SENSORS AND ACTUATORS B-CHEMICAL
·
2026
·
IF 8.3
Yongfei Huang,Li Zhang,Zhefeng Fan
Photodynamic therapy (PDT) holds great promise for tumor treatment, but its clinical translation is greatly hindered by the drawbacks of conventional photosensitizers (PSs), such as insufficient reactive oxygen species (ROS) generation, exclusive type‑II photoreaction, poor subcellular targeting, and compromised efficacy in hypoxic tumors. Herein, we rationally designed and synthesized a mitochondria‑targeted near‑infrared (NIR) photosensitizer Mito‑IsTp with a classic D-π-A architecture, using isophorone as the electron acceptor, methoxy‑modified triphenylamine as the electron donor, benzene as the π‑bridge, and triphenylphosphonium as the mitochondrial‑targeting group. Mito‑IsTp displays a maximum emission peak at 770 nm within the NIR‑I window, together with satisfactory photostability and solvent‑dependent optical performance. Upon 660 nm NIR light irradiation, Mito‑IsTp can simultaneously produce type‑I (•OH, O 2 -• ) and type‑II ( 1 O 2 ) ROS with much higher efficiency than commercial Rose Bengal and Chlorin e6 (Ce6). Confocal imaging verifies its excellent mitochondrial targeting ability in HeLa cells with a Pearson correlation coefficient of 0.97. In vitro experiments reveal negligible dark toxicity and efficient phototoxicity to induce cancer cell apoptosis through ROS-mediated mitochondrial damage. In vivo studies on HeLa tumor‑bearing nude mice further show that Mito‑IsTp ‑mediated PDT significantly suppresses tumor growth without obvious systemic toxicity or organ injury, confirmed by body weight recording, H&E staining, blood routine tests, and hemocompatibility assessment. This work presents a high‑performance NIR PS with dual‑pathway ROS generation and precise mitochondrial targeting, establishing a feasible paradigm for hypoxia‑resistant and mitochondria‑targeted tumor PDT.
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Advanced Optical Materials
·
2026
·Vol. 14
·期 17
·e71226
·
IF 7.2
Jinwei Liu,Jiaxin Li,Guojun Zheng,Chuan Liao,Jianhong Wu,Jianrong Qiu,Wenge Xiao
Cr 3+ emission can well cover the NIR-I region (700–950 nm), while Ni 2+ emission typically extends across the NIR-II region (1000–1700 nm), making the Cr 3+ –Ni 2+ co-doped phosphors among the most promising ultrabroadband NIR emitters for phosphor-converted light-emitting diodes (pc-LEDs). However, a pronounced gap or even spectral discontinuity between the two emission bands results in a severely imbalanced photon flux across the spectrum, thereby degrading multicomponent spectral detection accuracy and significantly limiting the practical applications of such NIR pc-LED devices. Here, we report a superstoichiometric spinel MgO· n Ga 2 O 3 :Cr 3+ ,Ni 2+ ( n > 1) phosphor, in which the excess Ga 2 O 3 increases the degree of cation inversion to achieve a long-wavelength Cr 3+ emission at 895 nm, substantially elevating the spectral gap height to a state-of-the-art value of ≈36%. Moreover, efficient energy transfer from Cr 3+ to Ni 2+ enables the optimized MgO·1.2Ga 2 O 3 :Cr 3+ ,Ni 2+ phosphor to demonstrate a high internal quantum efficiency of 97% and excellent thermal stability. Finally, the as-fabricated NIR pc-LED delivers an exceptional photoelectric efficiency of 21% at 20 mA and a maximum NIR output power of 62 mW at 350 mA. This work establishes a new pathway toward next-generation compact ultrabroadband NIR pc-LEDs featuring unprecedented spectral flatness and superior optoelectronic performance.
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ANALYTICAL CHEMISTRY
·
2026
·
IF 7.3
Jianying Li,Mingyue Luo,Kehui Zhang,Honghong Rao,Haile Liu,Ruibin Qiang,Zhentong Zhu,Marcin Frankowski,Zhonghua Xue
Conventional lateral flow immunoassay (LFIA) based on gold nanoparticles (AuNPs) often suffer from low detection sensitivity. Current signal enhancement strategies, such as metal in situ growth and enzyme catalysis, still face challenges, including poor stability of exogenous chromogenic reagents (prone to aggregation/degradation), uncontrollable enhancement processes, and strong background interference. To address these critical limitations, we developed an in situ, controllable, and background-free self-color-changing enhanced LFIA (SCCE-LFIA) utilizing novel cerium oxide nanoparticles coated with a polydopamine layer (CeO2@PDA NPs). The core of this method involves the H2O2-triggered oxidation of Ce3+ to Ce4+ on the nanoprobe surface, inducing a distinct colorimetric signal change from colorless/light brown to yellow/orange directly at the test line (T line). This intrinsic chemical-state-transition-driven signal enhancement fundamentally circumvents issues of uncontrollable enhancement processes, diffusion of chromogenic products, and nonspecific adsorption, thereby eliminating severe background interference. It strongly enables rapid and sensitive detection of cardiac troponin I (cTnI), a crucial clinical biomarker, with a low visual limit of detection (vLOD) of 0.8 ng/mL with only 30 s of coloration. This work establishes a precedent for the design of in situ, controllable, and background-free signal enhancement strategies, confirms the effectiveness of CeO2@PDA NPs as substitutes for traditional chromogenic substrates, and paves the way for the development of accurate and reliable point-of-care testing (POCT) in analytical chemistry and clinical diagnostics.
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Advanced Composites and Hybrid Materials
·
2026
·Vol. 9
·期 2
·129
·
IF 15.5
Yang Jingyi,Wang Shifa,Pan Zemeng,Deng Hua,Fang Leiming,Yang Hua,Zhang Huijun,Syed Asad,Gao Huajing
The development of multimodal anti-counterfeiting materials integrating photoluminescence and photochromic functions holds great significance for dynamic anti-counterfeiting and information storage. Nevertheless, traditional single-component systems typically encounter issues such as limited luminescence efficiency and a lack of diversity in color regulation methods. In this research, multi - dimensional regulation of optical properties was accomplished by fabricating a type I heterojunction of the Ba 0.5 Sr 0.5 TiO 3 (BST5)/high entropy spinel (Cd 0.2 Mg 0.2 Cu 0.2 Co 0.2 Ni 0.2 )Al 2 O 4 ((CdM)A). Phase structure and spectroscopic characterizations demonstrated that the interfacial strain remarkably facilitated the enrichment of oxygen vacancies and actuated the reversible transformation between Ti 4⁺ /Ti 3⁺ and Co 3⁺ /Co 2⁺ . This defect - color center synergistic effect not only remarkably enhances the fluorescence emission intensity but also imparts a reversible photochromic response to the sample. Further analysis indicates that the local lattice distortions and defects induced by the high entropy effect effectively enhance the efficiency of carrier migration and energy transfer. As a result, the composite system demonstrates stable cyclic luminescence - color change coupling properties under multi - wavelength excitations at 254, 302, and 365 nm. This research uncovers a unified mechanism characterized by type I band alignment and the synergy of oxygen vacancy (O V )/Ti³⁺/Co²⁺, thereby furnishing a solid theoretical foundation and compelling experimental evidence for the design of novel multi-modal dynamic anti-counterfeiting materials.
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Journal of Materials Chemistry A
·
2026
·
IF 9.5
Qing Cheng,Yuqi Zhang,Yingying Cao,Long Liu,Yanqiang Zhang
The novel ionic liquid-H2O2 propellants are urgently to solve the intrinsic ignition problem for achieving the aerospace applications. We addressed this issue by tuning the d-band center to adjust the catalyst's adsorption strength for IL/H2O2 toward the optimal value, thus enhancing catalytic activities for the efficient decomposition of H2O2 to generate reactive oxygen species. Herein, the regulation of the d-band center of Cu(I) in Cu(I)-MOF catalyst by precise ligand engineering design was studied. Remarkably, The Cu-S3 coordination of Cu-SH' shifts its d-band center closer to the Fermi level, promoting the adsorption of [BMIM]N(CN)2 and H2O2. Cu-SH' enables efficient H2O2 activation and robust •OH and 1 O2 generation to trigger the rapid self-ignition of [BMIM]N(CN)2-H2O2 propellant. The resulted tid as low as 18.4 ms is nearly 34% lower than that of homogeneous catalyst [FcCH2N(CH3)3]2[Cu2I4]. This work provides fundamental insights into the design of efficient ligand-based combustion catalysts for the higher performance of rockets and spacecrafts.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Yonghui Xuan,Xiang Li,Changling Yan,Gongke Wang
As traditional methods for detection of heavy metal pollution in water involve complex procedures and require expensive equipment, there is a great deal of interest in the development of rapid and simple methods for determining heavy metal ions in water. Here, a nanobiosensor based on molybdenum disulphide (MoS 2 ) nanosheets and fluorophore (FAM) labeled oligonucleotides was proposed, and fluorescence spectroscopy was adopted for detection of Hg 2+ or Ag + ions in aqueous solution. The principle underlying detection by the sensor involves the formation of T-Hg 2+ -T or C-Ag + -C mismatches by single-stranded DNA (ssDNA) rich in thymine (T) or cytosine (C), thereby forming stable double-stranded DNA (dsDNA) structures. By exploiting the different adsorption capacity of MoS 2 nanosheets for ssDNA and dsDNA, when oligonucleotides were in a single chain state, MoS 2 nanosheets possessed a strong adsorption capacity for ssDNA, resulting in fluorescence quenching of FAM. After the addition of Hg 2+ or Ag + , ssDNA formed double chains structure, the fluorescence recovered due to the weak adsorption capacity of MoS 2 nanosheets for dsDNA. Along this line, an “off-on” mode fluorescence nanobiosensor was designed to alternatively detect these two heavy metal ions in water. The sensor showed high sensitivity and excellent selectivity for both Hg 2+ and Ag + ions, with minimum detection limits of 6.8 nM and 8.9 nM, respectively.
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Small
·
2022
·Vol. 19
·期 11
·2204238
·
IF 15.153
Jing Wang,Jing Zhao,Fang Ma,Liuyun Gong,Yinliang Lu,Weiping Xiao,Hanmin Tang,Chengyi Gao,Yuetong Chen,Jun Ma,Zhan Gao,Jin Yan,Suxia Han
Over half of cancer patients are subjected to radiotherapy, but owing to the deficient amount of reactive oxygen radicals (ROS) and DNA double-strand breaks (DSBs), a fair number of them suffer from radiotherapy resistance and the subsequent short-term survival opportunity. To overcome it, many successes have been achieved in radiosensitizer discovery using physical strategy and/or biological strategy, but significant challenges remain regarding developing clinically translational radiosensitizers. Herein, a peptide-Au(I) infinite coordination supermolecule termed PAICS is developed that combined both physical and biological radiosensitization and possessed pharmaceutical characteristics including adequate circulatory stability, controllable drug release, tumor-prioritized accumulation, and the favorable body eliminability. As expected, monovalent gold ion endowed this supermolecule with high X-ray absorption and the subsequent radiosensitization. Furthermore, a peptide targeting CRM1, is assembled into the supermolecule, which successfully activates p53 and apoptosis pathway, thereby further sensitizing radiotherapy. As a result, PAICS showed superior ability for radiotherapy sensitization in vivo and maintained a favorable safety profile. Thus, the PAICS reported here will offer a feasible solution to simultaneously overcome both the pharmaceutical obstacles of physical and biological radiosensitizers and will enable the development of a class of nanomedicines for tumor radiotherapy sensitization.
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Food & Function
·
2022
·Vol. 13
·期 13
·7062-7074
·
IF 6.317
Fengwei Ma,Qingfang Deng,Huayong Lou,Jinyu Li,Su Xu,Wenneng Wu,Qihua Wen,Lei Tang,Xin Wang,Weidong Pan
Self-heal (Prunella vulgaris L.) is a perennial edible plant that is widely distributed across the world and is traditionally consumed as a food additive in soft drink beverages. In this study, to explore the functional components of P. vulgaris, an investigation of its ethanol extracts has been conducted by our group. As a result, twelve (1–12) vulgarisin-type diterpenoids with a special 5/6/4/5-fused ring skeleton, including six new ones (1–6), were obtained. Their structures including the absolute configuration were elucidated based on comprehensive spectroscopic evidence, ECD calculations, as well as single-crystal X-ray diffraction analyses. All the isolates were tested for neuroprotective effects against ischemia/reperfusion (I/R) on primary neuron cells through the oxygen and glucose deprivation and reperfusion (OGD/R) induced injury model. The results showed that all twelve vulgarisin-type diterpenoids possess promising neuroprotective activity at a concentration of 10 μM. Among them, compound 3 can significantly suppress cell apoptosis by regulating Bax/Bcl-2 protein expression and inhibiting cleaved caspase-3 and caspase-9 expression with a western blotting assay. Further research revealed that compound 3 could improve mitochondrial function by inhibiting mitochondrial cytochrome c release, reducing ROS levels, and maintaining the membrane potential. This work firstly reports vulgarisin-type diterpenoids possessing neuroprotective activity. These findings also suggest that daily consumption of P. vulgaris might prevent cerebral disorders via a mitochondria-related pathway.
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Journal of Inflammation Research
·
2022
·
IF 4.631
Huixia Feng,Guilin Chen,Yongli Zhang,Mingquan Guo
Background Dysosma versipellis ( D. versipellis ) has been traditionally used as a folk medicine for ages. However, the specific phytochemicals responsible for their correlated anti-inflammatory, anti-proliferative and antiviral activities remain unknown. Purpose This study aimed to explore the specific active components in D. versipellis responsible for its potential anti-inflammatory, anti-proliferative, and antiviral effects, and further elucidate the corresponding mechanisms of action. Methods Bioaffinity ultrafiltration coupled to liquid chromatography–mass spectrometry (UF-LC/MS) was firstly hired to fast screen for the anti-inflammatory, anti-proliferative and antiviral compounds from rhizomes of D. versipellis , and then further validation was conducted using in vitro inhibition assays and molecular docking. Results A total of 12, 12, 9 and 12 phytochemicals with considerable affinities to Topo I, Topo II, COX-2 and ACE2 were fished out, respectively. The anti-proliferative assay in vitro indicated that podophyllotoxin and quercetin exhibited comparably strong inhibitory rates on A549 and HT-29 cells compared with 5-FU and etoposide. Meanwhile, kaempferol displayed prominent dose-dependent inhibition against COX-2 with IC 50 value at 0.36 ± 0.02 μM lower than indomethacin at 0.73 ± 0.07 μM. Furthermore, quercetin exerted stronger inhibitory effect against ACE2 with IC 50 value at 104.79 ± 8.26 μM comparable to quercetin 3- O -glucoside at 135.25 ± 6.54 μM. Conclusion We firstly showcased an experimental investigation on the correlations between bioactive phytochemicals of D. versipellis and their multiple drug targets reflecting its potential pharmacological activities, and further constructed a multi-target and multi-component network to decipher its empirical traditional applications. It could not only offer a reliable and valuable experimental basis to better comprehend the curative effects of D. versipellis but also provide more new insights and strategies for other traditional medicinal plants.
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CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Yao Tong,Qin Wang,Xiaoting Liu,Enrou Mei,Xiaojuan Liang,Weidong Xiang
All-inorganic CsPbX 3 (X = Cl, Br, I) perovskite nanocrystals (PNCs) hold tremendous prospect in optoelectronics. Different from the previous method of preparing perovskite glass, the self-crystallization of CsPbX 3 (X = Cl, Br, I) PNCs glasses were successfully synthesized by introducing TiO 2 into the glass matrix without subsequent annealing and heat treatment engineering. The effective realization of self-crystallization was attributed to the nucleating agent changing the glass structure which has been confirmed by DSC, XPS, FTIR tests. As a nucleating agent, TiO 2 reduced the crystallization temperature of BSZ glasses and promoted controlled nucleation of PNCs. Surprisingly, the self-crystallized glass with high Photoluminescence quantum yield (PLQY) of 41.2% showed strong hydrothermal stability. After soaking in water for 30 days, the Pb 2+ escaped did not change significantly. The green-emitting LEDs made of BSZ-xTi achieved tunable colour coordinates of (0.1038–0.1177, 0.7376–0.7386). Furthermore, combining BSZ-2Ti with BrI 2 -2Ti on InGaN chip, the wide-color-gamut covering 93.15% of the Rec. 2020 standard was achieved. This study has an important role in guiding the synthesis of time-saving, environment-friendly and low-cost PNCs glasses, which made a contribution to deepening the understanding of the promoting effect of related nucleating agents on nucleation of PNCs.
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Advanced Optical Materials
·
2021
·Vol. 9
·期 11
·2100012
·
IF 9.926
Yao Tong,Qin Wang,Enrou Mei,Xiaojuan Liang,Wei Gao,Weidong Xiang
All-inorganic perovskite (CsPbX 3 , X = Cl, Br, I) nanocrystals (NCs) with promising optical properties are recognized as a rising star among photoelectric materials, but their inevitable instabilities limit extensive application. Herein, a new one-step strategy for encapsulating CsPbX 3 NCs with porous zeolite via the hot injection method is explored. By altering the mole ratio of PbX 2 , the emission wavelength of CsPbX 3 @zeolite is found to be regularly modulated from blue-emission (CsPbCl 2 Br@zeolite, 436 nm) to red-emission (CsPbBrI 2 @zeolite, 648 nm), thus enabling full spectrum adjustment. Due to the surface passivation of zeolite to CsPbX 3 NCs, CsPbX 3 @zeolite possess an outstanding quantum yield and display excellent thermal/photo/air stability. Subsequently, white light-emitting diodes based on green-CsPbBr 3 @zeolite and red-CsPbBrI 2 @zeolite are constructed and applied to the backlit display, achieving a wide color gamut of 134.2% for NTSC 1953 and 99.8% for Rec. 2020. The CsPbX 3 @zeolite implanted with a polymethyl methacrylate film is used to realize upconversion emission under an 800 nm laser at room temperature. Furthermore, amplified spontaneous radiation based on CsPbBr 3 @zeolite films is achieved. These results convincingly indicate broad application prospects for CsPbX 3 @zeolite prepared via this simple method.
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Journal of Materials Chemistry B
·
2020
·Vol. 8
·期 47
·10854-10866
·
IF 5.344
Cuifu Fang,Zhiwei Zhong,Teng Zhang,Shuang Jia,Xingwei Ding,Weimin Zhou,Xiaolei Wang
Problems such as massive hemorrhage caused by uncontrolled drug dosage are the main significant obstacles in clinical thrombolytic therapy, which are prominently due to the lack of targeting and controlled release ability of efficient thrombolytic drug systems. In recent years, our team demonstrated that the photothermal effect can facilitate the thrombolytic effect of urokinase plasminogen activator (uPA). However, conventional photothermal agents are relatively expensive or contain heavy metals. If drug delivery systems with low toxicity, minimized heavy metal elements and easy accessibility (preferably provided by human self) can be developed, they will be of value in the future related applications. Herein, uPA-loaded human black hair derived nanoparticles with gelatin capsules (uPA@HBHNP@GNCs) were applied for the first time as a thrombolytic system. Upon irradiation by near-infrared I window (NIR-I) laser or II window (NIR-II) laser, the photothermal effect of HBHNP was triggered to promote the melting of the gelatin encapsulated around the outer layer, thereby realizing the targeted release of uPA. The in vitro and in vivo experiments demonstrated that the deep response to NIR (especially II window) of this system exhibited a satisfactory thrombolytic effect with ideal biosafety. Briefly, the proposed hair derived drug delivery system has the characteristics of human source, low cost, minimum heavy metal components, deep response to NIR (II window) laser, and good biocompatibility, which is expected to be expanded to the treatment for some diseases, even in deep tissue areas.
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