SEPARATION AND PURIFICATION TECHNOLOGY
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2018
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IF 3.927
Qiang Wu,Mingyan Liu,Xiong Wang
A new type of absorbent was synthesized by grafting N-methyl-D-glucamine (MG) onto the surface of chitosan beads to separate boron element. The physicochemical properties of modified chitosan beads (CTS-MG) were examined by FT-IR and SEM analyses. The results indicated that MG had grafted on chitosan beads (CTS) successfully. Compared to surface of pure CTS, CTS-MG had a rougher surface. While the pH value ranged 3–8, CTS-MG would have a high efficiency of adsorption to boron. The characteristics of the adsorption process were evaluated by Langmuir and Freundlich adsorption isotherms , and the maximum adsorption capacity of CTS-MG was 20.36 mg·g −1 . When mass of absorbent was not lower than 0.1 g, the concentration of 10 ml boron solution would decrease from 50 to 0.5 mg/L. This absorption process fit to the pseudo-second-order kinetic model. CTS-MG had a comparatively high selectivity because general competing ions had little influence on the absorptive ability of CTS-MG. After 5 times adsorption-desorption cycles, absorptive capacity of CTS-MS did not decrease obviously. CTS-MG was hopefully used in the process of boron desorption in salt lake brine.
研究领域:
材料科学
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环境化学
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水处理
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DOI
高影响因子
Membranes
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2022
·Vol. 12
·期 2
·239
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IF 4.562
Xiaolong Sun,Longfei Yin,Huayue Zhu,Junhao Zhu,Jiahuan Hu,Xi Luo,He Huang,Yongqian Fu
In this study, chitosan and sugarcane cellulose were used as film-forming materials, while the inorganic agent zinc oxide (ZnO) and natural compound phenyllactic acid (PA) were used as the main bacteriostatic components to fabricate biodegradable antimicrobial composite membranes. The water absorption and antimicrobial properties were investigated by adjusting the concentration of PA. The scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) results demonstrated that the components of the composite membrane were successfully integrated. The addition of ZnO improved the mechanical and antimicrobial properties of the composite membrane, while the addition of PA with high crystallinity significantly reduced the water absorption and swelling. Moreover, the addition of 0.5% PA greatly improved the water absorption of the composite membrane. The results of antimicrobial experiments showed that PA improved the antimicrobial activity of the composite membrane againstStaphylococcus aureus,Escherichia coli,Aspergillus nigerandPenicillium rubens. Among them, 0.3% PA had the best antimicrobial effect againstS. aureus,E. coliandA. niger, while 0.7% PA had the best antimicrobial effect againstP. rubens.Keywords:composite membrane;phenyllactic acid;antimicrobial activity
研究领域:
材料科学
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生物学
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DOI
PubMed
高影响因子
Polymers
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2022
·Vol. 14
·期 13
·2704
·
IF 4.967
Xiangyu Jiao,Jiaxuan Xie,Mingda Hao,Yiping Li,Changtao Wang,Zhu Zhu,Yongqiang Wen
World hunger is on the rise, yet one-third of food is wasted. It is necessary to develop an effective food preservation method to reduce food waste. This article reports a composite film based on chitosan biguanidine hydrochloride(CBg) and poly (N-vinyl-2-pyrrolidone)(PVP) that can be used as a conformal coating for fresh produce. Due to the strong positive charge of CBg, the film has excellent antibacterial properties. Owing to the hydrogen bonds between CBg and PVP, the film has good flexibility and mechanical properties. In addition, the coating is washable, transparent, and can reduce the evaporation of water. The above characteristics mean the film has broad application prospects in the field of food preservation.Keywords:antimicrobial;chitosan derivative;coating;fruit
研究领域:
食品科学
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材料科学
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DOI
PubMed
高影响因子
BIOMACROMOLECULES
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2021
·
IF 6.988
Sizhao Zhang,Junpeng He,Shixian Xiong,Qi Xiao,Yunyun Xiao,Feng Ding,Hui Ji,Zhouyuan Yang,Zhengquan Li
Biomass aerogels have received extensive attention due to their unique natural characteristics. However, biomass-based chitosan aerogels are often confronted with the traditional issue concerning a weak skeleton structure, namely, the corresponding huge shrinkage for chitosan aerogels in the stage from the final gel to the aerogel. Herein, we put forward a new approach to enhance chitosan aerogels by introducing natural biomaterial cellulose nanocrystal (CNC). CNC is applied to connect/cross-link chitosan chains to form its networking construction through supramolecular interaction/physical entanglement, eventually realizing the enhancement of the chitosan aerogel network structure. Chitosan aerogels modified with CNC exhibit a high specific surface area of 578.43 cm2 g–1, and the pore size distribution is in the range of 20–60 nm, which is smaller than the mean free path of gas molecules (69 nm), triggering a “no convection” effect. Hence, the gaseous heat transfer of chitosan aerogel is effectively suppressed. Chitosan aerogels with the addition of CNC show an excellent thermal insulation property (0.0272 W m-1 K-1 at ambient condition) and an enhanced compressive strength (0.13 MPa at a strain of 3%). This improvement method of chitosan aerogel in enhancing the skeleton structure aspect provides a new kind of idea for strengthening the nanoscale morphology structure of biomass aerogels.
研究领域:
材料科学
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生物材料学
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DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
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2022
·
IF 10.723
Wenkun Zhang,Ting Huang,Yu Ren,Shuai Yang,Xinyao Zhao,Maosen Yuan,Jinyi Wang,Qin Tu
Pharmaceuticals and personal care products (PPCPs) are gaining attention due to their persistence in the environment. Therefore, the development of novel adsorbents to remove them is strongly anticipated. In this study, an improved dual ice-template assembly method had been used for the preparation of ZIF-67/QGO/SB-CS aerogel through ZIF-67, benzoquinone-modified graphene oxide (QGO), and sulfobetaine-modified chitosan (SB-CS) for the adsorption and removal of PPCPs in water. We reported for the first time that the chitosan composite aerogel has antifouling, bacterial filtration and oil-water separation abilities with excellent PPCPs adsorption performance and reusable, which would be a viable option for long-lasting adsorbents for PPCPs in water.
研究领域:
环境科学
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材料科学
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DOI
PubMed
高影响因子
TENSIDE SURFACTANTS DETERGENTS
·
2023
·Vol. 60
·期 5
·450-459
·
IF 1
Ya Xu,Zheng Ji,Yansong Zhang,Mengdie Sha,Chuanrun Li,Huchuan Wang
Chitosan and hydroxyapatite are commonly used materials for adsorption. In this work, chitosan was modified by polyethylene glycol and maleic anhydride. Subsequently, a hydroxyapatite-chitosan composite was synthesised by precipitation. The composite was characterised and analysed by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA) and X-ray photoelectron spectroscopy (XPS). Adsorption experiments were used to investigate the effects of external factors such as different pH values, adsorbent dosage, adsorption time and initial nickel ion concentration on the adsorption capacity of Ni 2+ and to discuss the mechanism of Ni 2+ removal by composites. The results show that the hydroxyapatite-chitosan composite has significant adsorption of Ni 2+ . The adsorption capacity of the hydroxyapatite-chitosan composite for Ni 2+ reaches 63.8 mg g −1 . The adsorption process is consistent with the pseudo-second-order kinetic model and the Langmuir isothermal model.
研究领域:
材料科学
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环境科学
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化学工程
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DOI
高影响因子
CARBOHYDRATE POLYMERS
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2015
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IF 4.074
Xiancai Jiang,Yulai Zhao,Linxi Hou
The AlCl 3 ·6H 2 O aqueous solution was used to dissolve chitosan (CS) and the CS/poly(vinyl alcohol) (PVA) blend films were prepared at the absence of acetic acid. AlCl 3 ·6H 2 O was retained in CS/PVA film and glycerol was added to form the complex plasticizer with AlCl 3 ·6H 2 O. The effect of glycerol on the water sorption , crystalline, thermal and mechanical properties of AlCl 3 ·6H 2 O doped CS/PVA film was studied by atomic force microscopy , X-ray diffraction, thermal gravity analysis and tensile testing, respectively. The experimental results showed that glycerol had a significant positive effect on the properties of AlCl 3 ·6H 2 O doped CS/PVA films. With the synergism effect of AlCl 3 ·6H 2 O and glycerol, the prepared CS/PVA films showed excellent mechanical properties. With the addition of 30 wt% glycerol, the AlCl 3 ·6H 2 O doped CS/PVA films behave the tensile strength of 39 MPa and elongation at break of 120%, respectively.
研究领域:
材料科学
·
高分子化学
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
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2026
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IF 6
Tao Wang,Yang Han,Jingyi Chen,Gaochao Zhou,Lixiao Cai,Tong Li,Xiaoxiao Guo,Jing Han
A nano-in-microneedle system delivers sulforaphane efficiently through the skin barrier for dermatitis treatment. • Network pharmacology predicts that sulforaphane treats irritant contact dermatitis by targeting multiple inflammatory pathways. • Chitosan nanoparticles encapsulate sulforaphane with high efficiency, protecting it from degradation and enabling sustained release. • The combined microneedle patch shows superior anti-inflammatory effects in mice, outperforming conventional dexamethasone ointment. • Methacrylated chitosan microneedles create microchannels, enhancing skin retention eleven-fold. Treatment of irritant contact dermatitis (ICD) is limited by the stratum corneum barrier, which hinders drug delivery and bioavailability. Sulforaphane (SFN) offers anti-inflammatory potential but suffers from poor stability and a short half-life. To address this, we developed a chitosan methacrylate (CSMA) hydrogel microneedle (MN) patch loaded with SFN-chitosan nanoparticles (SFN-CSNPs) for enhanced transdermal delivery.Network pharmacology identified 33 potential ICD-related targets of SFN, including SRC, EGFR, and JAK2, implicating pathways such as AGE-RAGE and Relaxin signaling. SFN-CSNPs were optimized via a Box-Behnken design, yielding nanoparticles with a size of 180–220 nm, PDI < 0.3, a Zeta potential of ∼ 24 mV, and a high encapsulation efficiency (91.94 ± 1.22%). These were incorporated into CSMA MNs using micromolding. The MN arrays exhibited robust mechanical strength (1.53 N/needle), enabling effective stratum corneum penetration. In vitro, the system achieved sustained release (183.6 ± 2.1 µg/cm 2 over 60 h) and 11-fold higher skin retention than the SFN solution. It also demonstrated excellent stability, retaining > 85% drug content after 30 days at 4 °C. In an ICD mouse model, SFN-CSNPs@CSMA MNs significantly reduced erythema, edema, and epidermal thickening (45.37 ± 2.86 µm), approaching normal levels (20.03 ± 3.20 µm), and outperformed both SFN-CSNPs solution and dexamethasone ointment. This nano-MN platform effectively overcomes skin barriers, enhances drug stability, and enables localized, sustained release, offering a promising strategy for delivering unstable natural compounds such as SFN to treat inflammatory skin diseases. Download: Download high-res image (210KB) Download: Download full-size image
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Zinan Wang,Min Zhang,Shan Liang,Yan Li
Pickering emulsions were prepared by using zein/chitosan nanoparticles as stabilizer and then incorporated into chitosan coatings. To improve the stability and performances, tea polyphenol and cinnamaldehyde (CA) were used to modulate the formation and functionalities of Pickering emulsions. The oil phase in Pickering emulsions were set at 5 % and 20 % to alter the hydrophobicity of chitosan coatings. Physical, structural, antioxidant and antibacterial activities of chitosan coatings with Pickering emulsions were characterized. Tea polyphenol significantly enhanced antioxidant capacity of chitosan coatings from 2.09 % to 57.61 % of DPPH value and from 2.63 % to 38.85 % of ABTS value. CA effectively increased the antibacterial activity of chitosan coatings against S. aureus and E. coli . Under 20 % oil content, the inhibition zones on S. aureus and E. coli increased from 3.03 ± 0.23 mm to 18.39 ± 1.22 mm and 7.66 ± 1.61 mm to 15.70 ± 1.75 mm, respectively. The preservative effect of chitosan coatings on fresh pork was further confirmed that the shelf-life of fresh pork could be extended by >4 days. These results suggested a great potential application of Pickering emulsion-incorporated chitosan coatings in the preservation of fresh pork.
研究领域:
食品科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Xinchen Du,Xingli Zhao,Yadong Liu,Yafang Chen,Ruxiang Li,Tongxing Zhang,Lianyong Wang
The development of self-elastic sponges with enhanced hemostatic and antibacterial properties to treat noncompressible hemorrhage and facilitate wound healing remains challenging. Herein, we prepared a chitosan sponge reinforced with lauric acid-modified quaternized chitosan (LQC) and attapulgite, features a porous structure, high self-elasticity, and rapid shape recovery. The incorporation of LQC conferred the sponge with an enhanced capacity to promote the adhesion, aggregation, and activation of blood cells, and resistance to infection by Staphylococcus aureus , Escherichia coli , and Methicillin-resistant Staphylococcus aureus ; the incorporation of attapulgite enhanced the hydrophilicity and mechanical strength of the sponge, and its ability to activate the intrinsic and extrinsic coagulation pathways. The sponge exhibited superior hemostatic capacity to commercial gauze and gelatin sponge when applied to rat and rabbit liver perforation wounds. Additionally, the wound healing efficacy of our biocompatible and biosafe sponge was higher than that of commercial 3 M Tegaderm dressing. Our sponge exhibits significant potential in noncompressible hemorrhage treatment, bacterial infection prevention, and wound healing promotion.
研究领域:
生物材料
·
止血
·
伤口愈合
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组织工程
·
抗菌材料
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2021
·
IF 13.273
Pei Liu,Mengna Li,Hongping Yu,Haoyu Fang,Junhui Yin,Daoyu Zhu,Qianhao Yang,Qinfei Ke,Yigang Huang,Yaping Guo,Youshui Gao,Changqing Zhang
Articular osteochondral defect is commonly seen after trauma or in patients with degenerative osteoarthritis. Currently, the treatment of osteochondral lesions is still challenging due to the limited healing ability of cartilage as well as the poorly effective traditional method. In this study, we fabricated a bilayer peptide-loaded scaffold consisting of CK2.1 coated β-glycerophosphate/chitosan ( [email protected] ) for cartilage regeneration and LL37 modified layered double hydroxide/chitosan ( [email protected] ) for subchondral bone regeneration, designed in an integrated strategy involving mesenchymal stem cells (MSCs) recruitment and multifunctional therapeutic biomaterials of bone regeneration and vascularization. The lower LC scaffold is highlighted with a biomimetic lamellar structural design, providing a novel platform for the integration of newborn bone tissue and blood vessels. In vitro results showed our peptide-loaded bilayer scaffold could induce the MSCs to differentiate into chondrocytes and osteoblasts in different layers respectively. [email protected] could also attract MSCs and promote vasculogenesis in vitro. Meanwhile, osteochondral defect could be efficiently repaired by this peptide-modified bilayered scaffold in the rabbit model. This study demonstrated that our composite scaffold could smartly enhance the repair of hyaline cartilage and subchondral bone defect, which shed light on a novel therapeutic strategy for the intervention of patients with articular osteochondral defect.
研究领域:
组织工程
·
再生医学
·
生物材料科学
·
骨科
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产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
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2015
·
IF 5.636
Jincan He,Gongke Li,Yuling Hu
Poor selectivity and biocompability remain problems in applying surface-enhanced Raman spectroscopy (SERS) for direct detection of proteins due to similar spectra of most proteins and overlapping Raman bands in complex mixtures. To solve these problems, an aptamer recognition induced target-bridged strategy based on magnetic chitosan (MCS) and silver/chitosan nanoparticles (Ag@CS NPs) using SERS was developed for detection of protein benefiting from specific affinity of aptamers and biocompatibility of chitosan (CS). In this process, one aptamer (or antibody) modified MCS worked as capture probes through the affinity binding site of protein. The other aptamer modified Raman report molecules encapsulated Ag@CS NPs were used as SERS sensing probes based on the other binding site of protein. The sandwich complexes of aptamer (antibody)/protein/aptamer were separated easily with a magnet from biological samples, and the concentration of protein was indirectly reflected by the intensity variation of SERS signal of Raman report molecules. To explore the universality of the strategy, three different kinds of proteins including thrombin, platelet derived growth factor BB (PDGF BB) and immunoglobulin E (lgE) were investigated. The major advantages of this aptamer recognition induced target-bridged strategy are convenient operation with a magnet, stable signal expressing resulting from preventing loss of report molecules with the help of CS shell, and the avoidance of slow diffusion-limited kinetics problems occurring on a solid substrate. To demonstrate the feasibility of the proposed strategy, the method was applied to detection of PDGF BB in clinical samples. The limit of detection (LOD) of PDGF BB was estimated to be 3.2 pg/mL. The results obtained from human serum of healthy persons and cancer patients using the proposed strategy showed good agreement with that of the ELISA method but with wider linear range, more convenient operation, and lower cost. The proposed strategy holds great potential in highly sensitive and selective analysis of target proteins in complex biological samples.
研究领域:
生物化学
·
分析化学
·
医学诊断
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）