FOOD HYDROCOLLOIDS
·
2024
·
IF 11
Hao Xu,Qianhan Ma,Chao Qiu,Jinpeng Wang,Zhengyu Jin,Yao Hu
Low aqueous dispersibility and poor stability severely restrict the bioaccessibility of curcumin in health-related products. Constructing highly effective delivery carriers is essential to overcome the limitation. In this study, a novel and simple self-assembly process driven by electrostatic interaction was developed to prepare cyclodextrin succinate/chitosan (SACD/CS) nanoparticles. Spherical SACD/CS nanoparticles were obtained by adjusting the ratio of SACD:CS to obtain an average size and ζ-potential of around 500 nm and 20 mV, respectively. By analyzing the intermolecular interactions and crystalline structure of SACD/CS nanoparticles, it is indicated that SACD could act as crosslinking nodes, and contributed to transformation of molecular arrangement in the nanoparticles. The noncytotoxic SACD/CS nanoparticles were further used as curcumin carriers and showed significant improvement on curcumin stability, with the retention index of curcumin under physiological conditions increased from 19% to 62%. Moreover, the Cur-SACD/CS nanoparticles displayed controlled release behavior of curcumin during in vitro digestion, with 9%, 22%, and 44% of curcumin released at the end of the oral, stomach, and small intestine stage, respectively. This study developed a novel and effective strategy for oral delivery of curcumin, showing promising potential for improving the bioaccessibility and bioavailability of bioactive compounds like curcumin.
✓ 已验证
产品关联
DOI
高影响因子
Marine Drugs
·
2024
·Vol. 22
·期 10
·443
·
IF 4.9
Hengjie Su,Xiaoqi Chen,Linna Mao,Ting Li
The electrospinning of pure chitosan nanofibers is highly sensitive to environmental humidity, which limits their production consistency and applicability. This study investigates the addition of sodium chloride (NaCl) to chitosan solutions to enhance spinnability and mitigate the effigurefects of low humidity. NaCl was incorporated into the electrospun chitosan solution, leading to increased conductivity and decreased viscosity. These modifications improved the electrospinning process. Comparative analyses between chitosan membranes (CM) and sodium-chloride-added chitosan membranes (SCM) revealed no significant differences in chemical structure, mechanical strength, or in vitro cell proliferation. This indicates that the addition of 1% (w/v) NaCl does not adversely affect the fundamental properties of the chitosan membranes. The findings demonstrate that NaCl addition is a viable strategy for producing electrospun chitosan nanofibers in low-humidity environments, maintaining their physicochemical properties while enhancing spinnability.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD HYDROCOLLOIDS
·
2024
·
IF 11
Qianzhu Lin,Chenxi Wang,Zhengyu Jin,Liming Jiang,Jinsheng Wen,David Julian McClements,Chao Qiu
Liquid oils can be converted into elastic solids by preparing oleogels using an emulsion-templated approach. In this study, we prepared emulsion gels using a layer-by-layer (LBL) electrostatic deposition approach. These emulsion gels were then used as templates to prepare oleogels. Initially, oil-in-water emulsion gels were formed using glycyrrhizic acid (GA) as a natural anionic surfactant to form and stabilize the oil droplets. Cationic chitosan (CS) was then added to these emulsions to form a biopolymer coating around the oil droplets. The GA/CS ratio in these emulsion gels played a critical role in determining the physical stability of the oleogels created from them. At a sufficiently high chitosan concentration (3% CS for samples with 1% GA, 2% CS for samples with 2% GA), the emulsion gels were resistant to destabilization during drying, which was attributed to the formation of a thick chitosan coating around the oil droplets. The oil loss from the optimized oleogels (GCOs1-3, GCOs2-2, GCOs2-3) during drying was relatively low (0.41%–1.08%), indicating their strong oil binding capacity. In contrast, non-optimized oleogels (2% GA, 1% CS) were prone to droplet coalescence and oil loss (74.2% ± 1.3%) during drying. The optimized oleogels (GCOs1-3, GCOs2-2, GCOs2-3) all had relatively high storage modulus (∼150 kPa) at a frequency of 1 rad/s. Overall, the interfacial engineering strategy used in this study may be useful for converting liquid oils into semi-solid materials, which may be useful for several applications in the food and other industries.
✓ 已验证
产品关联
DOI
高影响因子
Food Packaging and Shelf Life
·
2024
·
IF 8.5
Mei Bao,Honglei Mu,Ben Niu,Ruiling Liu,Huizhi Chen,Hangjun Chen,Lishu Wang,Yanchao Han,Guannan Wang,Haiyan Gao
2 The bioplastic film polyvinyl alcohol (PVA) /chitosan (CS), i.e., PC, formed by blending PVA with CS, exhibits excellent antioxidant properties and biodegradability. However, it lacks ultraviolet (UV) blocking ability, limiting its capacity to protect adipose-rich foods from photo-oxidation. Lignin possesses remarkable UV shielding ability that inhibits food photo-oxidation and extends shelf-life. However, the dark brown color of lignin negatively impacts the film color and transparency. To address these restrictions, this study incorporated acetylated lignin (ALG) loaded with halloysite nanotubes (HNTs) into conventional PC films (PC-HALG), resulting in a significant reduction in the color intensity of the film by almost 255.3 %, i.e., almost being colorless. The UV-A and UV-B shielding capacities of the PC films were increased by 1347 % and 617 %, respectively. Thus, ALG provided the PC films with excellent UV shielding capacity while reducing their color intensity and maintaining high transparency. Additionally, the loading of HNTS reduced lignin agglomeration, contributing to the improvement in transparency and enhancement of UV shielding effects in PC films. Furthermore, the PC-HALG film retained and even enhanced the biodegradability of the PC film, which exhibited degradability within one week. Freshness preservation experiments confirmed that the oxidation of pecan oil covered with the PC-HALG film under UV irradiation was reduced by 81.3 %–92.2 %. These findings suggest that this bioplastic film can be used in visually displaying food products while preventing their photo-oxidation. Mechanical properties, thermal stability, barrier properties, and antioxidant properties of the developed PC-HALG film were also characterized.
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Xueyan Li,Changlong Bi,Yuanfei Wang,Chong Peng,Yun Li,Shuyi Yang,E. Tao
To address the pH limitations of traditional Cr(VI) adsorbents, converting Cr(VI) anions into the more stable Cr(III) cations through a reduction reaction is an effective strategy. Therefore, in this study, gallic acid (GA), with a high redox potential, was selected as the reducing agent, together with chitosan (CS) as the substrate, and sodium alginate (SA) as the gelling agent. A novel SCG composite material was successfully prepared using the sol-gel crosslinking method, which efficiently captured and reduced Cr(VI) while immobilizing Cr(III). At pH = 4, t = 150 min, and T = 30 °C, 1 g/L of SCG can remove 94.7 % of Cr(VI), with a reduction rate of 67.5 %, achieving efficient and stable Cr(VI) removal over a wide pH range. Furthermore, the SCG material demonstrated good pH adaptability (It can still remove 84 % of Cr(VI) at pH = 7) and practical applicability. Comparative experiments and DFT calculation results showed that the introduction of GA not only helped form a more compact network structure but also interacted synergistically with CS, significantly promoting the removal of Cr(VI). In conclusion, the SCG composite material provides a new approach for the treatment of Cr(VI)-contaminated wastewater.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Mengxin Zhao,Yifu Liu,Chunhua Yin
Gold nanorods (AuNR) have received significant attention in tumor thermo-chemotherapy. However, insufficient thermal availability limits the in vivo highly efficient applications of AuNR in photothermal therapy. In this study, we have fabricated N-isopropylacrylamide grafted O -carboxymethyl chitosan nanoparticles (NCMC NPs) with thermo-responsive properties for co-encapsulating AuNR and doxorubicin (DOX), forming AuNR@NCMC/DOX nanocomposites (NCs). As a result of the thermo- and photothermal-responsiveness, AuNR@NCMC/DOX NCs exhibited irreversible aggregation at high temperature and under near-infrared (NIR) irradiation with an increase of size to 3 μm. When AuNR@NCMC/DOX NCs reached tumor sites following intravenous administration, they were located in the tumor vessels under NIR irradiation due to an embolization effect. This response enhanced tumor targeting, on-demand release, and the thermal performance of AuNR@NCMC/DOX NCs. We have observed higher tumor accumulation of DOX and AuNR with subsequent stronger inhibition of tumor growth than that achieved without NIR irradiation. The development of AuNR-based NCs with multiple smart responsivenesses at tumors can provide a promising paradigm for solid tumor treatment via the cooperative effects of photothermal therapy and chemoembolization.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Polymer Materials
·
2024
·
IF 4.4
Yarui Hou,Xiaohui Wang,Changli Ma,Zeqi Liu,Ran Li,Yiyuan Fan,He Cheng,Bin Yang,Kai Li,Qingye Liu
Crystalline aggregates are widely present in various organisms. Regulation of nanostructures is of vital importance to the revelation of life secrets as well as material fabrication. As a representative, chitosan displays polymorphic structures. In tendon chitosan, four polymer chains are packed into an orthorhombic cell, where the antiparallel neighboring chains are linked by two sets of N2···O6 hydrogen bonds, and water molecules are connected with N2, O3, and O5 as well as O6 atoms via hydrogen bonds to stabilize the hydrated structure. The transition from hydrated to anhydrous allomorphs, however, usually involved high-temperature annealing or multistep concentrated acid hydrolysis, which weakened the sustainability of chitosan. To address these issues, we proposed a more convenient strategy to achieve the polymorphic transitions under mild conditions. By subjecting chitosan microgels (CSM) to normal freezing treatment, the hydrated aggregates could be transferred into the anhydrous form. The X-ray diffraction (XRD) results clearly demonstrated that both the (020) and (200) diffraction peaks centered at 2θ = 10 and 19.8° gradually disappeared, while the (110) peak at 2θ = 14.8° indicated the occurrence of anhydrous crystals. Upon freezing, the water molecules that were inserted into the hydrated crystals were removed. Meanwhile, under the effects of N2···O6 intermolecular hydrogen bonding and hydrophobic association, the adjacent polymer chains reorganized into new microcrystalline domains. Moreover, the CSM particles exhibited a strong tendency for self-association during this process. By introducing CSM into the oil/water mixture system to form a Pickering emulsion, the resultant macroporous materials could be used as the oil absorbent through subsequent lyophilization. This work provides a different way to facilely regulate the microcrystalline structure of chitosan in a controllable manner, facilitating the construction of more functional materials.
✓ 已验证
产品关联
DOI
高影响因子
FOOD HYDROCOLLOIDS
·
2024
·
IF 11
Xuemei Sun,Huiyan Wang,Han Liang,Na Meng,Ninglin zhou
In this study, ZnO nanoparticles (ZnONPs) were loaded on lecithin-montmorillonite (LEC-Mt) and incorporated into chitosan (CS) for purpose of developing novel food packaging films. The performances of CS@ZnONPs/LEC-Mt films were investigated by X-ray diffraction (XRD), Fourier transform infrared spectrum (FTIR), Ultraviolet spectrum (UV), thermogravimetric analysis (TGA), scanning electron microscope (SEM) and energy dispersive X-ray (EDX) spectroscopy. In addition, the water-resistance performance, mechanical properties and antibacterial activity were studied. An appropriate increase of ZnONPs/LEC-Mt contents (3 wt% and below) could achieve a remarkable enhancement in elongation at break (E)and tensile strength (TS). Meanwhile, the moisture vapor transmission rate (MVTR) and moisture content (MC) of the CS@ZnONPs/LEC-Mt films also decreased with the incorporation of ZnONPs/LEC-Mt, which was beneficial for food preservation. CS@ZnONPs/LEC-Mt films manifested lower light transmission, MC (from 35.36% to 26.01%) and MVTR (from 0.2012 g∙m -2 ∙24 h -1 to 0.1717 g∙m -2 ∙24 h -1 ) values than those of CS film. Furthermore, CS@ZnONPs/LEC-Mt films possess a certain antibacterial activity against Escherichia coli and Staphylococcus aureus . Due to its good UV light barrier properties, mechanical properties and antibacterial property, CS@ZnONPs/LEC-Mt films showed its great potential in designing packaging films
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
·
2025
·Vol. 36
·期 1
·1-11
·
IF 4.5
Wang Yu-mei,Xin Tong,Deng Hao,Chen Jie,Tang Shen-lin,Liu Li-sheng,Chen Xiao-liang
Human hair keratin, a natural protein derived from human hair, has emerged prominently in the field of wound repair, showcasing its unique regenerative capabilities and extensive application potential. However, it is a challenge for the keratin to efficiently therapy the impaired wound healing, such as combined radiation-wound injury. Here, we report a keratin/chitosan (KRT/CS) film for skin repair of chronic wounds in in rats with combined radiation-wound injury. In brief, the KRT/CS film was characterized by scanning electron microscopy (SEM), mechanical property analysis, water absorption, and swelling analysis. A rat model of combined radiation-wound injury was employed to evaluate the therapeutic efficacy of the KRT/CS film. Finally, the systemic biotoxicity of KRT/CS film was assessed through histological analysis. The surface of KRT/CS film was uniform and smooth compared with the KRT film, and the mechanical property, swelling rate and water absorption rate of KRT/CS film were significantly improved, which can meet the application requirements of wound excipient dressing. Furthermore, the combined radiation-wound injury in rats was established that the wound closure rate was achieved 74.46% after 14 days of treatment with KRT/CS film, comparing to the single KRT membrane and commercially available Band-Aids. Histological analysis demonstrated that the amount of angiogenesis and collagen deposition in wounds treated with KRT/CS were significantly improved. These findings demonstrate the KRT/CS film as a promising therapeutic agent for combined radiation-wound injury. Graphical
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yunchang Fan,Qiang Zhou,Sheli Zhang,Yanhe Nie
Thiosulfate has been considered as a more environmentally-friendly alternative to cyanide salts for the extraction of gold from gold ores and the development of affordable, green and efficient adsorbents for the isolation of gold-thiosulfate complex (Au(S 2 O 3 ) 2 3− ) from the leaching solution remains a significant challenge. To address this issue, chitosan, a natural macromolecule , was selected as a carrier and chemically modified with ionic liquids . The ionic liquids modified chitosan showed greater adsorption capacity towards Au(S 2 O 3 ) 2 3− compared with pristine chitosan. The adsorption of Au(S 2 O 3 ) 2 3− on ionic liquid modified chitosan followed Freundlich isotherm and pseudo-second order kinetic models, involving an anion-exchange mechanism with liquid film diffusion as the rate-limiting step. The chitosan modified with butylimidazolium-based ionic liquid had an adsorption capacity of 5.0 mg g −1 for gold (10 mg L −1 of gold, pH 6, 2 g L −1 of adsorbent dosage), outperforming other reported adsorbents. The ionic liquid modified chitosan showed a high adsorption efficiency of up to 96.7 % for Au(S 2 O 3 ) 2 3− in an actual thiosulfate leaching solution with a desorption efficiency of 98.4 %, suggesting that the ionic liquid modified chitosan has the potential to be a eco-friendly, biocompatible and effective adsorbent for the recovery of Au(S 2 O 3 ) 2 3− .
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Frontiers in Bioscience-Landmark
·
2025
·Vol. 30
·期 1
·26299
·
IF 3.1
Zeliang Zhang,Wei Shang,Lisong Lin
Background:In this study, we prepared a porous gradient scaffold with hydroxyapatite microtubules (HAMT) and chitosan (CHS) and investigated osteogenesis induced by these scaffolds.Methods:The arrangement of wax balls in the mold can control the size and distribution of the pores of the scaffold, and form an interconnected gradient pore structure. The scaffolds were systematically evaluated in vitro and in vivo for biocompatibility, biological activity, and regulatory mechanisms.Results:The porosity of the four scaffolds was more than 80%. The 50% and 70% HAMT-CHS scaffolds formed an excellent gradient pore structure, with interconnected pores. Furthermore, the 70% HAMT-CHS scaffold showed better anti-compressive deformation ability. In vitro experiments indicated that the scaffolds had good biocompatibility, promoted the expression of osteogenesis-related genes and proteins, and activated the oxidative phosphorylation pathway to promote bone regeneration. Eight weeks after implanting the HAMT-CHS scaffold in rat skull defects, new bone formation was observed in vivo by micro-computed tomographic (CT) staining. The obtained data were statistically analyzed, and the p-value < 0.05 was statistically significant.Conclusion:HAMT-CHS scaffolds can accelerate osteogenesis in bone defects, potentially through the activation of the oxidative phosphorylation pathway. These results highlight the potential therapeutic application of HAMT-CHS scaffolds.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Science China-Materials
·
2025
·
IF 7.4
Huang Lin,Wang Wantao,Liu Lei,Ma Wenzheng,Fan Jinghao,Zhou Dan,Zhao Lei,Zheng Zhaomin,Liu Hongmei,Wu Decheng
The treatment of intervertebral disc (IVD) degeneration remains a significant challenge due to the unique ischemic structure of the IVD, which comprises the scavenging of inflammatory cytokines, alleviation of cellular oxidative stress responses, restoration of nuclei pulposus (NP) cell viability, and recovery of IVD biomechanical function. Herein, we developed an injectable microsphere (CS-MnO 2 @PC) by incorporating chitosan microspheres (CS) with manganese dioxide (MnO 2 ) nanozymes and celecoxib encapsulated in Pluronic F-127 (PC) nanosized micelles, via in situ redox or Schiff base reaction. The hybrid carrier demonstrates robust capabilities in scavenging free radicals, alleviating extracellular oxidative stress, and reducing inflammatory cytokines in NP cells, as evidenced by RT-qPCR and immuno-fluorescence staining assays. In vivo evaluations further indicate that this hybrid carrier helps preserve NP hydration and the lamellar structure of the annulus fibrosus (AF), as confirmed by radiological analysis and histological staining evaluations. These injectable chitosan microspheres, combining nanozymes and nanosized drug micelles, represent a promising therapeutic strategy for degenerative IVD.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）