MEDICINAL CHEMISTRY RESEARCH
·
2022
·Vol. 31
·期 6
·936-948
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IF 2.351
Hu Shijia,Li Yunqi,Kan Weiqiong,Ding Tingting,Gu Haijun,Zhang Ting,Yi Zhengfang,Chen Yihua
A series of diphenyl- N -heteroaromatic compounds were designed, synthesized, and evaluated for anticancer efficacies (antimigration and antiproliferation) against human cancer cell lines. The favorable 2 H -1,2,3-triazole compound 4a was optimized, leading to the discovery of compounds 4b and 4c with more potent antimigratory and antiproliferative activities. The transwell assay showed that compounds 4b and 4c dose-independently inhibited the migration of the two cancer cell lines (human breast cancer cell line MDA-MB-231 and pancreatic cancer cell line PANC1) with the low IC 50 values of 0.24 and 0.47 µM, respectively. The sulforhodamine-B (SRB) assay showed that compounds 4b and 4c inhibited the proliferation of PANC1 cells with the IC 50 values 0.86 µM and 1.41 µM, respectively. These results indicate that compounds 4b and 4c with 1,2,3-triazole scaffold may be further developed as potent anticancer agents in the future.
A series of novel diphenyl- N -heteroaromatics based on our previous published research work were synthesized and evaluated for their antimigration efficacies against MDA-MB-231 and PANC1 human cancer cell lines. Compound 4c dose-independently inhibited the migration of the two cancer cell lines (MDA-MB-231 and PANC1) with low IC 50 values 0.32 µM and 0.24 µM respectively.
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ELECTROCHIMICA ACTA
·
2021
·
IF 6.901
Shuyue Yang,Dongmei Zhang,Jie Xu,Zongping Zhang,Shibing Ni
High theoretical capacity and safety performance endow Li 3 VO 4 with great promising as anode material for Li-ion batteries. However, approaches and inner mechanisms to advance the performance of Li 3 VO 4 are limited. Herein, we demonstrate for the first time, continuously-high pseudocapacitive charge storage triggered by N doped MXene in a Li 3 VO 4 -based electrode, resulting in excellent comprehensive electrochemical performance. The hybrid electrode delivers high discharge capacity of 515.2 mAh g −1 after 500 cycles at 0.1 A g −1 . After periodic rate performance test from 0.1 to 2.0 A g −1 for 410 cycles, the capacity of the hybrid electrode can be fully recovered. Followed by additional 1000 cycles at 0.5 A g −1 , the hybrid electrode still delivers high discharge capacity of 457.6 mAh g −1 . The robust capacitive charge storage induced by N doped MXene and the remarkable comprehensive electrochemical performance are referential for the design of high performance Li 3 VO 4 -based anode material, and the facile approach is beneficial for mass production toward practical application. Graphical abstract Download : Download high-res image (210KB) Download : Download full-size image N doped MXene induced robust pseudocapacitive charge storage in a Li 3 VO 4 electrode is firstly demonstrated responsible for the excellent comprehensive electrochemical performance.
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INTERNATIONAL BIODETERIORATION & BIODEGRADATION
·
2020
·
IF 4.074
Chengcheng Feng,Ying Zhang,Lei Wang,Xiaoqian Li,Yiyang Chen,Jianhua Qu,Kai Zhen
Phthalate esters (PAEs) in the environment are mainly reported to be removed through the biochemical degradation by microorganisms . However, the adsorption of DBP is the initial process of using it as a carbon source. In this process, little is known about changes in cell surface properties at the subcellular level of degrading bacteria. In our work, Novosphingobium species DNB-S3 was found to be an efficient DBP-degrading bacterium with 95% DBP removal in 72 h at an initial concentration of 500 mg L −1 . In soil simulation experiment, the initial concentration of DBP decreased from 25 mg kg −1 to 1.9 mg kg −1 after the inoculation of DNB-S3. In addition, DNB-S3 also showed degradation capability on other PAEs. DNB-S3 was cultured under four treatment conditions with different carbon sources, namely MSM-DBP, MSM-GLU, MSM-DBP + GLU, and LB. The cell surface hydrophobicity , functional groups on cell surface and morphological changes of DNB-S3 were further investigated. Morphological studies showed that the presence of DBP induced the disappearance of microcapsule on DNB-S3. Infrared spectroscopy and Raman spectra of DNB-S3 surface showed that the lipid-containing groups on the outer membrane were externally exposed from cellular structure, resulting in an increase of cell surface hydrophobicity (CSH). Eventually, the high CSH indicates that DNB-S3 has an efficient ability of DBP uptake. Our research adds an interesting dimension to the degradation study of bacterially mediated organic pollutants and the uptake mechanisms of hydrocarbons.
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高影响因子
ENERGY & FUELS
·
2020
·
IF 3.421
Wei Zhao,Shanshan Ruan,Siyu Qian,Beibei Feng,Chengcheng Ao,Lei Wang,Fuyi Liu,Lidong Zhang
Catalytic combustion has become a promising technology to address the accelerating volatile organic compounds (VOCs) emissions. In this work, cobalt modified ZSM-5 zeolite catalysts (3–18 wt % Co) were prepared to investigate the combustion of n-butane (one typical model component of VOCs). The performances of catalysts were evaluated by conducting experiments in a flow tube reactor. XRD, BET, FT-IR, and XPS were also utilized to characterize their physicochemical properties. A significant enhancement of the catalytic activity was demonstrated in terms of the cobalt supported over ZSM-5, with an optimal cobalt loading of 7 wt %. The excellent catalytic activity of 7 wt % Co-ZSM-5 is mainly attributed to a higher concentration of active surface Co3+ species. Furthermore, DFT calculations indicated that the role of Co can enhance the activity by decreasing the activation barriers for C–H bond cleavage. In addition, the primary reaction mechanism of n-butane combustion on Co-ZSM-5 was also revealed.
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International Journal of Minerals Metallurgy and Materials
·
2020
·Vol. 27
·期 12
·1687-1694
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IF 1.713
Tian Dong-hua,Han Zhen-chao,Wang Ming-yong,Jiao Shu-qiang
Graphite materials are widely used as electrode materials for electrochemical energy storage. N-doping is an effective method for enhancing the electrochemical properties of graphite. A novel one-step N-doping method for complete and compact carbon paper was proposed for molten salt electrolysis in the LiCl-KCl-Li 3 N system. The results show that the degree of graphitization of carbon paper can be improved by the electrolysis of molten salts, especially at 2.0 V. Nitrogen gas was produced at the anode and nitrogen atoms can substitute carbon atoms of carbon paper at different sites to create nitrogen doping during the electrolysis process. The doping content of N in carbon paper is up to 13.0wt%. There were three groups of nitrogen atoms, i.e. quaternary N (N-Q), pyrrolic N (N-5), and pyridinic N (N-6) in N-doping carbon paper. N-doping carbon paper as an Al-ion battery cathode shows strong charge-recharge properties.
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Journal of Materials Chemistry C
·
2015
·Vol. 3
·期 12
·2933-2939
·
IF 4.696
Li Wang,Hong-Wei Song,Zhen-Xing Liu,Xu Ma,Ran Chen,Yong-Qiang Yu,Chun-Yan Wu,Ji-Gang Hu,Yan Zhang,Qiang Li,Lin-Bao Luo
In this study, we reported on the construction of p–n junctions based on crystalline Ga-doped CdS–polycrystalline ZnTe nanostructures (NSs) for optoelectronic device application. The coaxial nano-heterojunction was fabricated by a two-step growth method. It is found that the absorption edge of CdS:Ga–ZnTe:Sb core–shell NSs red shifted to about 580 nm, compared with CdS nanowires (520 nm). The as-fabricated core–shell p–n junction exhibited obvious rectification characteristics with a low turn-on voltage of ∼0.25 V. What is more, it showed stable and repeatable photoresponse to 638 nm light illumination, with a responsivity and a detectivity of 1.55 × 103 A W−1 and 8.7 × 1013 cm Hz1/2 W−1, respectively, much higher than other photodetectors with similar device configurations. The generality of this study suggests that the present coaxial CdS:Ga–ZnTe:Sb core–shell nano-heterojunction will have great potential applications in future nano-optoelectronic devices.
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KOREAN JOURNAL OF CHEMICAL ENGINEERING
·
2014
·Vol. 32
·期 6
·1158-1163
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IF 1.241
Yang Wenge,Wu Keyi,Hu Yonghong,Zhang Tuan,Guo Qirun,Yang Shouhai,Shi Ying
The solubility of N-ethylcarbazole in (ethanol+petroleum ether) binary solvent mixtures was measured with the temperature changing from 280.15 K to 316.15 K. The experimental data matched the solvent/Redlich-Kister (CNIBS/R-K) equation and the Jouyban-Acree equation. Computational results showed the CNIBS/R-K equation was more suitable than the Jouyban-Acree equation. The solution process in the thermodynamic properties, including the Gibbs energy, enthalpy, and entropy, was calculated by the van’t Hoff analysis.
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ChemCatChem
·
2025
·
IF 3.9
Xinquan Wu,Zhen Sun,Hao Li,Xiaolei Guo,Zhen-Feng Huang,Ruijie Gao,Chengxiang Shi,Xiangwen Zhang,Lun Pan,Ji-Jun Zou
Platinum-based catalysts are highly effective for the oxygen reduction reaction (ORR), but their prohibitive cost and insufficient activity impede large-scale commercialization. Herein, we report a Pt@Fe-NC electrocatalyst synthesized by depositing uniform platinum nanoparticles onto an iron–nitrogen–carbon (Fe–NC) support via an ethylene glycol reduction method. The Fe–NC support, prepared from an iron (II)-1,10-phenanthroline complex precursor to ensure high iron utilization, modulates the electronic structure of the Pt nanoparticles, thereby enhancing both catalytic activity and stability. The optimized Pt@Fe-NC catalyst (13.54 wt% Pt) exhibits exceptional ORR performance in acidic media, with a half-wave potential of 0.852 V and notable stability. When integrated into a zinc-air battery, the catalyst delivered a high specific capacity of 652.66 mAh g Zn −1 . Furthermore, a proton exchange membrane fuel cell (PEMFC) employing this catalyst achieved a high open-circuit voltage (OCV) of 0.964 V and a peak power density of 1.722 W cm −2 , outperforming most previously reported Pt-based catalysts. This study highlights a synergistic strategy between Pt nanoparticles and metal-nitrogen-carbon (M–N–C) supports to boost ORR performance, presenting a viable path toward advanced, cost-effective catalysts for energy conversion devices like PEMFCs and zinc-air batteries. Graphical A method of preparing Fe–NC loaded Pt nanoparticle catalysts is presented. The method is used to prepare Fe–NC substrate by loading iron complexes with 1,10-phenanthroline on carbon black and then Pt nanoparticles obtained by ethylene glycol reduction method are loaded on the Fe–NC substrate. The results show that the enhanced activity of the Pt@Fe-NC catalyst is due to the modification of the electronic structure of Fe on Pt in the Fe-NC support.
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DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Qingping Xin,Zhaoqi Qu,Xinghui Zhang,Xingwei Wang,Jiaxin Wu,Dengdi Wu,Wei Huang,Mengke Wang,Ningning Gao,Xiaoli Ding,Yuzhong Zhang
Composite membranes, which consist of a multi-layer membrane structure comprising an ultra-thin dense separation layer and a porous support layer, are used for gas separation. However, issues such as poor adhesion between layers often arise. In this study, a novel reverse-induced diffusion method was employed to achieve the in situ growth of a covalent organic framework COF (TaPa-1) on one side of polyacrylonitrile (PAN) at room temperature, resulting in the formation of a tightly bonded gutter layer. Subsequently, a metal-organic framework MOF (NH 2 -ZIF-8) was secondarily grown in situ on the TaPa-1 membrane to prepare a PAN/COF-MOF composite membrane with stable interlayer bonding. The TaPa-1 layer, with high gas permeability, and the NH 2 -ZIF-8 layer due to sheltering effect, with high gas selectivity, act synergistically to enable efficient gas sieving and rapid transport. When treating simulated flue gas (CO₂/N₂ = 1:4), the gas separation selectivity of the PAN/COF-MOF composite membrane reach 29.9, with a CO₂ permeability of 825 GPU, achieving excellent CO₂ separation performance. In this study, the PAN/COF-MOF composite membrane is constructed using the reverse-induced diffusion method, achieving stable interlayer bonding and synergistic separation, demonstrating excellent CO₂ permeability and selectivity.
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高影响因子
CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Qiang Hu,Tongqing Chen,Lingling Yan,Junhui Yi,Hongxin Cai,Liang Chen,Lingli Wang
A series of Nd 2 O 3 -decorated ZnO nanosheets were successfully synthesized through a facile hydrothermal approach for n-butanol sensing applications. The results demonstrate that Nd 2 O 3 modification significantly improves the sensing performance. The optimal sensor with 7.5 wt% Nd 2 O 3 loading (denoted as Nd2) achieves a high response of 1503.73 toward 100 ppm n-butanol (68 times higher than that of pure ZnO), along with a rapid recovery time of 3 s and a low detection limit of 500 ppb. Furthermore, the sensor exhibits excellent selectivity against common volatile organic compounds (VOCs) and long-term stability. Comprehensive performance analyses reveal that the performance enhancement originates from the synergistic effect of two fundamental mechanisms: the formation of Nd 2 O 3 /ZnO heterojunctions that effectively modulate the electron-depletion layer, and the increased oxygen vacancy concentration that promotes surface redox kinetics. This work not only highlights the application potential of Nd 2 O 3 /ZnO heterostructures in n-butanol detection, but also provides a feasible material design strategy for developing high-performance gas sensors.
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产品关联
DOI
高影响因子
BIOORGANIC CHEMISTRY
·
2025
·
IF 4.7
Ruobin Sun,Qipeng Yan,Wenhao Deng,Pengcheng Chen,Dan Wu,Pu Zheng
Achieving enzyme catalysis at high substrate concentrations is a substantial challenge in industrial biocatalysis, and the role of glycosylation in post-translational modifications that modulate enzyme substrate inhibition remains poorly understood. This study provides insights into the role of N -glycosylation in substrate inhibition by comparing the catalytic properties of d -lactonohydrolase ( d -Lac) derived from Fusarium moniliforme expressed in prokaryotic and eukaryotic hosts. Experimental evidence indicates that recombinant d -Lac expressed in Pichia pastoris ( Pp Lac-WT) exhibits higher hydrolysis rates at a substrate concentration of 400 g/L, with reduced substrate inhibition and enhanced stability compared to the recombinant d -Lac expressed in Escherichia coli ( Ec Lac-WT). Mutant Pp Lac-M1 achieves a conversion rate of 40 % at a substrate concentration of 400 g/L, with a space–time yield of d -pantoic acid reaching 91.1 g/L/h. Proteomics analysis reveals that residues N29 and N278, located approximately 10–20 Å from the active site undergo N -glycosylation in Pp Lac-WT. Using microsecond-scale molecular dynamics simulations and Markov state models, we elucidate the effects of glycosylation on the conformational flexibility of two key loops at the entrance of the binding pocket. Specifically, the loops in Pp Lac-WT can transition between open and closed states, whereas those in Ec Lac-WT tend to remain open. In high substrate concentration conditions, the open state causes congestion, leading to substrate inhibition. Shortest-path map analysis confirms that substrate entry is dynamically controlled by residue N29 on the loops surrounding the active site. Our findings enhance the understanding of the effects of glycosylation on enzyme conformational dynamics and provide insights into mitigating inhibition at high substrate concentrations.
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PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Wei Sun,Kang Guo,JinChen Fan,Yulin Min,Qunjie Xu
In this paper, we have adopted a simple and etching-free method to prepare mesoporous carbon spheres in one step. Selenium can be deposited in the internal cavity, which can avoid pulverization due to the combined effect of volume expansion and a solid–electrolyte interphase (SEI) film while charging and discharging. Therefore, the as-prepared selenium and nitrogen codoped mesoporous carbon nanosphere (Se@NMCS) composites can deliver an outstanding sodium-storage performance of 336.6 mAh g–1 at a present density of 200 mA g–1 and great long-cycling performance. For a further understanding of the Na+ storage mechanism of the Se@NMCS anode in sodium-ion batteries (SIBs), the phase evolution of the Se@NMCS anode has been explored during the charge/discharge process by conducting in situ Raman investigation.
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