FOOD CHEMISTRY
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2024
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IF 8.5
Jie Liu,Jiang Zhou,Qiang Xi,Shengyuan Yang,Wenfang Du,Fubing Xiao
Bisphenol A (BPA), an endocrine disruptor , is widely used in food packaging materials , including drink containers. Sensitive detection of BPA is crucial to food safety. Herein, we have developed a novel optical-driven hydrogel film sensor for sensitive BPA detection based on the displacement of spiropyran (SP) from β -cyclodextrin ( β -CD) cavity by BPA followed by the photochromism of the released SP. The released SP converts to the ring-opened merocyanine form which shows an enhanced red fluorescence in the dark. The sensor demonstrates a linear detection range from 0.1 to 20 μg mL −1 with a limit of detection at 0.027 μg mL −1 and a limit of quantification at 0.089 μg mL −1 . Notably, the proposed β -CD/SP hydrogel can be reused due to the reversible isomerization of SP and the reversible host–guest interaction. This sensor also shows good performance for BPA determination in real samples, indicating its great potential for food safety monitoring.
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JOURNAL OF HAZARDOUS MATERIALS
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2024
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IF 12.2
Yuan Meng,Minqi Liu,Yicheng Liao,Junhuai Luo,Xiaoli Fu,Peizhe Sun
This study systematically assessed the performance of a newly developed solid-phase extraction (SPE) material, cellulose-supported aminated β-cyclodextrin polymer (amine-β-CDP@Cellulose), in determining 44 xenobiotics, encompassing endocrine-disrupting chemicals (EDCs), pharmaceuticals, and food additives in urine samples. The primary objective of the research was to synthesize a new sorbent, optimize the extraction protocol, and elucidate the underlying adsorption and desorption mechanisms. Following optimization, it was observed that amine-β-CDP@Cellulose achieved recoveries ranging from 80 % to 120 % for 28 of the 44 targeted xenobiotics, with only three compounds showing recoveries below 50 %. The superior extraction performance of this novel material can be attributed to the synergistic effects of its structural components: charged functional groups introduced via the cross-linking agent, the hydrophobic cyclodextrin cavity that facilitates inclusion complexation, and abundant hydroxyl groups that enhance adsorption. Additionally, the study included a comparative analysis between amine-β-CDP@Cellulose and commercially available HLB resins. This comparative analysis revealed that the amine-β-CDP@Cellulose method effectively mitigated matrix interferences while maintaining comparable extraction efficiency to the HLB-based method. Collectively, these findings suggest that amine-β-CDP@Cellulose could serve as a sustainable and cost-effective material for extracting xenobiotics from complex matrices.
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KOREAN JOURNAL OF CHEMICAL ENGINEERING
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2024
·
IF 2.9
Wen Jie,Lyu Yanjun,Zhang Lianhong,Ma Yuling,Huang Xia,Zhu Wanyu
A novel method was developed to introduce β-cyclodextrin (β-CD) cage-like macromolecules into acrylic ester resin using metal oxides as a medium, resulting in high-oil-absorption resin composites. β-CD was first grafted onto the surface of cobalt-aluminum bimetallic oxide (CoAl-LDO) via a facile hydrothermal method in an alkaline environment, generating more pore structures. To enhance the hydrophobic properties of β-CD-grafted CoAl-LDO nanoparticles, KH-570 was employed as a modifier to modify nanoparticles. Finally, the β-CD-grafted CoAl-LDO/acrylic ester resin composite was successfully synthesized by suspension polymerization method. The oil absorption performance of the resin composite was evaluated using various solvents. Its saturated capacity reached 18.62 g/g for cyclohexane, 19.92 g/g for toluene, and a remarkable 31.42 g/g for trichloromethane. Even for diesel, a challenging oil due to its viscosity, the absorption reached a noteworthy 16.17 g/g. Further demonstrating its selectivity, the composite strictly adsorbed oil while repelling water. Notably, the impressive capacity remained largely unchanged after eight regeneration cycles.
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Acta Pharmaceutica Sinica B
·
2024
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IF 14.7
Mengyi Yan,Xiayun Chen,Xiaotong Li,Qianqian Liu,Baixue Yu,Yi Cen,Wei Zhang,Yibin Liu,Xinxuan Li,Ying Chen,Tao Wang,Shiying Li
The immunosuppressive phenotype of tumor cells extensively attenuates the immune activation effects of traditional treatments. In this work, a transferrin receptor (TfR) targeted immunostimulant (PTI) is fabricated for photodynamic immunotherapy against metastatic tumors by interrupting β -catenin signal pathway. To synthesize PTI, the photosensitizer conjugated TfR targeting peptide moiety (Palmitic-K(PpIX)-HAIYPRH) is unitized to encapsulate the transcription interrupter of ICG-001. On the one hand, the recognition of PTI and TfR can promote drug delivery into tumor cells to destruct primary tumors through photodynamic therapy and initiate an immunogenic cell death with the release of tumor-associated antigens. On the other hand, PTI will interrupt the binding between β -catenin and cAMP response element-binding protein (CREB), regulating the gene transcription to downregulate programmed death ligand 1 (PD-L1) while upregulating C–C motif chemokine ligand 4 (CCL4). Furthermore, the elevated CCL4 can recruit the dendritic cells to present tumor-specific antigens and promote T cells activation and infiltration, and the downregulated PD-L1 can avoid the immune evasion of tumor cells and activate systemic anti-tumor immunity to eradicate lung metastasis. This work may inspire the development of antibody antibody-free strategy to activate systemic immune response in consideration of immunosuppressive conditions.
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JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2024
·Vol. 171
·期 2
·027515
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IF 3.1
Xinqin Zhang,Rui Cao,Zehua Chen,Liling Zhou,Peipei Li,Hui Zhang,Ju Wu
Chloramphenicol (CAP), a broad-spectrum antibiotic, has severely impacted human health and the ecological environment, which brings an increasing demand for an efficient monitoring technology for rapid and sensitive antibiotic residue detection. Herein, a highly sensitive and selective electrochemical sensor was developed for detecting CAP, based on the synergistic effect of β-cyclodextrin (β-CD) and CuO-nanomaterials modifying glassy carbon electrode (GCE). Scanning electron microscopy (SEM) and X-ray diffraction analysis (XRD) spectrometry were used for morphological characterization. β-CD/CuO/GCE sensor with high-specific surface area and cavity structure was prepared by modifying GCE for further electrochemical testing. Experimental parameters were optimized using square wave stripping voltammetry. The developed sensor obtains an ultra-wide linear range from 1.0 × 10−7 mol l−1 to 5.0 × 10−4 mol l−1and the limit of detection is 0.5 × 10−7 mol l−1. The sensor displays high sensitivity, remarkable stability, and reproducibility; particularly more convenient than the Liquid chromatography-mass spectrometry (LC-MS) verification method. Furthermore, the applicability of the developed β-CD/CuO/GCE sensor was demonstrated by detecting CAP in food samples.
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FOOD CHEMISTRY
·
2025
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IF 9.8
Yong Xie,Qingqing Liu,Jia Shi,Renwei Zhu,Xiong Liu
Thermal processing of barley grains is a useful technique for modelling the physicochemical properties of β-glucans and their food applications. This study investigated the impacts of different thermal processing techniques—including flaking-roasting (FR), stir-frying (SF), steam flash-explosion (SFE), and popping expansion (PE)—on the gelation properties of hulless barley β-glucan. Results showed that PE-β-glucan showed the highest molecular weight ( M w 5243.6 ± 0.3 kDa), water holding capacity, solubility, zeta potential, gel stability, and texture properties, followed by native, SF-, and FR-β-glucan. However, SFE-β-glucan (lowest M w , 89.9 ± 0.2 kDa) failed to gel even at 60 mg/mL. Microstructure observations by atomic force microscope (AFM), confocal laser scanning microscope (CLSM), and transmission electron microscopy (TEM) indicated that PE-induced chain conformation changes primarily augmented cluster stability of β-glucan, strengthening gelation. Hence, β-glucan gel performance is jointly governed by molecular weight and chain conformation, both significantly altered by thermal processing.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Jiayan Lu,Qiao Zhang,Yunyan Hua,Yan Yan,Yungang Cao,Weiwei Li
This study investigated the encapsulation of three types essential oils (EOs, cinnamaldehyde, eugenol and thymol) with soy β-conglycinin (7S) for strawberry preservation. The FTIR, intrinsic fluorescence spectroscopy and molecular docking revealed that the antimicrobial compounds could bind to 7S through hydrophobic interaction and hydrogen bond, leading to the transformation of protein structure and changes in its particle size and hydrophobicity. The mean particle size of EO emulsion was smaller than that of control, especially the CEON group (290 nm), showed high stability against ions and pH. Cinnamaldehyde exhibited slower release compared to the others, might be due to stronger binding with 7S, leading to the formation of larger complexes. Among the three emulsions, CEON demonstrated superior antioxidant and antibacterial activity. In preservation tests, CEON reduced strawberry weight loss by 35 %, with minimal changes in soluble and solid content. Additionally, malondialdehyde production was 70 % of the control, effectively mitigating strawberry spoilage.
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EUROPEAN JOURNAL OF PHARMACOLOGY
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2025
·
IF 4.7
Yanyan Guo,Yingxue Yue,Huanhuan Wang,Ziyi Zhong,Bin Chen,Luan Shu,Jing Wang,Zhenhai Zhang
The insolubility and volatility of eugenol (EG) limit its clinical application. In this study, cyclodextrin (CD) was used to encapsulate EG and hydroxypropyl-β-cyclodextrin (HP-β-CD) with lower binding energy was selected by comparison. The preparation process optimization and characterization showed that the EG-HP-β-CD inclusion complex could be successfully prepared. More importantly, inclusion complex can significantly increase the solubility and stability of EG. In addition, in vitro release and transdermal studies, inclusion complex gel release curve conformed to the Higuchi equation, and the cumulative release rate reached 80% at 24 h, which provided good sustained release properties. Notably, inclusion complex gel increased EG skin retention by reducing the transdermal permeation rate and cumulative permeation amount. It was verified in the mouse psoriasis model that the inclusion complex gel group had better efficacy. By comparison, the epidermal thickness and inflammatory infiltration of inclusion complex group were improved, which was closely related to drug skin retention. The anti-inflammatory effect was revealed by regulating the expression of IL-17 A, IL-1β, IL-6, IL-23, and TNF-α, participating in JAK1/STAT3 pathway. The results provide a new idea and theoretical basis for the formulation design of volatile oil transdermal therapy for psoriasis.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
·
IF 5.4
Wen-Xuan Zhang,Jian-Feng Zhou,Hai-Xia Xu,Wen-Jun Wang,Ji-Guang Chen,Qing-Feng Zhang
Methyl-β-cyclodextrin (M-β-CD) exhibited the strongest complexation ability with astilbin (Ast) among three β-CD derivatives, i.e., M-β-CD, 2-hydroxyethyl-β-CD, and sulfobutylether-β-CD. The complexation reaction was investigated by UV spectroscopy, phase solubility, and NMR analysis. In simulated intestinal fluid (SIF), M-β-CD resulted in significant changes of Ast UV spectra through hindering the dissociation of 7-OH by complexation. Their formation constants ( K a) in water, simulated gastric fluid (SGF), and SIF were determined by the UV titration method with values of 6148.2 ± 558.9, 6596.3 ± 346.1, and 4602.2 ± 158.4 M⁻¹ , respectively. The Job’s plot showed that M-β-CD and Ast formed 1:1 inclusion complexes. Thermodynamic results revealed that the complexation was unfavourable at high temperature with negative ΔH and ΔS. The solubility of Ast linearly rose from 0.35 ± 0.03–3.57 ± 0.10 mM with the increase of M-β-CD concentration from 0 to 5.0 mM. The NMR analysis implied that the A ring of Ast was preferentially embedded in M-β-CD cavity. The Ast/M-β-CD complexes were prepared by co-grinding method and further characterized by SEM, XRD, DSC and FT-IR. These analysis revealed that Ast lost its crystal structure after complexation, and the secondary interactions between Ast and the M-β-CD were found. The complexes significantly improved the dissolution and solubility of Ast (>43 mg/mL). Furthermore, M-β-CD suppressed the crystallization of Ast, thereby maintaining its supersaturated status. Besides, the stability of Ast in SIF and SGF was also improved. Pharmacokinetic studies showed that Ast/M-β-CD complexes significantly enhanced the oral bioavailability of Ast by 11.89 times with C max of 642.28 ng/mL in rat plasma.
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Huili Du,Shiyue Yu,Yan Hu,Yafei Wu,Yuefei Zhang,Wei Chen,Sheng Tang,Yuanyuan Zhang
Covalent organic frameworks (COFs), featuring well-defined porosity, high surface area and tunable functionality, are promising materials for chromatographic separation. However, when directly used as stationary phases in HPLC, pristine COF-silica composites often exhibit inherent limitations, including excessive hydrophobicity and limited separation selectivity. To address these challenges, employing high-surface-area COF as a structural platform followed by targeted functionalization offers an effective solution. β-Cyclodextrin (β-CD), characterized by its unique cavity structure and multiple chiral centers, features hydrophobic inner edges and hydrophilic outer edges. This distinctive architecture enables β-CD to selectively form host-guest inclusion complexes with solutes, showcasing significant potential for enantiomeric separation. The integration of COF with β-CD synergistically combines their complementary advantages, establishing a versatile platform for simultaneous chiral and achiral separations. In this study, a β-CD-modified COF stationary phase (β-CD-TpBD-COF@Silica) was synthesized, employing β-CD as the chiral selector and imine-based TpBD-COF as the substrate. The β-CD facilitates stereoselective recognition via its intrinsic chiral cavity, while the TpBD-COF provides a robust immobilization platform for β-CD and synergistically enhances separation. The resulting β-CD-TpBD-COF@Silica composite integrates multiple separation mechanisms, such as hydrophobicity, hydrogen bonding and π-π interactions, to achieve multimodal separation, successfully separating hydrophobic analytes (alkylbenzenes, phenyl ketones), hydrophilic compounds (nucleosides, sulfonamides), and chiral molecules. Notably, the β-CD-TpBD-COF@Silica column exhibits outstanding repeatability and separation efficiency, achieving baseline resolutions of all analytes within 8 min, demonstrating robust chromatographic performance and operational stability. Furthermore, the β-CD-TpBD-COF@Silica column was applied to detect sulfonamides in milk, highlighting its practicality for real-world analysis. This work presents a rational design strategy for multifunctional COF-based stationary phases, offering enhanced selectivity for complex separation tasks.
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Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Kangping Huang,Tianwen Zheng,Xinyue Li,Ziyin Yang,Ruoxi Li,Yizhou Liu,Naijin Wu,Moxi Wang,Liqin Zhi,Huilong Luo,Wenxia Wei,Peizhong Li,Xiao Zhang,Heming Wang
β-cyclodextrin (βCD) can significantly improve the reactivity and long-term remediation performance of nano-zero-valent iron (nZVI), but the stability of composite and the migration performance in porous media have been less studied. In this study, a kind of βCD interface-modified iron-carbon composite (BC-nZVI@βCD) was synthesized, the Zeta potential measurements and sedimentation experiments were conducted to study the stability of materials. Afterwards, the migration behavior of BC-nZVI@βCD in porous media was explored by one-dimensional (1D) sand column experiments and a novel two-dimensional (2D) sand tank simulating the groundwater state. Specifically, in 1D sand column experiments, the primary focus was on investigating the relative effluent concentration ( C/C 0 ) and its distribution patterns within the sand column. In 2D sand tank experiment, the ERT technique was utilized to precisely and real-time monitor the migration behavior of the composite through changes in resistivity. The results showed that the suspensions of BC-nZVI@βCD had the best stability and slowest settling rate. 1D sand column migration experiments showed that the mobility of BC-nZVI@βCD was greatly enhanced, and C/C 0 was increased to 0.60. Moreover, the concentrations of Ca 2 + and SO 4 2- had little effect on migration performance. Humic acid (HA) promoted BC-nZVI@βCD migration at low concentrations (10 mM), while inhibited the migration at high concentrations (20 and 40 mM). In 2D sand tank, BC-nZVI@βCD also showed more excellent migration ability, with the migration distance of BC-nZVI@βCD clearly exceeded 0.40 m. Generally, this study provides a new approach for the study of stability and migration performance of iron-based materials.
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LANGMUIR
·
2025
·
IF 3.9
Zongli Ren,Yali Fang,Qiong Wu,Xin Ma
Dye wastewater poses a significant environmental threat, making the development of efficient and reusable adsorbents essential. In this study, we prepared a magnetic UiO-66 composite modified by β-CD (UiO-66@β-CD@Fe3O4) and evaluated the adsorption properties of this material on crystal violet and Congo red in aqueous solutions. β-CD was added to improve the host–guest interaction with dyes, and the Fe3O4 core made magnetic separation simple. Kinetic analysis supports the pseudo-second-order model, indicating that chemisorption is the main factor controlling the adsorption rate. Based on the Langmuir isotherm, the data suggest that adsorption occurs as a monolayer on a homogeneous surface. Maximum adsorption capacities were 542.75 mg/g for Congo red and 377.25 mg/g for crystal violet. Calculated thermodynamic values reflected an endothermic and energetically favorable adsorption mechanism. Additionally, the magnetic properties of UiO-66@β-CD@Fe3O4 enabled easy separation by using an external magnet. Strong adsorption performance was maintained by the material even after several adsorption–desorption cycles, indicating its reusability. UiO-66@β-CD@Fe3O4 exhibits promising performance in addressing dye-contaminated wastewater, confirming its application potential.
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