JOURNAL OF MATERIALS CHEMISTRY
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2012
·Vol. 22
·期 47
·24856-24861
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IF 5.968
Cheng-an Tao,Jianfang Wang,Shiqiao Qin,Yanan Lv,Yin Long,Hui Zhu,Zhenhua Jiang
A novel graphene oxide (GO)-based hydrogel with drug molecules as crosslinking agents was fabricated. Metformin hydrochloride (MFH), which has no aromatic groups, but only has N-containing functionalities, was chosen as a model drug. When a very small amount of MFH was introduced into a GO solution, a supramolecular assembled hydrogel was rapidly formed without any polymers or chemical additives. The gelation process can be influenced by the weight ratio of MFH to GO. The driving forces were hydrogen bonding and electrostatic attraction. Both air-dried and freeze-dried samples of GO–MFH hydrogels were utilized for controlled drug release in water (pH = 7) and hydrochloric acid (pH = 1, 3 and 5). The release mechanism of capsulated MFH was Fickian diffusion according to the fitted results. Both the freeze-dried and air-dried samples released around 74% of the MFH in a strongly acidic medium after 70 h, but only 50% in a neutral solution. This pH-sensitivity makes it a potential candidate for the controlled release of drugs in the acidic environment of the stomach.
研究领域:
材料科学
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药学
·
生物医学工程
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DOI
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2022
·Vol. 23
·期 16
·9081
·
IF 6.208
Wei Liu,Xiaoge Wang,Danyang Zhou,Xiangze Fan,Jinhua Zhu,Xiuhua Liu
A novel hydrogel (DOP/PEI-PBA) based on the “three-component” reaction of 2-formylphenylboric acid (2-FPBA), the primary amine group of polyethyleneimine (PEI) and the cis-o-dihydroxy groups ofDioscorea oppositaThunb polysaccharide (DOP) was designed in this work. The hydrogel can be easily prepared by simply mixing the three reactants at room temperature. The hydrogel had dual responsiveness to glucose and pH, and can realize the controllable release of insulin. Moreover, the hydrogel combining insulin and DOP can inhibit the reactive oxygen species (ROS) level and malondialdehyde (MDA) content, and promote glucose consumption as well as the level of superoxide dismutase (SOD), in high-glucose-induced injury in HL-7702 cells, which reflects the synergistic effect of insulin and DOP to protect hepatocytes from oxidative stress at the same time. Further in vitro cytotoxicity studies showed that the hydrogel had good biocompatibility and no obvious toxicity to cells. These indicate that the prepared hydrogel (DOP/PEI-PBA) can be expected to be applied in the clinical treatment of insulin deficiency in diabetes.Keywords:Dioscorea oppositaThunb polysaccharide;hydrogel;insulin;drug delivery
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PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
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2015
·
IF 3.088
Jing Li,Lu Xu,Baixue Yang,Zhihong Bao,Weisan Pan,Sanming Li
This work initially illustrated the formation mechanism of chiral mesoporous silica (CMS) in a brand new insight named biomimetic synthesis. Three kinds of biomimetic synthesized CMS (B-CMS, including B-CMS1, B-CMS2 and B-CMS3) were prepared using different pH or stirring rate condition, and their characteristics were tested with transmission electron microscope and small angle X-ray diffraction. The model drug indomethacin was loaded into B-CMS and drug loading content was measured using ultraviolet spectroscopy. The result suggested that pH condition influenced energetics of self-assembly process, mainly packing energetics of the surfactant, while stirring rate was the more dominant factor to determine particle length. In application, indomethacin loading content was measured to be 35.3%, 34.8% and 35.1% for indomethacin loaded B-CMS1, indomethacin loaded B-CMS2 and indomethacin loaded B-CMS3. After loading indomethacin into B-CMS carriers, surface area, pore volume and pore diameter of B-CMS carriers were reduced. B-CMS converted crystalline state of indomethacin to amorphous state, leading to the improved indomethacin dissolution. B-CMS1 controlled drug release without burst-release, while B-CMS2 and B-CMS3 released indomethacin faster than B-CMS1, demonstrating that the particle length, the ordered lever of multiple helixes, the curvature degree of helical channels and pore diameter greatly contributed to the release behavior of indomethacin loaded B-CMS.
研究领域:
材料科学
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药剂学
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DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
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2015
·Vol. 132
·期 38
·
IF 1.768
Chengying Jia,Junlong Song,Yongcan Jin,Orlando J. Rojas
We report a facile method to synthesize hollow silica microtubes (SMTs) from electrospun cellulose acetate fiber precursors. Specific surface areas of up to 765 m 2 /g (Brunauer–Emmett–Teller) were measured for the SMTs, which had a typical wall thickness of ∼100 nm and submicron inner diameters. An average pore size of 4.6 nm and pore volume of 0.41 cm 3 /g were derived from Barrett–Joyner–Halenda fitting, whereas Horvath–Kawazoe pore size distribution analysis revealed microporous median pore size and maximum pore volume of 0.7 nm and 0.18 cm 3 /g, respectively. The as-prepared SMTs featuring micro- and mesoporous structures in the walls where amino-functionalized to facilitate a very high drug loading (15% by weight). Drug release profile revealed sustained release rates (79% of acetylsalicylic acid was released after 6 h). It is concluded that the high drug loading and sustained release resulted from the advantageous integration of SMTs' hollow structure and wall mesoporosity. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132 , 42562.
研究领域:
材料科学
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药学
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DOI
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2015
·
IF 0.476
Jinping Du,Fazhao Fu,Xinyue Shi,Zongning Yin
The objectives of this work were to investigate the properties of the thiolated hyaluronic acid (HA) with different molecular weights (MWs) and to assess the effects of MW and dissolution medium on the release of ovalbumin from thiolated HA matrix tablets. Four HA-cysteine (HA-Cys) conjugates with increasing MWs (47, 101, 260 and 550 kDa) were synthesized. The resulting HA-Cys conjugates exhibited increased stability against hyaluronidase degradation, and such an effect became stronger with the increase of polymer MW. Swelling and erosion studies of HAs or HA-Cys conjugates based matrix tablets were performed in various media. We found that the water uptake capacity and erosion rate were strongly dependent on MW of HA, ionic strength and pH of the medium. Release studies showed that all investigated factors exerted effects on the drug release. Most of the release data based on HA matrix tablets followed super Case II transport but conformed to non-Fickian diffusion with HA-Cys conjugates. Taken together, this work managed to develop HA-Cys conjugates-based matrix tablets as controlled release systems for protein with tunable release rate through varying MWs of polymer.
研究领域:
生物材料学
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药剂学
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DOI
高影响因子
RSC Advances
·
2014
·Vol. 5
·期 5
·3248-3259
·
IF 3.708
Shao-Nan Lv,Chang-Jing Cheng,Ya-Ya Song,Zhi-Gang Zhao
Environmental stimuli-responsive nanosystems that can release their encapsulated or loaded substances in spatial-, temporal- and dosage-controlled fashions have attracted tremendous attention, especially from the field of nanomedicine. In this work, a novel temperature-switched controlled release nanosystem based on the molecular recognition of beta-cyclodextrin (β-CD) and thermosensitivity based on the phase transition of poly(N-isopropylacrylamide) (PNIPAM) is developed. This smart nanosystem consists of magnetic Fe3O4 colloidal nanocrystal clusters (MCNCs) core grafted with linear PNIPAM chains attached to numerous β-CD units, (denoted as Fe3O4@PNG–CD). β-CD units act as containers for the loading of hydrophobic model drugs, PNIPAM chains serve as intelligent “microvalves” for controlling the release of loaded model drugs, and MCNCs core can achieve a “site-specific targeting” function. The gating mechanism involves that temperature can significantly affect the association constants of β-CD toward model drug molecules in β-CD modified PNIPAM chains. The resultant Fe3O4@PNG–CD nanoparticles have excellent thermo-reversible adsorption/desorption properties for the loaded model drug 8-anilino-1-naphthalenesulfonic acid ammonium salt (ANS), and demonstrate a positive temperature “on–off” release fashion. By simply changing the temperature, the delivery rate can be effectively controlled. At temperature above the lower critical solution temperature (LCST) of the grafted PNG–CD chains (open gate), the delivery rate of ANS is fast, but very slow at temperature below the LCST (closed gate). These multifunctional nanoparticles provide a new mode for designing and engineering intelligent controlled release nanosystems.
研究领域:
纳米医学
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材料科学
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生物化学
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高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
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2015
·
IF 4.152
Yanfen Fang,Fang Du,Yanyun Xu,Haijing Meng,Jin Huang,Xiongwen Zhang,Wei Lu,Shiyuan Liu,Jiahui Yu
Gemcitabine, 2′,2′-difluoro-2′-deoxycytidine (dFdC), is the first-line antitumor agent in the treatment of pancreatic tumors. However, it possesses certain drawbacks, such as poor biological half-life resulted from rapid metabolism and the induction of resistance, leading to its restricted therapeutic potential. With the purpose of overcoming the above drawbacks, we developed a novel VESylated gemcitabine (VES-dFdC) prodrug by coupling the N 4 -amino group of the pyrimidine ring of dFdC to the carboxylic group of vitamin E succinate (VES). The resulting amphiphilic compound could protect the N 4 -amino group of the pyrimidine ring of dFdC from being degraded by cytidine deaminase. What is more, the prodrug was able to form nanocapsules in aqueous media (similar to the structure of cytomembrane), confirmed by transmission electron microscope (TEM). Their average particle size is about 107 nm with zeta potential of −33.4 mV measured by dynamic light scattering (DLS). VES-dFdC nanocapsules showed accelerated accumulative drug release profile in simulated lysosome environment (sodium acetate buffer pH 5 + cathepsin B, an enzyme in lysosome), due to the easily hydrolyzed property of amide bond by cathepsin B, while rather stable in PBS (pH 7.4) or sodium acetate buffer (pH 5.0) without cathepsin B, indicating their enhanced intracellular drug controlled release manner. Besides, VES-dFdC prodrug nanocapsules showed enhanced cellular uptake ability, and the amount of cellular uptake of the nanocapsules by the pancreatic cancer cell line BxPC-3 is seventy times higher than that of native gemcitabine in the first 1.5 h. Compared with free gemcitabine, VES-dFdC nanocapsules showed essentially increased growth inhibition activity against BxPC-3 cells, indicating its great potential as prodrug for pancreatic tumor therapy with improved antitumor activity.
研究领域:
药理学
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肿瘤学
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纳米医学
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产品关联
DOI
PubMed
高影响因子
PROGRESS IN ORGANIC COATINGS
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2018
·
IF 2.955
Yufeng Li,Cong Jia,Xiao Zhang,Yanghui Jiang,Min Zhang,Panfang Lu,Hongkun Chen
Nearly 1 billion tons of bagasse are discarded annually in the production process. In this work, a novel controlled release fertilizer was successfully produced by coating urea particles with bio-based epoxy (EPCU). The bio-based epoxy coating was synthesized from the liquefied bagasse (LB) and bisphenol-A diglycidyl ether (BDE) with the different mole ratios of LB to BDE. The chemical structure and microscopic morphology of EPCU were examined by FTIR, 1 HNMR, SEM. The nutrient release behaviors and mechanism of EPCUs were also discussed in detail. Results showed that EPCU3 improved the thermal stability by 60.3 °C (T 10% ), increased the nutrient release longevity by 12 times, and raised the water contact angle of surface by 12%, and then significantly slowed the nitrogen release rate of the EPCU. This work indicated that the environment-friendly EPCU with superior controlled release properties could be especially useful in horticultural and agricultural applications.
研究领域:
农业科学
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材料科学
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DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2018
·
IF 3.412
Yuanyuan Li,Dongjie Yang,Shuo Lu,Sulin Lao,Xueqing Qiu
Alkali lignin (AL), an anionic polymer, is a byproduct of the paper industry. AL was first modified by quaternization to synthesize quaternized alkali lignin (QAL). The aim of the present study is to reveal the effects of sodium dodecyl benzenesulfonate (SDBS) on the microstructure of QAL. The interaction between SDBS and QAL is studied by means of zeta potential, fluorescence spectrophotometer, and static contact angle measurement. The results indicated that there is an electrostatic interaction and a hydrophobic interaction between QAL and SDBS. The SDBS/QAL complex can self-assemble into lignin-based colloidal spheres (LCSs) in an ethanol/water mixture, which have remarkable avermectin (AVM) encapsulation efficiency and antiphotolysis performance. The cumulative release amount of AVM encapsulated by LCS (LCS@AVM) after 72 h was 77%, and the release was still going on. The release behaviors of LCS@AVM can be controlled by adjusting the ratio (w/w) of LCS to AVM. More than 85% of AVM could be preserved even after 96 h of UV irradiation. LCS showed controlled release and UV-blocking performance for AVM.
研究领域:
材料科学
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农业科学
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DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2016
·
IF 3.42
Yunfeng Hu,Guangli Ren,Liehua Deng,Jinglin Zhang,Huidi Liu,Shansong Mu,Ting Wu
In order to realize the controlled release and limited toxicity of triclosan (TC), a degradable UV-crosslinked hydrogel was prepared. For this purpose, the acryloyl chloride-modified polyactide-poly(ethylene glycol)-polylactide block copolymer was firstly synthesized and then mixed with photoinitiator to form the hydrogel rapidly under a low-intensity UV light. The properties of hydrogel, such as hydrogel strength, swelling and degradation, had been studied. The results showed that the properties of hydrogel could be modulated by the concentration of copolymer. After the encapsulation of TC, the sustained-release capability and antibacterial effect of the obtained hydrogel were studied. It was found that the sustained release of TC could potentially reduce the side effects of TC. With controlled antibacterial activity, the use of TC would be safer and more efficient. Moreover, the biocompatibility of hydrogel was also evaluated by in vitro and in vivo assays, suggesting the great potential application in the delivery of TC. The novel aspects of this study include the cytotoxicity study and the in vitro and in vivo assays, which might be useful for other researchers in this field.
研究领域:
材料科学
·
生物医学工程
·
药剂学
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DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2018
·
IF 3.412
Lu Liu,Tianlin Shen,Yuechao Yang,Bin Gao,Yuncong C. Li,Jiazhuo Xie,Yafu Tang,Shugang Zhang,Zhonghua Wang,Jianqiu Chen
To improve nitrogen (N) use efficiency and minimize environmental pollution caused by fertilizer overuse, novel bio-based large tablet controlled-release urea (LTCRU) was prepared using bio-based coating materials to coat large tablet urea (LTU) derived from urea prills (U). Nano fumed silica (NFS) was added to the bio-based coating materials to improve the slow-release properties. The surface area of the LTU and U was measured by three-dimensional scanning. In comparison to U, LTU had a smaller surface area/weight ratio, which can reduce the coating materials. Scanning electron microscopy analysis showed that the addition of NFS in bio-based coating materials reduced the porosity of the coating shells of LTCRUs and, thus, enhanced the N release longevity of the controlled-released fertilizer. Dependent upon the pores on the coating shells of LTCRU, two N release patterns were revealed. Because of the good release characteristics, the novel LTCRU shows great potential to support sustainable agricultural production.
研究领域:
农业科学
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环境科学
·
材料科学
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DOI
PubMed
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2013
·
IF 2.505
Li Zhang,Yakai Feng,Hong Tian,Changcan Shi,Miao Zhao,Jintang Guo
Novel biodegradable amphiphilic ABA triblock copolymers , i.e. poly(3(S)-methyl-morpholine-2,5-dione- co - p -dioxanone)-block-poly(ethylene glycol)-block-poly(3(S)-methyl-morpholine-2,5-dione- co - p -dioxanone) [P(MMD- co -PDO)- b -PEG- b -P(MMD- co -PDO)], were successfully prepared by ring-opening polymerization of 3(S)-methyl-morpholine-2,5-dione (MMD) and p -dioxanone (PDO) in the presence of poly(ethylene glycol) 6000 as an initiator. These triblock copolymers were characterized by 1 H NMR, 13 C NMR, Fourier transform infrared, gel permeation chromatography and differential scanning calorimetry measurements. P(MMD- co -PDO)- b -PEG- b -P(MMD- co -PDO) could self-assemble into stable nanosized microspheres with critical micellar concentrations of 0.41–0.66 μg/mL. The microspheres showed high hydrolytic degradation. In addition, doxorubicin (DOX) was chosen as a model drug and successfully encapsulated into the microspheres by hydrogen-bond interaction and hydrophobic effect . The transmission electron microscopy and dynamic light scattering measurements revealed that these microspheres were ellipsoidal nanoparticles with diameters ranged from 50 to 100 nm. These copolymer microspheres exhibited high loading capacity (LC), encapsulation efficiency (EE) of DOX and sustained drug release behavior in phosphate buffered solution (PBS). Moreover, the release rate of DOX from those microspheres in pH 4.0 PBS was faster than that in pH 7.4 due to pH sensitivity of the polymer–drug systems and the degradation of the matrix polymers . These amphiphilic depsipeptide multiblock copolymers would be potential promising carriers for anti-tumour drug delivery.
研究领域:
药剂学
·
生物材料
·
肿瘤学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）