Materials Today Communications
·
2024
·
IF 3.7
Zahra Nozhat,Shibo Wang,Asim Mushtaq,Tianhao Deng,M. Zubair Iqbal,Xiangdong Kong
Recently, nanoparticles (NPs) have been employed to enhance the distribution of new medications across the BBB. In this study, a synergistic nanoassembly has been prepared for magnetic resonance imaging-guided chemo-phototherapy of glioblastoma multiforme (GBM). In accordance, Fe 3 O 4 NPs are prepared with SiO 2 shell followed by the loading of an anticancerous drug temozolomide (TMZ) to generate Fe 3 O 4 @SiO 2 /TMZ NPs. Later, drug-loaded NPs are coated with platelet membrane (PLTM) to develop the final biocompatible form of nanoassembly as Fe 3 O 4 @SiO 2 /TMZ@PLTM NPs for synergistic therapy of GBM. We combined chemotherapy with photothermal therapy in a magnetically targeted TMZ-loaded Fe 3 O 4 @SiO 2 core-shell that was activated by near-infrared irradiation and then developed platelet membrane-coated Fe 3 O 4 @SiO 2 /TMZ to improve the precise delivery of drugs into GBM cells and enable a more efficient photothermal therapy. According to the cellular uptake findings, the Fe 3 O 4 @SiO 2 /TMZ@PLTM NPs possess a greater uptake compared to the uncoated Fe 3 O 4 @SiO 2 /TMZ NPs owing to the targeted binding of P-selectin on the surface of the PLTM to the CD44 receptors of GBM cells. Moreover, the nanoassembly has displayed a pH-responsive drug release and an excellent photothermal effect under NIR (808 nm, 1 W/cm 2 ) irradiation. After 10 min of irradiation, the temperature has been elevated to about 65 °C leading to the death of 80% of GBM cells in vitro. Additionally, the fabricated NPs possess a remarkable contrasting property for T 1 -weighted magnetic resonance imaging (MRI) due to the presence of superparamagnetic iron oxide NPs. These findings demonstrate the promising theranostic behaviour of fabricated Fe 3 O 4 @SiO 2 /TMZ@PLTM NPs for synergistic therapy of glioblastoma multiforme (GBM).
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Yaru Sun,Yan Liu,Yanyan Zou,Jun Wang,Fan Bai,Junbo Yan,Fenglei Huang
In this work, novel core–shell Fe 3 O 4 nanoparticles were prepared by self- assembly technology using phytate-melamine aggregates (PM) or phytate-melamine-Fe 3+ aggregates (PM-Fe) as building block. A polyurea (PUA) matrix was filled with magnetic nanoparticle. The influence of Fe 3 O 4 , Fe 3 O 4 @PM or Fe 3 O 4 @PM-Fe content and dispersion on the mechanical and electromagnetic wave (EMW) absorption properties of PUA composite were investigated. Good dispersion of modified Fe 3 O 4 in PUA matrix was obtained. Loading well-dispersed Fe 3 O 4 significantly enhanced the mechanical properties of their PUA nanocomposite under quasi-static tensile, nanoindentation, and dynamic compression tests. Excellent EMW absorption performance of PUA/Fe 3 O 4 @PM nanocomposite was desired. Although well-dispersed Fe 3 O 4 @PM could effectively enhance the mechanical properties, nonetheless it surprisingly plays a negative role in the EMW absorption performance. The Fe 3 O 4 @PM with high dispersion and interfacial compatibility in the PUA matrix was detrimental to EMW absorption performance, which contradicts the well accepted EMW absorption mechanisms. A novel mechanism and model were suggested, along with a fresh understanding of the role of Fe 3 O 4 in the EMW absorption of PUA composite. Furthermore, the Fe 3 O 4 @PM-Fe, obtained by constructing a conductive network on the surface of Fe 3 O 4 @PM, was used to investigate this assumption. The radar cross section simulation also demonstrated the superior EMW attenuation capability of PUA nanocomposites in the service condition. This work is beneficial to the development of EMW absorber, not limited to Fe 3 O 4 magnetic nanoparticles.
✓ 已验证
产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Zhihao Xu,Hezhong Ouyang,Haoda Zhang,Lei Sun,Shasha Li,Ruijiang Liu
A highly sensitive label-free electrochemical aptamer biosensor with magnetically induced self-assembly had been developed to detect gastrin-releasing peptide precursor (ProGRP), which is not only a highly specific tumour marker for small-cell lung cancer (SCLC), but also very stable in serum, and thus had robust clinical utility. Based on the advantages of high specific surface area and facile separation and recycling, magnetic α-Fe 2 O 3 /Fe 3 O 4 nanorods with the average length of 175 nm, the average diameter of 28 nm, and the saturation magnetization of 66.9 emu/g were used as the matrix, and Au nanoparticles (AuNPs) were loaded on the surfaces of the nanorods to enhance the electrochemical signal. The aptamer double-stranded probe with high specificity to the target protein was bound to the surface of α-Fe 2 O 3 /Fe 3 O 4 @Au. The thiol-modified oligonucleotides could quickly and stably bind to AuNPs to form Au-S, which provided a guarantee for the immobilization of the probe and the controllable self-assembled molecular layer. Then, the sensor after capturing the target was self-assembled on the surface of the magnetic glassy carbon electrode (MGCE) by liquid phase incubation for electrochemical detection. The construction and detection performance of the sensor were evaluated by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and differential pulse voltammetry (DPV). Under the optimized conditions, the sensor had remarkable linearity in the range of 0.1 pg/mL - 100 ng/mL (R 2 = 0.998), the limit of detection (LOD) was 17.51 fg/mL, while the limit of quantitation (LOQ) was 58.39 fg/mL. Additionally, the biosensor had excellent stability, reproducibility and anti-interference ability, as well as satisfactory recovery in spiked serum samples (99.46 %–103.32 %).
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2024
·
IF 5.8
Tauqeer Haidar Qamar,Sibt ul Hassan,Nouman Ahmed,Muhammad Javed Qasim,Sain Bux Jamali,Lei Ma,Shengxiang Huang,Lianwen Deng
The rational design of heterostructures with well-defined chemical composition and spatial configuration stands as a key approach in achieving exceptional performance in electromagnetic wave absorption. This innovative work investigated the electromagnetic wave absorption properties of flower-like CoS/Fe 3 O 4 @PPy composites synthesized by hydrothermal method and in situ polymerization. A comprehensive investigation was conducted into the phase composition, morphology, and absorption properties. Flower-like CoS/Fe 3 O 4 @PPy composite demonstrates remarkable microwave reflection loss of −58.4 dB and effective absorption bandwidth of 5.55 GHz in thickness of 3.1 mm. The superior performances are attributed to the synergistic interplay of interfacial polarization, dielectric loss, magnetic loss, and optimized impedance matching. Furthermore, sufficient decrease in radar cross-section value was observed for the optimal sample with reduction of 41.23 dBm². These results highlight the considerable potential of flower-like CoS/Fe 3 O 4 @PPy composites in addressing electromagnetic pollution and stealth applications.
✓ 已验证
产品关联
DOI
高影响因子
TALANTA
·
2024
·
IF 5.6
Xue Zhang,Yunsheng Shang,Qi Xie,Xingzhe Hu,Ke Wu,Lu-Lu Qu,Yingqiu Gu
Developing a Surface-enhanced Raman spectroscopy (SERS) method with excellent detecting ability, good recyclability and analyzing multiple pollutants rapidly are critical for evaluation of water quality in emergency pollution affairs. While constructing a multifunctional substrate with these characteristics to realize the application of SERS in water quality monitoring remains a challenge. In this work, a reusable Au@R–Fe 3 O 4 /g-C 3 N 4 SERS substrate is prepared by loading Au nanoparticles (Au NPs) on Fe 3 O 4 nanorings (R–Fe 3 O 4 ) and the formed Au@R–Fe 3 O 4 is further combined with g-C 3 N 4 nanosheets through a simple electrostatic assembly method. The Au@R–Fe 3 O 4 /g-C 3 N 4 nanocomposite presents multifunction of magnetic enrichment, SERS signal enhancement, multiple pollutants analyzing, and photocatalytic activity , which achieves quantitative detection of rhodamine B (RhB), tetracycline hydrochloride (TC), and 4-chlorophenol (4-CP), with detection limits of 5.30 × 10 −9 , 7.50 × 10 −8 , 7.69 × 10 −8 mol/L, respectively. Furthermore, the recyclable detection capability of Au@R–Fe 3 O 4 /g-C 3 N 4 for multi components is demonstrated by the strong SERS signal after 9 cycles of “detection-degradation” processes. Combined with good uniformity and stability, this SERS method based on Au@R–Fe 3 O 4 /g-C 3 N 4 substrate provides a new strategy for the multi-pollutants detection and degradation in water environment.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2024
·
IF 5.3
Zhiyuan Meng,Qinchao Wu,Xinyi Wu,Chunmei Yang,Wangjin Xu,Tingting Lin,You Liang,Xiaojun Chen
The enhancement of pesticide utilization efficiency for improved biological activity, while promoting crop growth to enhance disease resistance, holds significant importance in agricultural production. In this study, we developed an enzyme-responsive azoxystrobin (AZOX) delivery system using iron-based mesoporous materials as porous carriers and pectin (Pec) as an encapsulation agent to manage rice sheath blight. The resultant AZOX-AFS-Pec nanoparticles (NPs) exhibit high loading capacity and could intelligently release AZOX in acidic conditions in the presence of pectinase. Notably, AZOX-AFS-Pec NPs demonstrated improved wetting and adhesion properties on rice blades, thereby augmenting AZOX utilization. Furthermore, AZOX-AFS-Pec NPs enhanced fungicidal activity against rice sheath blight, with pot experiments revealing comparable control efficacy on rice sheath blight to AZOX suspension concentration (SC). Specifically, AZOX-AFS-Pec NPs exhibited superior prevention and prolonged protection against rice sheath blight compared to AZOX SC. Additionally, continuous release of Fe2+ and Fe3+ by AZOX-AFS-Pec NPs increased chlorophyll content and promoted rice growth. Moreover, these NPs increased salicylic acid (SA) levels in rice plants, fortifying disease resistance. Importantly, AZOX-AFS-Pec NPs demonstrated over a 2-fold reduction in acute toxicity to earthworms compared to AZOX SC. Therefore, stimuli-responsive AZOX-AFS-Pec NPs show great promise for enhancing pesticide effectiveness against pathogens, improving crop traits, and fortifying disease resistance.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Mengyao Han,Cuiling Wu,Jingyu Song,Lushun Yang,Ting Zhang,Yajie Chou,Xueyan Du
With the proliferation of electronic devices and wireless technologies, Electromagnetic Interference (EMI) has become a critical global concern. Correspondingly, the development of efficient EMI shielding materials with strong electromagnetic wave absorption and reflection is imperative. This study presents the fabrication of sandwich-structured composite films (SCFs) utilizing regenerated cellulose (RC) as the matrix, incorporating Ti 3 C 2 T x MXene and Fe 3 O 4 nanoparticles (Fe 3 O 4 NPs) as functional fillers. The SCFs (MXene/RC-Fe 3 O 4 /RC-MXene/RC) were fabricated using an immersion phase conversion method followed by mechanical pressing techniques. The resulting SCFs exhibit a conductivity of 23.8 S/m and a maximum EMI shielding effectiveness (SE) of 32.52 dB. This performance is attributed to the innovative sandwich architecture, which employs a “reflection-absorption-reflection” mechanism to attenuate electromagnetic waves. In addition, MXene is effectively dispersed in the cellulose matrix, enhancing the mechanical properties of the composite films. Notably, increasing the MXene content from 10 wt% to 40 wt% resulted in a tensile strength increase from 9.42 MPa to 17.10 MPa. This research elucidates a robust and scalable approach for the development of advanced electromagnetic shielding materials.
✓ 已验证
产品关联
DOI
高影响因子
Chemical Engineering and Processing-Process Intensification
·
2024
·
IF 3.8
Tianlei Yang,Yueping Guan,Buhui Ren,Yifan Sun,Xinping Jiang,Tao Li
For the application needs of histidine-rich protein separation, this study proposes to prepare a magnetic adsorbent enriched with copper ions and small particle size. Using a compression nebulizer, the magnetic + sodium alginate solution was broken into micrometer-sized droplets and cross-linked and cured with copper ion solution. The magnetic copper alginate microspheres (Cu 2+ -Alg@Fe 3 O 4 ) were obtained with an average particle size of 7.1 μm, a magnetic saturation intensity of 36.9 emu·g −1 , and a Cu 2+ content of 149.2 mg·g −1 .The adsorption equilibrium time of the Cu 2+ -Alg@Fe 3 O 4 microspheres on bovine hemoglobin(BHb) was 90 min, and the maximum adsorption amount was 4318.5 mg·g −1 . The Cu 2+ -Alg@Fe 3 O 4 microspheres also showed stable and good adsorption performance in five cyclic adsorption experiments.
✓ 已验证
产品关联
DOI
高影响因子
BioNanoScience
·
2025
·Vol. 15
·期 4
·1-11
·
IF 3.2
Heng Youqiang,Du Zhong,Chu Chenyang,Xiong Jiabao,Gao Yuxiang,Ma Rong,Wang Jing,Alifu Nuernisha,Ma Cailing
Cervical cancer remains one of the leading cause of cancer death in women. As the development of nanomedicine, multifunctional nanoplatforms which integrate imaging and therapy for effective diagnostics and therapeutics of cancer have attracted great attention in recent years. In this work, we have designed and developed a kind of multimodal imaging and treatment strategy which combined near-infrared (NIR) fluorescence imaging with magnetic resonance imaging (MRI) as well as photothermal therapy (PTT) via a multifunctional nanoplatform. The poly lactic-co-glycolic acid (PLGA) was utilized to encapsulate magnetic Fe 3 O 4 nanoparticles (NPs) and NIR fluorescent dye clinical indocyanine green (ICG), by which integrated the advantages of Fe 3 O 4 NPs and clinical ICG under 808-nm laser excitation, to achieve highly efficient dual-modal imaging-guided cervical tumor ablation. This work provides a promising approach for multimodal imaging diagnosis and PTT of cervical cancer.
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 34
·27034-27042
·
IF 3.84
Haicheng Liu,Wei Chen
A magnetic molecularly imprinted polymer (MSEP@MIP) adsorbent was prepared by using magnetic Fe3O4-modified sepiolite (MSEP) particles as magnetic carrier for the efficient removal of herbicide atrazine from aqueous solution. The composition, thermal stability, chemical structure, specific surface area, morphology, and magnetic properties of MSEP@MIP adsorbent were characterized by X-ray diffraction (XRD), thermo-gravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTIR), Brunauer–Emmett–Teller (BET) method, scanning electron microscopy (SEM) and vibrating sample magnetometry (VSM). Absorption isothermal and kinetics experiments were employed to investigate the adsorption capacity of atrazine onto MSEP@MIP. The prepared MSEP@MIP adsorbent was mesoporous. Compared with magnetic non-imprinted polymer (MSEP@NIP) and MSEP, MSEP@MIP showed greater removal efficiency for atrazine (about 91.3% for an initial concentration of 0.1 mg L−1). Kinetic studies demonstrated that the adsorption process onto MSEP@MIP followed a pseudo-second-order rate equation. Isotherm studies indicated that the atrazine adsorption onto MSEP@MIP was a monolayer molecular adsorption with a maximum adsorption amount of 69.53 mg g−1. Scatchard analysis showed that there are two different kinds of binding sites in MSEP@MIP. Furthermore, the thermodynamics parameters indicated that the reaction between MSEP@MIP and atrazine was physical, exothermic, and nonspontaneous in nature.
✓ 已验证
DOI
高影响因子
Journal of Inorganic and Organometallic Polymers and Materials
·
2019
·Vol. 29
·期 5
·1625-1636
·
IF 1.637
Zhang Rui,Zhu Xuyang,Liu Yi,Cai Youfeng,Han Qiong,Zhang Tongqing,Li Yu
In this work, the versatile filler (HNTs) consisted of a halloysite nanotube as skeleton and intermediate magnetic nanoparticles coating poly(dopamine + 3-aminopropyltriethoxysilane) derivate layer were prepared. PVDF membranes were then manufactured by incorporating a series of ratios of HNTs. The Fourier-transform infrared (FT-IR), X-ray diffraction (XRD), thermogravimetric analysis (TGA) and transmission electron microscope (TEM) results proved that the modified materials were successfully achieved. The morphologies of membranes were characterized by scanning electron microscope (SEM) and atom force microscope (AFM). Meanwhile the PVDF hybrid membranes exhibited a stronger hydrophilicity (contact angle is 53°), higher bovine serum albumin (BSA) rejection (99%) than pure membrane (87°and 54%), and hybrid membranes maintain a higher flux recovery rate (FRR) that attains 85.3% after two cycles. Besides, the composite membrane showed a good removal rate (97.2%) of methylene blue. According to above experimental parameters, the 6% (based on PVDF mass) HNTs composite membrane was defined as the experimental optimal selection, and it could provide a promising candidate for methylene blue solution separation.
✓ 已验证
DOI
高影响因子
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2018
·Vol. 18
·期 7
·4445-4456
·
IF 1.354
Liu Min-Chao,Liu Bing,Sun Xiang-Yu,Lin Hui-Chao,Lu Jia-Zheng,Jin Shu-Fang,Yan Si-Qi,Li Yan-Yu,Zhao Ping
The dose-dependent toxicity and low specificity against cancerous cells have restricted the clinical use of daunomycin (DNM). Titanium dioxide (TiO2) has been wildly used as an inorganic photodynamic therapy (PDT) agent and drug carrier. To facilitate the targeted drug delivery
and combined therapy, in the present study, TiO2-coated Fe3O4 nanoparticles (Fe3O4@TiO2 NPs) were employed to load DNM and the drug-loaded Fe3O4@TiO2-DNM Nps exhibited smart pH-controlled releasing
and satisfactory cytotoxicity as well as photocytotocity. The combination of prussian blue staining and fluorescence methods evidenced the effortless cell internalization of the fabricated Fe3O4@TiO2-DNM Nps for the cancer cells. The cell cycle status experiments
indicated that the as-prepared nanospheres arrested the S and G2/M periods of the cancer cell proliferation in the dark, and further induced the apoptosis under the irradiation of ultraviolet light. The cell apoptotic results revealed that the apoptosis induced by the Fe3O4@TiO2-DNM
Nps was in the early stage. The constructed Fe3O4@TiO2-DNM NPs have been endowed with multifunctions that allow them to selectively deliver combinatorial therapeutic payload and exhibit integrated therapeutic effectiveness to tumors.
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）