Liu,Zhiang Li,Fan Ding,Jie Liu,Weimin Wang,Kaikai Song,Ting Liu,Lina Hu
Solid polymer electrolytes (SPEs) have been considered the most promising separators for all-solid-state lithium metal batteries (ASSLMBs) due to their ease of processing and low cost. However, the practical applications of SPEs in ASSLMBs are limited by their low ionic conductivities and mechanical strength. Herein, we developed a three-dimensional (3D) interconnected MXene (Ti 3 C 2 T x ) network and Li 6.4 La 3 Zr 1.4 Ta 0.6 O 12 (LLZTO) particles synergistically reinforced polyethylene oxide (PEO)-based SPE, where the association of Li + with ether-oxygen in PEO could be significantly weakened through the Lewis acid-base interactions between the electron-absorbing group (Ti–F, −O–) of Ti 3 C 2 T x and Li + . Besides, the TFSI − in lithium salts could be immobilized by hydrogen bonds from the Ti–OH of Ti 3 C 2 T x . The 3D interconnected Ti 3 C 2 T x network not only alleviated the agglomeration of inorganic fillers (LLZTO), but also improved the mechanical strength of composite solid electrolyte (CSE). Consequently, the assembled Li||CSE||Li symmetric battery showed excellent cycling stability at 35 ℃ (stable cycling over 3000 h at 0.1 mA cm −2 , 0.1 mAh cm −2 ) and −2 ℃ (stable cycling over 2500 h at 0.05 mA cm −2 , 0.05 mAh cm −2 ). Impressively, the LiFePO 4 ||CSE||Li battery showed a high discharge capacity of 145.3 mAh/g at 0.3 C after 300 cycles at 35 ℃. This rational structural design provided a new strategy for the preparation of high-performance solid-state electrolytes for lithium metal batteries.
研究领域:
材料科学
·
电化学
·
能源存储
·
纳米技术
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Qiqi Wang,Changjun Mu,Ya'nan Yu,Xia Feng,Yang He,Li Chen
Current patients with chronic kidney disease (CKD) suffer from either accumulation of advanced glycation end products (AGEs) or inefficient clearance of the middle molecule uremic toxins, threatening their long-term survival rate. In particular, conventional hemodialysis membranes cannot prevent AGEs formation because of continuous oxidative stress from reactive oxygen species (ROS). Herein, a persistent ROS scavenging and efficient uremic toxin clearance of hemodialysis membrane is proposed by the in situ deposition of a gallic acid-Ti 3 C 2 T x MXene (GA-MXene) n multilayers through a self-assembly method, where n denotes the number of deposition layers. These hemodialysis membranes have a highly interconnecting composite laminate with tunable pore size. In the dialysis experiment, the (GA-MXene) 2 membrane with the vertical nano-slits shows the highest middle molecule uremic toxin clearance of 80.0% compared with state-of-the-art hemodialysis membranes, which has been approximately equal to the clearance of small molecule urea. Furthermore, GA conferring efficient ROS scavenging rate over dialysis treatment time allows anti-oxidative activities to inhibit AGEs’ formation. (GA-MXene) n multilayers enhanced the serum total antioxidant capacity and suppressed lipid peroxidation from oxidative damage. Ultimately, the (GA-MXene) n hemodialysis membranes provide excellent anticoagulant properties and cytocompatibility through the heparin-mimicking sulfonated Ti 3 C 2 T x MXene and biological activity of GA. This work facilitates the blood purification application of MXenes and opens up an avenue for developing functional multilayers for high-performance hemodialysis membranes and beyond.
研究领域:
材料科学
·
生物医学工程
·
纳米技术
·
肾脏医学
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产品关联
DOI
高影响因子
Nanoscale
·
2024
·Vol. 16
·期 9
·4811-4825
·
IF 5.8
Menghan Guo,Wenqing Wang,Bin Zhai,Jingtao Li,Liran Zhang,Jingchun Li,Kexin Luo,Rui Wang
Flammability feature of textiles is a big underlying risk causing fire disasters. The fabrication of reliable fire resistant and quick fire warning fabrics is imperative but challenging. Herein, three types of early fire-warning polyester fabrics, namely, FPP@AM-X, FPP@PM-X and FPP@AX-M1, with good flame retardant and piezoresistive sensing performance were developed by fabricating polyethyleneimine (PEI), ammonium polyphosphate (APP), phytic acid (PA) and MXenes onto phosphorus-containing flame retardant polyethylene terephthalate (FRPET) via polydopamine (PDA) mediated layer-by-layer self-assembly. Owing to the improved thermoelectric properties of MXenes, FPP@A5-M1 exhibited a maximum thermoelectric voltage of 0.59 mV at a temperature difference of 130 °C and can provide an ideal cyclic early fire warning response within 4 s. In addition, due to the synergistic flame retardant effect of MXenes and APP in the coating layer, FPP@A5-M1 could be self-extinguished within 2 s after ignition and the value of peak heat release ratio and total smoke production decreased by 41.9% and 30.4%, respectively. Besides, the MXene-based hybrid coated fabric can detect the movement of human fingers and elbows, illustrating its potential application in piezoresistive tension sensing. This work provides a new route to designing and developing multi-functional and smart fire protection fabrics.
研究领域:
材料科学
·
纺织工程
·
消防安全
·
智能纺织品
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产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2021
·
IF 4.821
Yunfei Wang,Wenjie Sun,Yixiao Li,Xuming Zhuang,Chunyuan Tian,Feng Luan,Xiuli Fu
Human immunodeficiency virus (HIV) is still a significant global health concern. Hence, developing a rapid and sensitive method for the detection of HIV is important in early detection. In this paper, we focus on the preparation of a sensitive electrochemical luminescence (ECL) biosensor that uses Ti 3 C 2 T x modified ZIF-8 as an ECL emitter to detect HIV-1 protein. This ECL biosensor used 0.05 M K 2 S 2 O 8 as the co-reactant and conductive carbon black combined with magnetic nanoparticles as the quenching agent. Under the optimized experimental conditions, the relationship was linear in the range from 1 fM to 1 nM (R 2 = 0.993) and the detection limit was 0.3 fM (S/N = 3). Finally, we used the constructed Ti 3 C 2 T x /ZIF-8 nanocomposites to detect HIV-1 in real serum samples and obtained great recoveries. The results demonstrated that this biosensor, which not only exhibited improved electrical conductivity but also demonstrated an excellent ECL response, could be a promising candidate for HIV-1 detection.
研究领域:
生物传感器
·
分析化学
·
材料科学
·
病毒学
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DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2020
·
IF 7.1
Fenghe Duan,Chuanpan Guo,Mengyao Hu,Yingpan Song,Minghua Wang,Linghao He,Zhihong Zhang,Riccardo Pettinari,Liming Zhou
A promising nanocarrier of the complementary DNA (cDNA) toward miRNA-155 was synthesized on the basis of the nanohybrid type of Ti 3 C 2 T x MXene nanosheets decorated using iron phthalocyanine quantum dots (FePc QDs) (denoted as Ti 3 C 2 T x @FePcQDs) to construct a novel ultrasensitive impedimetric aptasensing system for microRNA-155 (miRNA-155). Owing to π–π* stacking interaction between Ti 3 C 2 T x nanosheets and FePc QDs, the homogeneous nanostructure of the Ti 3 C 2 T x @FePcQD nanohybrid that comprises mixed-valence states (Ti 2+ /Ti 3+ and Fe 2+ /Fe 3+ ), multicomponent (Ti-O and Ti-C), and various N-related groups was achieved. The constructed Ti 3 C 2 T x @FePcQDs-based aptasensor displayed an ultrahigh sensitivity for detecting miRNA-155 with a low detection limit of 4.3 aM (S/N = 3) within the miRNA-155 concentration ranging from 0.01 fM to 10 pM. Compared with the individual component-based aptasensors and other reported miRNA-155 aptasensors, the proposed impedimetric aptasensing system exhibited substantial merits of a feasible preparation process, non-use of labels or electrochemical indicators, fast response time, and comprehensive sensing performances for detecting miRNA-155. This strategy for determining miRNAs can extensively be applied as the platform for anchoring other kinds of aptamers in detecting diverse targets, thus indicating its great potential application for the early diagnosis of cancer biomarkers.
研究领域:
纳米技术
·
生物传感器
·
分析化学
·
分子生物学
·
癌症研究
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Enpu Tan,Yu Liu,Chunyan Hu,Zhijia Zhu,Baojiang Liu
Moisture-enabled electricity generator (MEG) technology converts energy from the environment into green electricity by exploiting the interaction between atmospheric moisture and hydrophilic materials and has the advantages of a simple device structure, small geographical and temporal constraints, and environmental friendliness; therefore, it has great application value in serving as a power source for portable electronic devices. However, the high output performance of most MEG devices is dependent on high ambient relative humidity (RH), and current MEG technologies tend to be poorly flexible and lack wearability, which severely pose a barrier to their practical utilization. Here, we have developed a high-performance bilayer MEG with exceptional environmental adaptability and stretchability. By rationally combining Ti3C2Tx MXene-loaded cotton knitted fabrics (MC) and a stretchable double-network ionic hydrogel (IH) to form the MXene/cotton-ionic hydrogel MEG (MCIH-MEG), the MCIH-MEG with 230% stretchable capacity can continuously provide an open-circuit voltage (Voc) of 0.5 V and a short-circuit current (Isc) of 50 μA, which stem from the continuous water evaporation within the device and fast capillary water flow on MXene nanosheets, as well as redox reactions at the electrodes, which can achieve good electrical performance across a wide range of temperatures (0–80 °C) and RH levels (20–95%). Due to its flexibility, stable electrical output, and sensitivity to external stimuli, MCIH-MEG can be employed in the fabrication of self-powered sensors to detect simple weight changes or even complex gesture changes and in the construction of self-powered smart masks for respiratory monitoring.
研究领域:
能量收集
·
材料科学
·
纳米技术
·
柔性电子学
·
环境技术
·
传感器
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）