Micro & Nano Letters
·
2021
·Vol. 16
·期 6
·336-343
·
IF 1.102
Hang Hu,Defeng Xu
In the present work, docetaxel (DTX) and retinoic acid (RA) co-loaded micelles were developed for synergistic prostate cancer therapy. PEG-RA and RA-PEG-RA were synthesized and subsequently used for loading of DTX and RA. The as prepared DTX/RA@RA-PEG-RA micelles exhibit smaller size and higher drug loading capacity as compared to DTX/RA@PEG-RA micelles. The in vitro drug release study shows that DTX/RA@PEG-RA and DTX/RA@RA-PEG-RA micelles exhibit similar drug release behaviours in which DTX exhibits fast release and RA exhibits sustained release. Nile red (NR) was loaded into PEG-RA and RA-PEG-RA micelles to investigate the cellular uptake of the micelles by fluorescence microscope and flow cytometry. The results show that NR@RA-PEG-RA micelles exhibit slightly enhanced cellular uptake as compared to NR@PEG-RA micelles. The cellular uptake of DTX/RA@PEG-RA and DTX/RA@RA-PEG-RA micelles determined by HPLC also show similar results. In in vitro cytotoxicity against C4-2 and 22Rv1 cells, DTX in combination with RA exhibit synergistic antitumor effect, and DTX/RA@PEG-RA and DTX/RA@RA-PEG-RA micelles exhibit enhanced cytotoxicity against C4-2 cells and similar cytotoxicity against 22Rv1 cells as compared to DTX/RA. DTX/RA@PEG-RA and DTX/RA@RA-PEG-RA micelles show significant potential for prostate cancer therapy.
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CATALYSIS LETTERS
·
2020
·Vol. 151
·期 6
·1796-1804
·
IF 2.482
Wang Haiyan,Zhang Yating,Yan Fangfang,Zhang Hucheng
Abstract The biorenewable alcohols are identified as the promising energy in fuel cells, but the lack of efficient catalysts limits the electricity output. Here, we chemically grew the PdAg alloy nanoparticles (NPs) on reduced graphene oxide (RGO) to obtain Pd x Ag y (m)/RGO, and investigated the dependences of peak current densities on the metal loadings (m), Pd mole fractions (x), and sizes. The maximal peak currents of 1.86, 4.88, 14.3 and 13.6 × 10 4 mA cm −2 mg Pd −1 were respectively achieved in the electrooxidation reactions of methanol, ethanol, ethylene glycol and glycerol. It is shown that the interactions of PdAg NPs with RGO can control the catalytic efficiencies through mediating the electronic characteristics of metal NPs and the reactant absorptions. Except the catalysts for methanol oxidation reaction, the efficient catalysis possesses the same lattice structure in PdAg alloys with the optimized m, and gives a common descriptor to select the catalyst with high catalytic activity. Graph Abstarct
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Polymer Crystallization
·
2020
·Vol. 3
·期 5
·e10158
·
IF 0
Xiang Li,Xiaolei Dong,Jiale Zhou,Jianna Bao,Shichang Chen,Wangyang Lu,Xianming Zhang,Wenxing Chen
The end group modification of hydrogen bonding units has a significant effect on physical properties of covalent linked polymers. In this study, telechelic poly(ethylene glycol)s (PEG) with various molecular weights were functionalized by thymine (Thy), which was able to form self-complementary double hydrogen bonding. The physical properties of Thy-functionalized PEGs, including viscosity in solution or melt state, crystallization behavior, crystalline structure as well as lamellar structure were systemically investigated by comparison with hydroxyl-terminated PEGs. Crystallinity and melting temperature of linked PEG chains were decreased by the presence of Thy groups and the depression effects were strengthened by increase of Thy content. Crystallization rate and temperatures at which crystallization occurred were more complicated. Lower crystallization rate was obtained for Thy-functionalized PEGs with highest Thy content, a signature for confined crystallization by covalent links to Thy groups. However, in the case of moderate Thy content, the trend of crystallization rate was shifted to lower temperature regions, where the maximum and minimum of crystallization rates were comparable with free polymer chains. For Thy-functionalized PEGs with low Thy content, crystallization rates were similar with that of non-functionalized PEGs. The differences in supercoolings might give explanation on differences in crystallization behaviors among three conditions.
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Journal of Physical Chemistry C
·
2020
·
IF 4.189
Qiang Zhang,Zengsheng Weng,Kun Wu,Weilong Chen,Mangeng Lu
Two kinds of thiophene monomers (thiophene and thiophene carboxylic acid) are used to synthesize a series of polythiophene matrix materials with different ratios. Polythiophene carboxylic acid can form strong hydrogen bonds between molecules, and the conjugated thiophene ring can be used to obtain higher thermal conductivity. The core–shell structure of polythiophene-coated polyethylene glycol and nano zinc oxide was synthesized by in situ polymerization to form a shaped phase change composite. The electron micrograph shows this phenomenon very well. Comparing the thermal conductivity and heat storage performance of two different polythiophene matrix composites, it can be explained that the chemical interaction between molecules is conducive to the formation of heat conduction pathways. Thermal decomposition temperature of polythiophene carboxylic acid and its polyethylene glycol composite structure is about 10 °C higher than that of polythiophene, which, on the other hand, also indicates the tight molecular arrangement. It is derived from the differentiation of its molecular structure, and this compact structure plays a positive role in the improvement of its thermal conductivity. However, excessive intermolecular force hinders the regular arrangement of polyethylene glycol. Under the condition that the amount of thermal conductive filler is 25%, the thermal conductivity is increased from 0.895 to 1.05 W · m–1k–1 and the phase transition is decreased from 149 J/g to less than 135 J/g. Finally, the stability of the shaped phase change composite was good, the solid form was maintained near the phase transition temperature, and no leakage was observed.
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BIOMACROMOLECULES
·
2020
·
IF 6.092
Chao Chen,Ying Tian,Fenglong Li,Han Hu,Kai Wang,Zhengyang Kong,Wu Bin Ying,Ruoyu Zhang,Jin Zhu
Polylactic acid (PLA) is a biodegradable thermoplastic polyester produced from natural resources. Because of its brittleness, many tougheners have been developed. However, traditional toughening methods cause either the loss of modulus and strength or the lack of degradability. In this work, we synthesized a biobased and potentially biodegradable poly(butylene 2,5-furandicarboxylate)-b-poly(ethylene glycol) (PBFEG50) copolymer to toughen PLA, with the purpose of both keeping mechanical strength and enhancing the toughness. The blend containing 5 wt % PBFEG50 exhibited about 28.5 times increase in elongation at break (5.5% vs 156.5%). At the same time, the tensile modulus even strikingly increased by 21.6% while the tensile strength was seldom deteriorated. Such a phenomenon could be explained by the stretch-induced crystallization of the BF segment and the interconnected morphology of PBFEG50 domains in PLA5. The Raman spectrum was used to identify the phase dispersion of PLA and PBFEG50 phases. As the PBFEG50 content increased, the interconnected PBFEG50 domains start to separate, but their size increases. Interestingly, tensile-induced cavitation could be clearly identified in scanning electron microscopy images, which meant that the miscibility between PLA and PBFEG50 was limited. The crystallization of PLA/PBFEG50 blends was examined by differential scanning calorimetry, and the plasticizer effect of the EG segment on the PLA matrix could be confirmed. The rheological experiment revealed decreased viscosity of PLA/PBFEG50 blends, implying the possible greener processing. Finally, potential biodegradability of these blends was proved.
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PubMed
高影响因子
ADVANCED ENGINEERING MATERIALS
·
2020
·Vol. 22
·期 8
·2000162
·
IF 3.217
Qingxiao Meng,Jianyong Feng,Huiting Huang,Xiaopeng Han,Zhi Zhu,Tao Yu,Zhaosheng Li,Zhigang Zou
Both phase and morphology of perovskite films are very important for high-performance optoelectronic devices. Although a two-step method based on CsBr ethylene glycol monomethylether (EGME) solution can prepare pure-phase CsPbBr 3 films, they have a poor morphology due to excessive Ostwald ripening. Herein, a bi-solvent engineering strategy is demonstrated to simultaneously optimize phase and morphology of CsPbBr 3 films in a two-step solution method, which uses the bi-solvents of EGME and isopropanol (IPA) instead of EGME for CsBr solution at the second step. Optimizing the volume ratio of bi-solvents and immersion time can control the Ostwald ripening effectively and result in pure-phase, compact, and smooth CsPbBr 3 films. Finally, the prepared films are applied to perovskite solar cells (PSCs) with a structure of fluorine-doped tin oxide (FTO)/compact TiO 2 (c-TiO 2 )/CsPbBr 3 /carbon. In comparison with EGME, the champion power conversion efficiency (PCE) of devices from EGME/IPA bi-solvents increases from 3.57% to 7.29% owing mainly to higher coverage, smoother surface, and lower trap density of CsPbBr 3 films from EGME/IPA bi-solvents. This work provides a simple and efficient method for the preparation of high-quality CsPbBr 3 films.
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POLYMER DEGRADATION AND STABILITY
·
2020
·
IF 4.032
Shuo Fan,Chenchen Zhu,Dequn Wu,Xueli Wang,Jianyong Yu,Faxue Li
An inherent flame-retardant PA6 (FR-PA6) containing polydiphenylsiloxane (PDPS) was synthesized under the action of ethylene glycol (EG) via a facile “2-step” bulk polymerization. Inspiringly, EG acted not only as a ‘chain-linker’ to connect PA6 oligomer with PDPS moiety but also as a charring agent to increase the charring capacity of FR-PA6 after combustion. The prepared FR-PA6 reached 28.3% of limiting oxygen index (LOI), and passed the V-0 level of UL94 test with suppressed melt-dripping. After investigating the char residues and pyrolysis volatiles of FR-PA6 after combustion, the formation of silicon-rich protective layer was proved to be the essential factor to increase the flame retardancy of FR-PA6 via reducing the diffusion of pyrolysis volatiles, restricting the heat transfer and mass loss as well as preventing polymer melts from dripping. This work thus makes a worthwhile contribution to the development of FR-PA6 by offering a novel route that is easily accessible to industrial fabrication.
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JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2021
·
IF 3.517
Hongdan Shen,Quan Liu,Deju Liu,Shasha Yu,Xiao Wang,Mingbo Yang
The purpose of this study was to develop a novel drug-polymer conjugation (mPEG-b-PCL-DOX) and study on its toxicity, bio-safety, and in vitro antitumor activity of mPEG-b-PCL-DOX. The polymer methoxy poly(ethylene glycol)-block-poly(ε-caprolactone) (mPEG-b-PCL) was prepared by ring-opening polymerization. Then, succinic anhydride was reacted with mPEG-b-PCL via esterification reaction to produce mPEG-b-PCL-COOH. Finally, the polymer mPEG-b-PCL-DOX was obtained by conjugating DOX to mPEG-b-PCL-COOH by amidation. The Fourier transform infrared spectroscopy (FTIR) and 1H nuclear magnetic resonance (1H NMR) spectra were used to study the structures of obtained polymers. Transmission electron microscope (TEM) and Dynamic laser scattering (DLS) were employed to monitor the morphology and size distribution of mPEG-b-PCL-DOX nanoparticles (NPs). The mPEG-b-PCL-DOX NPs were administrated to KM rats by intraperitoneal injection to study the bio-safety of final NPs. The cell uptake and in vitro anti-tumor activity of final NPs were carried out with HCT116 cells as models. FTIR and 1H NMR spectra confirmed the obtaining of mPEG-b-PCL-DOX. The fabricated NPs were in round shapes with an average diameter of 300 nm. These NPs did not induce hemolysis and physiological or pathological changes in rats’s organs. Finally, cell teats showed that these NPs could be endocytosed by HCT 116 cells, and they had better anti-tumor effects than free DOX did. Therefore, the mPEG-b-PCL-DOX NPs had a potential application in anti-cancer therapy.
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PubMed
高影响因子
Journal of Materials Chemistry B
·
2021
·Vol. 9
·期 31
·6201-6211
·
IF 6.331
Jieqi Xie,Kangmi Shen,Honghao Zheng,Yuejun Yao,Yicheng Chen,Changyou Gao
Selective adhesion and migration of urethral epithelial cells (HUCs) over fibroblasts (FIBs) are very important in the reconstruction of the urethral epithelial layer and prevention of ureteral scarring and stenosis. In this study, unsaturated polyurethane (PPFU-CO-SS) films were co-grafted with a cell-resisting poly(ethylene glycol) (PEG) layer and HUC-selective Cys-Ala-Gly (CAG) peptides, whose physicochemical changes were confirmed by X-ray photon spectroscopy, fluorescence spectroscopy and water contact angle measurements. The adhesion and activation of platelets on the PEG/CAG grafted surface were significantly reduced compared to those on the PPFU-CO-SS, resulting in a similar status as that on a PEG-grafted surface. The HUC-selective material could obviously promote the adhesion and migration of HUCs. The ratio of the urethral epithelial cells to fibroblasts on the PEG/CAG grafted surface was nearly 3-fold that on the unmodified PPFU-CO-SS in a co-culture competitive environment. The urethral epithelial cells cultured on the PEG/CAG grafted surface also had the highest migration rate, which was 2.24-fold compared to that on the PPFU-CO-SS control.
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PubMed
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2019
·
IF 2.298
Zhen Liu,Gui Chen,Fa Zhou,Jianhan Huang
Herein, imidazolium salt incorporated poly(N-vinylimidazole-co-ethylene glycol dimethacrylate) was developed for adsorption of Congo Red (CR) and Hg2+ from aqueous solution. By the introduction of N-vinylimidazole and p-dichloroxylene on the skeletons, this polymer contained not only ionized imidazole moieties but also plenty of mesopores, endowing the polymer with excellent adsorption of CR and Hg2+. The maximum capacity at 298 K reached 503.0 and 240.0 mg/g, respectively. The Langmuir model described the equilibrium data well, and a chemical interaction in forms of electrostatic interaction, hydrogen bonding, and chelating interaction was involved in the adsorption with adsorption enthalpies of 9.99 and 17.28 kJ/mol, respectively. The adsorption was a fast process, and less than 20 min was sufficient to attain the equilibrium with pseudo-second-order rate constants of 4.003 × 10–3 and 9.830 × 10–4 g/(mg·min), respectively.
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International Journal of Refrigeration
·
2019
·
IF 3.177
Tao Jia,Shengshan Bi,Jiangtao Wu,Panyuan Li
Experimental solubilities of difluoromethane (R32) in polyol ester (POE), polyvinylether (PVE), and polyalkylene glycol (PAG) base oils were measured in the temperatures range from 273 K to 351 K based on the isochoric method. The experimental setup was checked by measuring the solubility of carbon dioxide in n -decane at pressures from 0.1 to 4.6 MPa. The expanded uncertainty ( k = 2) of the measured solubility data was estimated to be less than 2.8%. The experimental solubility data were correlated using the Peng–Robinson (PR) equation of state (EOS) and Wilson activity coefficient model. The absolute average deviations of the experimental data and calculated values for R32 in POE, PVE, and PAG base oils were 1.74%, 0.73%, and 0.97%, respectively. The solubility of R32 in three base oil were calculated and compared at same temperatures and pressures, and the results showed that the solubility order of R32 in the three base oils was: PAG > PVE > POE.
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Frontiers of Chemical Science and Engineering
·
2018
·Vol. 12
·期 3
·457-466
·
IF 2.643
Shang Jiaojiao,Yao Guo,Guo Ronghui,Zheng Wei,Gu Long,Lan Jianwu
Biodegradable poly(ether-imide-ester) elastomers were synthesized from succinic acid, 1,4-butanediol, polyethylene glycol 1000 and N ′, N -bis(2-carboxyethyl)- pyromellitimide which was derived from pyromellitic dianhydride and glycine. The chemical structures, crystallinities, thermal stabilities, mechanical properties, hydrophilicities and biodegradabilities of these elastomers were investigated. The hard segments of the linear aliphatic poly (ether-ester) exhibited monoclinic chain packing. Increasing the amount of aromatic bisimide moieties in the poly (ether-ester) reduced the crystallinity of the material and improved the thermal stability and tensile strength of the elastomers. In addition, introducing a suitable amount of aromatic bisimide moieties into the poly(ether-ester) backbones endowed the elastomers with improved biodegradability but too many aromatic bisimide groups reduced the biodegradability of the elastomers.
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危险品化学品经营许可证（带存储）