Journal of Bionic Engineering
·
2023
·Vol. 20
·期 5
·1956-1966
·
IF 4
Fu Ye,Ai Shulun,Guo Zhiguang,Liu Weimin
Oily wastewater pollution is an urgent problem to be solved. Complicated preparation process, toxic hydrophobic modifiers and poor mechanical properties limit the application of polysaccharide-based aerogel in oil–water separation. Inspired by the Strider’s Leg structure in nature, an eco-friendly and reusable polysaccharide-based composite aerogel was prepared by hydrophobic modification with zein for efficient oil–water separation. The introduction of hydrophobic zein into aerogel by simple immersion method without the use of toxic modifiers can build micro/nanostructures similar to the villi on a water strider’s leg to increase the surface roughness and the hydrophobicity. And three degradable, non-toxic and economical polysaccharides including chitosan, carboxylated cellulose nanofibers and starch were used to construct aerogel skeleton, endowing aerogel with porous structures and good mechanical properties. The resulting composite aerogel (ZOMA) showed low density (0.11 g/cm 3 ), good oil absorption capacity (9 g/g), high flux oil–water separation (5595 L m −2 h −1 ) and excellent oil–water separation performance (99.8%). And ZOMA still had good tensile strength and elasticity after 50 compression cycles. After 10 cycles of absorption and desorption, ZOMA aerogel remained still more than 90% of its initial absorption capacity. This study provides new insight for the design of environmentally friendly and efficient adsorbents for oil–water separation.
研究领域:
材料科学
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环境科学
·
生物仿生学
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Nutrition & Diabetes
·
2024
·Vol. 14
·期 1
·1-9
·
IF 4.6
Li Hui,Fang Yujiao,Wang Da,Shi Bowen,Thompson Garth J.
Background Quantitative mapping of the brain’s metabolism is a critical tool in studying and diagnosing many conditions, from obesity to neurodegenerative diseases. In particular, noninvasive approaches are urgently required. Recently, there have been promising drug development approaches for the treatment of disorders related to glucose metabolism in the brain and, therefore, against obesity-associated diseases. One of the most important drug targets to emerge has been the Glucagon-like peptide-1 (GLP-1) and its receptor (GLP-1R). GLP and GLP-1R play an important role in regulating blood sugar and maintaining energy homeostasis. However, the macroscopic effects on brain metabolism and function due to the presence of GLP-1R are unclear. Methods To explore the physiological role of GLP-1R in mouse brain glucose metabolism, and its relationship to brain function, we used three methods. We used deuterium magnetic resonance spectroscopy (DMRS) to provide quantitative information about metabolic flux, fluorodeoxyglucose positron emission tomography (FDG-PET) to measure brain glucose metabolism, and resting state-functional MRI (rs-fMRI) to measure brain functional connectivity. We used these methods in both mice with complete GLP-1R knockout (GLP-1R KO) and wild-type C57BL/6N (WT) mice. Results The metabolic rate of GLP-1R KO mice was significantly slower than that of WT mice ( p = 0.0345, WT mice 0.02335 ± 0.057 mM/min, GLP-1R KO mice 0.01998 ± 0.07 mM/min). Quantification of the mean [ 18 F]FDG signal in the whole brain also showed significantly reduced glucose uptake in GLP-1R KO mice versus control mice ( p = 0.0314). Observing rs-fMRI, the functional brain connectivity in GLP-1R KO mice was significantly lower than that in the WT group ( p = 0.0032 for gFCD, p = 0.0002 for whole-brain correlation, p < 0.0001 for ALFF). Conclusions GLP-1R KO mice exhibit impaired brain glucose metabolism to high doses of exogenous glucose, and they also have reduced functional connectivity. This suggests that the GLP-1R KO mouse model may serve as a model for correlated metabolic and functional connectivity loss.
研究领域:
神经科学
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代谢疾病
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药理学
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成像技术
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PubMed
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Electrocatalysis
·
2019
·Vol. 10
·期 3
·253-261
·
IF 2.311
Pan Yi,Fang Yini,Jin Haonan,Zhang Ming,Wang Lina,Ma Shijie,Zhu Han,Du Mingliang
The development of low-cost, highly active, and robust electrocatalysts for catalyzing the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) holds a pivotal role in electrocatalytic water splitting. Herein, a two-step method was presented to synthesize CoS 2 /CoP heterostructures grown on carbon cloth (CoS 2 /CoP/CC). The precursor Co(OH)F/CC synthesized through the hydrothermal process can be successfully converted into CoS 2 /CoP/CC catalyst via gas-phase phosphorization and sulfurization. The as-obtained CoS 2 /CoP/CC exhibited promising performances for HER and OER with low overpotentials of 90 and 334 mV at a current density of 10 mA cm −2 in 1.0 M KOH, respectively. The improved electrocatalytic performance of the CoS 2 /CoP/CC can be attributed to the strong electron interactions and synergistic efforts between CoS 2 and CoP, abundant active sites of the heterostructures, and enhanced smaller charge-transfer resistance.
研究领域:
电催化
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材料科学
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能量转换
·
氢气生产
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Cell Death Discovery
·
2026
·
IF 10.4
Hao Wenli,Gao Song,Guo Suhan,Luo Jingjing,Li Siyu,Lu Junze,Jiang Lulu,Lu Jie,Wang Nan,Ran Aijia,Qian Xiaoyun,Gao Xia,Yu Chenjie,Cheng Cheng
Lipid metabolism is an important biological process that maintains the dynamic balance of several key functions, such as intracellular energy metabolism, signal transduction, and membrane remodeling. However, the role of lipid metabolism in auditory function and the underlying mechanisms remain unclear. Our results reveal that the neomycin exposure disrupts lipid metabolism in auditory system. We find that neomycin-induced hair cells (HC) damage leads to abnormal lipid droplets (LD) accumulation. Further research reveals that decreased YAP expression is a key factor that contributes to abnormal LD accumulation. In both in vivo and in vitro studies, Yap overexpression reduces abnormal LD accumulation and mitigated HC damage. To further investigate its downstream mechanisms, we perform a cross-analysis of Yap -related and lipid metabolism–related genes, identifying that Cox2 is a key downstream target of Yap that contributes to LD accumulation and HC damage. Our work provides clear evidence for the role of lipid metabolism in neomycin-induced hearing loss and elucidates underlying mechanism of Yap/Cox2 pathway. These findings provide new perspectives and avenues for the clinical treatment of sensorineural hearing loss.
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Advanced Composites and Hybrid Materials
·
2026
·
IF 15.5
Cheng Xinyuan,Zhang Miaoqian,Shen Kuankuan,Chen Minzhang,Lu Ang
Power density is one of the most critical factors determining the practical applicability of thermoelectric materials. To enhance this property, herein, hierarchically structured hydrogels composed of carboxymethyl cellulose, phytic acid, polyaniline and Fe 3+ (CPPF) were prepared via a one-pot approach. At the nanometer scale, the CPPF nanoparticles and nanofibers formed a continuous network structure via multiply covalent and non-covalent interactions. The continuous distribution of polyaniline within the hydrogel matrix facilitates the redox reactions occurring within the hydrogel bulk and enhances ion diffusion, which imparts distinctive electrochemical properties along with superior energy storage and discharge capabilities. The maximum thermopower values of -2.8 mV·K − 1 (n-type) and 3.79 mV·K − 1 (p-type) were achieved. Using a single hydrogel unit for external discharge, the peak energy densities of 274.11 J·m − 2 and 319.83 J·m − 2 , alongside peak average power densities of 4.57 W·m − 2 and 5.33 W·m − 2 , were attained, higher than the previous literatures. A thermoelectric module comprising 40 p-n legs was constructed and successfully powered a light bulb, demonstrating outstanding potential for real-world applications. In addition, at the micrometer scale, the bamboo-like closed-cell structure exhibits tunable mechanical stiffness and achieving a maximum compressive stress of 6.5 MPa, while the soft variant demonstrated bendable and foldable properties with notable elasticity. The present work demonstrates a novel hierarchically structured hydrogel with both superior energy density and mechanical property, which supplies new ideas for the designation of high-performance hydrogel based thermoelectric materials.
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CHEMICAL PAPERS
·
2026
·
IF 2.7
Li Ze
To improve the drug performance of the antibiotic gatifloxacin (GAT), a novel molecular salt was designed and synthesized using cinnamic acid (CIA), a phenolic acid nutrient with inherent antibacterial activity. This salt-forming strategy modifies the solid-state structure of GAT without altering its covalent framework, leading to enhanced physicochemical and antibacterial properties. The obtained GAT-CIA molecular salt was thoroughly characterized by single-crystal X-ray diffraction, thermal analysis, and powder X-ray diffraction. Structural studies revealed that proton transfer from CIA to the piperazine nitrogen of GAT generates a quaternary hydrogen-bonded motif, resulting in a two-dimensional layered architecture. Compared with pure GAT, the molecular salt exhibits significantly improved solubility, intrinsic dissolution rate, and membrane permeability, especially under neutral pH conditions. Furthermore, antibacterial assays demonstrated that GAT-CIA possesses stronger inhibitory activity against several bacterial strains, owing to the enhanced physiochemical property arising from the cocrystallization of GAT and CIA. This work provides a practical cocrystallization approach to simultaneously optimize the biopharmaceutical properties and antibacterial efficacy of fluoroquinolone antibiotics. Graphic abstract A novel molecular salt of the antibacterial drug gatifloxacin (GAT) with CIA has been assembled and systematically characterized. The results showed that both the physicochemical properties and antibacterial activities of GAT were improved. The alternative text for this image may have been generated using AI.
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Carbon Letters
·
2026
·
IF 6.2
Hou Lin,Yang Xiaopeng,Li Yali,Yang Yilin,Han Yuying,Hu Rui,Ding Lixin,Hou Xingyu
Herein, biomass-derived carbon dots (BD-CDs) were synthesized via a solid-state pyrolysis method. A combination of various characterization techniques, including fluorescence lifetime decay, Fourier-transform infrared spectroscopy, and Zeta potential measurements, was employed to elucidate the group binding mechanism between BD-CDs and glutathione (GSH). Upon application to actual samples, including tomatoes, cucumbers, and celery, the method exhibited exceptional analytical efficacy. Calibration curves comprising two distinct segments (0-120 µM and 120-260 µM), coupled with a detection limit of 0.02 µM. This strategy provides a dependable method for the highly sensitive detection of GSH within intricate matrices, presenting auspicious potential for further development and application within the domains of biosensing and pharmaceutical analysis.
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Light-Science & Applications
·
2026
·Vol. 15
·期 1
·200
·
IF 24
Fang Ziyi,Pan Xiaofeng,Zhang Qi’an,Wu Mingzhi,Liu Yang,Ma Qidong,Ren Biyun,Wang Yanze,Liu Shengqiang,Zulfiqar Maryam,Ju Ming-Gang,Gan Jiulin,Li Leipeng,Wang Feng,Peng Dengfeng
Materials exhibiting mechanoluminescence (ML) that directly convert mechanical stimuli into light hold significant potential for real-time stress sensing and intelligent photonic systems. However, most high-performance ML systems rely on complex multicomponent compounds that often suffer from limited intensity, stability, and scalability, largely due to poorly understood mechanisms. Herein, we report a simple Al 2 O 3 :Cr 3+ oxide that exhibits unprecedented ML intensity, enabled by a well-defined mechanical-to-optical energy conversion process. The self-recoverable ML arises from stress-induced ionization of electrons from luminescence centers, followed by their recapture upon stress release. By precisely tuning the doping levels, annealing conditions, and heterojunction interfaces, Al 2 O 3 :Cr 3+ phosphors achieved intense, reproducible, and thermally stable near-infrared emission. Notably, high-temperature annealing dramatically enhanced the ML intensity, with thermodynamic and kinetic analyses revealing increases in the carrier and defect concentrations by several orders of magnitude, accounting for the exceptional brightness. By leveraging the chemical robustness, abundance, and low cost of alumina, we demonstrated the flexible ML paper for stress visualization and multi-level anti-counterfeiting, as well as in-situ grown Al 2 O 3 :Cr 3+ luminescent layers on Cr–Al alloys for passive, real-time stress monitoring. This study establishes Al 2 O 3 as a durable and scalable oxide platform for next-generation self-recoverable ML materials, bridging fundamental research and practical sensing technologies.
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JOURNAL OF FLUORESCENCE
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2026
·
IF 3.4
Liu Tianhui,Yan Yiling,Chen Zhenni,Zhao Chengfei
In recent years, fluorescent sensors based on carbon quantum dots (CQDs) have been widely reported for pharmaceutical detection owing to their numerous advantages. In this study, a Fe³⁺-mediated fluorescence “off–on” sensor based on nitrogen-doped carbon quantum dots (N-CQDs) was developed for the selective detection of tiopronin (TPN). Briefly, highly fluorescent N-CQDs were synthesized via a one-step hydrothermal method using citric acid monohydrate and diethylenetriamine. XPS, FT-IR, UV-Vis, fluorescence spectroscopy, and DLS confirmed that the N-CQDs exhibit uniform size, aqueous stability, excitation-independent fluorescence, and a high quantum yield of 62.99%. Fe³⁺ selectively bound to N-CQDs to form a complex, resulting in fluorescence quenching. Subsequently, upon the addition of TPN, the fluorescence of N-CQDs showed a proportional recovery. During this process, the competitive coordination between TPN and Fe³⁺ led to the release of Fe³⁺ from the N-CQDs, thereby restoring the quenched fluorescence. The limit of detection (LOD) of TPN was 80 μmol/L, with a linear range of 0.2–0.7 mmol/L and an R² value of 0.9993. The content of TPN in enteric-coated tablets was quantified using this method, yielding recovery rates ranging from 92.59% to 104.22%. This method is simple, rapid, and reliable, offering good sensitivity without the need for expensive reagents or complex equipment. Graphical The alternative text for this image may have been generated using AI. Schematic illustration of the synthesis of N-CQDs and their application as an “off–on” fluorescent probe for TPN detection via Fe³⁺-mediated
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Nature Communications
·
2026
·
IF 18.1
Yu Hongwei,Xin Xing,Ge Jiawen,Luo Yunyun,Cui Yanming,Zang Xu-Feng,Xu Tonghui,Zheng Tianle,Mandic Zoran,Xia Yongyao,Zhou Mingjiong
Lithium metal batteries offer a pathway toward next-generation energy storage due to their high specific energy. However, their implementation remains challenging, particularly under lean electrolyte conditions, where unstable interfaces and inefficient ion transport severely limit cycling stability. Here, we show a bifunctional ligand-bridged electrolyte by integrating ethyl difluoroacetate into a lithium nitrate/triethyl phosphate matrix. Incorporating ethyl difluoroacetate as a dynamic bridging agent drives the formation of interconnected ionic aggregates through synergistic H δ+ − O δ− hydrogen bonding with anions and coordination interactions with Li⁺, thereby accelerating interfacial kinetics and suppressing parasitic reactions. The electrolyte further enables weakly coordinating solvents to engage in the solvation sheath via non-classical hydrogen bonding, facilitating the formation of a robust, inorganic-rich solid electrolyte interphase. This design enables the realization of high-capacity (14 Ah) Li ‖ Ni95 pouch cells, which achieve a specific energy of 606.8 Wh kg −1 while maintaining 92.9% capacity retention after 75 cycles at rates of 0.1 C/0.2 C. These findings demonstrate a viable electrolyte strategy for enabling high-performance lithium metal batteries under practical conditions.
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MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 7
·1-7
·
IF 5.3
Wang Shirong,Wei Zaiwa,Li Liangxian,Luo Yu,Huang Zhimei,Yang Xing,Tang Yafang
CRISPR-Cas12a with robust trans-cleavage activity were employed to mitigate background fluorescence signal, achieving sensitive detection of miRNA-21. The activation of trans-cleavage activity of Cas12a was achieved by utilizing cDNA as a trigger. Upon the presence of target miRNA-21, cDNA hybridizes with it forming a DNA/RNA double-stranded structure. Exonuclease III (ExoIII) facilitates the degradation of cDNA, releasing the target for subsequent cycles. Due to cDNA degradation, the trans-cleavage activity of Cas12a remains unactivated and does not disrupt the synthesis template of copper nanoparticles. Addition of Cu 2+ and AA leads to the formation of highly fluorescent copper nanoparticles. Conversely, in absence of miRNA-21, intact cDNA activates trans-cleavage activity of Cas12a, resulting in degradation of the synthesis template and failure in synthesizing fluorescent copper nanoparticles. This method exhibits excellent selectivity with a low limit of detection (LOD) at 5 pM. Furthermore, we successfully applied this approach to determine miRNA-21 in cell lysates and human serum samples, providing a new approach for sensitive determination of biomarkers in biochemical research and disease diagnosis. Graphical Abstract
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产品关联
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Journal of Food Measurement and Characterization
·
2023
·Vol. 17
·期 4
·3918-3926
·
IF 3.4
Xu Lingfeng,Zou Ying,Wu Kui,Han Runlin,Huang Yanrong,Yi Xiuguang
Effective and non-invasive inspection method toward viscosity is expected to ease the burden of continued increased health problems worldwide. Herein, we proposed that viscosity is one of the most important markers in the liquid microenvironment. Then, a natural product was further developed from resveratrol derivate, polydatin, as an activatable molecular sensor for monitoring liquid micro-environmental viscosity alterations for metamorphic extent determination. This natural molecular sensor was constructed by the single double bond alternating conjugate structure, which can rotate freely in the low viscosity media, and in the highly viscous media, bright fluorescent signals are specifically activated (around 383 nm, 53-fold), endowing the natural sensor with the capacity to avoid autofluorescence from the additives and achieving high signal-to-noise ratio imaging. With the lower detection limit 1.125 cP, the sensor polydatin exhibits higher viscosity sensitive coefficient (0.60), and 75.5 nm of Stokes shift was found in the distilled water. Afterward, polydatin achieved non-invasively identifying the thickening effects of food thickeners. In addition, the capability of polydatin to evaluate the deterioration extent of liquids with viscosity as a robust marker was explored. It was found that the viscosity level in microenvironments is highly dependent on the liquid food metamorphic period. The fluorescent intensity increment and viscosity value changes were fitted into a linear equation. We expected that this approach would reinvigorate the fluorescent analytical methods toward liquid safety inspection.
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危险品化学品经营许可证（带存储）