CHEMICO-BIOLOGICAL INTERACTIONS
·
2022
·
IF 5.168
Yi Yang,Xiangjie Wang,Haolin Zhang,Jiali Li,Jingyi Chen,Miao Yu,Guangxing Li,Ruili Zhang,Ming Ge
Organophosphorus flame retardants (OPFRs) are increasingly being used in many industries since brominated flame retardants (BFRs) have been phase-out. However, OPFRs are associated with environmental pollution and animal health risks, especially in the farming industry. Nevertheless, no study has evaluated the toxicity of OPFRs, as a new flame retardant, on avian species. In order to investigate the specific toxic effects of 2-ethylhexyl diphenyl phosphate (EHDPHP) exposure on chickens and the molecular biological mechanisms that cause damage to the organism, the chicken liver has been studied as a potential target organ for toxic effects. In this study, 7-day-old male chickens were treated with different concentrations of EHDPHP to further investigate the toxicity and mechanisms of OPRs on birds. The samples were taken at 14 d, 28 d, and 42 d for analysis. EHDPHP exposure affected the growth and development of chickens. Furthermore, the microstructural and ultrastructural observations clearly reflected the damage caused by EHDPHP exposure to the livers. The levels of the liver tissue asparate aminotransferase (AST) and alanine aminotransferase (ALT) decreased with increasing gavage dose. In contrast, the levels of oxidative stress in chicken liver and the mRNA expression of related factors increased with increasing gavage dose. In addition, EHDPHP exposure increased liver tissue iron content and affected mRNA expression and protein levels of ferroptosis-related factors in livers. Besides, ferroptosis causes inflammation, thus promoting the synthesis and release of inflammatory factors. This research indicates that EHDPHP can damage chicken livers through oxidative stress and ferroptosis.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Analytical Cellular Pathology
·
2022
·
IF 4.133
Yingru Zhang,Yiyang Zhao,Jingwen Liu,Chunpu Li,Ying Feng,Shasha Jiang,Xiaoting Sun,Xueqing Hu,Yan Wang
Tanshinone IIA (TanIIA) is the main active ingredient in the fat-soluble components isolated from Salvia miltiorrhiza Bunge. Our previous studies have convincingly proved that TanIIA is an effective drug against human colorectal carcinoma cells. In order to further demonstrate the effect of TanIIA on CRC, we carried out exploratory research about it in vivo and in vitro. The results demonstrated that TanIIA were observably more effective than control group in preventing tumor growth, and it has increased the survival time. Cancer cells viability and proliferation were accompanied by concentration and time dependent decline reached with TanIIA. We found that TanIIA altered the morphology of cytoskeleton and it could obviously induce apoptosis of colorectal cancer cells and block the cells in the G0/G1 phase. TanIIA also increased phosphorylation of p38MAPK, upregulated ATF-2 expression and downregulated Transgelin-2 expression, which could be reversed by SB203580, a p38MAPK-specific inhibitor. Our results suggested that TanIIA could induce apoptosis of colorectal cancer and block the cells in G0/G1 phase involved in downregulating the expression of Transgelin-2 through p38MAPK signal pathway.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Catalysts
·
2022
·Vol. 12
·期 10
·1100
·
IF 4.501
Jingxin Tan,Guoqiang Wei,Zhen Wang,Hui Su,Lingtao Liu,Chunhu Li,Junjie Bian
Zn1−xCdxS catalysts with Zeolitic Imidazolate Framework-8 (ZIF-8) as the precursor were successfully prepared by ion exchange method, and the ability and electrochemical properties of a series of ZIF-8, ZnS and Zn1−xCdxS catalysts in photocatalytic degradation of 2-CP and TC were investigated. Doping of Cd ions was able to modulate the ZnS band gap width and improve the utilization of visible light by the photocatalyst. The nanocage catalysts with hollow structure of Zn1−xCdxS have better photocatalytic response. The removal of photocatalytic pollutants was up to 90% under optimal conditions. Using a Peroxymonosulfate (PMS)-assisted system to improve the degradation efficiency of 2-chlorophenol and tetracycline hydrochloride under visible light, we present a possible mechanism of Zn1−xCdxS as a photocatalyst for degradation in persistent pollutants and in PMS-assisted photocatalysis. Four active species, O2−, h+, -OH, and SO4•−, can be generated to degrade 2-chlorophenol and tetracycline hydrochloride under PMS-assisted activation. Zn1−xCdxS nanocage with high activity and stability provides a feasible approach to catalytically remove persistent pollutants from aqueous solutions under visible light conditions.Keywords:nanocage photocatalyst;Zn1−xCdxS;2-CP;TC;PMS;degradation
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF BIOTECHNOLOGY
·
2022
·
IF 3.595
Feng Cheng,Wei-Bang Xie,Xiao-Fan Gao,Rong-Liang Chu,Shen-Yuan Xu,Ya-Jun Wang,Yu-Guo Zheng
( S )-2-chlorophenylglycine (( S )-CPG) is a key chiral intermediate for the synthesis of clopidogrel . Herein, a novel, efficient and environmentally friendly chemo-enzymatic route for the preparation of optically pure ( S )-CPG was developed. A straightforward chemical synthesis of the corresponding prochiral keto acid substrate (2-chlorophenyl)glyoxylic acid (CPGA) was developed with 91.7% yield, which was enantioselectively aminated by leucine dehydrogenase (LeuDH) to ( S )-CPG. Moreover, protein engineering of LeuDH was performed via directed evolution and semi-rational design. A beneficial variant Es LeuDH-F362L with enlarged substrate-binding pocket and increased hydrogen bond between K77 and substrate CPGA was constructed, which exhibited 2.1-fold enhanced specific activity but decreased thermal stability . Coupled with a glucose dehydrogenase from Bacillus megaterium ( Bm GDH) for NADH regeneration, Es LeuDH-F362L completely converted up to 0.5 M CPGA to ( S )-CPG in 8 h at 40 °C.
✓ 已验证
DOI
PubMed
高影响因子
Environmental Science-Nano
·
2022
·Vol. 9
·期 9
·3407-3416
·
IF 9.473
Han Song,Xinwen Ou,Mengye Wang,Yan Zhang,Zhang Lin
H2 production during the transformation of Fe(OH)2 into magnetite (i.e., Schikorr reaction), has a significant impact on many environmental applications, including the long-term effectiveness of permeable reactive barriers composed of zerovalent iron and the stability of geological radioactive waste repository. However, the reactivity of the Schikorr reaction is not systematically evaluated and its chemical mechanism still remains controversial. Here, we investigate water reduction on the Fe(OH)2 surfaces with the help of an interface-reaction model between water and Fe(OH)2. The Fe(OH)2 hexagonal nanosheets prepared using a coprecipitation method possess dominantly exposed (001) and (100) facets. As unveiled by the DFT simulations, the (001) Fe(OH)2 facet only exposes OH, which is, therefore, inert to water reduction. Moreover, the active Fe-exposed (100) Fe(OH)2 facet is more thermodynamically favourable for water adsorption and dissociation than the (101) and (102) facets. However, the high energy barrier for water dissociation (2.79 eV) may restrict the rate of water reduction on the Fe(OH)2 facet. In addition, the capacity of (100), (101), and (102) Fe(OH)2 facets to adsorb OH− is stronger than that for H2O, which further inhibits water reduction. Furthermore, DOS calculations manifest that Fe d orbitals play a significant role in H2O adsorption, indicating that manipulating the electronic structure of the Fe site is a critical path to mediate water reduction in Fe(OH)2. Our study provides new insights into the understanding of the mechanism of the phase transformation of Fe(OH)2 under anaerobic conditions in environmental and earth sciences.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF BIOMATERIALS APPLICATIONS
·
2022
·
IF 2.712
Shuang Yang,Linhao Lan,Mingda Gong,Ke Yang,Xiaoming Li
An effective dressing is essential for wound healing. In fact, the wettability performance is one of the most important factors of a wound dressing. The fundamental functions of a wound dressing involve the absorption of excess exudates and maintenance of optimal moisture at the wound by controlling water evaporation. Here, we designed a type of chitosan (CS) sponge and PCL nanofibrous membrane composite dressing with asymmetric wettability surfaces as wound healing materials for biomedical applications. The hydrophobic surfaces of the composite dressing were waterproof and could efficiently control the water vapor transmission rate, whereas the hydrophilic surface of the CS sponge had good cytocompatibility and water-absorbing capability. Insulin-like growth factor-2 (IGF-2) was added to the CS sponge, and exhibited a stimulatory effect on fibroblasts migration and proliferation. Therefore, the fabricated CS sponge and PCL membrane composite dressing had excellent cytocompatibility, vapor transmission rate, and liquid absorption and asymmetric wettability, suggesting its potential as a promising alternative to traditional wound dressing.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Electrocatalysis
·
2022
·Vol. 13
·期 6
·818-829
·
IF 2.933
Dong Zhichen,Wu Jian,Guo Xingjia
In this work, we prepared cubic nickel oxide (NiO) nanosheets and constructed NiO with oxygen defects induced by halogen Cl ions (NiO-Vo1). Cubic nickel oxide nanosheets were used as catalysts for electrocatalytic oxygen evolution reaction (OER) and oxidation of chiral 2-butanol. Under artificial simulated sunlight, NiO-Vo1 exhibited good photo-electrocatalytic OER activity and catalytic stability. The high catalytic activity is mainly attributed to the activation of nickel active sites by the halide ion-induced oxygen defect and the enhancement of photoinduced electron–hole separation efficiency. Furthermore, the electrocatalytic performance of oxygen-deficient nickel oxide for the oxidation of chiral 2-butanol was investigated. The results show the catalytic activity of NiO-Vo1 for electrocatalytic oxidation of 2-butanol to butanone compared with NiO. Interestingly, there is no significant difference in the electrocatalytic activity of NiO for (R)-(-)-2-butanol and (S)-( +)-2-butanol oxidation. When NiO-Vo1 was used as the catalyst, the catalytic oxidation reaction rate of (R)-(-)-2-butanol alcohol was significantly higher than that of (S)-( +)-2-butanol alcohol. At 1.77 V vs RHE voltage, the (R)-(-)-2-butanol alcohol has obvious oxidation reaction while the (S)-( +)-2-butanol alcohol is almost absent, realizing the selective electrocatalytic oxidation of (R)-(-)-2-butanol alcohol. This may be attributed to the difference in the interaction strength of chiral molecules with the surface defects of NiO after applying a voltage during the catalytic process, resulting in different catalytic activities. Here, our proposed strategy through the synergistic effect of applied voltage and surface defects provides a new approach for chiral molecule synthesis and efficient chiral resolution. The halide ion-induced defect-catalyst provides a new strategy for the preparation of efficient electrocatalytic water splitting OER and alcohol-selective oxidation catalysts. Graphical Abstract
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2022
·Vol. 12
·期 20
·12932-12937
·
IF 4.036
Shaoying Sun,Xing Zhang,Yanqing Li,Xianzhao Shao,Jianwei Ji,Junhai Liu,Wei Wang,Zhizhou Li,Xiaohui Ji
New solid acid catalysts were prepared by bisphenol A, paraformaldehyde and chlorosulfonic acid, and applied to hydroxylalkylation/alkylation (HAA) of 2-methylfuran (2-MF) and cyclohexanone. After optimizing the reaction conditions, the conversion of 2-MF reached 99% and the yield of 5,5′-(cyclohexane-1,1-diyl)bis(2-methylfuran) acquired 98%. The activity and catalytic efficiency were higher than those of Amberlyst 15 and Amberlyst 36 resins, which could be rationalized by high acid strength. At the same time, the catalysts were characterized by acid–base titration and FTIR. Hydrodeoxygenation (HDO) of HAA products of 2-methylfuran and cyclopentanone were processed on the Ni/SiO2 catalyst prepared by wet impregnation method to further convert into aviation kerosene, and the yield reached 93%.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INORGANIC CHEMISTRY
·
2022
·
IF 5.436
Dan Zhao,Wen Liu,Ya-Nan Li,Rui-Juan Zhang,Li-Na Zhang
A modulated structure with symmetrical characteristic higher than three-dimensional is a fascinating crystallographic type, and it is randomly encountered by researchers. Herein, we prepared 0.1 mm level single crystals of Na3La(VO4)2 and determined its structure to be a (3 + 1)-dimensional modulated structure using the X-ray diffraction analysis method for single crystals. Its super space group was determined to be Pca21(0β0)000. On the other hand, we introduced Tb3+ into the Na3La(VO4)2 host lattice to fabricate phosphors Na3La1-x(VO4)2:xTb3+ and studied their photoluminescence properties. Interestingly, for the strong absorption of the Na3La(VO4)2 host lattice in the range of 200–400 nm, the traditional 330–385 nm light is unable to efficiently excite Tb3+ ions in the Na3La(VO4)2 host to generate luminescence of Tb3+. Instead, Na3La1–x(VO4)2:xTb3+ is suitable to be excited by 487 nm to generate emitting light at 543, 584, and 622 nm, due to Tb3+ characteristic 4f → 4f transitions of 5D4 → 7FJ (J = 5, 4, 3). Hence, the Tb3+-doped Na3La(VO4)2 phosphors have potential applications for white-light-emitting diodes.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ELECTROPHORESIS
·
2022
·Vol. 43
·期 15
·1601-1610
·
IF 3.595
Ying Zhang,Ming Zhao,Cheng-Bo Wang,Yu Wang,Stanislas Nsanzamahoro,Ling-Ling Zhu,Wei-Feng Wang,Jun-Li Yang
Prolyl hydroxylase domain 2 (PHD2) is a key enzyme regulating the expression of hypoxia inducible factor (HIF). Its inhibitors can improve the expression of HIF and downstream genes, which can treat hypoxia-related diseases. Therefore, the establishment of a reliable PHD2 inhibitors screening method is of great significance for the drug development of hypoxia-related diseases. In this work, an accurate, rapid, and simple screening method for PHD2 inhibitors was introduced by capillary zone electrophoresis (CZE). In order to improve the detection sensitivity, the derivative reaction of α-ketoglutaric acid (α-OG) and 1,2-diaminobenzene (OPD) was used to enhance the UV absorption of α-OG (the substrate in the enzymatic reaction). The CZE method selected 20 mM Na 2 B 4 O 7 buffer (pH 9.0) as the separation buffer, +25 kV as the separation voltage, 25°C as the cartridge temperature, and 210 nm as the detection wavelength. Under this condition, the analysis of a single sample can be realized within 9 min. Compared with the existing reported methods, the present work can directly screen the PHD2 inhibitory activity of traditional Chinese medicine (TCM) extracts, which is of significance for the target-purification of bioactive individual compounds from TCMs. Under the optimal conditions, the PHD2 inhibitor screening platform was successfully established, and it was found that 70% methanol/water extracts of Astragali Radix and Codonopsis pilosula had good PHD2 inhibitory activity. Furthermore, the present work provides a novel approach for screening the PHD2 inhibitory activity of TCM extracts and the discovery of anti-hypoxia bioactive compounds.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2022
·
IF 3.119
Guangyu Xu,Fanyuan Zhang,Zhenghui Li
In this study, the solubility of 5-chloropyrazin-2-amine in four aqueous solutions (methanol, ethanol, n-propanol, and ethylene glycol (EG)) plus water was determined by a gravimetric method at temperatures ranging from T = 278.15 to 323.15 K at 101.2 kPa pressure. Experimental results indicated that 5-chloropyrazin-2-amine solubility positively increased with increasing temperature at a given solvent composition and decreased with increasing mass fraction of water in each system. The order of solubility from high to low on the mole fraction scale was as follows: methanol (0.02007, 323.15 K) > ethanol (0.01308, 323.15 K) > n-propanol (3.827 × 10–3, 323.15 K) > water (1.569 × 10–3, 323.15 K). Similarly, the solubility of 5-chloropyrazin-2-amine was higher in (methanol + water) than in the other three cosolvent mixtures. The solid phase crystal of 5-chloropyrazin-2-amine was tested by X-ray powder diffraction (XPRD) and the results showed no polymorphic transformation, solvate formation, or crystal transition during entire experiments. The experimental solubility values of 5-chloropyrazin-2-amine were correlated by three thermodynamic models. The results show that the largest relative average deviation (RAD) and root mean square deviation (RMSD) data were no more than 5.38% and 2.34 × 10–4, respectively. The Jouyban–Acree model gave the best correlation result in this study.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF POLYMER RESEARCH
·
2022
·Vol. 29
·期 2
·1-9
·
IF 3.061
Song Tao,Wang Qingyin,Li Jianguo,Chen Xuejun,Liu Shaoying,Wang Gongying
A new copolyesters of poly(2-[4-(2-hydroxyethoxy)phenoxy]ethyl-co-1,4-cyclohexylenedimethylene terephthalate) (PHCT) with different compositions were synthesized from terephthalic acid, 1,4-cyclohexanedimethanol and hydroquinone bis(2-hydroxyethyl) ether (HQEE) via esterification-polycondensation reaction. The synthesized copolyesters were analyzed by 1 H-NMR, FT-IR, GPC, intrinsic viscosity, DSC, TGA and tensile testing, respectively. The 1 H-NMR and FT-IR analysis confirm the successful introduction of HQEE into poly(1,4-cyclohexylenedimethylene terephthalate (PCT) chains. The introduction of HQEE into PCT chains can effectively lower the melting point of PCT, making it easier to process. The glass transition temperature of PHCT is higher than 70 ℃ and it has the comparable thermal stabilities to PCT. In addition, introducing HQEE into PCT chains can effectively improve the molecular weights of PCT, thus imparting PHCT with better mechanical performance relative to PCT. The PHCT is a tough polymer, which owns the higher Young’s modulus (above 300 MPa), the higher tensile strength (above 39 MPa) and the higher elongation at break (above 226%).
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）