Soft Matter
·
2015
·Vol. 11
·期 39
·7817-7826
·
IF 4.029
Caili Dai,Xuepeng Wu,Weitao Li,Qin You,Mingwei Zhao,Mingyong Du,Yifei Liu,Yuyang Li
To understand the role of electrostatic interactions and hydrogen bonds in the formation of wormlike micelles with the aid of sodium salicylate, two quaternary ammonium surfactants with the headgroup decorated by one hydroxyethyl group N-cetyl-N-(2-hydroxyethyl)dimethylammonium bromide and two hydroxyethyl groups N-cetyl-N,N-di(2-hydroxyethyl)methylammonium bromide, abbreviated as CHEMAB and CDHAB, respectively, were synthesized in this work. Single crystal X-ray diffraction was used to study the intermolecular interactions of surfactants, and 1H NMR and rheological measurements were employed to investigate the molecular arrangement and morphology of the wormlike micelles. The synergistic interactions of hydrogen bonding and more effective shielding of electrostatic repulsion contribute to the formation and viscoelastic behavior of wormlike micelles. The results also revealed the aggregation behavior of surfactants with hydroxyethyl headgroups in aqueous solutions.
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CHINESE SCIENCE BULLETIN
·
2013
·Vol. 58
·期 19
·2379-2386
·
IF 1.319
Chen YuQi,Cao Jie,Zhu HongYan,Cui SiSi,Wang AQin,Qian ZhiYu,Gu YueQing
In this study, an amphiphilic copolymer folate-succinyl-methionine-chitosan-octyl (FSMCO) was successfully synthesized step by step for self-assembling polymeric micelles. The copolymers formed micelle-like nanoparticles by their amphiphilic characteristics and structures were examined by UV-Vis absorption and Fourier transform spectroscopy. The sizes of blank and ICG derivative-loaded micelles measured by dynamic light scattering were about 170 and 140 nm, respectively, which were spherical in shape with an average zeta potential of −10 mV. Further studies on the stability showed that the micellar solutions maintain their sizes at room temperature for 1 month without distinct aggregation or dissociation. ICG derivative was much better photostable after being entrapped by the new carrier. The prepared FSMCO micelles displayed a good drug loading content (11.7%), entrapment efficiency (66.5%) and sustained release rate for the model drug fluorescein. The copolymers demonstrated weeny cytotoxicity toward Bel-7402, L02 and A549 cells when incubated for 2 d. Ligands modified micelles endowed preferable cell targeting capability and beautiful cell inhibition of HCPT-FSMCO on Bel-7402 tumor cells. This kind of polymeric micelles may be a promising nanovehicle in delivering near-infrared dyes for tumors imaging and chemotherapeutic drugs for cancer therapeutics.
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Nanoscale Advances
·
2026
·
IF 6.3
Aiyun Yang,Jie Meng,Zhiqiang Zhu,Yuanfang Lu,Xiuwei Wang,Zhen Guan,Shen Li,Haiyan Xu,Zhichao Wang,Jianhua Wang
Malignant peripheral nerve sheath tumors (MPNSTs) are fatal and highly aggressive soft tissue tumors that are associated with patients with neurofibromatosis type 1 (NF1). Traditional treatment methods have limited effects, so new treatment strategies need to be developed. Lithium carbonate (Li2CO3) is a type of psychotropic drug and has also been proven to play an important role in tumor treatment. Its nanoscale structure could achieve better therapeutic effects and reduce toxicity. In this study, we utilized MPNST cells (S462) derived from pediatric patients to develop polymeric nanomicelles loaded with Li2CO3 and determined their effects on the proliferation and apoptosis of MPNST cells and the related signaling mechanisms. The results indicated that LM significantly enhanced cellular uptake when exposed to the same concentration of extracellular Li2CO3. Free Li2CO3 inhibited cell proliferation in a concentration-dependent manner. Using a lower concentration could achieve the same or even stronger antitumor effect. The free drug and LM significantly increased the proportion of cells in the G1 and G2/M phases and inhibited the proportion of cells in the S phase (DNA synthesis phase). The effect of LM on the cell cycle was more significant compared with the free drug group. LM also significantly induced apoptosis in MPNST cells. The mechanism study revealed that LM increased the intracellular reactive oxygen species level and thereby inhibited the phosphorylation of ERK. After treatment with the antioxidant NAC, the expression of p-ERK increased, indicating that LM enhanced antitumor activity against MPNST cells by regulating the ROS–ERK signaling pathway. Our results suggested that encapsulating Li2CO3 in nanocarriers might reduce the required dosage and minimize adverse effects, which would provide a promising strategy for optimizing lithium-based therapies in MPNSTs.
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Materials Today Communications
·
2026
·
IF 4.9
Lei Nie,Xinran Li,Jingyu Li,Yanfang Sun,Guohua Jiang
Nanoparticle-reinforced composite hydrogels have been widely used for tissue engineering and biomedicine. In particular, hydrogels with multiple functionalization, such as self-healing, antibacterial, and cytocompatible properties, can facilitate their use in wound-healing and bio-adhesive applications. In this work, the multifunctional composite hydrogels were fabricated using silk fibroin (SF) and gelatin methacrylate (GelMA), incorporating silver-doped reduced graphene oxide (Ag@rGO) nanosheets and curcumin-loaded PF127 (PF127-Cur) micelles. The obtained hydrogels possessed an interconnected microstructure, good swelling properties (250–350%), and strong adhesion to the surface of different matrices, including rubber, metal, glass, plastic, wood, and finger skin. In addition, the hydrogels demonstrated self-healing, injectability, and electrical conductivity. Furthermore, the designed composite hydrogels demonstrated good antibacterial properties against the typical bacteria, Gram-positive S. aureus and Gram-negative E. coli . CCK-8 assay, fluorescent images, and cell scratch assay confirmed that the composite hydrogels exhibited excellent cytocompatibility and cell pre-migration ability. The obtained data confirmed that the designed hydrogels possessed great potential for biomedical applications, such as wound healing and bio-adhesives.
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Materials Today Bio
·
2026
·
IF 10.2
Yuxiu Wang,Haoyang Yuan,Ye Zhang,Yu Zhang,Tian Yin,Haibing He,Xing Tang,Yanjiao Wang,Jingxin Gou,Guofei Li
The immunosuppressive tumor microenvironment and poor drug targeting remain major obstacles in bladder cancer (BC) therapy. To address this, a combination strategy integrating chemotherapy and immunotherapy was employed by co-delivering epirubicin (EPI) and the immune modulator imiquimod (IMQ) using a folate-modified nanocarrier. A hydroxyethyl starch-based epirubicin prodrug modified with folic acid (FA-HES-EPI) was first synthesized to improve tumor selectivity. FA-HES-EPI/IMQ micelles were then fabricated via nanoprecipitation by encapsulating IMQ into the hydrophobic core, aiming to achieve synergistic therapeutic efficacy. Folate modification conferred tumor-targeting capability to the micelles and promoted efficient cellular uptake via folate receptor–mediated endocytosis. The acid-sensitive hydrazone bond enabled controlled release of both EPI and IMQ in the acidic tumor microenvironment, thereby enhancing their combined chemo-immunotherapeutic effects. In an orthotopic BC model, FA-HES-EPI/IMQ micelles significantly enhanced drug accumulation at the tumor site, repolarized M2-type tumor-associated macrophages (TAMs) toward the M1 phenotype, remodeled the tumor stroma, and achieved a tumor inhibition rate of 96.7 %, markedly surpassing that of FA-HES-EPI micelles (86.6 %) and free EPI (62.3 %), with negligible systemic toxicity. This pH-responsive co-delivery system represents a promising approach to improve both efficacy and safety in bladder cancer treatment.
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EUROPEAN POLYMER JOURNAL
·
2026
·
IF 6.3
Yangyang Hu,Ammara Aslam,Runsha Zhai,Yinan Zeng,Silu Wang,Haofei Yang,Anjie Dong,Jianhua Zhang
Due to the advantages of precisely spatiotemporal control and noninvasive manner, the photo-activated micelles derived from photo-responsive block copolymers have found extensive applications in controllable drug delivery systems. However, their practical utility is often constrained, due to the commercial unavailability and high difficulty in synthesis of polymerizable photosensitive monomers, tough challenge in integration of robust blood circulation ability, high toxicity of the metabolite of conventional photo-sensitive O-nitrobenzyl and azobenzene molecules. Herein, a methacryloyl-carrying, polymerizable photoacid generator (MAPDST) was synthesized and used as monomer to prepare amphiphilic photo-responsive block copolymers (PPMT) by RAFT copolymerization with acid-cleavable monomer (TTMA) in the presence of hydrophilic PEGlyated macro-RAFT agent. The structure and physicochemical characteristics of PPMT and corresponding photo-responsive micelles (PPMT NPs) were characterized. The results demonstrated that the PPMT NPs can not only have a high stability for storage and blood circulation as well as good biocompatibility, but also can quickly generate protons and thus strong acidity under UV irradiation, leading to a significant swelling and disassembly by hydrolysis of acid-cleavable TTMA segment and thus achieving a photo-switchable on–off drug release profile. This study indicated the synergistic integration of photoacid and acid-cleavable groups in polymers can provide a facile and promising strategy to endow acid-sensitive polymers and corresponding nanocarriers with desirable photo-responsiveness by photo-triggered cascade reactions. Apparently, considering the multifarious acid-sensitive groups, this new strategy can expand the substrate range of photo-responsive polymer materials and offer alternatives to develop photo-sensitive materials without the limitations associated with conventional photosensitive reagents.
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International Journal of Nanomedicine
·
2023
·
IF 8
Wen-jing Zhu,Shu-di Yang,Chen-xi Qu,Qiao-ling Zhu,Wei-liang Chen,Fang Li,Zhi-qiang Yuan,Yang Liu,Ben-gang You,Xue-nong Zhang
Multidrug resistance (MDR) is a major obstacle for the clinical therapy of malignant human cancers. The discovery of RNA interference provides efficient gene silencing within tumor cells for reversing MDR. In this study, a new “binary polymer” low-density lipoprotein–N-succinyl chitosan–cystamine–urocanic acid (LDL–NSC–SS–UA) with dual pH/redox sensitivity and targeting effect was synthesized for the co-delivery of breast cancer resistance protein small interfering RNA (siRNA) and paclitaxel (PTX). In vivo, the co-delivering micelles can accumulate in tumor tissue via the enhanced permeability and retention effect and the specific recognition and combination of LDL and LDL receptor, which is overexpressed on the surface of tumor cell membranes. The siRNA–PTX-loaded micelles inhibited gene and drug release under physiological conditions while promoting fast release in an acid microenvironment or in the presence of glutathione. The micelles escaped from the lysosome through the proton sponge effect. Additionally, the micelles exhibited superior antitumor activity and downregulated the protein and mRNA expression levels of breast cancer resistance protein in MCF-7/Taxol cells. The biodistribution and antitumor studies proved that the siRNA–PTX-loaded micelles possessed prolonged circulation time with a remarkable tumor-targeting effect and effectively inhibited tumor growth. Therefore, the novel dual pH/redox-sensitive polymers co-delivering siRNA and PTX with excellent biocompatibility and effective reversal of MDR demonstrate a considerable potential in cancer therapy.
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ChemNanoMat
·
2023
·Vol. 10
·期 3
·e202300499
·
IF 3.8
Xiaozhu Zhao,Zongxin Li,Fengchuan Guo,Naipu He,Wen Li,Xuerui Zhao
Graphical The morphology of micelles in surfactant-free emulsion was regulated by adjusting the oil-water ratio and concentration of amphiphilic copolymer. Subsequently, polymer micelles served as templates to direct the assembly of ZIF-8 crystals in the surfactant-free emulsion to fabricate polymer/ZIF-8 composite materials (ZIF-8@CSP) with various structures. An amphiphilic chitosan-g-poly N-(3-dimethylaminopropyl) methacrylamide (CS-g-PDMAPMA, CSP) was proposed and synthesized by reversible addition-fragmentation chain transfer polymerization (RAFT), and further employed as emulsifier to construct a surfactant-free emulsion. The morphology of micelles in surfactant-free emulsion was regulated by adjusting the oil-water ratio and concentration of amphiphilic copolymer. Subsequently, polymer micelles served as templates to direct the assembly of ZIF-8 crystals in the surfactant-free emulsion to fabricate polymer/ZIF-8 composite materials (ZIF-8@CSP) with various structures. Specifically, ZIF-8@CSP with various architectures such as spheres, rods, cubes, leaf-shaped flakes, cross-flowers and wrinkled cubes were obtained by varying the concentration of CSP, the addition sequence of ZIF-8 precursors and the ratio of oil-water.
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Soft Matter
·
2020
·Vol. 17
·期 5
·1437-1444
·
IF 3.14
Huijiao Cao,Wenlin Xu,Xia Guo
Wormlike micelles (or reverse wormlike micelles) are flexible cylindrical chains that are normally formed in water (or a nonpolar organic solvent) at 25.0 °C or above; the formation of wormlike micelles at lower temperatures is rare. Here, we have reported wormlike micelles formed at low temperature using an ionic liquid surfactant (1-octadecyl-3-nonyl imidazolium bromide) in polar organic solvents (including 1,3-propanediol, 1,2-propylene glycol, N,N-dimethylformamide, and glycerol/1,2-propylene glycol mixture) in the absence of any additives. The viscoelasticity and morphology of the wormlike micelles were studied using rheology, small-angle X-ray scattering, and cryo-transmission electron microscopy. The viscoelastic properties of the wormlike micelles in polar solvents are affected by the solvent type (or the weight ratio of glycerol to 1,2-propylene glycol), surfactant concentration, and temperature. Moreover, the G′ and G′′ crossover twice in the dynamic curves, which is different from the case in water. The first crossover (at low frequency) corresponds to the relaxation time for the alkyl chains to disentangle from the transient network, and the second crossover (at high frequency) is related to the segmental motion of the chains. Furthermore, the tribological performance of these wormlike micelles is investigated at low temperature. It is found that the protective film (formed by the physical adhesion of the wormlike micelles on the surface of friction disk pair) and the tribochemical reaction together lead to good antifriction and antiwear performance, which indicates the application prospects of these wormlike micelles in low-temperature lubrication.
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ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Yalei Miao,Xiaoshuang Niu,Aijun Wu,Menghan Wu,Shengzhe Jin,Panke Zhang,Wenshan Zhao,Xubo Zhao
Since block copolymers are able to self-assemble into various polymeric architectures, it is intriguing to explore a unique self-assembly strategy for polymers. Two different metallic oxides [manganese dioxide (MnO2) and zinc oxide (ZnO)] are displayed herein to demonstrate this self-assembly mechanism of polymers. In situ generation of metallic oxides induces self-assembly of block copolymers to form polymeric hybrid micelles with tunable stability in aqueous solutions. These final ZnO-cross-linked polymeric micelles exhibited a high drug loading capacity of 0.41 mg mg–1 toward doxorubicin (DOX), whereas DOX-loaded ZnO-cross-linked polymeric micelles could be broken down into Zn2+ and polymer scraps, which facilitated drug release in tumor microenvironments. Both in vitro and in vivo investigations showed that the drug-loaded ZnO-cross-linked polymeric micelles effectively suppressed tumor growth. Accordingly, the present study demonstrates a novel strategy of polymer self-assembly for fabricating polymeric architectures that can potentially provide insight for developing other polymeric architectures.
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ACS Applied Bio Materials
·
2019
·
IF 0
Beibei Lu,Zhourui Xiao,Zhenyuan Wang,Binshen Wang,Weiwei Zhao,Xing Ma,Jiaheng Zhang
Redox-responsive ferrocene (Fc)-grafted supramolecular block copolymers functionalized with hyaluronic acid (HA-g-β-CD/Fc-polymers or HAP) or folic acid (FA-g-β-CD/Fc-polymers or FAP) were synthesized by host–guest interaction. The copolymer structures were characterized by Fourier transform infrared spectroscopy, nuclear magnetic resonance, and gel permeation chromatography. The block copolymers self-assemble into spherical micellar aggregates in aqueous solution, and exhibit reversible redox characteristics in the presence of an oxidant and reductant. The tunable redox response was evaluated by transmission electron microscopy, ultraviolet–visible spectroscopy, cyclic voltammetry and dynamic light scattering. The micelles rapidly release DOX under oxidative and acidic condition in vitro. Furthermore, presence of HA and FA on the micelles enabled effective uptake by the CD44 and FA receptor-overexpressing cancer cells. Taken together, the redox responsive Fc-block copolymer micelles have good biocompatibility, biodegradability, low toxicity, and high selectivity, and are a highly promising drug delivery system for cancer therapy.
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CARBOHYDRATE POLYMERS
·
2018
·
IF 5.158
Abishek Jung Poudel,Feng He,Lixia Huang,Lin Xiao,Guang Yang
A supramolecular hydrogel system was prepared by the host-guest interaction between the α-cyclodextrin (α-CD) and poly (ethylene glycol) (PEG) chains of the poly (ethylene glycol)- block -poly (lactic acid) (PEG- b -PLA) micelles. The formation of inclusion complex (IC) crystals between α-CD and the PEG chains of the micelles was verified by different techniques. Rheological studies indicated that the gelation kinetics and the mechanical strength of the hydrogels could be modulated by the α-CD concentration. Also, the shear-thinning and self-healing properties of the hydrogels were confirmed. Doxorubicin (DOX) could be encapsulated into the hydrogels via the micelles and be released from the hydrogels sustainably, with the release rate dependent on the α-CD concentration. The released DOX showed higher inhibition efficacy against HeLa cells compared with the free drug. These attractive features, together with the superior biocompatibility, make the present hydrogels an potential injectable drug delivery system for tumour treatment.
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