TOXICOLOGY AND APPLIED PHARMACOLOGY
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2020
·
IF 3.347
Cong Zhang,Lei Sheng,Ming Yuan,Junjie Hu,Yan Meng,Yong Wu,Liang Chen,Huifan Yu,Shan Li,Guohua Zheng,Zhenpeng Qiu
Orlistat (Xenical™), a US Food and Drug Administration (FDA)-approved anti-obesity drug, shows efficacy against multiple tumor types, including hepatocellular carcinoma (HCC), due to its ability to inhibit fatty acid synthase (FASN) activity. However, whether orlistat affects hepatocellular malignant transformation during hepatocarcinogenesis in vivo is unknown. This study assessed the antisteatotic and antitumorigenic efficacy of orlistat in a rapid HCC FVB/N mouse model established via hydrodynamic transfection of activated forms of AKT and c-Met proto-oncogenes. Human hepatoma cell lines were used for mechanical validation in vitro . Hematoxylin and eosin staining, immunohistochemistry, and immunoblotting were applied for the mechanistic investigation. The results revealed that when orlistat was administered in the early stage of AKT/c-Met-triggered hepatocarcinogenesis, it resulted in the elimination of hepatic tumor burden. Mechanistically, orlistat efficiently elevated PTEN expression and suppressed AKT/SREBP1/FASN signaling both in vivo and in vitro , impairing AKT/c-Met-driven de novo lipogenesis and aberrant proliferation. Altogether, this study demonstrates the antilipogenic and antiproliferative efficacy of orlistat in hepatocarcinogenesis, suggesting that orlistat may be beneficial for the treatment of HCC, especially in NAFLD-related HCCs featuring activated AKT/mTOR cascade and increased lipogenesis in livers.
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高影响因子
ChemElectroChem
·
2020
·Vol. 7
·期 14
·3082-3088
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IF 4.154
Jinzhou Yang,Zong-Bao Yu,Wei Sun,Yue Li,Hongda Wu,Zhongxing Geng,Zhanxu Yang
Graphical One for both : A composite catalyst consisting of WP nanorods, WS 2 , and carbon is presented here. It demonstrates hydrogen evolution reaction (HER) activity and long-term chronopotentiometric stability as well as suitability in both acid electrolyte and alkaline electrolyte. Thorough characterization is performed to uncover the reasons behind uncover the enhanced HER. Through a stepwise synthesis, intercalation followed by chemical vapor deposition (CVD) method, WP nanorods have been grown on the surface of WS 2 /C composite. Compared to WS 2 /C, WP nanorods@WS 2 /C demonstrate better hydrogen evolution reaction (HER) activity and long-term chronopotentiometric stability as well as suitability in both acid electrolyte and alkaline electrolyte. In order to uncover the enhanced HER property reason, systematic characterizations were applied to assist analyzing. The characterizations used include X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy (XPS), electrochemical impedance spectroscopy (EIS), electrochemical active surface area (ECSA), Raman, and BET. Based on the analysis, it points that improved ECSA, synergy between WS 2 and WP nanorods, and enhanced degree of graphitization as well, leads to better HER activities of WP nanorods@WS 2 /C over WS 2 /C. This work highlights significant role of WP nanorods in WP/WS 2 /C three-phase composite in electrocatalytic hydrogen evolution and may evoke new interest in related nanostructure study.
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CHEMICAL ENGINEERING SCIENCE
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2020
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IF 3.871
Yongwan Gu,Yunyan Li,Jiaoxia Zhang,Huiying Zhang,Chunhua Wu,Jing Lin,Juying Zhou,Yuhang Fan,Vignesh Murugadoss,Zhanhu Guo
Pd/C catalysts were prepared by an incipient-wetness impregnation and their catalytic performance in disproportionation of rosin was investigated. The texture structure, groups on the activated carbon surfaces, and acidity were characterized by N 2 physisorption-desorption, Fourier transform infrared spectroscopy (FTIR), and temperature-programmed desorption (TPD). The Pd/AC3 (treated at 443 K) had the highest Pd dispersion (23.60%) with the highest specific surface area of activated carbon (1057 m 2 /g). Nevertheless, the Pd/AC0 (original carbon black) had the lowest Pd dispersion (13.07%) with a lower specific surface area of original activated carbon (994 m 2 /g). Pd/AC3 presented a considerable catalytic activity in the rosin disproportionation reaction, with 64.15% dehydroabietic acid and without abietic acid in product. However, Pd/AC0 (Pd supported on the original carbon) showed a much lower catalytic activity in the rosin disproportionation reaction, with 42.64% dehydroabietic acid and 3.59% abietic acid in product.
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高影响因子
Green Energy & Environment
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2020
·
IF 6.395
Yu Qiu,Li Ma,Qingfeng Kong,Min Li,Dongxu Cui,Shuai Zhang,Dewang Zeng,Rui Xiao
Operating chemical looping process at mid-temperatures (550–750 °C) presents exciting potential for the stable production of hydrogen. However, the reactivity of oxygen carriers is compromised by the detrimental effect of the relatively low temperatures on the redox kinetics. Although the reactivity at mid-temperature can be improved by the addition of noble metals, the high cost of these noble metal containing materials significantly hindered their scalable applications. In the current work, we propose to incorporate earth-abundant metals into the iron-based spinel for hydrogen production in a chemical looping scheme at mid-temperatures. Mn 0.2 Co 0.4 Fe 2.4 O 4 shows a high hydrogen production performance at the average rate of ∼0.62 mmol g −1 min −1 and a hydrogen yield of ∼9.29 mmol g −1 with satisfactory stability over 20 cycles at 550 °C. The mechanism studies manifest that the enhanced hydrogen production performance is a result of the improved oxygen-ion conductivity to enhance reduction reaction and high reactivity of reduced samples with steam. The performance of the oxygen carriers in this work is comparable to those noble-metal containing materials, enabling their potential for industrial applications.
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高影响因子
COMPOSITES PART B-ENGINEERING
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2020
·
IF 7.635
Jianwei Li,Yuanqing Ding,Qiang Gao,Hongming Zhang,Xinhai He,Zhonglei Ma,Bin Wang,Guangcheng Zhang
Developing ultrathin, lightweight, flexible and efficient electromagnetic interference (EMI) shielding materials is still a long-standing issue. Herein, a series of biomass derived carbon composite films with superior EMI shielding performance are reported. The cotton derived carbon fabric wrapped with CoFe alloy nanoparticles (CCF@CoFe) was prepared by pyrolysis at temperature of 600–800 °C and subsequently encapsulated by polyimide (PI) resin to obtain the CCF@CoFe/PI films. The prepared composite films present favorable flexibility, remarkable tensile strength of ~10 MPa and exceptional EMI shielding efficiency of ~32 dB over the X-band with the thickness of 0.16 mm. In addition, the EMI shielding performance of the composite films can be adjusted by changing the CoFe loading content and pyrolysis temperature, and an EMI shielding efficiency of ~62 dB is achieved by stacking 6 layers of nanocomposite films, shielding 99.999937% of incident electromagnetic waves with thickness of only 0.98 mm. In view of excellent comprehensive properties, this ultrathin and low-cost biomass derived films are highly promising materials for EMI shielding in practical applications.
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Food & Function
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2021
·Vol. 12
·期 20
·9912-9921
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IF 5.396
Mohan Zhang,Shuai Chen,Yuhua Dai,Ting Duan,Yuying Xu,Xiaolin Li,Jun Yang,Xinqiang Zhu
Aspartame (ASP) and sucralose (SUC) are non-nutritive sweeteners which are widely consumed worldwide. They are considered safe for human consumption, but their effects on certain physiological aspects, such as the lifespan or health status, of the organism have not yet been studied in depth and only limited data are available in the literature. The objectives of this study were to evaluate the effects of ASP and SUC on the lifespan and health indexes using Caenorhabditis elegans (C. elegans) as a model system. Interestingly, it was shown that at the concentrations tested, ASP (0.03–3 mg mL−1) showed an increasing trend of the mean lifespan of C. elegans, with a significant increase of 27.6% compared to the control at 3 mg mL−1. Similarly, SUC (ranging from 0.03 to 10 mg mL−1) also significantly increased the mean lifespan by 20.3% and 22.3% at 0.03 and 0.3 mg mL−1, respectively. However, 10 mg mL−1 SUC had a negative effect on the lifespan, though it did not reach a statistically significant level. In addition, ASP and SUC decreased lipofuscin accumulation and transiently improved motility, indicating improved health status. Nonetheless, they had different effects on food intake and intestinal fat deposition (IFD) at different intervals of time. Taken together, our findings revealed that ASP and SUC can prolong the lifespan and improve the health status of C. elegans.
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高影响因子
IONICS
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2021
·Vol. 27
·期 9
·3975-3985
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IF 2.817
Wang Zhiyi,Wang Yutian,Tang Jingtao,Wang Kaizhao,Chen Tianyou,Wang Kaijun,Hu Jin
Among the currently studied nitrogen-doped Pt-C catalysts, the environmental friendliness of the nitrogen source and the stability of Pt-C catalysts for fuel cells are urgent issues to be solved. In this study, nitrogen-doped platinum-based catalyst (CSC/BP-Pt) with excellent stability for the ORR is prepared by a self-doping method based on chitosan (CS), a green biomass material with both nitrogen and carbon sources, in combination with conductive carbon black (BP2000). Finally, the N content of the catalyst is as high as 5.8 wt%, which is higher than most comparable catalysts (3–5 wt%). And electrochemical tests show that the CSC/BP-Pt electrochemical active surface area (ECSA) = 154.1 m 2 /g Pt , half-wave potential (E 1/2 = 0.85 V RHE ) has a better electrochemical performance than the commercial Pt/C (20 wt%), while the half-wave potential is reduced at 10,000 cycles of cyclic voltammetry with almost no attenuation (only 7 mVcompared to 31 mV of Pt/C). Besides, possible mechanisms to improve the activity and stability of CSC/BP-Pt are preliminarily proposed.
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Advanced Composites and Hybrid Materials
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2021
·Vol. 4
·期 4
·1292-1301
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IF 5.693
Zhang Pengxiang,Zhang Xihua,Li Bin,Xu Lingan,Dang Feng,Li Bao-Wen
Improving the interfacial impedance matching and attenuation ability of a microwave absorber is an important strategy to obtain excellent microwave absorbing performance. Here, we prepared an ultralight, hierarchical porous single-atom Co–N–C microwave absorber, in which evenly distributed single-atom Co is anchored in a porous N-doped carbon framework by N–Co bond via a facile bio-inspired method. These doped single atoms provide abundant highly active atomic absorption sites on the carbon skeleton, and considerable defects including pyridinic-N, pyrrolic-N, oxidized N, and so forth are introduced into the carbon framework owing to single Co atom doping. These doped single Co atoms and introduced defects act together as strong dipolar/interfacial polarization units, which lead to better impedance matching and a significant increase in attenuation capability of the absorber. The metal Co exists in form of a single atom, benefiting light weight of the absorber. Therefore, an extremely strong reflection loss (RL) value of − 60.9 dB is achieved at a lower filler content of 10 wt% with the absorber thickness of 2.5 mm, and the effective frequency bandwidth covered from 10.4 to 15.1 GHz with a thickness of 2.0 mm at a low filler content of 10 wt%. This research offers a novel route for designing a microwave absorber to improve microwave absorption performance and is expected to a wider range of absorbing materials with different structures. Graphical abstract
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高影响因子
Catalysts
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2021
·Vol. 11
·期 8
·925
·
IF 4.146
Qijun Wang,Ya-Wei Zhou,Zhao Jin,Chunguang Chen,Hong Li,Wen-Bin Cai
Carbon-supported PtRu nanoalloy (PtRu/C) is widely used as the anode catalyst for direct methanol fuel cells (DMFC), and an aqueous phase synthesis of PtRu/C is in high demand due to for energy-saving and environmentally-benign considerations, however, it is very challenging to attain stoichiometric reduction, good dispersion and a high alloying degree. Herein, we report a facile aqueous phase approach with dimethylamine borane (DMAB) as the reducing agent to synthesize a PtRu/C(DMAB). TEM, XRD, XPS and ICP-AES characterizations indicate that the structural parameters in the PtRu/C(DMAB) are improved significantly as compared to those obtained in a PtRu/C(NaBH4) and a commercial PtRu/C, contributing to an enhanced electrocatalytic performance. It turns out that the PtRu/C(DMAB) exhibits the highest methanol electro-oxidation (MOR) performance among all of the tested samples, with the peak current up to 1.8 times as much as that of the state-of-the-art commercial PtRu/C, corroborating the highest output power density in comparative DMFC tests. In-situ attenuated total reflection infrared (ATR-IR) spectroscopy correlates the higher methanol electro-oxidation performance of the PtRu/C(DMAB) with its enhanced CO resistance and CO2generation. This simple aqueous synthetic approach may provide an alternative route for developing efficient anode electrocatalysts of DMFCs.Keywords:PtRu/C catalyst;methanol electro-oxidation reaction;aqueous phase synthesis;dimethylamine borane;direct methanol fuel cell;in-situ ATR-IR
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高影响因子
Journal of the Taiwan Institute of Chemical Engineers
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2021
·
IF 5.876
Xiuhui Zhai,Xiang Wang,Xinle Pang,Jun Zhang,Qiong Wu,Weidan Na,Yingmei Zhou,Lin Tian
Exploiting effective and low-cost electrocatalysts toward water oxidation is of vital significance for boosting overall water splitting. Herein, we proposed a simple method for constructing dendritic N-doped carbon/ manganese oxides (N-C/MnO x ) hybrid nanocomposites by annealing the composite of nitrogen-doped carbon quantum dots (N-CQDs) and γ-MnOOH (γ-MnOOH@N-CQDs) at different temperatures under N 2 /O 2 atmosphere. The obtained N-C/MnO x exhibited remarkable electrocatalytic activity and stability for oxygen evolution reaction (OER) owing to their unique dendritic structure, rich oxygen vacancies, optimized electronic structure, abundant Mn-C/N, and large electrochemical active area. Among of the prepared N-C/MnO x hybrid nanocomposites, N-C/Mn 2 O 3 showed the best performance toward OER with an overpotential of merely 347 mV to reach to 10 mA cm −2 , along with a small Tafel slope of 75.51 mV dec −1 . More remarkably, by combining Pt/C with N-C/Mn 2 O 3 for overall water splitting, a battery voltage of only 1.67 V is needed to reach the 10 mA cm −2 , rivaling the activity of the state-of-the-art IrO 2 ‖ Pt/C couple.
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高影响因子
Journal of Magnesium and Alloys
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2021
·
IF 10.088
Bogu Liu,Bao Zhang,Haixiang Huang,Xiaohong Chen,Yujie Lv,Zhongyu Li,Jianguang Yuan,Ying Wu
Ni and carbon materials exhibit remarkable catalysis for the hydriding reaction of Mg. But the underlying mechanism of Ni/C hybrid catalysis is still unclear. In this work, density functional theory (DFT) calculation is applied to investigate the effect of Ni/C co-incorporation on the hydriding reaction of Mg crystal. The morphology and crystal structure of the Ni/C co-incorporated Mg sample show that the co-incorporated structure is credible. The transition state searching calculation suggests that both the incorporations of Ni and C are beneficial for the H 2 dissociation. But Ni atom has a dramatic improvement for H 2 dissociation and makes the H diffusion become limiting step of the hyriding reaction. The Ni d z 2 orbit and H s orbit accept the electrons and combine together compactly, while the Ni d xy orbit is half-occupied. The catalytic effect of Ni on H 2 dissociation can be ascribed to the bridging effect of Ni d xy orbit. The incorporation of C can weaken the over-strong interaction between Ni and H which hindered the H diffusion on Mg(0001). The Ni/C co-incorporated Mg(0001) shows the best performance during hyriding reaction compared with the clean and single incorporated Mg(0001).
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高影响因子
COMPOSITES SCIENCE AND TECHNOLOGY
·
2021
·
IF 8.528
Zhe Wang,Yuetao Liu,Dejin Zhang,Kaiming Zhang,Chuanhui Gao,Yumin Wu
Due to the good elasticity and stretchability, conductive composites can be widely used as sensitive strain sensors in health monitoring, electronic skin and intelligent robotics . However, the preparation of conductive material that integrates excellent mechanical properties , efficient self-healing properties and sensitive sensing properties remains a challenge. Here, we developed a stable and sensitive self-healing strain sensor based on silicone conductive composites and further evaluated the sensing properties by monitoring the motion of human muscles and joints . Disulfide bonds and multiple hydrogen bonds were introduced into the dynamic silicone supramolecular network through the dehydration reactions of amino groups with carboxyl groups and the addition reactions of amino groups with isocyanate groups . Furthermore, the addition of natural small molecule L-citrulline modified MXenes (C-MXenes) through esterification imparted the material good electrical conductivity . The mechanical strain and stress could reach to 413% and 4.78 MPa, respectively. Due to the dynamic disulfide and multiple hydrogen bonds, the conductive composites could spontaneously achieve self-healing with multiple cycles. Even if the sample was repaired, it could still sense the human motion precisely. Moreover, the material exhibited outstanding sensitive of strain. And the GF (gauge factor) was 3.3821. This excellent performance and simple preparation procedure of silicone conductive composites could be developed as a new generation of wearable sensor devices.
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