JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
·
2020
·
IF 2.598
Kaijie Wang,Jinping Zhao,Wenwen Zhang,Minglin Zhu,Ming Xu,Dan Li,Hongjie Shi,Ming Zhang,Jiajun Shi,Zhe Dong
Aortic dissection (AD) is a serious condition and a health issue on a global scale. β-Aminopropionitrile–induced AD in mice is similar to the pathogenesis of AD in humans. Resveratrol (RSV) is a natural polyphenolic substance that provides anti-inflammatory and cardiovascular effects, but the role of RSV in AD is unclear. In this study, we investigated the effects and mechanisms of RSV on β-aminopropionitrile–induced AD in mice. Our results indicate that RSV can prevent the occurrence of AD. More meaningfully, we found that the protective effect comprises an increase in sirtuin 1 (SIRT1) expression in endothelial cells for the reconstruction of their structure, reducing the recruitment of inflammatory cells by endothelial cells and inhibiting the inflammation response, thereby suppressing the occurrence of AD.
✓ 已验证
DOI
PubMed
高影响因子
Molecular Medicine Reports
·
2017
·Vol. 15
·期 3
·1179-1187
·
IF 1.692
Shanshan Wang,Qian Meng,Qing Xie,Man Zhang
Multidrug resistance (MDR) is a significant barrier to the effective treatment of bladder cancer. In order to improve the management of bladder cancer, it is crucial to identify strategies that may reverse MDR. The effects of three herbal medicines, ginsenoside Rh2, (‑)‑epigallocatechin gallate (EGCG) and resveratrol (RES) on bladder cancer were determined. The effect of these three herbal medicines against the drug resistance in adriamycin (ADM)‑resistant pumc‑91 cells (pumc‑91/ADM) was assessed using the Cell Counting Kit‑8 cell proliferation assay system. Cell cycle distribution analysis was performed using flow cytometry following treatment with RES. The mRNA and protein expression levels of multidrug resistance protein 1 (MRP1), lung resistance protein (LRP), glutathione S‑transferase (GST), B cell leukemia/lymphoma‑2 (BCL‑2) and topoisomerase‑II (Topo‑II) were evaluated using reverse transcription‑quantitative polymerase chain reaction and immunofluorescence, respectively. RES enhanced the cytotoxicity of anticancer agents on pumc‑91/ADM cells; however, Rh2 and EGCG were unable to induce a similar effect. Additionally, RES treatment led to S phase cell cycle arrest accompanied by a decrease in the number of cells in the G1 phase. A significant decrease of MRP1, LRP, GST, BCL‑2 levels and an increase of Topo‑II levels were observed in RES groups compared with the control group. RES effectively reversed ADM resistance in pumc‑91/ADM cells and the underlying molecular mechanism may be associated with the alteration of MRP1, LRP, GST, BCL‑2 and Topo‑II expression levels. Therefore, RES may be a potential candidate for reversing drug resistance in bladder cancer chemotherapy.
✓ 已验证
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2018
·
IF 4.946
Xiao-Pei Hu,Fa-Wen Yin,Da-Yong Zhou,Hong-Kai Xie,Bei-Wei Zhu,Xiao-Chi Ma,Xiang-Ge Tian,Chao Wang,Fereidoon Shahidi
Lipophenols, esterified phenols with fatty acids, have attracted increasing attention because of their better protective effects in lipid-based food matrices from oxidation. However, little is known about their digestion. In this study, the digestive stability of resveratrol (RSV) esters with caprylic acid (RCAPs) in a model gastrointestinal digestion system was evaluated. The results demonstrated that RCAPs were relatively stable without hydrolysis in mouth and gastric phases. However, in the intestinal phase, pancreatic lipase rather than phospholipase A 2 could hydrolyze monoester and diesters to free RSV. After 120 min of incubation at 37 °C, 53.68% of monoester and 11.36% of diesters were hydrolyzed. However, no hydrolysis of the triester was noticed. Obviously, the level of hydrolysis of RCAPs was negatively correlated with the degree of substitution. Therefore, it was speculated that RSV in fatty acid ester forms could partially be absorbed by intestinal lumen in the form of free RSV.
✓ 已验证
DOI
PubMed
高影响因子
Mathematical Biosciences and Engineering
·
2022
·Vol. 19
·期 8
·8019-8034
·
IF 2.194
Han G,Wang B,Jia M,Ding S,Qiu W,Mi Y,Mi Z,Qin Y,Zhu W,Liu X,Li W
The preparation of amorphous solid dispersions using polymers is a commonly used formulation strategy for enhancing the solubility of poorly water-soluble drugs. However, a single polymer often does not bring significantly enhance the solubility or amorphous stability of a poorly water-soluble drug. We found an application of a unique and novel binary polymeric blend in the preparation of solid dispersions. The main purpose of this study is to optimize and evaluate resveratrol (Res) amorphous solid dispersions with a novel polymeric system of poly (vinyl pyrrolidone) (PVP) and carboxymethyl chitosan (CMCS). The influence of three different release factors, the ratio of CMCS to the polymer mixture (CMCS% = X 1 ), the ratio of Res to the polymer mixture (Res% = X 2 ) and the surfactant (Tween 80 = X 3 ), on the characteristics of released Res at various times (Q 5 and Q 30 ) was investigated. The computer optimization and contour plots were used to predict the levels of the independent variables as X 1 = 0.17, X 2 = 0.10 and X 3 = 2.94 for maximized responses of Q 5 and Q 30 . Fourier transform infrared spectroscopy (FTIR) results revealed that each polymer formed hydrogen bonds with Res. The solid performance and physical stability of the optimized ternary dispersions were studied with scanning electron microscopy (SEM), powder X-ray diffraction (XRD), modulated differential scanning calorimetry (MDSC) and dissolution testing. SEM, XRD and MDSC analysis demonstrated that the Res was amorphous, and MDSC showed no evidence of phase separation during storage. Dissolution testing indicated a more than fourfold increase in the apparent solubility of the optimized ternary dispersions, which maintained high solubility after 90 days. In our research, we used CMCS as a new carrier in combination with PVP, which not only improved the in vitro dissolution of Res but also had better stability.
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF PHARMACEUTICAL SCIENCES
·
2025
·
IF 3.8
Ping-fu Huang,Wen-Min Niu,Lu-lu Liu,Guan-qiao Wang,Jun Chen,Zhou-xun Dong,Jia-bing Tong
Paclitaxel (PTX), categorized as a BCS Class IV anti-tumor agent, is integral to clinical treatment, however, the insolubility of PTX leads to diminished bioavailability. Resveratrol (RES), a bioactive compound present in various dietary sources, has the potential to augment the anti-tumor effectiveness of PTX. This research aims to formulate a co-amorphous system consisting of PTX and RES to enhance the solubility and bioavailability of PTX. The co-amorphous system was synthesized via the solvent evaporation technique and subsequently characterized using powder X-ray diffraction, Fourier-transform infrared spectroscopy, differential scanning calorimetry, Raman spectroscopy, and thermal analysis. Molecular dynamics simulations illustrated the interactions between PTX and RES, which facilitated an increase in apparent solubility and in vitro dissolution rates. Furthermore, in vitro cytotoxicity assays, Caco-2 cell model studies, and in vivo anti-tumor experiments demonstrated that the PTX-RES combination exhibited enhanced anti-tumor efficacy relative to other treatment groups. Pharmacokinetic evaluations revealed that the oral bioavailability of the PTX-RES complex surpassed that of pure PTX. These findings substantiate that the PTX-RES co-amorphous system significantly improves the physicochemical properties and anti-tumor activity of PTX. Additionally, this study presents a promising approach for enhancing the solubility and bioavailability of compounds with poor solubility.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
KEY ENGINEERING MATERIALS
·
2020
·
IF 0
Benchawan Chamsai,Wipada Samprasit,Praneet Opanasopit,Pontip Benjasirimongkol,Pornsak Sriamornsak
Resveratrol (Res) loaded nanostructured lipid carriers (NLCs) were prepared by high shear homogenization and ultrasonication technique. Caprylic/capric glyceride (IM) was used as a liquid lipid, while glyceryl monostearate (GMS), beeswax (BW), palmitic acid (PA) and myristic acid (MA) at various concentrations (5, 10, 15, and 20 %w/w) were solid lipids. Polyoxyethylene 20 sorbitan monooleate or polysorbate 80 (Tween® 80) was use as a surfactant. The results showed that all concentration of PA and MA can be prepared the smaller particle NLC than that using GMS and BW according to the small molecule of MA and PA. The zeta potential of Res loaded NLCs were negative charge (-24.30 to -37.80 mV), which could be considered as a stable system. The stability studies revealed that NLCs with MA and PA showed a - high stability in particle size and zeta potential after storage at 40 ± 2°C /75 %RH for 3 months. These results suggested the MA and PA were suitable solid lipids for the NLCs preparation which have potential to be a nanoparticulate carrier for Res delivery.
✓ 已验证
DOI
RUSSIAN JOURNAL OF GENERAL CHEMISTRY
·
2024
·Vol. 94
·期 7
·1710-1719
·
IF 0.9
Han D.,Wang J.,Yang H.,Ran T.,Lu H.,Wang L.,Yan Z.
Abstract In the present study, carbon dots (CDs) were synthesized by solvothermal method using 1,4-diethynylbenzene as carbon source. The CDs exhibited the spherical particles as observed from transmission electron microscopy (TEM) image with the average particle size of 2.25±0.51 nm. The fluorescence quantum yield of the final CDs was 13% under excitation at 460 nm. The fluorescence intensity of CDs is diminished at both acidic and basic conditions, while a good linear relationship was realized at pH = 2–7 with the coefficient of determination ( R 2 ) of 0.9984 and the minimum detection limit (LOD) of 0.6 with good reversibility and cyclicity for pH detection. trans -resveratrol (t-res) was found to enhance the fluorescence of CDs well and the fluorescence intensity showed a good linear relationship to t-res within the concentration range of 10–100 μM with the coefficient of determination R 2 of 0.9993 and the LOD of 3 μM. The recoveries of the wines ranged from 100.36–102.40% with the relative standard deviations (RSD) of 2.56–3.48%. Thus, the CDs are extremely sensitive to t-res. Alkynyl ligand is used to prepare CDs, which illustrate the potential application for pH and t-res detection.
✓ 已验证
产品关联
DOI
高影响因子
Nutrients
·
2026
·Vol. 18
·期 14
·2384
·
IF 5.8
Ruiying Luo,Qing Peng,Su Wu,Shuwen Liu,Chan Wang
Background:Hyperlipidemia represents a pivotal risk factor for multiple cardiovascular and metabolic diseases, creating an urgent demand for safe, effective novel therapeutic interventions. Resveratrol (RES), a natural plant polyphenol, has exhibited great potential as a hypolipidemic agent for hyperlipidemia treatment.Methods:In this work, we established a high-fat diet (HFD)-induced hyperlipidemic mouse model to systematically investigate the lipid-regulating efficacy of RES.Results:Oral administration of RES significantly decreased serum levels of total cholesterol and low-density lipoprotein cholesterol, while markedly increasing high-density lipoprotein cholesterol concentrations. Histopathological analyses further demonstrated that RES alleviated HFD-induced hepatic and ileal injury. Moreover, RES significantly decreased the circulating levels of several bile acids (BAs), including taurodeoxycholic acid, taurolithocholic acid, lithocholic acid, and tauro-(α + β)-muricholic acid. RES also ameliorated HFD-induced gut microbial dysbiosis, as evidenced by a reduction in theFirmicutes/Bacteroidetesratio, increased relative abundances ofnon_f_Muribaculaceae,Lactobacillus,Ileibacterium, andBacteroides, and decreased abundances ofLachnospiraceae_NK4A136_groupandunclassified f_Lachnospiraceae. Spearman correlation analysis revealed significant associations between gut microbial taxa and BA profiles, suggesting that coordinated regulation of the gut microbiota and BA metabolism contributes to the hypolipidemic effects of RES.Conclusions:Collectively, RES alleviates HFD-induced hyperlipidemia by remodeling gut microbiota composition and restoring bile acid metabolic homeostasis.
✓ 已验证
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
·
2026
·Vol. 61
·期 1
·
IF 3.3
Jin Danping,Amna Dua,Wang Qingcheng,Yao Jingzi,Zhang Xinxin,Li Zhi,Lang Hongjie,Chen Yunyun,Zhong Kang,Li Sijuan,Shen Qing
To develop a green and functional hydrogel for potential application as a wound dressing, in this study, composite hydrogels were prepared using corn starch and chitosan as the matrix, with citric acid (CA) at a series of concentrations (5%–20%, wt/wt) serving as a green crosslinking agent. Resveratrol (Res) was loaded into these hydrogels, and the influences of CA concentration on the swelling and gel characteristics of the composite hydrogels were systematically investigated. The results demonstrated that the hydrogel crosslinked with 10% CA (designated as SCA10%) exhibited the optimal comprehensive performance, achieving an equilibrium swelling ratio of 228% and appropriate gel strength. Structural analysis confirmed the formation of crosslinking between CA and starch/chitosan, as well as the successful loading of Res into the hydrogel matrix. Notably, microscopic images revealed that the incorporation of Res resulted in a more well-developed and uniform porous structure in SCA10%-Res. Additionally, this composite hydrogel showed robust antibacterial activity. Collectively, the prepared starch-chitosan-CA-Res hydrogel holds significant potential for applications in wound repair and localised drug delivery. It also provides a valuable reference for the green fabrication of natural polymer-based functional materials.
✓ 已验证
DOI
高影响因子
ACS Omega
·
2025
·
IF 4.3
Jun Zuo,Haigang Feng,Yi Zhu,Hongju Xie,Shaolin Ma,Fei Zhang
Our previous study has confirmed that resveratrol (Res) can suppress hypertrophic scar through a variety of mechanisms, such as autophagy inhibition, apoptosis induction, and oxidative stress reduction. However, the primary obstacle to the pharmaceutical use of Res is its poor bioavailability. Here, an injectable and temperature-responsive hydrogel containing mesoporous silica nanoparticles loaded with Res (MSN@Res) was employed for the repair of hypertrophic scars, formulated by fine-tuning the combination of aldehyde-functionalized Pluronic F127 (F127-CHO, FC) and hyaluronic acid modified with adipic dihydrazide (AHA). This hybrid hydrogel exhibited suitable porosity, robust mechanical characteristics, and sustained release capability for Res. In vitro cellular tests indicated that the 8%FC/AHA hydrogel possesses minimal cytotoxicity and excellent biocompatibility. Additionally, the 8%FC/AHA-MSN@Res hydrogel showed nearly full antiproliferative activity against hypertrophic scar fibroblasts. The 8%FC/AHA-MSN@Res hydrogel was subsequently applied to treat hypertrophic scars in the rat tails. The findings indicated that this composite hydrogel significantly improved the overall results, diminished the thickness of both the epidermis and dermis, and reduced the scar size. In addition, the hydrogel could suppress oxidative stress, downregulate the expression of p38-MAPK, HIF-1α, p53, and LC3-II, and upregulate caspase-3 expression in hypertrophic scars, which indicated that the composite hydrogel inhibits cellular autophagy, induces apoptosis of fibroblasts in hypertrophic scars, and then reduces the cell viability and collagen deposition, finally resulting in an acceleration of scar regression. This research validated that this composite hydrogel has the potential to serve as a highly effective therapeutic approach with promising prospects for clinical application in the treatment of hypertrophic scars.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EXPERIMENTAL AND MOLECULAR PATHOLOGY
·
2026
·
IF 4.1
Ziqing Zhou,Shaoming Wu,Xiaoran Zhang,Guanbin Chen,Hengyue Ma,Ming Li,Yuchuan Liu,Ting Wang
Resveratrol (RSV), a globally utilized nutraceutical compound, is primarily recognized for its human health benefits, contributing to its widespread and often unregulated use in daily life and clinical settings. However, its influence on cellular stemness remains poorly understood. While numerous reports suggest anti-tumor properties, systematic and robust evidence is lacking. This study employed high-throughput RNA sequencing, RNA interference, RT-qPCR, and whole-mount in situ hybridization, and used the planarian Dugesia japonica as a stem cell model, aiming to investigate the effects of varying RSV concentrations on blastema regeneration following amputation and analyze the associated mechanism. We demonstrated a biphasic effect of RSV on anterior blastema regeneration: low-concentration RSV (5 μM) promoted regeneration, whereas high-concentration RSV (50 μM) caused significant inhibition. RNA-seq identified Smad4 as a key mediator; its inhibition exacerbated the regenerative deficit under low concentration. Intriguingly, PiwiA expression increased in the anterior blastema at both RSV concentrations, most notably at low concentration condition. Conversely, the late stem cell marker Agat1 was significantly suppressed by high-concentration RSV. These findings indicated that RSV promoted stem cell proliferation. Critically, low-concentration RSV enhanced both proliferation and differentiation, while high-concentration RSV inhibited differentiation independently of Smad4 . This study provided the first in vivo evidence at the whole-organism level that RSV concentration dictated divergent stem cell differentiation fates, offering a scientific basis for its rational evaluation and application.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Zhang Fang,Zhang Nenghua,Wang Chunji,Zhang Li,Yang Yujia,Jia Yue,Huang Xiaowen,Li Minghui,Tang Jie,Xu Long
Polystyrene nanoparticles (PS-NPs) can undergo surface functionalization under environmental conditions, and their accumulation in living organisms may pose a potential reproductive toxicity risk to males, though the underlying mechanisms remain incompletely understood. This study employed integrated transcriptomic and metabolomic analyses to investigate the molecular mechanisms of testicular injury in male ICR mice induced by a 28-day exposure to plain PS-NPs (PS), amino-modified PS-NPs (PS-NH₂), and carboxyl-modified PS-NPs (PS-COOH) (0.08 μm; 50 mg/kg/day), and to evaluate the concurrent protective effects of resveratrol (RES; 100 mg/kg/day). Results showed that PS-NH₂ and PS-COOH caused severe spermatogenic impairment concurrent with blood-testis barrier disruption and inflammation, marked by mislocalization of ZO-1, occludin, and vimentin, and an imbalance between upregulated TNF-α and downregulated IL-10. RES treatment effectively alleviated these alterations. Transcriptomic analysis identified 1633 differentially expressed genes, primarily associated with lipid metabolism, spermatogenesis, and apoptosis. KEGG enrichment indicated significant involvement of the PI3K-AKT signaling pathway. Metabolomic profiling identified 158 differentially expressed metabolites, linked to pathways such as pyrimidine metabolism, bile secretion, and cholesterol metabolism. Integrated multi-omics analysis suggested that different types of PS-NPs affected distinct biological pathways: the PS group was mainly associated with taurine metabolism, the PS-NH₂ group with bile secretion and cholesterol metabolism, and the PS-COOH group with bile secretion and insulin resistance. RT-qPCR analyses confirmed that PS-NPs significantly upregulated the mRNA expression of inflammatory markers ( TNF-α , IL-10 ) and pro-apoptotic factors ( BAX , caspase-3 ), alongside a downregulation of PI3K , AKT , caspase-9 , and caspase-8 . Increased protein levels of p-AKT, PI3K, the BAX/BCL-2 ratio, and cleaved caspase-3 were observed, concomitant with decreased levels of caspase-3, caspase-9, and caspase-8. These effects were partially ameliorated by RES treatment. Our data indicate that functionalized PS-NPs induce severe testicular damage, potentially via activation of the PI3K-AKT pathway, alongside induced inflammation and apoptosis. Metabolic disturbances such as those in bile secretion may be contributing factors. Importantly, RES treatment effectively mitigates these adverse effects. Collectively, our study elucidates a key mechanism underlying PS-NPs reproductive toxicity and proposes a promising therapeutic intervention with RES. Graphical abstract
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）