ANALYTICAL CHEMISTRY
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2026
·
IF 7.3
Jianying Li,Mingyue Luo,Kehui Zhang,Honghong Rao,Haile Liu,Ruibin Qiang,Zhentong Zhu,Marcin Frankowski,Zhonghua Xue
Conventional lateral flow immunoassay (LFIA) based on gold nanoparticles (AuNPs) often suffer from low detection sensitivity. Current signal enhancement strategies, such as metal in situ growth and enzyme catalysis, still face challenges, including poor stability of exogenous chromogenic reagents (prone to aggregation/degradation), uncontrollable enhancement processes, and strong background interference. To address these critical limitations, we developed an in situ, controllable, and background-free self-color-changing enhanced LFIA (SCCE-LFIA) utilizing novel cerium oxide nanoparticles coated with a polydopamine layer (CeO2@PDA NPs). The core of this method involves the H2O2-triggered oxidation of Ce3+ to Ce4+ on the nanoprobe surface, inducing a distinct colorimetric signal change from colorless/light brown to yellow/orange directly at the test line (T line). This intrinsic chemical-state-transition-driven signal enhancement fundamentally circumvents issues of uncontrollable enhancement processes, diffusion of chromogenic products, and nonspecific adsorption, thereby eliminating severe background interference. It strongly enables rapid and sensitive detection of cardiac troponin I (cTnI), a crucial clinical biomarker, with a low visual limit of detection (vLOD) of 0.8 ng/mL with only 30 s of coloration. This work establishes a precedent for the design of in situ, controllable, and background-free signal enhancement strategies, confirms the effectiveness of CeO2@PDA NPs as substitutes for traditional chromogenic substrates, and paves the way for the development of accurate and reliable point-of-care testing (POCT) in analytical chemistry and clinical diagnostics.
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Journal of Materials Chemistry A
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2026
·
IF 9.5
Qing Cheng,Yuqi Zhang,Yingying Cao,Long Liu,Yanqiang Zhang
The novel ionic liquid-H2O2 propellants are urgently to solve the intrinsic ignition problem for achieving the aerospace applications. We addressed this issue by tuning the d-band center to adjust the catalyst's adsorption strength for IL/H2O2 toward the optimal value, thus enhancing catalytic activities for the efficient decomposition of H2O2 to generate reactive oxygen species. Herein, the regulation of the d-band center of Cu(I) in Cu(I)-MOF catalyst by precise ligand engineering design was studied. Remarkably, The Cu-S3 coordination of Cu-SH' shifts its d-band center closer to the Fermi level, promoting the adsorption of [BMIM]N(CN)2 and H2O2. Cu-SH' enables efficient H2O2 activation and robust •OH and 1 O2 generation to trigger the rapid self-ignition of [BMIM]N(CN)2-H2O2 propellant. The resulted tid as low as 18.4 ms is nearly 34% lower than that of homogeneous catalyst [FcCH2N(CH3)3]2[Cu2I4]. This work provides fundamental insights into the design of efficient ligand-based combustion catalysts for the higher performance of rockets and spacecrafts.
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Advanced Composites and Hybrid Materials
·
2026
·Vol. 9
·期 2
·129
·
IF 15.5
Yang Jingyi,Wang Shifa,Pan Zemeng,Deng Hua,Fang Leiming,Yang Hua,Zhang Huijun,Syed Asad,Gao Huajing
The development of multimodal anti-counterfeiting materials integrating photoluminescence and photochromic functions holds great significance for dynamic anti-counterfeiting and information storage. Nevertheless, traditional single-component systems typically encounter issues such as limited luminescence efficiency and a lack of diversity in color regulation methods. In this research, multi - dimensional regulation of optical properties was accomplished by fabricating a type I heterojunction of the Ba 0.5 Sr 0.5 TiO 3 (BST5)/high entropy spinel (Cd 0.2 Mg 0.2 Cu 0.2 Co 0.2 Ni 0.2 )Al 2 O 4 ((CdM)A). Phase structure and spectroscopic characterizations demonstrated that the interfacial strain remarkably facilitated the enrichment of oxygen vacancies and actuated the reversible transformation between Ti 4⁺ /Ti 3⁺ and Co 3⁺ /Co 2⁺ . This defect - color center synergistic effect not only remarkably enhances the fluorescence emission intensity but also imparts a reversible photochromic response to the sample. Further analysis indicates that the local lattice distortions and defects induced by the high entropy effect effectively enhance the efficiency of carrier migration and energy transfer. As a result, the composite system demonstrates stable cyclic luminescence - color change coupling properties under multi - wavelength excitations at 254, 302, and 365 nm. This research uncovers a unified mechanism characterized by type I band alignment and the synergy of oxygen vacancy (O V )/Ti³⁺/Co²⁺, thereby furnishing a solid theoretical foundation and compelling experimental evidence for the design of novel multi-modal dynamic anti-counterfeiting materials.
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Advanced Optical Materials
·
2026
·Vol. 14
·期 17
·e71226
·
IF 7.2
Jinwei Liu,Jiaxin Li,Guojun Zheng,Chuan Liao,Jianhong Wu,Jianrong Qiu,Wenge Xiao
Cr 3+ emission can well cover the NIR-I region (700–950 nm), while Ni 2+ emission typically extends across the NIR-II region (1000–1700 nm), making the Cr 3+ –Ni 2+ co-doped phosphors among the most promising ultrabroadband NIR emitters for phosphor-converted light-emitting diodes (pc-LEDs). However, a pronounced gap or even spectral discontinuity between the two emission bands results in a severely imbalanced photon flux across the spectrum, thereby degrading multicomponent spectral detection accuracy and significantly limiting the practical applications of such NIR pc-LED devices. Here, we report a superstoichiometric spinel MgO· n Ga 2 O 3 :Cr 3+ ,Ni 2+ ( n > 1) phosphor, in which the excess Ga 2 O 3 increases the degree of cation inversion to achieve a long-wavelength Cr 3+ emission at 895 nm, substantially elevating the spectral gap height to a state-of-the-art value of ≈36%. Moreover, efficient energy transfer from Cr 3+ to Ni 2+ enables the optimized MgO·1.2Ga 2 O 3 :Cr 3+ ,Ni 2+ phosphor to demonstrate a high internal quantum efficiency of 97% and excellent thermal stability. Finally, the as-fabricated NIR pc-LED delivers an exceptional photoelectric efficiency of 21% at 20 mA and a maximum NIR output power of 62 mW at 350 mA. This work establishes a new pathway toward next-generation compact ultrabroadband NIR pc-LEDs featuring unprecedented spectral flatness and superior optoelectronic performance.
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Frontiers in Bioengineering and Biotechnology
·
2025
·
IF 4.8
Mingliang He,Yi Pan,Jiayi Li,Yaqin Qi,Kangbei Zhu,Fangjie Zhang
Purpose This study aimed to address the limitations of synthetic meshes in incisional hernia repair by developing a bioactive composite mesh combining poly(lactic-co-glycolic acid) (PLGA), type I collagen, and bone marrow mesenchymal stem cells (BMSCs). Methods The PLGA scaffolds, fabricated via freeze-drying, were modified with collagen to enhance biocompatibility and loaded with BMSCs to promote tissue regeneration. In vitro and in vivo evaluations in a rat ventral hernia model assessed biomechanical properties, anti-adhesion efficacy, and tissue integration. Results The PLGA-Collagen I-BMSCs mesh exhibited superior anti-adhesion performance, reduced inflammatory cell infiltration by 73.3%, and enhanced neovascularization compared to commercial meshes (Sepramesh™ and Parietex™). BMSCs modulated TGF-β1/Smad3 signaling to mitigate fibrosis, while collagen alignment improved mechanical recovery. The composite mesh degraded at a rate matching tissue regeneration, with 10% PLGA maintaining structural integrity for 20 weeks. Histological analysis revealed organized collagen deposition and minimal adhesions (Nair grade 0–1 in 100% of cases). Conclusion These findings highlight the potential of the PLGA-Collagen I-BMSCs composite as an innovative intraperitoneal onlay mesh (IPOM) solution, offering mechanical stability, anti-adhesive properties, and regenerative bioactivity. This strategy shifts hernia repair from passive support to active tissue regeneration, providing a foundation for next-generation hernia repair materials.
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MOLECULES
·
2023
·Vol. 28
·期 5
·2250
·
IF 4.6
Zixuan Chen,Yuan-Yuan Zhao,Li Li,Ziqing Li,Shuwen Fu,Yihui Xu,Bi-Yuan Zheng,Meirong Ke,Xingshu Li,Jian-Dong Huang
Phthalocyanines are potentially promising photosensitizers (PSs) for photodynamic therapy (PDT), but the inherent defects such as aggregation-caused quenching effects and non-specific toxicity severely hinder their further application in PDT. Herein, we synthesized two zinc(II) phthalocyanines (PcSA and PcOA) monosubstituted with a sulphonate group in the alpha position with “O bridge” and “S bridge” as bonds and prepared a liposomal nanophotosensitizer ([email protected]) by thin-film hydration method to regulate the aggregation of PcSA in the aqueous solution and enhance its tumor targeting ability.[email protected]exhibited highly efficient production of superoxide radical (O2∙−) and singlet oxygen (1O2) in water under light irradiation, which were 2.6-fold and 15.4-fold higher than those of free PcSA, respectively. Furthermore,[email protected]was able to accumulate selectively in tumors after intravenous injection with the fluorescence intensity ratio of tumors to livers was 4.1:1. The significant tumor inhibition effects resulted in a 98% tumor inhibition rate after[email protected]was injected intravenously at an ultra-low[email protected]dose (0.8 nmol g−1PcSA) and light dose (30 J cm−2). Therefore, the liposomal[email protected]is a prospective nanophotosensitizer possessing hybrid type I and type II photoreactions with efficient photodynamic anticancer effects.Keywords:photodynamic therapy;phthalocyanine;liposome;fluorescence imaging;anticancer
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Materials Chemistry Frontiers
·
2023
·Vol. 7
·期 17
·3657-3667
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IF 7
Lirong Wang,Ji Qi,Ke Zhang,Zeyan Zhuang,Keke Ding,Xu Chen,Hong Shan,Dan Ding,Anjun Qin,Ben Zhong Tang
Fluorescence and magnetic resonance imaging (FL/MRI) has received much attention due to their complementary characteristics. However, the simultaneous enhancement of fluorescence and MR signals plus the efficacy of the treatment is still a major challenge. To tackle this difficulty, we put forward a strategy of aggregation and de-aggregation based on luminogens with aggregation-induced emission (AIE) features. NIR II photosensitizer 4,4′-(6,7-diphenyl-[1,2,5]thiadiazolo[3,4-g]quinoxaline-4,9-diyl)bis(N,N-diphenylaniline) (TQ-TPA) with type I reactive oxygen species (ROS) generation ability and amphiphilic 2TPE-Gd were synthesized, and both of them showed the AIE feature. During the construction of nanomicelles, hydrophobic TQ-TPA spontaneously aggregated into the core of the nanomicelles formed by 1,2-distearoyl-sn-glycerol-3-phosphoethanolamine-N-methoxy(polyethylene glycol)-2000 (DSPE-PEG). Meanwhile, aggregates of 2TPE (tetraphenylethylene)-Gd in aqueous solution could be de-aggregated and inserted into the interface, and formed TGdTT nanomicelles (NMs). Based on this strategy and the AIE feature, the TGdTT NMs exhibited strong NIR II fluorescence and type I ROS generation ability, and enhanced T1 relaxivity (r1). Moreover, in vitro, in vivo, and pharmacokinetics results demonstrated that these nanomicelles have good biosafety and a long blood circulation time. Finally, they allowed successful realization of complementary MR/NIR II fluorescence dual-modal imaging-guided photodynamic therapy (PDT) to inhibit tumor growth. This work demonstrated that the aggregation and de-aggregation strategy of AIEgens in core–shell nanomicelles is very attractive for constructing multifunctional theranostic probes.
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Foods
·
2023
·Vol. 12
·期 8
·1668
·
IF 5.2
Haibo Zhou,Sen Zhang,Lianghua Chen,Yimei Liu,Luhong Shen,Jiuliang Zhang
For many centuries, Gardenia (Gardenia jasminoidesEllis) was highly valued as a food homologous Chinese herbal medicine with various bioactive compounds, including crocin I and geniposide. However, the functional mechanism underlying the hypoglycemic effect of gardenia is absent in the literature. To evaluate the effect of gardenia and its different extracts on type 2 diabetes mellitus (T2DM) in in vivo and in vitro experiments, the dried gardenia powder was extracted using 60% ethanol and eluted at different ethanol concentrations to obtain the corresponding purified fragments. After that, the active chemical compositions of the different purified gardenia fragments were analyzed using HPLC. Then, the hypoglycemic effects of the different purified gardenia fragments were compared using in vitro and in vivo experiments. Finally, the different extracts were characterized using UPLC-ESI-QTOF-MS/MS and the mass spectrometric fragmentation pathway of the two main compounds, geniposide and crocin I, were identified. The experimental results indicated that the inhibitory effect of the 40% EGJ (crocin I) on the α-glucosidase was better than the 20% EGJ (geniposide) in vitro. However, the inhibitory effect of geniposide on T2DM was better than crocin I in the animal experiments. The different results in vivo and in vitro presumed potentially different mechanisms between crocin I and geniposide on T2DM. This research demonstrated that the mechanism of hypoglycemia in vivo from geniposide is not only one target of the α-glucosidase but provides the experimental background for crocin I and the geniposide deep processing and utilization.Keywords:gardenia;α-glucosidase;crocin I;geniposide;type 2 diabetes mellitus
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Small
·
2022
·Vol. 19
·期 11
·2204238
·
IF 15.153
Jing Wang,Jing Zhao,Fang Ma,Liuyun Gong,Yinliang Lu,Weiping Xiao,Hanmin Tang,Chengyi Gao,Yuetong Chen,Jun Ma,Zhan Gao,Jin Yan,Suxia Han
Over half of cancer patients are subjected to radiotherapy, but owing to the deficient amount of reactive oxygen radicals (ROS) and DNA double-strand breaks (DSBs), a fair number of them suffer from radiotherapy resistance and the subsequent short-term survival opportunity. To overcome it, many successes have been achieved in radiosensitizer discovery using physical strategy and/or biological strategy, but significant challenges remain regarding developing clinically translational radiosensitizers. Herein, a peptide-Au(I) infinite coordination supermolecule termed PAICS is developed that combined both physical and biological radiosensitization and possessed pharmaceutical characteristics including adequate circulatory stability, controllable drug release, tumor-prioritized accumulation, and the favorable body eliminability. As expected, monovalent gold ion endowed this supermolecule with high X-ray absorption and the subsequent radiosensitization. Furthermore, a peptide targeting CRM1, is assembled into the supermolecule, which successfully activates p53 and apoptosis pathway, thereby further sensitizing radiotherapy. As a result, PAICS showed superior ability for radiotherapy sensitization in vivo and maintained a favorable safety profile. Thus, the PAICS reported here will offer a feasible solution to simultaneously overcome both the pharmaceutical obstacles of physical and biological radiosensitizers and will enable the development of a class of nanomedicines for tumor radiotherapy sensitization.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2023
·
IF 4.4
Yonghui Xuan,Xiang Li,Changling Yan,Gongke Wang
As traditional methods for detection of heavy metal pollution in water involve complex procedures and require expensive equipment, there is a great deal of interest in the development of rapid and simple methods for determining heavy metal ions in water. Here, a nanobiosensor based on molybdenum disulphide (MoS 2 ) nanosheets and fluorophore (FAM) labeled oligonucleotides was proposed, and fluorescence spectroscopy was adopted for detection of Hg 2+ or Ag + ions in aqueous solution. The principle underlying detection by the sensor involves the formation of T-Hg 2+ -T or C-Ag + -C mismatches by single-stranded DNA (ssDNA) rich in thymine (T) or cytosine (C), thereby forming stable double-stranded DNA (dsDNA) structures. By exploiting the different adsorption capacity of MoS 2 nanosheets for ssDNA and dsDNA, when oligonucleotides were in a single chain state, MoS 2 nanosheets possessed a strong adsorption capacity for ssDNA, resulting in fluorescence quenching of FAM. After the addition of Hg 2+ or Ag + , ssDNA formed double chains structure, the fluorescence recovered due to the weak adsorption capacity of MoS 2 nanosheets for dsDNA. Along this line, an “off-on” mode fluorescence nanobiosensor was designed to alternatively detect these two heavy metal ions in water. The sensor showed high sensitivity and excellent selectivity for both Hg 2+ and Ag + ions, with minimum detection limits of 6.8 nM and 8.9 nM, respectively.
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ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Fengmei Zhu,Yuan Gao,Chunli Zhao,Jiacheng Pi,Jianbei Qiu
Near-infrared phosphor-converted light-emitting diodes (NIR pc-LEDs) offer numerous advantages, including compact size, tunable emission spectra, energy efficiency, and high integration potential. These features make them highly promising for various applications, such as night vision monitoring, food safety inspection, biomedical imaging, and theragnostics. All-inorganic halide double-perovskite materials, known for their large absorption cross section, excellent defect tolerance, and long carrier diffusion radius, serve as unique matrices for constructing near-infrared fluorescent materials. In this study, we successfully prepared the all-inorganic metal halide double-perovskite Cs2NaYCl6:Cr3+ using a grinding–sintering method. A small fraction of the [YCl6] octahedra within the host material’s lattice was substituted with Cr3+ ions, resulting in the creation of the Cs2NaYCl6:Cr3+ phosphor. When excited with λ = 310 nm UV light, the phosphor exhibited a broad emission range spanning from 800 to 1400 nm, covering the NIR-I and NIR-II regions. It had a broad bandwidth emission of 185 nm and achieved a fluorescence quantum yield of 20.2%. The unique broadband emission of the phosphor originates from the weak crystal field environment provided by the Cs2NaYCl6 host matrix, which enhances the luminescence properties of the Cr3+ ions. To create NIR pc-LEDs, the phosphor was encapsulated onto a commercially available UV LED chip operating at 310 nm. The potential application of these NIR pc-LEDs in night vision imaging was successfully validated.
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Journal of Inflammation Research
·
2022
·
IF 4.631
Huixia Feng,Guilin Chen,Yongli Zhang,Mingquan Guo
Background Dysosma versipellis ( D. versipellis ) has been traditionally used as a folk medicine for ages. However, the specific phytochemicals responsible for their correlated anti-inflammatory, anti-proliferative and antiviral activities remain unknown. Purpose This study aimed to explore the specific active components in D. versipellis responsible for its potential anti-inflammatory, anti-proliferative, and antiviral effects, and further elucidate the corresponding mechanisms of action. Methods Bioaffinity ultrafiltration coupled to liquid chromatography–mass spectrometry (UF-LC/MS) was firstly hired to fast screen for the anti-inflammatory, anti-proliferative and antiviral compounds from rhizomes of D. versipellis , and then further validation was conducted using in vitro inhibition assays and molecular docking. Results A total of 12, 12, 9 and 12 phytochemicals with considerable affinities to Topo I, Topo II, COX-2 and ACE2 were fished out, respectively. The anti-proliferative assay in vitro indicated that podophyllotoxin and quercetin exhibited comparably strong inhibitory rates on A549 and HT-29 cells compared with 5-FU and etoposide. Meanwhile, kaempferol displayed prominent dose-dependent inhibition against COX-2 with IC 50 value at 0.36 ± 0.02 μM lower than indomethacin at 0.73 ± 0.07 μM. Furthermore, quercetin exerted stronger inhibitory effect against ACE2 with IC 50 value at 104.79 ± 8.26 μM comparable to quercetin 3- O -glucoside at 135.25 ± 6.54 μM. Conclusion We firstly showcased an experimental investigation on the correlations between bioactive phytochemicals of D. versipellis and their multiple drug targets reflecting its potential pharmacological activities, and further constructed a multi-target and multi-component network to decipher its empirical traditional applications. It could not only offer a reliable and valuable experimental basis to better comprehend the curative effects of D. versipellis but also provide more new insights and strategies for other traditional medicinal plants.
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