Materials Today Communications
·
2023
·
IF 3.8
Ran Feng,Jiazhi Meng,Hualei Yuan,Xu Zhang,Chunlang Gao,Chaogang Ban,Yizhong Guo,Kaiwen Wang
Cancers, Down’s syndrome, Alzheimer’s and other diseases of gene mutation always occur with anomalous changes of DNA nucleic acid base. Therefore, the development of highly sensitive and reproducible nucleic acid sensors that based upon surface enhanced Raman scattering (SERS) is of immense interest for clinical medical analysis and diagnosis. Herein, a rationally designed core-shell assembly of Au nanoparticle wrapped with Au doped Bi 5 O 7 Br nanotube with eliminated fluorescent background and notable chemical enhancement effect was exploited and served as a SERS sensor for detection of adenine. Especially, we found the fluorescent background was remarkably suppressed in Raman spectra by introducing Au element into Bi 5 O 7 Br. The sensor exhibited a maximum SERS enhancement factor of up to 5.45 × 10 7 and a detection limit as low as 10 −11 M after constructing Au nanoparticle/Au atom doped Bi 5 O 7 Br heterojunction . More importantly, good reproducibility and long term stability under work condition were achieved. To gain in-depth understanding into chemical mechanism (CM) of the Raman signal enhancement, density functional calculations (DFTs) were combined with atom-specific model derived via aberration corrected transmission electron microscope (AC-TEM) to demonstrate the enhanced charge transfer (CT) and substrate-adsorbate adsorption. The doping and coupling strategy holds the potential to fabricate high signal-to-noise ratio SERS sensors for other molecule detection.
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Energy & Environmental Materials
·
2022
·
IF 13.443
Guanglin Zhang,Jie Sun,Genwang Wei,Shan Zhang,Zhengyi He,Huijuan Wu,Bingkun Wang,Siwei Yang,Guqiao Ding,Zhiduo Liu,Zhiwen Jin,Caichao Ye,Gang Wang
Nitrogen-doped three-dimensional graphene (N-doped 3D-graphene) is a graphene derivative with excellent adsorption capacity, large specific surface area, high porosity, and optoelectronic properties. Herein, N-doped 3D-graphene/Si heterojunctions were grown in situ directly on silicon (Si) substrates via plasma-assisted chemical vapor deposition (PACVD), which is promising for surface-enhanced Raman scattering (SERS) substrates candidates. Combined analyses of theoretical simulation, incorporating N atoms in 3D-graphene are beneficial to increase the electronic state density of the system and enhance the charge transfer between the substrate and the target molecules. The enhancement of the optical and electric fields benefits from the stronger light-matter interaction improved by the natural nano-resonator structure of N-doped 3D-graphene. The as-prepared SERS substrates based on N-doped 3D-graphene/Si heterojunctions achieve ultra-low detection for various molecules: 10 −8 M for methylene blue (MB) and 10 −9 M for crystal violet (CRV) with rhodamine (R6G) of 10 −10 M. In practical detected, 10 −8 M thiram was precisely detected in apple peel extract. The results indicate that N-doped 3D-graphene/Si heterojunctions based-SERS substrates have promising applications in low-concentration molecular detection and food safety.
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JOURNAL OF MOLECULAR STRUCTURE
·
2023
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IF 3.8
Xiyue Wang,Shang Gao,Junfu Wang,Xinying Fan,Chi Song,Chuanwei Zhou,Shuyun Shi,Dandan Wang,Hongji Li
In this work, a novel sensor for selective detection of 2,6-dichlorophenol (2,6-DCP) is developed by combining the selectivity of molecular imprinting technology (MIPs) with the sensitivity of SERS technology. In order to enhance SERS activity of the substrate, Ag nanoparticles are loaded on Ta 2 O 5 particles by means of photodeposition. The synthesized Ta 2 O 5 @Ag is combined with MIL-101 (Fe) to enrich more target molecules and reduce the limit of detection. Finally, Ta 2 O 5 /Ag/MIL-101(Fe)@MIPs (TAM@MIPs) is synthesized by precipitation polymerization for selective detection of 2,6-DCP. When the concentration of 2,6-DCP changes between the range of 10 −2 ∼ 10 −9 M, the Raman intensity and concentration present a good linear relationship. The correlation coefficient (R 2 ) is 0.9969 and the limit of detection (LOD) of 2,6-DCP is 10 −9 M. Furthermore, Under UV-irradiation, the TAM@MIPs also presents photocatalytic performance, which can effectively degrade the organic interfering molecule adsorbed on its surface and present high-efficiency reproducibility. This method broadens the application field of SERS detection and provides a new procedure for the phenolic pollutant detection.
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Materials Chemistry Frontiers
·
2023
·Vol. 7
·期 8
·1624-1632
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IF 7
Kangkang Wang,Zhexue Chen,Yueqi Li,Yong Zhang
Semiconductor quantum dots (QDs) are of great interest for a wide range of applications. Herein, we report the top-down production of CdSe QDs with a super small size (about 3 nm) and high yield (14%). The as-produced QDs exhibit different optical properties from those of colloidal QDs. This is probably due to the generation of numerous bare edges during the process of silica-assisted ball-milling. The CdSe QD-based substrate could serve as a surface-enhanced Raman scattering (SERS) substrate for the ultrasensitive recognition of probe molecules at trace levels, which are mainly attributed to the special edge–edge interactions and charge transfer (CT) enhancement mechanism. The substrate exhibits good reproducibility, uniformity, and high enhancement factor (5.05 × 106) with an expansion of the ultra-low limit of detection (LOD) to 10−10 M. It has also been successfully used in the reliable, quantitative, and label-free detection of uric acid (UA) at a low concentration (1 μM), which facilitates the early prevention of gout disease. This QD-based platform not only confirms the feasibility of SERS analysis but also provides ideas for the early detection of residues.
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FOOD CHEMISTRY
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2023
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IF 8.8
Xianlong Zhang,Yiheng Shi,Panpan Wang,Di Wu,Jianghua Liu,Rui Huang,Yongning Wu,Guoliang Li
Inspired by a biomineralization behavior, we prepared a nanoflower-like artificial clickase (namely LCN clickase) for portable and sensitive click SERS immunoassay of foodborne bacterial pathogen. Encouraged by its high click catalytic activity to trigger Cu(I)-catalyzed azide-alkyne cycloaddition reaction, LCN clickase was successfully used for establishing a novel click SERS immunoassay by combining the clickase-mediated SERS signal variation at Raman-silent region. The developed method not only effectively eliminated the interferences between Raman reporter and biological species, but also reduced the complex sample matrix interference. Compared with traditional CuAAC-based immunoassays, the established method avoided the superfluous dissolution process of nanocatalysts and eliminated the requirement of reducing agent during detection, thereby shortening detection time and improving detection reliability. Impressively, the proposed method showed high selectivity and sensitivity for detection of Salmonella enterica serovar Paratyphi B with a low LOD of 20 CFU/mL, exhibiting a great potential in detection of foodborne bacterial pathogen in food samples.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2022
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IF 6.371
Yalan He,Dongling Wu,Qian Liu,Jun Tang,Rong Chang,Tao Wang
Ag nanosheets (AgNS) exhibit enormous potential because of their unique structure and properties. However, the commonly used methods to synthesize AgNS have some disadvantages, such as long reaction time or high reaction temperature, or they involve toxicity and irritating corrosion solvents, which greatly limit their development and application. In this study, AgNS with edge lengths of 500–600 nm, and thicknesses of 25–30 nm are rapidly synthesized by ethylene glycol/deionized water (EG/DI water, solvent), poly(vinylpyrrolidone) (PVP, capping agent), ascorbic acid ( L -AA, reducing agent) at 0 °C in only 30 min. This study provides a fast and facile approach for the stable and large-scale production of AgNS. Benefiting from the unique structure of the prepared AgNS, as the SERS substrate it can be used to detect dye molecules (R6G), and achieves a superb enhancement factor of 8.7 × 10 7 . What’s more, it is also successfully realized practical detection of antibiotic benzylpenicillin sodium (NaBP) in milk. The results indicate that the AgNS produced by a simple and efficient method may serve as a high-efficiency SERS substrate for speedy chemical contamination detection.
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PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2022
·Vol. 25
·期 3
·1649-1658
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IF 3.945
Jun Dong,Haoran Wu,Yi Cao,Jiaxin Yuan,Qingyan Han,Wei Gao,Chengyun Zhang,Jianxia Qi,Mengtao Sun
In this study, a capillary device based on the surface plasmon-enhanced Raman scattering effect was prepared by a simple and easy method. First, the capillary was treated with APTES solution. Due to the electrostatic effect, gold nanoparticles could be easily and tightly assembled in the capillary inner wall. On this basis, the effects of changing the concentration of APTES, the concentration of colloids and the soaking time of the capillary in the colloids on the assembly of gold nanoparticles on the inner wall of the capillary were studied, and the SERS enhancement effect under different conditions was analyzed, and the optimal solution was successfully found. At the same time, the reason why the capillary substrate shows better SERS performance than the traditional planar substrate is deeply discussed. Since the nanoparticles can be attached to the upper and lower surfaces of the inner wall of the capillary, the utilization rate of nanoparticles and laser is improved, thereby achieving higher enhancement. For the detection of the probe molecule rhodamine 6G, it was proved that the substrate has good uniformity and the lowest detection limit can reach 10−10 M. Finally, the real-life pesticide thiram and the food additive aspartame were tested, and the detection limits could reach 10−6 M and 0.25 g L−1. It is confirmed that the prepared capillary shows excellent SERS performance and can be used for rapid detection in various fields.
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MICROCHEMICAL JOURNAL
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2022
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IF 5.304
Yan-Hua Yuan,Hai-Xin Gu,Qi-Yuan Xie,Jun Zhang
Surface-enhanced Raman scattering (SERS) technology has been widely used in the field of environmental pollutant detection due to its fast and intuitive characteristics and low water interference. Herein, a low-cost and flexible SERS substrate was fabricated by transferring gold nanoparticles (NPs) onto polydimethylsiloxane (AuNPs@PDMS) membranes, which enabled highly sensitive detection of aromatic amine pollutants in wastewater after fire suppression. Finite time domain-difference calculations confirmed that the uniformly distributed NP gap significantly enhanced the localized electromagnetic field. The AuNPs@PDMS substrate performed satisfactorily in testing for rhodamine 6G (R6G) with a detection limit (LOD) of 5.5 × 10 −10 M. This substrate also demonstrated high reproducibility for detection of different concentrations of R6G and the relative standard deviation (RSD) was <7 %. These excellent SERS properties made AuNPs@PDMS a promising substrate in the detection of aniline and benzidine. Quantitative analysis of aniline and benzidine was achieved with LODs of 4.5 × 10 −9 and 7.8 × 10 −9 M, respectively. In addition, this substrate could be applied in rapid analysis of mixtures in wastewater after fire suppression using SERS without any complex pretreatments, displaying a great potential for rapid, high-sensitivity, and on-site detection of contaminants in fire-fighting sites.
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ANALYST
·
2022
·Vol. 147
·期 24
·5785-5795
·
IF 5.227
Xuanyu Sha,Guoqiang Fang,Guangxu Cao,Shuzhi Li,Wuliji Hasi,Siqingaowa Han
Drug abuse is a global social issue of concern. As the drug market expands, there is an urgent need for technological methods to rapidly detect drug abuse to meet the needs of different situations. Here, we present a strategy for the rapid identification of benzodiazepines (midazolam and diazepam) using surface-enhanced Raman scattering (SERS) combined with neural networks (CNN). The method uses a self-assembled silver nanoparticle paper-based SERS substrate for detection. Then, a SERS spectrum intelligent recognition model based on deep learning technology was constructed to realize the rapid and sensitive distinction between the two drugs. In this work, a total of 560 SERS spectra were collected, and the qualitative and quantitative identification of the two drugs in water and a beverage (Sprite) was realized by a trained convolutional neural network (CNN). The predicted concentrations for each scenario could reach 0.1–50 ppm (midazolam in water), 0.5–50 ppm (midazolam in water and diazepam in Sprite), and 5–150 ppm (diazepam in Sprite), with a strong coefficient of determination (R2) larger than 0.9662. The advantage of this method is that the neural network can extract data features from the entire SERS spectrum, which makes up for information loss when manually identifying the spectrum and selecting a limited number of characteristic peaks. This work clearly clarifies that the combination of SERS and deep learning technology has become an inevitable development trend, and also demonstrates the great potential of this strategy in the practical application of SERS.
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BIOSENSORS & BIOELECTRONICS
·
2023
·
IF 12.6
Huanhuan Li,Wenhui Geng,Zhixiong Qi,Waqas Ahmad,Suleiman A. Haruna,Quansheng Chen
In this work, a stimuli-responsive SERS biosensor was fabricated for tetracycline (TTC) by “signal-on” strategy using (EDTA)-driven polyethyleneimine grafted calcium carbonate ( [email protected] 3 ) microcapsule and chitosan-Fe magnetic microbeads ( [email protected] ). Initially, aptamer conjugated magnetic-bead [email protected] @Apt with superparamagnetism and excellent biocompatibility was employed as capture probe, which facilitated the rapid and easy magnetic separation. Subsequently, the PEI cross-linked layer and aptamer network layer were constructed onto the outer layer of CaCO 3 @4-ATP microcapsule to form sensing probes ( [email protected] 3 @ [email protected] ) via the layer-by-layer assembly method. In the presence of TTC, a sandwich SERS-assay was exploited by aptamer recognition induced target-bridged strategy. When the solution of EDTA was added, the core layer of CaCO 3 would be dissolved quickly, destroying the microcapsule to release 4-ATP. The released 4-ATP could be quantitatively monitored by dripping the supernatant onto the [email protected] SERS platform, resulting in a strong Raman “signal-on”. Under the optimal conditions, a good linear relationship was established with a correlation coefficient ( R 2 ) of 0.9938 and a LOD of 0.03 ng/mL. Additionally, the application capacity of the biosensor to detect TTC was also affirmed in food matrixes, and the results were consistent with the standard ELISA method ( P > 0.05). Hence, this SERS biosensor affords extensive application prospects for TTC detection with multiple merits such as high sensitivity, environment friendliness, and high stability.
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ANALYTICAL CHEMISTRY
·
2023
·
IF 7.4
Xiaoming Su,Xinyu Liu,Yangcenzi Xie,Mingyang Chen,Hong Zhong,Ming Li
The prevalence of fentanyl abuse raises global public health concerns with an unprecedented surge in overdose deaths. Rapid identification and quantification of fentanyl in biofluids is of paramount importance to combat fentanyl abuse for law enforcement agencies and promptly treat patients for medical professionals. Herein, a freestanding surface-enhanced Raman spectroscopy (SERS) biosensor with excellent condensing enrichment capability, termed FrEnSERS biosensor, is reported for quantitative label-free detection of trace fentanyl in biofluids. This biosensor comprises a reduced graphene oxide membrane decorated with high-density hydrophobic Au nanostars. A combination of the high SERS enhancement and the focusing effect for analyte enrichment of the hydrophobic surface accounts for the remarkable SERS performance of the FrEnSERS biosensor. We demonstrate that the FrEnSERS biosensor achieves the sensitive and quantitative detection of fentanyl in both serum and urine over a wide dynamic range spanning more than 4 orders of magnitude, with a limit of detection of 0.47 ng/mL for serum samples and 0.73 ng/mL for urine samples. Our biosensor is sensitive, cost-effective, and reliable for rapid quantitative analysis of fentanyl in biofluids with great promise for forensic analysis and clinical diagnosis.
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RSC Advances
·
2023
·Vol. 13
·期 8
·5002-5012
·
IF 3.9
Tianxing Wang,Panpan Xiao,Li Ye,Pengcheng Zhu,Lin Zhuang
The combination of plasmonic metals and photonic crystal (PC) structure is considered to have potential for further enhancement of the surface-enhanced Raman scattering (SERS) effect in comparison with conventional metal SERS substrates. Many studies have suggested that SERS signals probably suffer from an often-neglected effect of strong surface plasmon resonance (SPR)-induced photothermal heating during SERS detection. Herein, we have discovered that the photothermal heating problem arises in a traditional hybrid substrate that is prepared by doping plasmonic Au nanoparticles (NPs) into the voids of an opal PC (Au-PC). This happens mainly because excess Au agglomerates formed by non-uniformly distributed Au NPs can cause a strong SPR effect under laser illumination. To fully address this issue, we have employed an improved hybrid substrate that is fabricated by substituting Au NPs in Au-PC with an Au-loaded magnetic framework (AuMF). The AuMF can effectively prevent the aggregation of Au NPs and ensure sufficient hot spots for SERS. This novel substrate prepared by doping AuMFs into a PC (AuMF-PC) was free of strong photothermal heating and showed high SERS intensity and reproducibility of the SERS signal compared with Au-PC. For practical applications, we have demonstrated AuMF-PC as an appropriate candidate for the SERS assay of the trace thiol pesticide thiram, and it enables recycling and reuse to achieve low cost.
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